4bh6 - Revision history

OCA at 11:51, 20 December 2023

OCA — Wed, 20 Dec 2023 11:51:18 GMT

←Older revision		Revision as of 11:51, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='4bh6' size='340' side='right'caption='[[4bh6]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='4bh6' size='340' side='right'caption='[[4bh6]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bh6]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BH6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BH6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bh6]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BH6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BH6 FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non~~-~~Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bh6 OCA], [https://pdbe.org/4bh6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bh6 RCSB], [https://www.ebi.ac.uk/pdbsum/4bh6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bh6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bh6 OCA], [https://pdbe.org/4bh6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bh6 RCSB], [https://www.ebi.ac.uk/pdbsum/4bh6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bh6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CDH1_YEAST CDH1_YEAST]] Activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C). During telophase and in the subsequent G1 phase of the cell cycle, recognizes and binds proteins containing a destruction box (D-box) and an additional degradation signal termed the KEN box including ASE1, CDC20, the B-type cyclins CLB2 and CLB3, the polo-like kinase CDC5 and HSL1, and recruits them in a C-box-dependent manner to the APC/C for ubiquitination and subsequent proteolysis. Required for exit from mitosis, cytokinesis and formation of prereplicative complexes in G1. Probably is the target of a BUB2-dependent spindle checkpoint pathway.<ref>PMID:10329618</ref> <ref>PMID:11566880</ref> <ref>PMID:11448992</ref> [[https://www.uniprot.org/uniprot/ACM1_YEAST ACM1_YEAST]] Negative regulator of GDH1, the activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C), and which is required for exit from mitosis, cytokinesis and formation of prereplicative complexes in G1.<ref>PMID:17030612</ref>	+	[https://www.uniprot.org/uniprot/CDH1_YEAST CDH1_YEAST] Activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C). During telophase and in the subsequent G1 phase of the cell cycle, recognizes and binds proteins containing a destruction box (D-box) and an additional degradation signal termed the KEN box including ASE1, CDC20, the B-type cyclins CLB2 and CLB3, the polo-like kinase CDC5 and HSL1, and recruits them in a C-box-dependent manner to the APC/C for ubiquitination and subsequent proteolysis. Required for exit from mitosis, cytokinesis and formation of prereplicative complexes in G1. Probably is the target of a BUB2-dependent spindle checkpoint pathway.<ref>PMID:10329618</ref> <ref>PMID:11566880</ref> <ref>PMID:11448992</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Barford, D]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: Chao~~, W C.H~~]]	+	[[Category: Barford D]]
-	[[Category: Cronin, N]]	+	[[Category: Chao WCH]]
-	[[Category: He, J]]	+	[[Category: Cronin N]]
-	[[Category: Yang, J]]	+	[[Category: He J]]
-	[[Category: Zhang, Z]]	+	[[Category: Yang J]]
-	~~[[Category: Acm1]]~~	+	[[Category: Zhang Z]]
-	~~[[Category: Anaphase promoting complex]]~~	+
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: D box]]~~	+
-	~~[[Category: Ubiquitination~~]]	+

OCA at 07:13, 31 August 2022

OCA — Wed, 31 Aug 2022 07:13:42 GMT

←Older revision		Revision as of 07:13, 31 August 2022
Line 3:		Line 3:
	<StructureSection load='4bh6' size='340' side='right'caption='[[4bh6]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='4bh6' size='340' side='right'caption='[[4bh6]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bh6]] is a 16 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BH6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4BH6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bh6]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BH6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BH6 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4bh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bh6 OCA], [~~http~~://pdbe.org/4bh6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4bh6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4bh6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4bh6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bh6 OCA], [https://pdbe.org/4bh6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bh6 RCSB], [https://www.ebi.ac.uk/pdbsum/4bh6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bh6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CDH1_YEAST CDH1_YEAST]] Activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C). During telophase and in the subsequent G1 phase of the cell cycle, recognizes and binds proteins containing a destruction box (D-box) and an additional degradation signal termed the KEN box including ASE1, CDC20, the B-type cyclins CLB2 and CLB3, the polo-like kinase CDC5 and HSL1, and recruits them in a C-box-dependent manner to the APC/C for ubiquitination and subsequent proteolysis. Required for exit from mitosis, cytokinesis and formation of prereplicative complexes in G1. Probably is the target of a BUB2-dependent spindle checkpoint pathway.<ref>PMID:10329618</ref> <ref>PMID:11566880</ref> <ref>PMID:11448992</ref> [[~~http~~://www.uniprot.org/uniprot/ACM1_YEAST ACM1_YEAST]] Negative regulator of GDH1, the activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C), and which is required for exit from mitosis, cytokinesis and formation of prereplicative complexes in G1.<ref>PMID:17030612</ref>	+	[[https://www.uniprot.org/uniprot/CDH1_YEAST CDH1_YEAST]] Activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C). During telophase and in the subsequent G1 phase of the cell cycle, recognizes and binds proteins containing a destruction box (D-box) and an additional degradation signal termed the KEN box including ASE1, CDC20, the B-type cyclins CLB2 and CLB3, the polo-like kinase CDC5 and HSL1, and recruits them in a C-box-dependent manner to the APC/C for ubiquitination and subsequent proteolysis. Required for exit from mitosis, cytokinesis and formation of prereplicative complexes in G1. Probably is the target of a BUB2-dependent spindle checkpoint pathway.<ref>PMID:10329618</ref> <ref>PMID:11566880</ref> <ref>PMID:11448992</ref> [[https://www.uniprot.org/uniprot/ACM1_YEAST ACM1_YEAST]] Negative regulator of GDH1, the activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C), and which is required for exit from mitosis, cytokinesis and formation of prereplicative complexes in G1.<ref>PMID:17030612</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:42, 13 March 2019

OCA — Wed, 13 Mar 2019 13:42:08 GMT

←Older revision		Revision as of 13:42, 13 March 2019
Line 1:		Line 1:

	==Insights into degron recognition by APC coactivators from the structure of an Acm1-Cdh1 complex==		==Insights into degron recognition by APC coactivators from the structure of an Acm1-Cdh1 complex==
-	<StructureSection load='4bh6' size='340' side='right' caption='[[4bh6]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<StructureSection load='4bh6' size='340' side='right'caption='[[4bh6]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bh6]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BH6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BH6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bh6]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BH6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BH6 FirstGlance]. <br>
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Barford, D]]		[[Category: Barford, D]]
	[[Category: Chao, W C.H]]		[[Category: Chao, W C.H]]

OCA at 17:50, 5 August 2016

OCA — Fri, 05 Aug 2016 17:50:08 GMT

←Older revision		Revision as of 17:50, 5 August 2016
Line 1:		Line 1:
		+
	==Insights into degron recognition by APC coactivators from the structure of an Acm1-Cdh1 complex==		==Insights into degron recognition by APC coactivators from the structure of an Acm1-Cdh1 complex==
	<StructureSection load='4bh6' size='340' side='right' caption='[[4bh6]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='4bh6' size='340' side='right' caption='[[4bh6]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bh6]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BH6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BH6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bh6]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BH6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BH6 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bh6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bh6 RCSB], [http://www.ebi.ac.uk/pdbsum/4bh6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bh6 OCA], [http://pdbe.org/4bh6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bh6 RCSB], [http://www.ebi.ac.uk/pdbsum/4bh6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bh6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4bh6" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Atcc 18824]]
	[[Category: Barford, D]]		[[Category: Barford, D]]
	[[Category: Chao, W C.H]]		[[Category: Chao, W C.H]]

OCA at 20:45, 25 December 2014

OCA — Thu, 25 Dec 2014 20:45:44 GMT

←Older revision		Revision as of 20:45, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4bh6\| PDB=4bh6 \| SCENE= }}~~	+	==Insights into degron recognition by APC coactivators from the structure of an Acm1-Cdh1 complex==
-	===Insights into degron recognition by APC coactivators from the structure of an Acm1-Cdh1 complex===	+	<StructureSection load='4bh6' size='340' side='right' caption='[[4bh6]], [[Resolution\|resolution]] 2.90Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23707760}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4bh6]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BH6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BH6 FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bh6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bh6 RCSB], [http://www.ebi.ac.uk/pdbsum/4bh6 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/CDH1_YEAST CDH1_YEAST]] Activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C). During telophase and in the subsequent G1 phase of the cell cycle, recognizes and binds proteins containing a destruction box (D-box) and an additional degradation signal termed the KEN box including ASE1, CDC20, the B-type cyclins CLB2 and CLB3, the polo-like kinase CDC5 and HSL1, and recruits them in a C-box-dependent manner to the APC/C for ubiquitination and subsequent proteolysis. Required for exit from mitosis, cytokinesis and formation of prereplicative complexes in G1. Probably is the target of a BUB2-dependent spindle checkpoint pathway.<ref>PMID:10329618</ref> <ref>PMID:11566880</ref> <ref>PMID:11448992</ref> [[http://www.uniprot.org/uniprot/ACM1_YEAST ACM1_YEAST]] Negative regulator of GDH1, the activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C), and which is required for exit from mitosis, cytokinesis and formation of prereplicative complexes in G1.<ref>PMID:17030612</ref>		[[http://www.uniprot.org/uniprot/CDH1_YEAST CDH1_YEAST]] Activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C). During telophase and in the subsequent G1 phase of the cell cycle, recognizes and binds proteins containing a destruction box (D-box) and an additional degradation signal termed the KEN box including ASE1, CDC20, the B-type cyclins CLB2 and CLB3, the polo-like kinase CDC5 and HSL1, and recruits them in a C-box-dependent manner to the APC/C for ubiquitination and subsequent proteolysis. Required for exit from mitosis, cytokinesis and formation of prereplicative complexes in G1. Probably is the target of a BUB2-dependent spindle checkpoint pathway.<ref>PMID:10329618</ref> <ref>PMID:11566880</ref> <ref>PMID:11448992</ref> [[http://www.uniprot.org/uniprot/ACM1_YEAST ACM1_YEAST]] Negative regulator of GDH1, the activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C), and which is required for exit from mitosis, cytokinesis and formation of prereplicative complexes in G1.<ref>PMID:17030612</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The anaphase-promoting complex/cyclosome (APC/C) regulates sister chromatid segregation and the exit from mitosis. Selection of most APC/C substrates is controlled by coactivator subunits (either Cdc20 or Cdh1) that interact with substrate destruction motifs-predominantly the destruction (D) box and KEN box degrons. How coactivators recognize D box degrons and how this is inhibited by APC/C regulatory proteins is not defined at the atomic level. Here, from the crystal structure of S. cerevisiae Cdh1 in complex with its specific inhibitor Acm1, which incorporates D and KEN box pseudosubstrate motifs, we describe the molecular basis for D box recognition. Additional interactions between Acm1 and Cdh1 identify a third protein-binding site on Cdh1 that is likely to confer coactivator-specific protein functions including substrate association. We provide a structural rationalization for D box and KEN box recognition by coactivators and demonstrate that many noncanonical APC/C degrons bind APC/C coactivators at the D box coreceptor.

-	~~==About this Structure==~~	+	Insights into Degron Recognition by APC/C Coactivators from the Structure of an Acm1-Cdh1 Complex.,He J, Chao WC, Zhang Z, Yang J, Cronin N, Barford D Mol Cell. 2013 May 22. pii: S1097-2765(13)00329-8. doi:, 10.1016/j.molcel.2013.04.024. PMID:23707760<ref>PMID:23707760</ref>
-	~~[[4bh6]] is a 16 chain structure with sequence from [http:~~/~~/en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.~~il/oca-bin/ocashort?id=4BH6 OCA]~~.	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:023707760</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Barford, D.]]	+	[[Category: Barford, D]]
-	[[Category: Chao, W C.H.]]	+	[[Category: Chao, W C.H]]
-	[[Category: Cronin, N.]]	+	[[Category: Cronin, N]]
-	[[Category: He, J.]]	+	[[Category: He, J]]
-	[[Category: Yang, J.]]	+	[[Category: Yang, J]]
-	[[Category: Zhang, Z.]]	+	[[Category: Zhang, Z]]
	[[Category: Acm1]]		[[Category: Acm1]]
	[[Category: Anaphase promoting complex]]		[[Category: Anaphase promoting complex]]

OCA at 08:53, 19 June 2013

OCA — Wed, 19 Jun 2013 08:53:41 GMT

←Older revision		Revision as of 08:53, 19 June 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4bh6\| PDB=4bh6 \| SCENE= }}
		+	===Insights into degron recognition by APC coactivators from the structure of an Acm1-Cdh1 complex===
		+	{{ABSTRACT_PUBMED_23707760}}

-	~~The entry 4bh6~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/CDH1_YEAST CDH1_YEAST]] Activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C). During telophase and in the subsequent G1 phase of the cell cycle, recognizes and binds proteins containing a destruction box (D-box) and an additional degradation signal termed the KEN box including ASE1, CDC20, the B-type cyclins CLB2 and CLB3, the polo-like kinase CDC5 and HSL1, and recruits them in a C-box-dependent manner to the APC/C for ubiquitination and subsequent proteolysis. Required for exit from mitosis, cytokinesis and formation of prereplicative complexes in G1. Probably is the target of a BUB2-dependent spindle checkpoint pathway.<ref>PMID:10329618</ref> <ref>PMID:11566880</ref> <ref>PMID:11448992</ref> [[http://www.uniprot.org/uniprot/ACM1_YEAST ACM1_YEAST]] Negative regulator of GDH1, the activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C), and which is required for exit from mitosis, cytokinesis and formation of prereplicative complexes in G1.<ref>PMID:17030612</ref>

-	~~Authors~~: ~~He, J~~.~~, Chao, W~~.C.~~H., Zhang, Z~~.~~, Yang, J~~.~~, Cronin, N~~.~~, Barford, D~~.	+	==About this Structure==
		+	[[4bh6]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BH6 OCA].

-	~~Description~~: ~~Insights into degron recognition by APC coactivators from the structure of an~~ Acm1~~-Cdh1~~ complex	+	==Reference==
		+	<ref group="xtra">PMID:023707760</ref><references group="xtra"/><references/>
		+	[[Category: Saccharomyces cerevisiae]]
		+	[[Category: Barford, D.]]
		+	[[Category: Chao, W C.H.]]
		+	[[Category: Cronin, N.]]
		+	[[Category: He, J.]]
		+	[[Category: Yang, J.]]
		+	[[Category: Zhang, Z.]]
		+	[[Category: Acm1]]
		+	[[Category: Anaphase promoting complex]]
		+	[[Category: Cell cycle]]
		+	[[Category: D box]]
		+	[[Category: Ubiquitination]]

OCA: Protected "4bh6" [edit=sysop:move=sysop]

OCA — Wed, 17 Apr 2013 19:42:10 GMT

Protected "4bh6" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:42, 17 April 2013

OCA: New page: '''Unreleased structure''' The entry 4bh6 is ON HOLD until Paper Publication Authors: He, J., Chao, W.C.H., Zhang, Z., Yang, J., Cronin, N., Barford, D. Description: Insights into degr...

OCA — Wed, 17 Apr 2013 19:42:09 GMT

New page: '''Unreleased structure''' The entry 4bh6 is ON HOLD until Paper Publication Authors: He, J., Chao, W.C.H., Zhang, Z., Yang, J., Cronin, N., Barford, D. Description: Insights into degr...

New page

'''Unreleased structure'''

The entry 4bh6 is ON HOLD until Paper Publication

Authors: He, J., Chao, W.C.H., Zhang, Z., Yang, J., Cronin, N., Barford, D.

Description: Insights into degron recognition by APC coactivators from the structure of an Acm1-Cdh1 complex