4b80 - Revision history

OCA at 11:45, 20 December 2023

OCA — Wed, 20 Dec 2023 11:45:24 GMT

←Older revision		Revision as of 11:45, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='4b80' size='340' side='right'caption='[[4b80]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4b80' size='340' side='right'caption='[[4b80]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4b80]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B80 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B80 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4b80]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B80 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B80 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A36:N-[2-(DIETHYLAMINO)ETHYL]-1-(4-FLUOROPHENYL)METHANESULFONAMIDE'>A36</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P4C:O-ACETALDEHYDYL-HEXAETHYLENE+GLYCOL'>P4C</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1c2b\|1c2b]], [[1c2o\|1c2o]], [[1j06\|1j06]], [[1j07\|1j07]], [[1ku6\|1ku6]], [[1maa\|1maa]], [[1mah\|1mah]], [[1n5m\|1n5m]], [[1n5r\|1n5r]], [[1q83\|1q83]], [[1q84\|1q84]], [[2c0p\|2c0p]], [[2c0q\|2c0q]], [[2h9y\|2h9y]], [[2ha0\|2ha0]], [[2ha2\|2ha2]], [[2ha3\|2ha3]], [[2ha4\|2ha4]], [[2ha5\|2ha5]], [[2ha6\|2ha6]], [[2ha7\|2ha7]], [[2jey\|2jey]], [[2jez\|2jez]], [[2jf0\|2jf0]], [[2jge\|2jge]], [[2jgf\|2jgf]], [[2jgg\|2jgg]], [[2jgh\|2jgh]], [[2jgi\|2jgi]], [[2jgj\|2jgj]], [[2jgk\|2jgk]], [[2jgl\|2jgl]], [[2jgm\|2jgm]], [[2whp\|2whp]], [[2whq\|2whq]], [[2whr\|2whr]], [[2wls\|2wls]], [[2wu3\|2wu3]], [[2wu4\|2wu4]], [[2xud\|2xud]], [[2xuf\|2xuf]], [[2xug\|2xug]], [[2xuh\|2xuh]], [[2xui\|2xui]], [[2xuj\|2xuj]], [[2xuk\|2xuk]], [[2xuo\|2xuo]], [[2xup\|2xup]], [[2xuq\|2xuq]], [[4a16\|4a16]], [[4a23\|4a23]], [[4ara\|4ara]], [[4arb\|4arb]], [[4b7z\|4b7z]], [[4b81\|4b81]], [[4b82\|4b82]], [[4b83\|4b83]], [[4b84\|4b84]], [[4b85\|4b85]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A36:N-[2-(DIETHYLAMINO)ETHYL]-1-(4-FLUOROPHENYL)METHANESULFONAMIDE'>A36</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P4C:O-ACETALDEHYDYL-HEXAETHYLENE+GLYCOL'>P4C</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b80 OCA], [https://pdbe.org/4b80 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b80 RCSB], [https://www.ebi.ac.uk/pdbsum/4b80 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b80 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b80 OCA], [https://pdbe.org/4b80 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b80 RCSB], [https://www.ebi.ac.uk/pdbsum/4b80 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b80 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.	+	[https://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Acetylcholinesterase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Akfur, C]]	+	[[Category: Mus musculus]]
-	[[Category: Allgardsson, A]]	+	[[Category: Akfur C]]
-	[[Category: Andersson~~, C D~~]]	+	[[Category: Allgardsson A]]
-	[[Category: Berg, L]]	+	[[Category: Andersson CD]]
-	[[Category: Ekstrom, F]]	+	[[Category: Berg L]]
-	[[Category: Forsgren, N]]	+	[[Category: Ekstrom F]]
-	[[Category: Linusson, A]]	+	[[Category: Forsgren N]]
-	[[Category: Qian, W]]	+	[[Category: Linusson A]]
-	~~[[Category: Hydrolase]]~~	+	[[Category: Qian W]]
-	~~[[Category: Inhibitor~~]]	+

OCA at 07:03, 31 August 2022

OCA — Wed, 31 Aug 2022 07:03:06 GMT

←Older revision		Revision as of 07:03, 31 August 2022
Line 3:		Line 3:
	<StructureSection load='4b80' size='340' side='right'caption='[[4b80]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4b80' size='340' side='right'caption='[[4b80]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4b80]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B80 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=4B80 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4b80]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B80 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B80 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A36:N-[2-(DIETHYLAMINO)ETHYL]-1-(4-FLUOROPHENYL)METHANESULFONAMIDE'>A36</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P4C:O-ACETALDEHYDYL-HEXAETHYLENE+GLYCOL'>P4C</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A36:N-[2-(DIETHYLAMINO)ETHYL]-1-(4-FLUOROPHENYL)METHANESULFONAMIDE'>A36</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P4C:O-ACETALDEHYDYL-HEXAETHYLENE+GLYCOL'>P4C</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2b\|1c2b]], [[1c2o\|1c2o]], [[1j06\|1j06]], [[1j07\|1j07]], [[1ku6\|1ku6]], [[1maa\|1maa]], [[1mah\|1mah]], [[1n5m\|1n5m]], [[1n5r\|1n5r]], [[1q83\|1q83]], [[1q84\|1q84]], [[2c0p\|2c0p]], [[2c0q\|2c0q]], [[2h9y\|2h9y]], [[2ha0\|2ha0]], [[2ha2\|2ha2]], [[2ha3\|2ha3]], [[2ha4\|2ha4]], [[2ha5\|2ha5]], [[2ha6\|2ha6]], [[2ha7\|2ha7]], [[2jey\|2jey]], [[2jez\|2jez]], [[2jf0\|2jf0]], [[2jge\|2jge]], [[2jgf\|2jgf]], [[2jgg\|2jgg]], [[2jgh\|2jgh]], [[2jgi\|2jgi]], [[2jgj\|2jgj]], [[2jgk\|2jgk]], [[2jgl\|2jgl]], [[2jgm\|2jgm]], [[2whp\|2whp]], [[2whq\|2whq]], [[2whr\|2whr]], [[2wls\|2wls]], [[2wu3\|2wu3]], [[2wu4\|2wu4]], [[2xud\|2xud]], [[2xuf\|2xuf]], [[2xug\|2xug]], [[2xuh\|2xuh]], [[2xui\|2xui]], [[2xuj\|2xuj]], [[2xuk\|2xuk]], [[2xuo\|2xuo]], [[2xup\|2xup]], [[2xuq\|2xuq]], [[4a16\|4a16]], [[4a23\|4a23]], [[4ara\|4ara]], [[4arb\|4arb]], [[4b7z\|4b7z]], [[4b81\|4b81]], [[4b82\|4b82]], [[4b83\|4b83]], [[4b84\|4b84]], [[4b85\|4b85]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1c2b\|1c2b]], [[1c2o\|1c2o]], [[1j06\|1j06]], [[1j07\|1j07]], [[1ku6\|1ku6]], [[1maa\|1maa]], [[1mah\|1mah]], [[1n5m\|1n5m]], [[1n5r\|1n5r]], [[1q83\|1q83]], [[1q84\|1q84]], [[2c0p\|2c0p]], [[2c0q\|2c0q]], [[2h9y\|2h9y]], [[2ha0\|2ha0]], [[2ha2\|2ha2]], [[2ha3\|2ha3]], [[2ha4\|2ha4]], [[2ha5\|2ha5]], [[2ha6\|2ha6]], [[2ha7\|2ha7]], [[2jey\|2jey]], [[2jez\|2jez]], [[2jf0\|2jf0]], [[2jge\|2jge]], [[2jgf\|2jgf]], [[2jgg\|2jgg]], [[2jgh\|2jgh]], [[2jgi\|2jgi]], [[2jgj\|2jgj]], [[2jgk\|2jgk]], [[2jgl\|2jgl]], [[2jgm\|2jgm]], [[2whp\|2whp]], [[2whq\|2whq]], [[2whr\|2whr]], [[2wls\|2wls]], [[2wu3\|2wu3]], [[2wu4\|2wu4]], [[2xud\|2xud]], [[2xuf\|2xuf]], [[2xug\|2xug]], [[2xuh\|2xuh]], [[2xui\|2xui]], [[2xuj\|2xuj]], [[2xuk\|2xuk]], [[2xuo\|2xuo]], [[2xup\|2xup]], [[2xuq\|2xuq]], [[4a16\|4a16]], [[4a23\|4a23]], [[4ara\|4ara]], [[4arb\|4arb]], [[4b7z\|4b7z]], [[4b81\|4b81]], [[4b82\|4b82]], [[4b83\|4b83]], [[4b84\|4b84]], [[4b85\|4b85]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=4b80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b80 OCA], [~~http~~://pdbe.org/4b80 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4b80 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4b80 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4b80 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b80 OCA], [https://pdbe.org/4b80 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b80 RCSB], [https://www.ebi.ac.uk/pdbsum/4b80 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b80 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.	+	[[https://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 29:		Line 29:
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Lk3 transgenic mice]]
	[[Category: Akfur, C]]		[[Category: Akfur, C]]
	[[Category: Allgardsson, A]]		[[Category: Allgardsson, A]]

OCA at 08:00, 15 April 2020

OCA — Wed, 15 Apr 2020 08:00:40 GMT

←Older revision		Revision as of 08:00, 15 April 2020
Line 1:		Line 1:

	==Mus musculus Acetylcholinesterase in complex with N-(2-Diethylamino-ethyl)-1-(4-fluoro-phenyl)-methanesulfonamide==		==Mus musculus Acetylcholinesterase in complex with N-(2-Diethylamino-ethyl)-1-(4-fluoro-phenyl)-methanesulfonamide==
-	<StructureSection load='4b80' size='340' side='right' caption='[[4b80]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='4b80' size='340' side='right'caption='[[4b80]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4b80]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B80 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4B80 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4b80]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B80 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=4B80 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A36:N-[2-(DIETHYLAMINO)ETHYL]-1-(4-FLUOROPHENYL)METHANESULFONAMIDE'>A36</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P4C:O-ACETALDEHYDYL-HEXAETHYLENE+GLYCOL'>P4C</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A36:N-[2-(DIETHYLAMINO)ETHYL]-1-(4-FLUOROPHENYL)METHANESULFONAMIDE'>A36</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P4C:O-ACETALDEHYDYL-HEXAETHYLENE+GLYCOL'>P4C</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2b\|1c2b]], [[1c2o\|1c2o]], [[1j06\|1j06]], [[1j07\|1j07]], [[1ku6\|1ku6]], [[1maa\|1maa]], [[1mah\|1mah]], [[1n5m\|1n5m]], [[1n5r\|1n5r]], [[1q83\|1q83]], [[1q84\|1q84]], [[2c0p\|2c0p]], [[2c0q\|2c0q]], [[2h9y\|2h9y]], [[2ha0\|2ha0]], [[2ha2\|2ha2]], [[2ha3\|2ha3]], [[2ha4\|2ha4]], [[2ha5\|2ha5]], [[2ha6\|2ha6]], [[2ha7\|2ha7]], [[2jey\|2jey]], [[2jez\|2jez]], [[2jf0\|2jf0]], [[2jge\|2jge]], [[2jgf\|2jgf]], [[2jgg\|2jgg]], [[2jgh\|2jgh]], [[2jgi\|2jgi]], [[2jgj\|2jgj]], [[2jgk\|2jgk]], [[2jgl\|2jgl]], [[2jgm\|2jgm]], [[2whp\|2whp]], [[2whq\|2whq]], [[2whr\|2whr]], [[2wls\|2wls]], [[2wu3\|2wu3]], [[2wu4\|2wu4]], [[2xud\|2xud]], [[2xuf\|2xuf]], [[2xug\|2xug]], [[2xuh\|2xuh]], [[2xui\|2xui]], [[2xuj\|2xuj]], [[2xuk\|2xuk]], [[2xuo\|2xuo]], [[2xup\|2xup]], [[2xuq\|2xuq]], [[4a16\|4a16]], [[4a23\|4a23]], [[4ara\|4ara]], [[4arb\|4arb]], [[4b7z\|4b7z]], [[4b81\|4b81]], [[4b82\|4b82]], [[4b83\|4b83]], [[4b84\|4b84]], [[4b85\|4b85]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2b\|1c2b]], [[1c2o\|1c2o]], [[1j06\|1j06]], [[1j07\|1j07]], [[1ku6\|1ku6]], [[1maa\|1maa]], [[1mah\|1mah]], [[1n5m\|1n5m]], [[1n5r\|1n5r]], [[1q83\|1q83]], [[1q84\|1q84]], [[2c0p\|2c0p]], [[2c0q\|2c0q]], [[2h9y\|2h9y]], [[2ha0\|2ha0]], [[2ha2\|2ha2]], [[2ha3\|2ha3]], [[2ha4\|2ha4]], [[2ha5\|2ha5]], [[2ha6\|2ha6]], [[2ha7\|2ha7]], [[2jey\|2jey]], [[2jez\|2jez]], [[2jf0\|2jf0]], [[2jge\|2jge]], [[2jgf\|2jgf]], [[2jgg\|2jgg]], [[2jgh\|2jgh]], [[2jgi\|2jgi]], [[2jgj\|2jgj]], [[2jgk\|2jgk]], [[2jgl\|2jgl]], [[2jgm\|2jgm]], [[2whp\|2whp]], [[2whq\|2whq]], [[2whr\|2whr]], [[2wls\|2wls]], [[2wu3\|2wu3]], [[2wu4\|2wu4]], [[2xud\|2xud]], [[2xuf\|2xuf]], [[2xug\|2xug]], [[2xuh\|2xuh]], [[2xui\|2xui]], [[2xuj\|2xuj]], [[2xuk\|2xuk]], [[2xuo\|2xuo]], [[2xup\|2xup]], [[2xuq\|2xuq]], [[4a16\|4a16]], [[4a23\|4a23]], [[4ara\|4ara]], [[4arb\|4arb]], [[4b7z\|4b7z]], [[4b81\|4b81]], [[4b82\|4b82]], [[4b83\|4b83]], [[4b84\|4b84]], [[4b85\|4b85]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4b80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b80 OCA], [http://pdbe.org/4b80 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4b80 RCSB], [http://www.ebi.ac.uk/pdbsum/4b80 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4b80 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=4b80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b80 OCA], [http://pdbe.org/4b80 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4b80 RCSB], [http://www.ebi.ac.uk/pdbsum/4b80 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4b80 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Akfur, C]]		[[Category: Akfur, C]]

OCA at 05:59, 11 July 2018

OCA — Wed, 11 Jul 2018 05:59:46 GMT

←Older revision		Revision as of 05:59, 11 July 2018
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4b80]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B80 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B80 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4b80]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B80 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B80 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A36:N-[2-(DIETHYLAMINO)ETHYL]-1-(4-FLUOROPHENYL)METHANESULFONAMIDE'>A36</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG~~</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG~~</scene>, <scene name='pdbligand=P4C:O-ACETALDEHYDYL-HEXAETHYLENE+GLYCOL'>P4C</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A36:N-[2-(DIETHYLAMINO)ETHYL]-1-(4-FLUOROPHENYL)METHANESULFONAMIDE'>A36</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P4C:O-ACETALDEHYDYL-HEXAETHYLENE+GLYCOL'>P4C</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2b\|1c2b]], [[1c2o\|1c2o]], [[1j06\|1j06]], [[1j07\|1j07]], [[1ku6\|1ku6]], [[1maa\|1maa]], [[1mah\|1mah]], [[1n5m\|1n5m]], [[1n5r\|1n5r]], [[1q83\|1q83]], [[1q84\|1q84]], [[2c0p\|2c0p]], [[2c0q\|2c0q]], [[2h9y\|2h9y]], [[2ha0\|2ha0]], [[2ha2\|2ha2]], [[2ha3\|2ha3]], [[2ha4\|2ha4]], [[2ha5\|2ha5]], [[2ha6\|2ha6]], [[2ha7\|2ha7]], [[2jey\|2jey]], [[2jez\|2jez]], [[2jf0\|2jf0]], [[2jge\|2jge]], [[2jgf\|2jgf]], [[2jgg\|2jgg]], [[2jgh\|2jgh]], [[2jgi\|2jgi]], [[2jgj\|2jgj]], [[2jgk\|2jgk]], [[2jgl\|2jgl]], [[2jgm\|2jgm]], [[2whp\|2whp]], [[2whq\|2whq]], [[2whr\|2whr]], [[2wls\|2wls]], [[2wu3\|2wu3]], [[2wu4\|2wu4]], [[2xud\|2xud]], [[2xuf\|2xuf]], [[2xug\|2xug]], [[2xuh\|2xuh]], [[2xui\|2xui]], [[2xuj\|2xuj]], [[2xuk\|2xuk]], [[2xuo\|2xuo]], [[2xup\|2xup]], [[2xuq\|2xuq]], [[4a16\|4a16]], [[4a23\|4a23]], [[4ara\|4ara]], [[4arb\|4arb]], [[4b7z\|4b7z]], [[4b81\|4b81]], [[4b82\|4b82]], [[4b83\|4b83]], [[4b84\|4b84]], [[4b85\|4b85]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2b\|1c2b]], [[1c2o\|1c2o]], [[1j06\|1j06]], [[1j07\|1j07]], [[1ku6\|1ku6]], [[1maa\|1maa]], [[1mah\|1mah]], [[1n5m\|1n5m]], [[1n5r\|1n5r]], [[1q83\|1q83]], [[1q84\|1q84]], [[2c0p\|2c0p]], [[2c0q\|2c0q]], [[2h9y\|2h9y]], [[2ha0\|2ha0]], [[2ha2\|2ha2]], [[2ha3\|2ha3]], [[2ha4\|2ha4]], [[2ha5\|2ha5]], [[2ha6\|2ha6]], [[2ha7\|2ha7]], [[2jey\|2jey]], [[2jez\|2jez]], [[2jf0\|2jf0]], [[2jge\|2jge]], [[2jgf\|2jgf]], [[2jgg\|2jgg]], [[2jgh\|2jgh]], [[2jgi\|2jgi]], [[2jgj\|2jgj]], [[2jgk\|2jgk]], [[2jgl\|2jgl]], [[2jgm\|2jgm]], [[2whp\|2whp]], [[2whq\|2whq]], [[2whr\|2whr]], [[2wls\|2wls]], [[2wu3\|2wu3]], [[2wu4\|2wu4]], [[2xud\|2xud]], [[2xuf\|2xuf]], [[2xug\|2xug]], [[2xuh\|2xuh]], [[2xui\|2xui]], [[2xuj\|2xuj]], [[2xuk\|2xuk]], [[2xuo\|2xuo]], [[2xup\|2xup]], [[2xuq\|2xuq]], [[4a16\|4a16]], [[4a23\|4a23]], [[4ara\|4ara]], [[4arb\|4arb]], [[4b7z\|4b7z]], [[4b81\|4b81]], [[4b82\|4b82]], [[4b83\|4b83]], [[4b84\|4b84]], [[4b85\|4b85]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
Line 23:		Line 23:
	==See Also==		==See Also==
	*[[Acetylcholinesterase 3D structures\|Acetylcholinesterase 3D structures]]		*[[Acetylcholinesterase 3D structures\|Acetylcholinesterase 3D structures]]
-	*[[3D structures of acetylcholinesterase\|3D structures of acetylcholinesterase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:43, 17 January 2018

OCA — Wed, 17 Jan 2018 07:43:03 GMT

←Older revision		Revision as of 07:43, 17 January 2018
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Acetylcholinesterase\|Acetylcholinesterase]]	+	*[[Acetylcholinesterase 3D structures\|Acetylcholinesterase 3D structures]]
	*[[3D structures of acetylcholinesterase\|3D structures of acetylcholinesterase]]		*[[3D structures of acetylcholinesterase\|3D structures of acetylcholinesterase]]
	== References ==		== References ==

OCA at 19:21, 4 August 2016

OCA — Thu, 04 Aug 2016 19:21:30 GMT

←Older revision		Revision as of 19:21, 4 August 2016
Line 1:		Line 1:
		+
	==Mus musculus Acetylcholinesterase in complex with N-(2-Diethylamino-ethyl)-1-(4-fluoro-phenyl)-methanesulfonamide==		==Mus musculus Acetylcholinesterase in complex with N-(2-Diethylamino-ethyl)-1-(4-fluoro-phenyl)-methanesulfonamide==
	<StructureSection load='4b80' size='340' side='right' caption='[[4b80]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4b80' size='340' side='right' caption='[[4b80]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4b80]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B80 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B80 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4b80]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B80 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B80 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A36:N-[2-(DIETHYLAMINO)ETHYL]-1-(4-FLUOROPHENYL)METHANESULFONAMIDE'>A36</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=P4C:O-ACETALDEHYDYL-HEXAETHYLENE+GLYCOL'>P4C</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A36:N-[2-(DIETHYLAMINO)ETHYL]-1-(4-FLUOROPHENYL)METHANESULFONAMIDE'>A36</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=P4C:O-ACETALDEHYDYL-HEXAETHYLENE+GLYCOL'>P4C</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2b\|1c2b]], [[1c2o\|1c2o]], [[1j06\|1j06]], [[1j07\|1j07]], [[1ku6\|1ku6]], [[1maa\|1maa]], [[1mah\|1mah]], [[1n5m\|1n5m]], [[1n5r\|1n5r]], [[1q83\|1q83]], [[1q84\|1q84]], [[2c0p\|2c0p]], [[2c0q\|2c0q]], [[2h9y\|2h9y]], [[2ha0\|2ha0]], [[2ha2\|2ha2]], [[2ha3\|2ha3]], [[2ha4\|2ha4]], [[2ha5\|2ha5]], [[2ha6\|2ha6]], [[2ha7\|2ha7]], [[2jey\|2jey]], [[2jez\|2jez]], [[2jf0\|2jf0]], [[2jge\|2jge]], [[2jgf\|2jgf]], [[2jgg\|2jgg]], [[2jgh\|2jgh]], [[2jgi\|2jgi]], [[2jgj\|2jgj]], [[2jgk\|2jgk]], [[2jgl\|2jgl]], [[2jgm\|2jgm]], [[2whp\|2whp]], [[2whq\|2whq]], [[2whr\|2whr]], [[2wls\|2wls]], [[2wu3\|2wu3]], [[2wu4\|2wu4]], [[2xud\|2xud]], [[2xuf\|2xuf]], [[2xug\|2xug]], [[2xuh\|2xuh]], [[2xui\|2xui]], [[2xuj\|2xuj]], [[2xuk\|2xuk]], [[2xuo\|2xuo]], [[2xup\|2xup]], [[2xuq\|2xuq]], [[4a16\|4a16]], [[4a23\|4a23]], [[4ara\|4ara]], [[4arb\|4arb]], [[4b7z\|4b7z]], [[4b81\|4b81]], [[4b82\|4b82]], [[4b83\|4b83]], [[4b84\|4b84]], [[4b85\|4b85]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2b\|1c2b]], [[1c2o\|1c2o]], [[1j06\|1j06]], [[1j07\|1j07]], [[1ku6\|1ku6]], [[1maa\|1maa]], [[1mah\|1mah]], [[1n5m\|1n5m]], [[1n5r\|1n5r]], [[1q83\|1q83]], [[1q84\|1q84]], [[2c0p\|2c0p]], [[2c0q\|2c0q]], [[2h9y\|2h9y]], [[2ha0\|2ha0]], [[2ha2\|2ha2]], [[2ha3\|2ha3]], [[2ha4\|2ha4]], [[2ha5\|2ha5]], [[2ha6\|2ha6]], [[2ha7\|2ha7]], [[2jey\|2jey]], [[2jez\|2jez]], [[2jf0\|2jf0]], [[2jge\|2jge]], [[2jgf\|2jgf]], [[2jgg\|2jgg]], [[2jgh\|2jgh]], [[2jgi\|2jgi]], [[2jgj\|2jgj]], [[2jgk\|2jgk]], [[2jgl\|2jgl]], [[2jgm\|2jgm]], [[2whp\|2whp]], [[2whq\|2whq]], [[2whr\|2whr]], [[2wls\|2wls]], [[2wu3\|2wu3]], [[2wu4\|2wu4]], [[2xud\|2xud]], [[2xuf\|2xuf]], [[2xug\|2xug]], [[2xuh\|2xuh]], [[2xui\|2xui]], [[2xuj\|2xuj]], [[2xuk\|2xuk]], [[2xuo\|2xuo]], [[2xup\|2xup]], [[2xuq\|2xuq]], [[4a16\|4a16]], [[4a23\|4a23]], [[4ara\|4ara]], [[4arb\|4arb]], [[4b7z\|4b7z]], [[4b81\|4b81]], [[4b82\|4b82]], [[4b83\|4b83]], [[4b84\|4b84]], [[4b85\|4b85]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b80 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b80 RCSB], [http://www.ebi.ac.uk/pdbsum/4b80 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b80 OCA], [http://pdbe.org/4b80 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4b80 RCSB], [http://www.ebi.ac.uk/pdbsum/4b80 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4b80 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4b80" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Acetylcholinesterase\|Acetylcholinesterase]]		*[[Acetylcholinesterase\|Acetylcholinesterase]]
		+	*[[3D structures of acetylcholinesterase\|3D structures of acetylcholinesterase]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Akfur, C]]		[[Category: Akfur, C]]
	[[Category: Allgardsson, A]]		[[Category: Allgardsson, A]]

OCA at 18:41, 24 December 2014

OCA — Wed, 24 Dec 2014 18:41:01 GMT

←Older revision		Revision as of 18:41, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b80 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b80 RCSB], [http://www.ebi.ac.uk/pdbsum/4b80 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b80 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b80 RCSB], [http://www.ebi.ac.uk/pdbsum/4b80 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:14, 21 December 2014

OCA — Sun, 21 Dec 2014 09:14:20 GMT

←Older revision		Revision as of 09:14, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4b80\| PDB=4b80 \| SCENE= }}~~	+	==Mus musculus Acetylcholinesterase in complex with N-(2-Diethylamino-ethyl)-1-(4-fluoro-phenyl)-methanesulfonamide==
-	===Mus musculus Acetylcholinesterase in complex with N-(2-Diethylamino-ethyl)-1-(4-fluoro-phenyl)-methanesulfonamide===	+	<StructureSection load='4b80' size='340' side='right' caption='[[4b80]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23984975}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4b80]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B80 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B80 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A36:N-[2-(DIETHYLAMINO)ETHYL]-1-(4-FLUOROPHENYL)METHANESULFONAMIDE'>A36</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=P4C:O-ACETALDEHYDYL-HEXAETHYLENE+GLYCOL'>P4C</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2b\|1c2b]], [[1c2o\|1c2o]], [[1j06\|1j06]], [[1j07\|1j07]], [[1ku6\|1ku6]], [[1maa\|1maa]], [[1mah\|1mah]], [[1n5m\|1n5m]], [[1n5r\|1n5r]], [[1q83\|1q83]], [[1q84\|1q84]], [[2c0p\|2c0p]], [[2c0q\|2c0q]], [[2h9y\|2h9y]], [[2ha0\|2ha0]], [[2ha2\|2ha2]], [[2ha3\|2ha3]], [[2ha4\|2ha4]], [[2ha5\|2ha5]], [[2ha6\|2ha6]], [[2ha7\|2ha7]], [[2jey\|2jey]], [[2jez\|2jez]], [[2jf0\|2jf0]], [[2jge\|2jge]], [[2jgf\|2jgf]], [[2jgg\|2jgg]], [[2jgh\|2jgh]], [[2jgi\|2jgi]], [[2jgj\|2jgj]], [[2jgk\|2jgk]], [[2jgl\|2jgl]], [[2jgm\|2jgm]], [[2whp\|2whp]], [[2whq\|2whq]], [[2whr\|2whr]], [[2wls\|2wls]], [[2wu3\|2wu3]], [[2wu4\|2wu4]], [[2xud\|2xud]], [[2xuf\|2xuf]], [[2xug\|2xug]], [[2xuh\|2xuh]], [[2xui\|2xui]], [[2xuj\|2xuj]], [[2xuk\|2xuk]], [[2xuo\|2xuo]], [[2xup\|2xup]], [[2xuq\|2xuq]], [[4a16\|4a16]], [[4a23\|4a23]], [[4ara\|4ara]], [[4arb\|4arb]], [[4b7z\|4b7z]], [[4b81\|4b81]], [[4b82\|4b82]], [[4b83\|4b83]], [[4b84\|4b84]], [[4b85\|4b85]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b80 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b80 RCSB], [http://www.ebi.ac.uk/pdbsum/4b80 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The molecular interactions between the enzyme acetylcholinesterase (AChE) and two compound classes consisting of N-[2-(diethylamino)-ethyl]-benzenesulfonamides and N-[2-(diethylamino)-ethyl]-benzenemethanesulfonamides have been investigated using organic synthesis, enzymatic assays, X-ray crystallography, and thermodynamic profiling. The inhibitors' aromatic properties were varied to establish structure-activity relationships (SAR) between the inhibitors and the peripheral anionic site (PAS) of AChE. The two structurally similar compound classes proved to have distinctly divergent SARs in terms of their inhibition capacity of AChE. Eight X-ray structures revealed that the two sets have different conformations in PAS. Furthermore, thermodynamic profiles of the binding between compounds and AChE revealed class-dependent differences of the entropy/enthalpy contributions to the free energy of binding. Further development of the entropy-favored compound class resulted in the synthesis of the most potent inhibitor, and an extension beyond the established SARs. The divergent SARs will be utilized to develop reversible inhibitors of AChE into reactivators of nerve agent inhibited AChE.

-	~~==Function==~~	+	Divergent Structure-Activity Relationships of Structurally Similar Acetylcholinesterase Inhibitors.,Andersson CD, Forsgren N, Akfur C, Allgardsson A, Berg L, Engdahl C, Qian W, Ekstrom FJ, Linusson A J Med Chem. 2013 Aug 28. PMID:23984975<ref>PMID:23984975</ref>
-	~~[[http://www~~.~~uniprot~~.~~org~~/~~uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.~~	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4b80]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4B80 OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:023984975</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Acetylcholinesterase\|Acetylcholinesterase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Akfur, C.]]	+	[[Category: Akfur, C]]
-	[[Category: Allgardsson, A.]]	+	[[Category: Allgardsson, A]]
-	[[Category: Andersson, C D.]]	+	[[Category: Andersson, C D]]
-	[[Category: Berg, L.]]	+	[[Category: Berg, L]]
-	[[Category: Ekstrom, F.]]	+	[[Category: Ekstrom, F]]
-	[[Category: Forsgren, N.]]	+	[[Category: Forsgren, N]]
-	[[Category: Linusson, A.]]	+	[[Category: Linusson, A]]
-	[[Category: Qian, W.]]	+	[[Category: Qian, W]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Inhibitor]]		[[Category: Inhibitor]]

OCA at 04:06, 12 September 2013

OCA — Thu, 12 Sep 2013 04:06:33 GMT

←Older revision		Revision as of 04:06, 12 September 2013
Line 1:		Line 1:
	{{STRUCTURE_4b80\| PDB=4b80 \| SCENE= }}		{{STRUCTURE_4b80\| PDB=4b80 \| SCENE= }}
	===Mus musculus Acetylcholinesterase in complex with N-(2-Diethylamino-ethyl)-1-(4-fluoro-phenyl)-methanesulfonamide===		===Mus musculus Acetylcholinesterase in complex with N-(2-Diethylamino-ethyl)-1-(4-fluoro-phenyl)-methanesulfonamide===
		+	{{ABSTRACT_PUBMED_23984975}}

	==Function==		==Function==
Line 7:		Line 8:
	==About this Structure==		==About this Structure==
	[[4b80]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B80 OCA].		[[4b80]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B80 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023984975</ref><references group="xtra"/><references/>
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]

OCA at 10:53, 4 September 2013

OCA — Wed, 04 Sep 2013 10:53:26 GMT

←Older revision		Revision as of 10:53, 4 September 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4b80\| PDB=4b80 \| SCENE= }}
		+	===Mus musculus Acetylcholinesterase in complex with N-(2-Diethylamino-ethyl)-1-(4-fluoro-phenyl)-methanesulfonamide===

-	~~The entry 4b80 is ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.

-	~~Authors~~: ~~Andersson, C~~.D.~~, Forsgren, N~~., Akfur, C., Allgardsson, A., Berg, L.~~, Qian, W.,~~ Ekstrom, F., Linusson, A.	+	==About this Structure==
-		+	[[4b80]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B80 OCA].
-	~~Description~~: ~~Mus musculus Acetylcholinesterase in complex with N-(2-Diethylamino-ethyl)-1-(4-fluoro-phenyl)-methanesulfonamide~~	+	[[Category: Acetylcholinesterase]]
		+	[[Category: Mus musculus]]
		+	[[Category: Akfur, C.]]
		+	[[Category: Allgardsson, A.]]
		+	[[Category: Andersson, C D.]]
		+	[[Category: Berg, L.]]
		+	[[Category: Ekstrom, F.]]
		+	[[Category: Forsgren, N.]]
		+	[[Category: Linusson, A.]]
		+	[[Category: Qian, W.]]
		+	[[Category: Hydrolase]]
		+	[[Category: Inhibitor]]