4b9q - Revision history

OCA at 11:46, 20 December 2023

OCA — Wed, 20 Dec 2023 11:46:27 GMT

←Older revision		Revision as of 11:46, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='4b9q' size='340' side='right'caption='[[4b9q]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='4b9q' size='340' side='right'caption='[[4b9q]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4b9q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B9Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B9Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4b9q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B9Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B9Q FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ATP:ADENOSINE~~-~~5-TRIPHOSPHATE'>ATP</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~MSE~~:~~SELENOMETHIONINE~~'>~~MSE~~</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td><~~td class~~=~~"sblockDat"><div style~~=~~'overflow~~: ~~auto; max-height: 3em;~~'>~~[[1bpr\|1bpr]], [[1dg4\|1dg4]], [[1dkg\|1dkg]], [[1dkx\|1dkx]], [[1dky\|1dky]], [[1dkz\|1dkz]], [[1q5l\|1q5l]], [[2bpr\|2bpr]]~~</~~div~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b9q OCA], [https://pdbe.org/4b9q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b9q RCSB], [https://www.ebi.ac.uk/pdbsum/4b9q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b9q ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b9q OCA], [https://pdbe.org/4b9q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b9q RCSB], [https://www.ebi.ac.uk/pdbsum/4b9q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b9q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DNAK_ECOLI DNAK_ECOLI]] Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock.[HAMAP-Rule:MF_00332]	+	[https://www.uniprot.org/uniprot/DNAK_ECOLI DNAK_ECOLI] Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock.[HAMAP-Rule:MF_00332]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kopp, J]]	+	[[Category: Kopp J]]
-	[[Category: Mayer~~, M P~~]]	+	[[Category: Mayer MP]]
-	[[Category: Sinning, I]]	+	[[Category: Sinning I]]
-	~~[[Category: Chaperone~~]]	+

OCA at 07:04, 31 August 2022

OCA — Wed, 31 Aug 2022 07:04:54 GMT

←Older revision		Revision as of 07:04, 31 August 2022
Line 3:		Line 3:
	<StructureSection load='4b9q' size='340' side='right'caption='[[4b9q]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='4b9q' size='340' side='right'caption='[[4b9q]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4b9q]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B9Q OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4B9Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4b9q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B9Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B9Q FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bpr\|1bpr]], [[1dg4\|1dg4]], [[1dkg\|1dkg]], [[1dkx\|1dkx]], [[1dky\|1dky]], [[1dkz\|1dkz]], [[1q5l\|1q5l]], [[2bpr\|2bpr]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1bpr\|1bpr]], [[1dg4\|1dg4]], [[1dkg\|1dkg]], [[1dkx\|1dkx]], [[1dky\|1dky]], [[1dkz\|1dkz]], [[1q5l\|1q5l]], [[2bpr\|2bpr]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4b9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b9q OCA], [~~http~~://pdbe.org/4b9q PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4b9q RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4b9q PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4b9q ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b9q OCA], [https://pdbe.org/4b9q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b9q RCSB], [https://www.ebi.ac.uk/pdbsum/4b9q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b9q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DNAK_ECOLI DNAK_ECOLI]] Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock.[HAMAP-Rule:MF_00332]	+	[[https://www.uniprot.org/uniprot/DNAK_ECOLI DNAK_ECOLI]] Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock.[HAMAP-Rule:MF_00332]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Heat Shock ~~Proteins~~\|Heat Shock ~~Proteins~~]]	+	*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:58, 13 March 2019

OCA — Wed, 13 Mar 2019 12:58:13 GMT

←Older revision		Revision as of 12:58, 13 March 2019
Line 1:		Line 1:

	==Open conformation of ATP-bound Hsp70 homolog DnaK==		==Open conformation of ATP-bound Hsp70 homolog DnaK==
-	<StructureSection load='4b9q' size='340' side='right' caption='[[4b9q]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='4b9q' size='340' side='right'caption='[[4b9q]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4b9q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B9Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B9Q FirstGlance]. <br>		<table><tr><td colspan='2'>[[4b9q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B9Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B9Q FirstGlance]. <br>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
		+	[[Category: Large Structures]]
	[[Category: Kopp, J]]		[[Category: Kopp, J]]
	[[Category: Mayer, M P]]		[[Category: Mayer, M P]]
	[[Category: Sinning, I]]		[[Category: Sinning, I]]
	[[Category: Chaperone]]		[[Category: Chaperone]]

OCA at 13:22, 4 August 2016

OCA — Thu, 04 Aug 2016 13:22:38 GMT

←Older revision		Revision as of 13:22, 4 August 2016
Line 1:		Line 1:
		+
	==Open conformation of ATP-bound Hsp70 homolog DnaK==		==Open conformation of ATP-bound Hsp70 homolog DnaK==
	<StructureSection load='4b9q' size='340' side='right' caption='[[4b9q]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='4b9q' size='340' side='right' caption='[[4b9q]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4b9q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B9Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B9Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4b9q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B9Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B9Q FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bpr\|1bpr]], [[1dg4\|1dg4]], [[1dkg\|1dkg]], [[1dkx\|1dkx]], [[1dky\|1dky]], [[1dkz\|1dkz]], [[1q5l\|1q5l]], [[2bpr\|2bpr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bpr\|1bpr]], [[1dg4\|1dg4]], [[1dkg\|1dkg]], [[1dkx\|1dkx]], [[1dky\|1dky]], [[1dkz\|1dkz]], [[1q5l\|1q5l]], [[2bpr\|2bpr]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b9q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b9q RCSB], [http://www.ebi.ac.uk/pdbsum/4b9q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b9q OCA], [http://pdbe.org/4b9q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4b9q RCSB], [http://www.ebi.ac.uk/pdbsum/4b9q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4b9q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4b9q" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Heat Shock Proteins\|Heat Shock Proteins]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Kopp, J]]		[[Category: Kopp, J]]
	[[Category: Mayer, M P]]		[[Category: Mayer, M P]]
	[[Category: Sinning, I]]		[[Category: Sinning, I]]
	[[Category: Chaperone]]		[[Category: Chaperone]]

OCA at 15:00, 24 December 2014

OCA — Wed, 24 Dec 2014 15:00:12 GMT

←Older revision		Revision as of 15:00, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b9q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b9q RCSB], [http://www.ebi.ac.uk/pdbsum/4b9q PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b9q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b9q RCSB], [http://www.ebi.ac.uk/pdbsum/4b9q PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DNAK_ECOLI DNAK_ECOLI]] Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock.[HAMAP-Rule:MF_00332]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 16:27, 9 December 2014

OCA — Tue, 09 Dec 2014 16:27:22 GMT

←Older revision		Revision as of 16:27, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4b9q.~~png~~\|~~left~~\|~~200px~~]]	+	==Open conformation of ATP-bound Hsp70 homolog DnaK==
		+	<StructureSection load='4b9q' size='340' side='right' caption='[[4b9q]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4b9q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B9Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B9Q FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bpr\|1bpr]], [[1dg4\|1dg4]], [[1dkg\|1dkg]], [[1dkx\|1dkx]], [[1dky\|1dky]], [[1dkz\|1dkz]], [[1q5l\|1q5l]], [[2bpr\|2bpr]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b9q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b9q RCSB], [http://www.ebi.ac.uk/pdbsum/4b9q PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Central to the chaperone function of Hsp70s is the transition between open and closed conformations of their polypeptide substrate binding domain (SBD), which is regulated through an allosteric mechanism via ATP binding and hydrolysis in their nucleotide binding domain (NBD). Although the structure of the closed conformation of Hsp70s is well studied, the open conformation has remained elusive. Here, we report on the 2.4 A crystal structure of the ATP-bound open conformation of the Escherichia coli Hsp70 homolog DnaK. In the open DnaK structure, the beta sheet and alpha-helical lid subdomains of the SBD are detached from one another and docked to different faces of the NBD. The contacts between the beta sheet subdomain and the NBD reveal the mechanism of allosteric regulation. In addition, we demonstrate that docking of the beta sheet and alpha-helical lid subdomains to the NBD is a sequential process influenced by peptide and protein substrates.

-	~~{{STRUCTURE_4b9q\| PDB=4b9q \| SCENE= }}~~	+	Structure and Dynamics of the ATP-Bound Open Conformation of Hsp70 Chaperones.,Kityk R, Kopp J, Sinning I, Mayer MP Mol Cell. 2012 Nov 1. pii: S1097-2765(12)00823-4. doi:, 10.1016/j.molcel.2012.09.023. PMID:23123194<ref>PMID:23123194</ref>

-	~~===Open conformation~~ of ~~ATP-bound Hsp70 homolog DnaK===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_23123194}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[4b9q]] is a 4 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B9Q OCA].~~	+	</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Kopp, J.]]	+	[[Category: Kopp, J]]
-	[[Category: Mayer, M P.]]	+	[[Category: Mayer, M P]]
-	[[Category: Sinning, I.]]	+	[[Category: Sinning, I]]
	[[Category: Chaperone]]		[[Category: Chaperone]]

OCA at 09:28, 21 November 2012

OCA — Wed, 21 Nov 2012 09:28:45 GMT

←Older revision		Revision as of 09:28, 21 November 2012
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-	[[Image:4b9q.~~jpg~~\|left\|200px]]	+	[[Image:4b9q.png\|left\|200px]]

	{{STRUCTURE_4b9q\| PDB=4b9q \| SCENE= }}		{{STRUCTURE_4b9q\| PDB=4b9q \| SCENE= }}
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	===Open conformation of ATP-bound Hsp70 homolog DnaK===		===Open conformation of ATP-bound Hsp70 homolog DnaK===

		+	{{ABSTRACT_PUBMED_23123194}}

	==About this Structure==		==About this Structure==

OCA at 06:54, 14 November 2012

OCA — Wed, 14 Nov 2012 06:54:07 GMT

←Older revision		Revision as of 06:54, 14 November 2012
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-	~~'''Unreleased structure'''~~	+	[[Image:4b9q.jpg\|left\|200px]]

-	~~The entry~~ 4b9q ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4b9q\| PDB=4b9q \| SCENE= }}

-	~~Authors: Kopp, J., Mayer, M.P., Sinning, I., ,~~	+	===Open conformation of ATP-bound Hsp70 homolog DnaK===

-	~~Description~~: ~~Open conformation of ATP~~-~~bound Hsp70 homolog DnaK~~	+
		+	==About this Structure==
		+	[[4b9q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B9Q OCA].
		+	[[Category: Escherichia coli]]
		+	[[Category: Kopp, J.]]
		+	[[Category: Mayer, M P.]]
		+	[[Category: Sinning, I.]]
		+	[[Category: Chaperone]]

OCA at 06:44, 19 September 2012

OCA — Wed, 19 Sep 2012 06:44:17 GMT

←Older revision		Revision as of 06:44, 19 September 2012
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4b9q is ON HOLD	+	The entry 4b9q is ON HOLD until Paper Publication

	Authors: Kopp, J., Mayer, M.P., Sinning, I., ,		Authors: Kopp, J., Mayer, M.P., Sinning, I., ,

	Description: Open conformation of ATP-bound Hsp70 homolog DnaK		Description: Open conformation of ATP-bound Hsp70 homolog DnaK

OCA: Protected "4b9q" [edit=sysop:move=sysop]

OCA — Wed, 12 Sep 2012 04:43:10 GMT

Protected "4b9q" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:43, 12 September 2012