4bjx - Revision history

OCA at 11:01, 9 May 2024

OCA — Thu, 09 May 2024 11:01:28 GMT

←Older revision		Revision as of 11:01, 9 May 2024
Line 3:		Line 3:
	<StructureSection load='4bjx' size='340' side='right'caption='[[4bjx]], [[Resolution\|resolution]] 1.59Å' scene=''>		<StructureSection load='4bjx' size='340' side='right'caption='[[4bjx]], [[Resolution\|resolution]] 1.59Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bjx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BJX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bjx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BJX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=73B:4-[(2S,4R)-1-ACETYL-4-[(4-CHLOROPHENYL)AMINO]-2-METHYL-1,2,3,4-TETRAHYDROQUINOLIN-6-YL]BENZOIC+ACID'>73B</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.59Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=73B:4-[(2S,4R)-1-ACETYL-4-[(4-CHLOROPHENYL)AMINO]-2-METHYL-1,2,3,4-TETRAHYDROQUINOLIN-6-YL]BENZOIC+ACID'>73B</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bjx OCA], [https://pdbe.org/4bjx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bjx RCSB], [https://www.ebi.ac.uk/pdbsum/4bjx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bjx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bjx OCA], [https://pdbe.org/4bjx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bjx RCSB], [https://www.ebi.ac.uk/pdbsum/4bjx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bjx ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>	+	[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).	+	[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chung, C]]	+	[[Category: Chung C]]
-	~~[[Category: Dna binding protein]]~~	+
-	~~[[Category: Epigenetic reader]]~~	+
-	~~[[Category: Histone]]~~	+
-	~~[[Category: Inhibitor~~]]	+

OCA at 07:16, 31 August 2022

OCA — Wed, 31 Aug 2022 07:16:09 GMT

←Older revision		Revision as of 07:16, 31 August 2022
Line 3:		Line 3:
	<StructureSection load='4bjx' size='340' side='right'caption='[[4bjx]], [[Resolution\|resolution]] 1.59Å' scene=''>		<StructureSection load='4bjx' size='340' side='right'caption='[[4bjx]], [[Resolution\|resolution]] 1.59Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bjx]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4BJX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bjx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BJX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=73B:4-[(2S,4R)-1-ACETYL-4-[(4-CHLOROPHENYL)AMINO]-2-METHYL-1,2,3,4-TETRAHYDROQUINOLIN-6-YL]BENZOIC+ACID'>73B</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=73B:4-[(2S,4R)-1-ACETYL-4-[(4-CHLOROPHENYL)AMINO]-2-METHYL-1,2,3,4-TETRAHYDROQUINOLIN-6-YL]BENZOIC+ACID'>73B</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4bjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bjx OCA], [~~http~~://pdbe.org/4bjx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4bjx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4bjx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4bjx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bjx OCA], [https://pdbe.org/4bjx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bjx RCSB], [https://www.ebi.ac.uk/pdbsum/4bjx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bjx ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>	+	[[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).	+	[[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:58, 21 May 2019

OCA — Tue, 21 May 2019 07:58:21 GMT

←Older revision		Revision as of 07:58, 21 May 2019
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Bromodomain-containing protein\|Bromodomain-containing protein]]	+	*[[Bromodomain-containing protein 3D structures\|Bromodomain-containing protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:12, 13 March 2019

OCA — Wed, 13 Mar 2019 13:12:46 GMT

←Older revision		Revision as of 13:12, 13 March 2019
Line 1:		Line 1:

	==N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH GSK1324726A (I-BET726)==		==N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH GSK1324726A (I-BET726)==
-	<StructureSection load='4bjx' size='340' side='right' caption='[[4bjx]], [[Resolution\|resolution]] 1.59Å' scene=''>	+	<StructureSection load='4bjx' size='340' side='right'caption='[[4bjx]], [[Resolution\|resolution]] 1.59Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bjx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BJX FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bjx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BJX FirstGlance]. <br>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Chung, C]]		[[Category: Chung, C]]
	[[Category: Dna binding protein]]		[[Category: Dna binding protein]]

OCA at 11:42, 11 August 2016

OCA — Thu, 11 Aug 2016 11:42:33 GMT

←Older revision		Revision as of 11:42, 11 August 2016
Line 1:		Line 1:
		+
	==N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH GSK1324726A (I-BET726)==		==N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH GSK1324726A (I-BET726)==
	<StructureSection load='4bjx' size='340' side='right' caption='[[4bjx]], [[Resolution\|resolution]] 1.59Å' scene=''>		<StructureSection load='4bjx' size='340' side='right' caption='[[4bjx]], [[Resolution\|resolution]] 1.59Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4bjx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BJX FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bjx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BJX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=73B:4-[(2S,4R)-1-ACETYL-4-[(4-CHLOROPHENYL)AMINO]-2-METHYL-1,2,3,4-TETRAHYDROQUINOLIN-6-YL]BENZOIC+ACID'>73B</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=73B:4-[(2S,4R)-1-ACETYL-4-[(4-CHLOROPHENYL)AMINO]-2-METHYL-1,2,3,4-TETRAHYDROQUINOLIN-6-YL]BENZOIC+ACID'>73B</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bjx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bjx RCSB], [http://www.ebi.ac.uk/pdbsum/4bjx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bjx OCA], [http://pdbe.org/4bjx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bjx RCSB], [http://www.ebi.ac.uk/pdbsum/4bjx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bjx ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4bjx" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Bromodomain-containing protein\|Bromodomain-containing protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:48, 4 January 2015

OCA — Sun, 04 Jan 2015 13:48:24 GMT

←Older revision		Revision as of 13:48, 4 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_4bjx\| PDB=4bjx \| SCENE= }}~~	+	==N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH GSK1324726A (I-BET726)==
-	===N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH GSK1324726A (I-BET726)===	+	<StructureSection load='4bjx' size='340' side='right' caption='[[4bjx]], [[Resolution\|resolution]] 1.59Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24009722}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4bjx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BJX FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=73B:4-[(2S,4R)-1-ACETYL-4-[(4-CHLOROPHENYL)AMINO]-2-METHYL-1,2,3,4-TETRAHYDROQUINOLIN-6-YL]BENZOIC+ACID'>73B</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bjx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bjx RCSB], [http://www.ebi.ac.uk/pdbsum/4bjx PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>		[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
-		+	== Function ==
-	==Function==	+
	[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).		[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	BET family proteins are epigenetic regulators known to control expression of genes involved in cell growth and oncogenesis. Selective inhibitors of BET proteins exhibit potent anti-proliferative activity in a number of hematologic cancer models, in part through suppression of the MYC oncogene and downstream Myc-driven pathways. However, little is currently known about the activity of BET inhibitors in solid tumor models, and whether down-regulation of MYC family genes contributes to sensitivity. Here we provide evidence for potent BET inhibitor activity in neuroblastoma, a pediatric solid tumor associated with a high frequency of MYCN amplifications. We treated a panel of neuroblastoma cell lines with a novel small molecule inhibitor of BET proteins, GSK1324726A (I-BET726), and observed potent growth inhibition and cytotoxicity in most cell lines irrespective of MYCN copy number or expression level. Gene expression analyses in neuroblastoma cell lines suggest a role of BET inhibition in apoptosis, signaling, and N-Myc-driven pathways, including the direct suppression of BCL2 and MYCN. Reversal of MYCN or BCL2 suppression reduces the potency of I-BET726-induced cytotoxicity in a cell line-specific manner; however, neither factor fully accounts for I-BET726 sensitivity. Oral administration of I-BET726 to mouse xenograft models of human neuroblastoma results in tumor growth inhibition and down-regulation MYCN and BCL2 expression, suggesting a potential role for these genes in tumor growth. Taken together, our data highlight the potential of BET inhibitors as novel therapeutics for neuroblastoma, and suggest that sensitivity is driven by pleiotropic effects on cell growth and apoptotic pathways in a context-specific manner.

-	~~==About this Structure==~~	+	BET inhibition silences expression of MYCN and BCL2 and induces cytotoxicity in neuroblastoma tumor models.,Wyce A, Ganji G, Smitheman KN, Chung CW, Korenchuk S, Bai Y, Barbash O, Le B, Craggs PD, McCabe MT, Kennedy-Wilson KM, Sanchez LV, Gosmini RL, Parr N, McHugh CF, Dhanak D, Prinjha RK, Auger KR, Tummino PJ PLoS One. 2013 Aug 23;8(8):e72967. doi: 10.1371/journal.pone.0072967. eCollection, 2013. PMID:24009722<ref>PMID:24009722</ref>
-	~~[[4bjx]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Human Human]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4BJX OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024009722</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Human]]		[[Category: Human]]
-	[[Category: Chung, C.]]	+	[[Category: Chung, C]]
	[[Category: Dna binding protein]]		[[Category: Dna binding protein]]
	[[Category: Epigenetic reader]]		[[Category: Epigenetic reader]]
	[[Category: Histone]]		[[Category: Histone]]
	[[Category: Inhibitor]]		[[Category: Inhibitor]]

OCA at 06:07, 23 April 2014

OCA — Wed, 23 Apr 2014 06:07:20 GMT

←Older revision		Revision as of 06:07, 23 April 2014
Line 1:		Line 1:
	{{STRUCTURE_4bjx\| PDB=4bjx \| SCENE= }}		{{STRUCTURE_4bjx\| PDB=4bjx \| SCENE= }}
	===N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH GSK1324726A (I-BET726)===		===N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH GSK1324726A (I-BET726)===
		+	{{ABSTRACT_PUBMED_24009722}}

	==Disease==		==Disease==
Line 9:		Line 10:

	==About this Structure==		==About this Structure==
-	[[4bjx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJX OCA].	+	[[4bjx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJX OCA].

	==Reference==		==Reference==
-	<references group="xtra"/><references/>	+	<ref group="xtra">PMID:024009722</ref><references group="xtra"/><references/>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Chung, C.]]		[[Category: Chung, C.]]
	[[Category: Dna binding protein]]		[[Category: Dna binding protein]]

OCA at 07:31, 2 October 2013

OCA — Wed, 02 Oct 2013 07:31:39 GMT

←Older revision		Revision as of 07:31, 2 October 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4bjx\| PDB=4bjx \| SCENE= }}
		+	===N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH GSK1324726A (I-BET726)===

-	~~The entry 4bjx~~ is ~~ON HOLD~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>

-	~~Authors~~: ~~Chung, C~~.	+	==Function==
		+	[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

-	~~Description~~: N-~~TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH GSK1324726A (I-BET726)~~	+	==About this Structure==
		+	[[4bjx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJX OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Chung, C.]]
		+	[[Category: Dna binding protein]]
		+	[[Category: Epigenetic reader]]
		+	[[Category: Histone]]
		+	[[Category: Inhibitor]]

OCA: Protected "4bjx" [edit=sysop:move=sysop]

OCA — Thu, 02 May 2013 06:56:58 GMT

Protected "4bjx" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:56, 2 May 2013

OCA: New page: '''Unreleased structure''' The entry 4bjx is ON HOLD Authors: Chung, C. Description: N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH GSK1324726A (I-BET726)

OCA — Thu, 02 May 2013 06:56:57 GMT

New page: '''Unreleased structure''' The entry 4bjx is ON HOLD Authors: Chung, C. Description: N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH GSK1324726A (I-BET726)

New page

'''Unreleased structure'''

The entry 4bjx is ON HOLD

Authors: Chung, C.

Description: N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH GSK1324726A (I-BET726)