4ba8 - Revision history

OCA at 10:08, 14 June 2023

OCA — Wed, 14 Jun 2023 10:08:09 GMT

←Older revision		Revision as of 10:08, 14 June 2023
Line 1:		Line 1:

	==High resolution NMR structure of the C mu3 domain from IgM==		==High resolution NMR structure of the C mu3 domain from IgM==
-	<StructureSection load='4ba8' size='340' side='right'caption='[[4ba8~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='4ba8' size='340' side='right'caption='[[4ba8]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ba8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BA8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BA8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ba8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BA8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BA8 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ba8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ba8 OCA], [https://pdbe.org/4ba8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ba8 RCSB], [https://www.ebi.ac.uk/pdbsum/4ba8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ba8 ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ba8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ba8 OCA], [https://pdbe.org/4ba8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ba8 RCSB], [https://www.ebi.ac.uk/pdbsum/4ba8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ba8 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/IGHM_MOUSE IGHM_MOUSE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Buchner, J]]	+	[[Category: Buchner J]]
-	[[Category: Graewert~~, M A~~]]	+	[[Category: Graewert MA]]
-	[[Category: Groll, M]]	+	[[Category: Groll M]]
-	[[Category: Kern, T]]	+	[[Category: Kern T]]
-	[[Category: Madl, T]]	+	[[Category: Madl T]]
-	[[Category: Mueller, R]]	+	[[Category: Mueller R]]
-	[[Category: Peschek, J]]	+	[[Category: Peschek J]]
-	[[Category: Sattler, M]]	+	[[Category: Sattler M]]
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunoglobulin constant region~~]]	+

OCA at 07:05, 31 August 2022

OCA — Wed, 31 Aug 2022 07:05:33 GMT

←Older revision		Revision as of 07:05, 31 August 2022
Line 3:		Line 3:
	<StructureSection load='4ba8' size='340' side='right'caption='[[4ba8]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='4ba8' size='340' side='right'caption='[[4ba8]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ba8]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BA8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4BA8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ba8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BA8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BA8 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ba8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ba8 OCA], [~~http~~://pdbe.org/4ba8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ba8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ba8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ba8 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ba8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ba8 OCA], [https://pdbe.org/4ba8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ba8 RCSB], [https://www.ebi.ac.uk/pdbsum/4ba8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ba8 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:08, 13 March 2019

OCA — Wed, 13 Mar 2019 13:08:25 GMT

←Older revision		Revision as of 13:08, 13 March 2019
Line 1:		Line 1:

	==High resolution NMR structure of the C mu3 domain from IgM==		==High resolution NMR structure of the C mu3 domain from IgM==
-	<StructureSection load='4ba8' size='340' side='right' caption='[[4ba8]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='4ba8' size='340' side='right'caption='[[4ba8]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ba8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BA8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BA8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ba8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BA8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BA8 FirstGlance]. <br>
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Buchner, J]]		[[Category: Buchner, J]]

OCA at 16:02, 11 August 2016

OCA — Thu, 11 Aug 2016 16:02:04 GMT

←Older revision		Revision as of 16:02, 11 August 2016
Line 1:		Line 1:
		+
	==High resolution NMR structure of the C mu3 domain from IgM==		==High resolution NMR structure of the C mu3 domain from IgM==
	<StructureSection load='4ba8' size='340' side='right' caption='[[4ba8]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='4ba8' size='340' side='right' caption='[[4ba8]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ba8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BA8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BA8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ba8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BA8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BA8 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ba8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ba8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ba8 RCSB], [http://www.ebi.ac.uk/pdbsum/4ba8 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ba8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ba8 OCA], [http://pdbe.org/4ba8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ba8 RCSB], [http://www.ebi.ac.uk/pdbsum/4ba8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ba8 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 13:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ba8" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Buchner, J]]		[[Category: Buchner, J]]
	[[Category: Graewert, M A]]		[[Category: Graewert, M A]]

OCA at 12:29, 4 January 2015

OCA — Sun, 04 Jan 2015 12:29:30 GMT

←Older revision		Revision as of 12:29, 4 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_4ba8\| PDB=4ba8 \| SCENE= }}~~	+	==High resolution NMR structure of the C mu3 domain from IgM==
-	===High resolution NMR structure of the C mu3 domain from IgM===	+	<StructureSection load='4ba8' size='340' side='right' caption='[[4ba8]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_23733956}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4ba8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BA8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BA8 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ba8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ba8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ba8 RCSB], [http://www.ebi.ac.uk/pdbsum/4ba8 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	IgM is the first antibody produced during the humoral immune response. Despite its fundamental role in the immune system, IgM is structurally only poorly described. In this work we used X-ray crystallography and NMR spectroscopy to determine the atomic structures of the constant IgM Fc domains (Cmicro2, Cmicro3, and Cmicro4) and to address their roles in IgM oligomerization. Although the isolated domains share the typical Ig fold, they differ substantially in dimerization properties and quaternary contacts. Unexpectedly, the Cmicro4 domain and its C-terminal tail piece are responsible and sufficient for the specific polymerization of Cmicro4 dimers into covalently linked hexamers of dimers. Based on small angle X-ray scattering data, we present a model of the ring-shaped Cmicro4 structure, which reveals the principles of IgM oligomerization.

-	~~==About this Structure==~~	+	High-resolution structures of the IgM Fc domains reveal principles of its hexamer formation.,Muller R, Grawert MA, Kern T, Madl T, Peschek J, Sattler M, Groll M, Buchner J Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10183-8. doi:, 10.1073/pnas.1300547110. Epub 2013 Jun 3. PMID:23733956<ref>PMID:23733956</ref>
-	~~[[4ba8]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full experimental information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4BA8 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:023733956</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Buchner, J.]]	+	[[Category: Buchner, J]]
-	[[Category: Graewert, M A.]]	+	[[Category: Graewert, M A]]
-	[[Category: Groll, M.]]	+	[[Category: Groll, M]]
-	[[Category: Kern, T.]]	+	[[Category: Kern, T]]
-	[[Category: Madl, T.]]	+	[[Category: Madl, T]]
-	[[Category: Mueller, R.]]	+	[[Category: Mueller, R]]
-	[[Category: Peschek, J.]]	+	[[Category: Peschek, J]]
-	[[Category: Sattler, M.]]	+	[[Category: Sattler, M]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Immunoglobulin constant region]]		[[Category: Immunoglobulin constant region]]

OCA at 14:08, 3 July 2013

OCA — Wed, 03 Jul 2013 14:08:52 GMT

←Older revision		Revision as of 14:08, 3 July 2013
Line 4:		Line 4:

	==About this Structure==		==About this Structure==
-	[[4ba8]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BA8 OCA].	+	[[4ba8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BA8 OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:023733956</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:023733956</ref><references group="xtra"/><references/>
		+	[[Category: Mus musculus]]
	[[Category: Buchner, J.]]		[[Category: Buchner, J.]]
	[[Category: Graewert, M A.]]		[[Category: Graewert, M A.]]

OCA at 11:30, 3 July 2013

OCA — Wed, 03 Jul 2013 11:30:17 GMT

←Older revision		Revision as of 11:30, 3 July 2013
Line 1:		Line 1:
	{{STRUCTURE_4ba8\| PDB=4ba8 \| SCENE= }}		{{STRUCTURE_4ba8\| PDB=4ba8 \| SCENE= }}
	===High resolution NMR structure of the C mu3 domain from IgM===		===High resolution NMR structure of the C mu3 domain from IgM===
		+	{{ABSTRACT_PUBMED_23733956}}

	==About this Structure==		==About this Structure==
-	[[4ba8]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]~~. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BA8 OCA].	+	[[4ba8]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BA8 OCA].
-	~~[[Category~~: ~~Mus musculus]]~~	+
		+	==Reference==
		+	<ref group="xtra">PMID:023733956</ref><references group="xtra"/><references/>
	[[Category: Buchner, J.]]		[[Category: Buchner, J.]]
	[[Category: Graewert, M A.]]		[[Category: Graewert, M A.]]

OCA at 21:02, 19 June 2013

OCA — Wed, 19 Jun 2013 21:02:18 GMT

←Older revision		Revision as of 21:02, 19 June 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4ba8\| PDB=4ba8 \| SCENE= }}
		+	===High resolution NMR structure of the C mu3 domain from IgM===

-	~~The entry~~ 4ba8 is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
-		+	[[4ba8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BA8 OCA].
-	~~Authors~~: ~~Mueller~~, R.~~, Kern, T.,~~ Graewert, M.A., Madl, T., Peschek, J.~~, Groll, M.,~~ Sattler, M.~~, Buchner, J.~~	+	[[Category: Mus musculus]]
-		+	[[Category: Buchner, J.]]
-	~~Description~~: ~~High resolution NMR structure of the C mu3 domain from IgM~~	+	[[Category: Graewert, M A.]]
		+	[[Category: Groll, M.]]
		+	[[Category: Kern, T.]]
		+	[[Category: Madl, T.]]
		+	[[Category: Mueller, R.]]
		+	[[Category: Peschek, J.]]
		+	[[Category: Sattler, M.]]
		+	[[Category: Immune system]]
		+	[[Category: Immunoglobulin constant region]]

OCA: Protected "4ba8" [edit=sysop:move=sysop]

OCA — Wed, 19 Sep 2012 06:44:41 GMT

Protected "4ba8" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:44, 19 September 2012

OCA: New page: '''Unreleased structure''' The entry 4ba8 is ON HOLD until Paper Publication Authors: Mueller, R., Kern, T., Graewert, M.A., Madl, T., Peschek, J., Groll, M., Sattler, M., Buchner, J. ...

OCA — Wed, 19 Sep 2012 06:44:40 GMT

New page: '''Unreleased structure''' The entry 4ba8 is ON HOLD until Paper Publication Authors: Mueller, R., Kern, T., Graewert, M.A., Madl, T., Peschek, J., Groll, M., Sattler, M., Buchner, J. ...

New page

'''Unreleased structure'''

The entry 4ba8 is ON HOLD until Paper Publication

Authors: Mueller, R., Kern, T., Graewert, M.A., Madl, T., Peschek, J., Groll, M., Sattler, M., Buchner, J.

Description: High resolution NMR structure of the C mu3 domain from IgM