4bih - Revision history

OCA at 11:52, 20 December 2023

OCA — Wed, 20 Dec 2023 11:52:11 GMT

←Older revision		Revision as of 11:52, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='4bih' size='340' side='right'caption='[[4bih]], [[Resolution\|resolution]] 2.46Å' scene=''>		<StructureSection load='4bih' size='340' side='right'caption='[[4bih]], [[Resolution\|resolution]] 2.46Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bih]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Staa8 Staa8~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BIH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BIH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bih]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_NCTC_8325 Staphylococcus aureus subsp. aureus NCTC 8325]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BIH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BIH FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.459Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[4big\|4big]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bih OCA], [https://pdbe.org/4bih PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bih RCSB], [https://www.ebi.ac.uk/pdbsum/4bih PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bih ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bih OCA], [https://pdbe.org/4bih PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bih RCSB], [https://www.ebi.ac.uk/pdbsum/4bih PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bih ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Y052_STAA8 Y052_STAA8]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Staa8~~]]	+	[[Category: Staphylococcus aureus subsp. aureus NCTC 8325]]
-	[[Category: Bottomley~~, M J~~]]	+	[[Category: Bottomley MJ]]
-	[[Category: Liberatori, S]]	+	[[Category: Liberatori S]]
-	[[Category: Malito, E]]	+	[[Category: Malito E]]
-	[[Category: Schluepen, C]]	+	[[Category: Schluepen C]]
-	[[Category: Spraggon, G]]	+	[[Category: Spraggon G]]
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Protective immunity]]~~	+
-	~~[[Category: Tandem lipoprotein~~]]	+

OCA at 07:14, 31 August 2022

OCA — Wed, 31 Aug 2022 07:14:56 GMT

←Older revision		Revision as of 07:14, 31 August 2022
Line 3:		Line 3:
	<StructureSection load='4bih' size='340' side='right'caption='[[4bih]], [[Resolution\|resolution]] 2.46Å' scene=''>		<StructureSection load='4bih' size='340' side='right'caption='[[4bih]], [[Resolution\|resolution]] 2.46Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bih]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Staa8 Staa8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BIH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4BIH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bih]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staa8 Staa8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BIH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BIH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4big\|4big]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4big\|4big]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4bih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bih OCA], [~~http~~://pdbe.org/4bih PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4bih RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4bih PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4bih ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bih OCA], [https://pdbe.org/4bih PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bih RCSB], [https://www.ebi.ac.uk/pdbsum/4bih PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bih ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:58, 13 March 2019

OCA — Wed, 13 Mar 2019 13:58:09 GMT

←Older revision		Revision as of 13:58, 13 March 2019
Line 1:		Line 1:

	==Crystal structure of the conserved staphylococcal antigen 1A, Csa1A==		==Crystal structure of the conserved staphylococcal antigen 1A, Csa1A==
-	<StructureSection load='4bih' size='340' side='right' caption='[[4bih]], [[Resolution\|resolution]] 2.46Å' scene=''>	+	<StructureSection load='4bih' size='340' side='right'caption='[[4bih]], [[Resolution\|resolution]] 2.46Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bih]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staa8 Staa8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BIH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BIH FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bih]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staa8 Staa8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BIH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BIH FirstGlance]. <br>
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Staa8]]		[[Category: Staa8]]
	[[Category: Bottomley, M J]]		[[Category: Bottomley, M J]]

OCA at 10:47, 4 August 2016

OCA — Thu, 04 Aug 2016 10:47:49 GMT

←Older revision		Revision as of 10:47, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the conserved staphylococcal antigen 1A, Csa1A==		==Crystal structure of the conserved staphylococcal antigen 1A, Csa1A==
	<StructureSection load='4bih' size='340' side='right' caption='[[4bih]], [[Resolution\|resolution]] 2.46Å' scene=''>		<StructureSection load='4bih' size='340' side='right' caption='[[4bih]], [[Resolution\|resolution]] 2.46Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bih]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Staphylococcus_aureus_subsp._aureus_nctc_8325 Staphylococcus aureus subsp. aureus nctc 8325~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BIH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BIH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bih]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staa8 Staa8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BIH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BIH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4big\|4big]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4big\|4big]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bih OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bih RCSB], [http://www.ebi.ac.uk/pdbsum/4bih PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bih OCA], [http://pdbe.org/4bih PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bih RCSB], [http://www.ebi.ac.uk/pdbsum/4bih PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bih ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4bih" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Staphylococcus aureus subsp. aureus nctc 8325~~]]	+	[[Category: Staa8]]
	[[Category: Bottomley, M J]]		[[Category: Bottomley, M J]]
	[[Category: Liberatori, S]]		[[Category: Liberatori, S]]

OCA at 10:05, 21 December 2014

OCA — Sun, 21 Dec 2014 10:05:44 GMT

←Older revision		Revision as of 10:05, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4bih\| PDB=4bih \| SCENE= }}~~	+	==Crystal structure of the conserved staphylococcal antigen 1A, Csa1A==
-	===Crystal structure of the conserved staphylococcal antigen 1A, Csa1A===	+	<StructureSection load='4bih' size='340' side='right' caption='[[4bih]], [[Resolution\|resolution]] 2.46Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23895222}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4bih]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_nctc_8325 Staphylococcus aureus subsp. aureus nctc 8325]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BIH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BIH FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4big\|4big]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bih OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bih RCSB], [http://www.ebi.ac.uk/pdbsum/4bih PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In the human pathogen Staphylococcus aureus there exists an enormous diversity of proteins containing domains of unknown function (DUF). Here, we characterized the family of conserved staphylococcal antigens (Csa) classified as DUF576 and taxonomically restricted to S. aureus. The 18 Csa paralogs in S. aureus Newman are highly similar at the sequence level yet were found to be expressed in multiple cellular localizations. Extracellular Csa1A was shown to be post-translationally processed and released. Molecular interaction studies revealed Csa1A interacts with other Csa paralogs, suggesting that these proteins are involved in the same cellular process. The structures of Csa1A and Csa1B were determined by X-ray crystallography, unveiling a peculiar structure with limited structural similarity to other known proteins. Our results provide the first detailed biological characterization of this family and confirm the uniqueness of this family also at the structural level. We also provide evidence that Csa family members elicit protective immunity in in vivo animal models of Staphylococcal infections, indicating a possible important role of these proteins in S.aureus biology and pathogenesis. These findings identify the Csa family as new potential vaccine candidates, and underline the importance of mining the bacterial unknown proteome to identify new targets for preventive vaccines.

-	~~==About this Structure==~~	+	Mining the bacterial unknown proteome: identification and characterization of a novel family of highly conserved protective antigens in Staphylococcus aureus.,Schluepen C, Malito E, Marongiu A, Schirle M, McWhinnie E, Lo Surdo P, Biancucci M, Falugi F, Nardi-Dei V, Marchi S, Fontana MR, Lombardi B, De Falco MG, Rinaudo CD, Spraggon G, Nissum M, Bagnoli F, Grandi G, Bottomley MJ, Liberatori S Biochem J. 2013 Jul 29. PMID:23895222<ref>PMID:23895222</ref>
-	~~[[4bih]] is~~ a ~~4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_nctc_8325~~ Staphylococcus aureus ~~subsp~~. ~~aureus nctc 8325]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4BIH OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:023895222</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Staphylococcus aureus subsp. aureus nctc 8325]]		[[Category: Staphylococcus aureus subsp. aureus nctc 8325]]
-	[[Category: Bottomley, M J.]]	+	[[Category: Bottomley, M J]]
-	[[Category: Liberatori, S.]]	+	[[Category: Liberatori, S]]
-	[[Category: Malito, E.]]	+	[[Category: Malito, E]]
-	[[Category: Schluepen, C.]]	+	[[Category: Schluepen, C]]
-	[[Category: Spraggon, G.]]	+	[[Category: Spraggon, G]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Protective immunity]]		[[Category: Protective immunity]]
	[[Category: Tandem lipoprotein]]		[[Category: Tandem lipoprotein]]

OCA at 20:54, 7 August 2013

OCA — Wed, 07 Aug 2013 20:54:36 GMT

←Older revision		Revision as of 20:54, 7 August 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4bih\| PDB=4bih \| SCENE= }}
		+	===Crystal structure of the conserved staphylococcal antigen 1A, Csa1A===
		+	{{ABSTRACT_PUBMED_23895222}}

-	~~The entry~~ 4bih is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
		+	[[4bih]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_nctc_8325 Staphylococcus aureus subsp. aureus nctc 8325]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BIH OCA].

-	~~Authors~~: ~~Malito, E~~., Bottomley, M.J., ~~Spraggon, G~~., Schluepen, C., ~~Liberatori, S~~.	+	==Reference==
-		+	<ref group="xtra">PMID:023895222</ref><references group="xtra"/><references/>
-	~~Description~~: ~~Crystal structure of the conserved staphylococcal antigen 1A, Csa1A~~	+	[[Category: Staphylococcus aureus subsp. aureus nctc 8325]]
		+	[[Category: Bottomley, M J.]]
		+	[[Category: Liberatori, S.]]
		+	[[Category: Malito, E.]]
		+	[[Category: Schluepen, C.]]
		+	[[Category: Spraggon, G.]]
		+	[[Category: Immune system]]
		+	[[Category: Protective immunity]]
		+	[[Category: Tandem lipoprotein]]

OCA: Protected "4bih" [edit=sysop:move=sysop]

OCA — Wed, 17 Apr 2013 19:43:27 GMT

Protected "4bih" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:43, 17 April 2013

OCA: New page: '''Unreleased structure''' The entry 4bih is ON HOLD until Paper Publication Authors: Malito, E., Bottomley, M.J., Spraggon, G., Schluepen, C., Liberatori, S. Description: Crystal stru...

OCA — Wed, 17 Apr 2013 19:43:26 GMT

New page: '''Unreleased structure''' The entry 4bih is ON HOLD until Paper Publication Authors: Malito, E., Bottomley, M.J., Spraggon, G., Schluepen, C., Liberatori, S. Description: Crystal stru...

New page

'''Unreleased structure'''

The entry 4bih is ON HOLD until Paper Publication

Authors: Malito, E., Bottomley, M.J., Spraggon, G., Schluepen, C., Liberatori, S.

Description: Crystal structure of the conserved staphylococcal antigen 1A, Csa1A