4b9e - Revision history

OCA at 11:46, 20 December 2023

OCA — Wed, 20 Dec 2023 11:46:13 GMT

←Older revision		Revision as of 11:46, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='4b9e' size='340' side='right'caption='[[4b9e]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='4b9e' size='340' side='right'caption='[[4b9e]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4b9e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Pseae Pseae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B9E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B9E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4b9e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B9E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B9E FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAH:FLUOROACETIC+ACID'>FAH</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.4Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4b9a\|4b9a]]</div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAH:FLUOROACETIC+ACID'>FAH</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b9e OCA], [https://pdbe.org/4b9e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b9e RCSB], [https://www.ebi.ac.uk/pdbsum/4b9e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b9e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b9e OCA], [https://pdbe.org/4b9e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b9e RCSB], [https://www.ebi.ac.uk/pdbsum/4b9e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b9e ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9I229_PSEAE Q9I229_PSEAE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Pseae~~]]	+	[[Category: Pseudomonas aeruginosa PAO1]]
-	[[Category: Schmidberger~~, J W~~]]	+	[[Category: Schmidberger JW]]
-	[[Category: Schneider, G]]	+	[[Category: Schneider G]]
-	[[Category: Schnell, R]]	+	[[Category: Schnell R]]
-	~~[[Category: Defluorinase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Monofluoroacetate~~]]	+

OCA at 07:04, 31 August 2022

OCA — Wed, 31 Aug 2022 07:04:30 GMT

←Older revision		Revision as of 07:04, 31 August 2022
Line 3:		Line 3:
	<StructureSection load='4b9e' size='340' side='right'caption='[[4b9e]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='4b9e' size='340' side='right'caption='[[4b9e]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4b9e]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B9E OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4B9E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4b9e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B9E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B9E FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAH:FLUOROACETIC+ACID'>FAH</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAH:FLUOROACETIC+ACID'>FAH</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4b9a\|4b9a]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4b9a\|4b9a]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4b9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b9e OCA], [~~http~~://pdbe.org/4b9e PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4b9e RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4b9e PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4b9e ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b9e OCA], [https://pdbe.org/4b9e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b9e RCSB], [https://www.ebi.ac.uk/pdbsum/4b9e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b9e ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:45, 13 March 2019

OCA — Wed, 13 Mar 2019 13:45:51 GMT

←Older revision		Revision as of 13:45, 13 March 2019
Line 1:		Line 1:

	==Structure of a putative epoxide hydrolase from Pseudomonas aeruginosa, with bound MFA.==		==Structure of a putative epoxide hydrolase from Pseudomonas aeruginosa, with bound MFA.==
-	<StructureSection load='4b9e' size='340' side='right' caption='[[4b9e]], [[Resolution\|resolution]] 1.40Å' scene=''>	+	<StructureSection load='4b9e' size='340' side='right'caption='[[4b9e]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4b9e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B9E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B9E FirstGlance]. <br>		<table><tr><td colspan='2'>[[4b9e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B9E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B9E FirstGlance]. <br>
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Pseae]]		[[Category: Pseae]]
	[[Category: Schmidberger, J W]]		[[Category: Schmidberger, J W]]

OCA at 02:47, 11 December 2016

OCA — Sun, 11 Dec 2016 02:47:05 GMT

←Older revision		Revision as of 02:47, 11 December 2016
Line 1:		Line 1:
		+
	==Structure of a putative epoxide hydrolase from Pseudomonas aeruginosa, with bound MFA.==		==Structure of a putative epoxide hydrolase from Pseudomonas aeruginosa, with bound MFA.==
	<StructureSection load='4b9e' size='340' side='right' caption='[[4b9e]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='4b9e' size='340' side='right' caption='[[4b9e]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4b9e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B9E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B9E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4b9e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B9E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B9E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAH:FLUOROACETIC+ACID'>FAH</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAH:FLUOROACETIC+ACID'>FAH</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4b9a\|4b9a]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4b9a\|4b9a]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b9e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b9e RCSB], [http://www.ebi.ac.uk/pdbsum/4b9e PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b9e OCA], [http://pdbe.org/4b9e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4b9e RCSB], [http://www.ebi.ac.uk/pdbsum/4b9e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4b9e ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4b9e" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Pseudomonas aeruginosa pao1~~]]	+	[[Category: Pseae]]
	[[Category: Schmidberger, J W]]		[[Category: Schmidberger, J W]]
	[[Category: Schneider, G]]		[[Category: Schneider, G]]

OCA at 17:35, 9 December 2014

OCA — Tue, 09 Dec 2014 17:35:03 GMT

←Older revision		Revision as of 17:35, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4b9e.~~jpg~~\|~~left~~\|~~200px~~]]	+	==Structure of a putative epoxide hydrolase from Pseudomonas aeruginosa, with bound MFA.==
		+	<StructureSection load='4b9e' size='340' side='right' caption='[[4b9e]], [[Resolution\|resolution]] 1.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4b9e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B9E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B9E FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAH:FLUOROACETIC+ACID'>FAH</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4b9a\|4b9a]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b9e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b9e RCSB], [http://www.ebi.ac.uk/pdbsum/4b9e PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bacterial infections are increasingly difficult to treat owing to the spread of antibiotic resistance. A major concern is Gram-negative bacteria, for which the discovery of new antimicrobial drugs has been particularly scarce. In an effort to accelerate early steps in drug discovery, the EU-funded AEROPATH project aims to identify novel targets in the opportunistic pathogen Pseudomonas aeruginosa by applying a multidisciplinary approach encompassing target validation, structural characterization, assay development and hit identification from small-molecule libraries. Here, the strategies used for target selection are described and progress in protein production and structure analysis is reported. Of the 102 selected targets, 84 could be produced in soluble form and the de novo structures of 39 proteins have been determined. The crystal structures of eight of these targets, ranging from hypothetical unknown proteins to metabolic enzymes from different functional classes (PA1645, PA1648, PA2169, PA3770, PA4098, PA4485, PA4992 and PA5259), are reported here. The structural information is expected to provide a firm basis for the improvement of hit compounds identified from fragment-based and high-throughput screening campaigns.

-	~~{{STRUCTURE_4b9e\| PDB=4b9e \| SCENE= }}~~	+	The AEROPATH project targeting Pseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discovery.,Moynie L, Schnell R, McMahon SA, Sandalova T, Boulkerou WA, Schmidberger JW, Alphey M, Cukier C, Duthie F, Kopec J, Liu H, Jacewicz A, Hunter WN, Naismith JH, Schneider G Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jan 1;69(Pt 1):25-34. doi:, 10.1107/S1744309112044739. Epub 2012 Dec 25. PMID:23295481<ref>PMID:23295481</ref>

-	~~===Structure~~ of ~~a putative epoxide hydrolase from Pseudomonas aeruginosa, with bound MFA~~.~~===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_23295481}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[4b9e]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B9E OCA].~~	+	</StructureSection>
	[[Category: Pseudomonas aeruginosa pao1]]		[[Category: Pseudomonas aeruginosa pao1]]
-	[[Category: Schmidberger, J W.]]	+	[[Category: Schmidberger, J W]]
-	[[Category: Schneider, G.]]	+	[[Category: Schneider, G]]
-	[[Category: Schnell, R.]]	+	[[Category: Schnell, R]]
	[[Category: Defluorinase]]		[[Category: Defluorinase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Monofluoroacetate]]		[[Category: Monofluoroacetate]]

OCA at 12:49, 6 February 2013

OCA — Wed, 06 Feb 2013 12:49:03 GMT

←Older revision		Revision as of 12:49, 6 February 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4b9e.jpg\|left\|200px]]

-	~~The entry~~ 4b9e ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4b9e\| PDB=4b9e \| SCENE= }}

-	~~Authors: Schmidberger~~, ~~J.W., Schnell, R., Schneider, G~~.	+	===Structure of a putative epoxide hydrolase from Pseudomonas aeruginosa, with bound MFA.===

-	~~Description:~~ Structure of a ~~putative epoxide hydrolase~~ from Pseudomonas aeruginosa, ~~with bound MFA~~.	+	{{ABSTRACT_PUBMED_23295481}}
		+
		+	==About this Structure==
		+	[[4b9e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B9E OCA].
		+	[[Category: Pseudomonas aeruginosa pao1]]
		+	[[Category: Schmidberger, J W.]]
		+	[[Category: Schneider, G.]]
		+	[[Category: Schnell, R.]]
		+	[[Category: Defluorinase]]
		+	[[Category: Hydrolase]]
		+	[[Category: Monofluoroacetate]]

OCA at 19:59, 26 September 2012

OCA — Wed, 26 Sep 2012 19:59:06 GMT

←Older revision		Revision as of 19:59, 26 September 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4b9e is ON HOLD	+	The entry 4b9e is ON HOLD until Paper Publication

	Authors: Schmidberger, J.W., Schnell, R., Schneider, G.		Authors: Schmidberger, J.W., Schnell, R., Schneider, G.

	Description: Structure of a putative epoxide hydrolase from Pseudomonas aeruginosa, with bound MFA.		Description: Structure of a putative epoxide hydrolase from Pseudomonas aeruginosa, with bound MFA.

OCA: Protected "4b9e" [edit=sysop:move=sysop]

OCA — Wed, 12 Sep 2012 04:42:51 GMT

Protected "4b9e" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:42, 12 September 2012

OCA: New page: '''Unreleased structure''' The entry 4b9e is ON HOLD Authors: Schmidberger, J.W., Schnell, R., Schneider, G. Description: Structure of a putative epoxide hydrolase from Pseudomonas aer...

OCA — Wed, 12 Sep 2012 04:42:50 GMT

New page: '''Unreleased structure''' The entry 4b9e is ON HOLD Authors: Schmidberger, J.W., Schnell, R., Schneider, G. Description: Structure of a putative epoxide hydrolase from Pseudomonas aer...

New page

'''Unreleased structure'''

The entry 4b9e is ON HOLD

Authors: Schmidberger, J.W., Schnell, R., Schneider, G.

Description: Structure of a putative epoxide hydrolase from Pseudomonas aeruginosa, with bound MFA.