4bfd - Revision history

OCA at 11:50, 20 December 2023

OCA — Wed, 20 Dec 2023 11:50:03 GMT

←Older revision		Revision as of 11:50, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='4bfd' size='340' side='right'caption='[[4bfd]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4bfd' size='340' side='right'caption='[[4bfd]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bfd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BFD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bfd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BFD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8T3:N-[3-[(1S,3S,6S)-5-AZANYL-3-METHYL-4-AZABICYCLO[4.1.0]HEPT-4-EN-3-YL]-4-FLUORANYL-PHENYL]-5-CHLORANYL-PYRIDINE-2-CARBOXAMIDE'>8T3</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4bek\|4bek]], [[4bel\|4bel]], [[4bfb\|4bfb]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8T3:N-[3-[(1S,3S,6S)-5-AZANYL-3-METHYL-4-AZABICYCLO[4.1.0]HEPT-4-EN-3-YL]-4-FLUORANYL-PHENYL]-5-CHLORANYL-PYRIDINE-2-CARBOXAMIDE'>8T3</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bfd OCA], [https://pdbe.org/4bfd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bfd RCSB], [https://www.ebi.ac.uk/pdbsum/4bfd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bfd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bfd OCA], [https://pdbe.org/4bfd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bfd RCSB], [https://www.ebi.ac.uk/pdbsum/4bfd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bfd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>	+	[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Memapsin 2]]~~	+	[[Category: Banner DW]]
-	[[Category: Banner~~, D W~~]]	+	[[Category: Benz J]]
-	[[Category: Benz, J]]	+	[[Category: Stihle M]]
-	[[Category: Stihle, M]]	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 07:11, 31 August 2022

OCA — Wed, 31 Aug 2022 07:11:37 GMT

←Older revision		Revision as of 07:11, 31 August 2022
Line 3:		Line 3:
	<StructureSection load='4bfd' size='340' side='right'caption='[[4bfd]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4bfd' size='340' side='right'caption='[[4bfd]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bfd]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=4BFD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bfd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BFD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8T3:N-[3-[(1S,3S,6S)-5-AZANYL-3-METHYL-4-AZABICYCLO[4.1.0]HEPT-4-EN-3-YL]-4-FLUORANYL-PHENYL]-5-CHLORANYL-PYRIDINE-2-CARBOXAMIDE'>8T3</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8T3:N-[3-[(1S,3S,6S)-5-AZANYL-3-METHYL-4-AZABICYCLO[4.1.0]HEPT-4-EN-3-YL]-4-FLUORANYL-PHENYL]-5-CHLORANYL-PYRIDINE-2-CARBOXAMIDE'>8T3</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bek\|4bek]], [[4bel\|4bel]], [[4bfb\|4bfb]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4bek\|4bek]], [[4bel\|4bel]], [[4bfb\|4bfb]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=4bfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bfd OCA], [~~http~~://pdbe.org/4bfd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4bfd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4bfd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4bfd ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bfd OCA], [https://pdbe.org/4bfd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bfd RCSB], [https://www.ebi.ac.uk/pdbsum/4bfd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bfd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>	+	[[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 08:14, 4 November 2020

OCA — Wed, 04 Nov 2020 08:14:40 GMT

←Older revision		Revision as of 08:14, 4 November 2020
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH CHEMICAL LIGAND==		==CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH CHEMICAL LIGAND==
-	<StructureSection load='4bfd' size='340' side='right' caption='[[4bfd]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='4bfd' size='340' side='right'caption='[[4bfd]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bfd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFD OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4BFD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bfd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=4BFD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8T3:N-[3-[(1S,3S,6S)-5-AZANYL-3-METHYL-4-AZABICYCLO[4.1.0]HEPT-4-EN-3-YL]-4-FLUORANYL-PHENYL]-5-CHLORANYL-PYRIDINE-2-CARBOXAMIDE'>8T3</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8T3:N-[3-[(1S,3S,6S)-5-AZANYL-3-METHYL-4-AZABICYCLO[4.1.0]HEPT-4-EN-3-YL]-4-FLUORANYL-PHENYL]-5-CHLORANYL-PYRIDINE-2-CARBOXAMIDE'>8T3</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bek\|4bek]], [[4bel\|4bel]], [[4bfb\|4bfb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bek\|4bek]], [[4bel\|4bel]], [[4bfb\|4bfb]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4bfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bfd OCA], [http://pdbe.org/4bfd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bfd RCSB], [http://www.ebi.ac.uk/pdbsum/4bfd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bfd ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=4bfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bfd OCA], [http://pdbe.org/4bfd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bfd RCSB], [http://www.ebi.ac.uk/pdbsum/4bfd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bfd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Beta secretase\|Beta secretase]]	+	*[[Beta secretase 3D structures\|Beta secretase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
	[[Category: Banner, D W]]		[[Category: Banner, D W]]

OCA at 09:05, 4 August 2016

OCA — Thu, 04 Aug 2016 09:05:43 GMT

←Older revision		Revision as of 09:05, 4 August 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH CHEMICAL LIGAND==		==CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH CHEMICAL LIGAND==
	<StructureSection load='4bfd' size='340' side='right' caption='[[4bfd]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4bfd' size='340' side='right' caption='[[4bfd]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bfd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BFD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bfd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BFD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8T3:N-[3-[(1S,3S,6S)-5-AZANYL-3-METHYL-4-AZABICYCLO[4.1.0]HEPT-4-EN-3-YL]-4-FLUORANYL-PHENYL]-5-CHLORANYL-PYRIDINE-2-CARBOXAMIDE'>8T3</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8T3:N-[3-[(1S,3S,6S)-5-AZANYL-3-METHYL-4-AZABICYCLO[4.1.0]HEPT-4-EN-3-YL]-4-FLUORANYL-PHENYL]-5-CHLORANYL-PYRIDINE-2-CARBOXAMIDE'>8T3</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bek\|4bek]], [[4bel\|4bel]], [[4bfb\|4bfb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bek\|4bek]], [[4bel\|4bel]], [[4bfb\|4bfb]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bfd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bfd RCSB], [http://www.ebi.ac.uk/pdbsum/4bfd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bfd OCA], [http://pdbe.org/4bfd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bfd RCSB], [http://www.ebi.ac.uk/pdbsum/4bfd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bfd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4bfd" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
	[[Category: Banner, D W]]		[[Category: Banner, D W]]

OCA at 08:01, 24 December 2014

OCA — Wed, 24 Dec 2014 08:01:12 GMT

←Older revision		Revision as of 08:01, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bfd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bfd RCSB], [http://www.ebi.ac.uk/pdbsum/4bfd PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bfd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bfd RCSB], [http://www.ebi.ac.uk/pdbsum/4bfd PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:34, 21 December 2014

OCA — Sun, 21 Dec 2014 09:34:40 GMT

←Older revision		Revision as of 09:34, 21 December 2014
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-	~~{{STRUCTURE_4bfd\| PDB=4bfd \| SCENE= }}~~	+	==CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH CHEMICAL LIGAND==
-	===CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH CHEMICAL LIGAND===	+	<StructureSection load='4bfd' size='340' side='right' caption='[[4bfd]], [[Resolution\|resolution]] 2.30Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23735744}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4bfd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BFD FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8T3:N-[3-[(1S,3S,6S)-5-AZANYL-3-METHYL-4-AZABICYCLO[4.1.0]HEPT-4-EN-3-YL]-4-FLUORANYL-PHENYL]-5-CHLORANYL-PYRIDINE-2-CARBOXAMIDE'>8T3</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bek\|4bek]], [[4bel\|4bel]], [[4bfb\|4bfb]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bfd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bfd RCSB], [http://www.ebi.ac.uk/pdbsum/4bfd PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A series of amides bearing a variety of amidine head groups was investigated as BACE1 inhibitors with respect to inhibitory activity in a BACE1 enzyme as well as a cell-based assay. Determination of their basicity as well as their properties as substrates of P-glycoprotein revealed that a 2-amino-1,3-oxazine head group would be a suitable starting point for further development of brain penetrating compounds for potential Alzheimer's disease treatment.

-	~~==Function==~~	+	BACE1 inhibitors: A head group scan on a series of amides.,Woltering TJ, Wostl W, Hilpert H, Rogers-Evans M, Pinard E, Mayweg A, Gobel M, Banner DW, Benz J, Travagli M, Pollastrini M, Marconi G, Gabellieri E, Guba W, Mauser H, Andreini M, Jacobsen H, Power E, Narquizian R Bioorg Med Chem Lett. 2013 May 18. pii: S0960-894X(13)00585-4. doi:, 10.1016/j.bmcl.2013.05.003. PMID:23735744<ref>PMID:23735744</ref>
-	~~[[http~~:~~//www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing~~ of ~~the amyloid precursor protein (APP)~~. ~~Cleaves at the N~~-~~terminus of the~~ A~~-beta peptide sequence~~, ~~between residues 671 and 672 of APP~~, ~~leads to the generation and extracellular release of beta-cleaved soluble APP~~, ~~and a corresponding cell~~-~~associated C~~-~~terminal fragment which is later released by gamma-secretase~~.~~<ref>PMID~~:~~10677483<~~/~~ref>~~ <ref>PMID:~~20354142~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4bfd]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4BFD OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[Beta secretase\|Beta secretase]]		*[[Beta secretase\|Beta secretase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:023735744</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
-	[[Category: Banner, D W.]]	+	[[Category: Banner, D W]]
-	[[Category: Benz, J.]]	+	[[Category: Benz, J]]
-	[[Category: Stihle, M.]]	+	[[Category: Stihle, M]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 14:02, 10 July 2013

OCA — Wed, 10 Jul 2013 14:02:44 GMT

←Older revision		Revision as of 14:02, 10 July 2013
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	==About this Structure==		==About this Structure==
	[[4bfd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFD OCA].		[[4bfd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFD OCA].
		+
		+	==See Also==
		+	*[[Beta secretase\|Beta secretase]]

	==Reference==		==Reference==

OCA at 15:48, 19 June 2013

OCA — Wed, 19 Jun 2013 15:48:47 GMT

←Older revision		Revision as of 15:48, 19 June 2013
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-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4bfd\| PDB=4bfd \| SCENE= }}
		+	===CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH CHEMICAL LIGAND===
		+	{{ABSTRACT_PUBMED_23735744}}

-	~~The entry 4bfd~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>

-	~~Authors~~: ~~BANNER, D~~.W.~~, BENZ, J~~.~~, STIHLE, M~~.	+	==About this Structure==
		+	[[4bfd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFD OCA].

-	~~Description~~: ~~CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH CHEMICAL LIGAND~~	+	==Reference==
		+	<ref group="xtra">PMID:023735744</ref><references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Memapsin 2]]
		+	[[Category: Banner, D W.]]
		+	[[Category: Benz, J.]]
		+	[[Category: Stihle, M.]]
		+	[[Category: Hydrolase]]

OCA at 00:37, 4 April 2013

OCA — Thu, 04 Apr 2013 00:37:06 GMT

←Older revision		Revision as of 00:37, 4 April 2013
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4bfd is ON HOLD	+	The entry 4bfd is ON HOLD until Paper Publication

	Authors: BANNER, D.W., BENZ, J., STIHLE, M.		Authors: BANNER, D.W., BENZ, J., STIHLE, M.

	Description: CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH CHEMICAL LIGAND		Description: CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH CHEMICAL LIGAND

OCA: Protected "4bfd" [edit=sysop:move=sysop]

OCA — Wed, 27 Mar 2013 08:05:36 GMT

Protected "4bfd" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:05, 27 March 2013