4bmh - Revision history

OCA at 11:02, 9 May 2024

OCA — Thu, 09 May 2024 11:02:28 GMT

←Older revision		Revision as of 11:02, 9 May 2024
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	<StructureSection load='4bmh' size='340' side='right'caption='[[4bmh]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='4bmh' size='340' side='right'caption='[[4bmh]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bmh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Streptomyces_sviceus_atcc_29083~~ Streptomyces sviceus ~~atcc~~ 29083]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BMH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BMH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bmh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_sviceus_ATCC_29083 Streptomyces sviceus ATCC 29083]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BMH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BMH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bmh OCA], [https://pdbe.org/4bmh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bmh RCSB], [https://www.ebi.ac.uk/pdbsum/4bmh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bmh ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bmh OCA], [https://pdbe.org/4bmh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bmh RCSB], [https://www.ebi.ac.uk/pdbsum/4bmh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bmh ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/B5HKU0_9ACTN B5HKU0_9ACTN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Streptomyces sviceus ~~atcc~~ 29083]]	+	[[Category: Streptomyces sviceus ATCC 29083]]
-	[[Category: Davies~~, G J~~]]	+	[[Category: Davies GJ]]
-	[[Category: He, Y]]	+	[[Category: He Y]]
-	[[Category: Turkenburg~~, J P]]~~	+	[[Category: Turkenburg JP]]
-	~~[[Category: Hat]]~~	+
-	~~[[Category: O-glcnacase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 07:18, 31 August 2022

OCA — Wed, 31 Aug 2022 07:18:34 GMT

←Older revision		Revision as of 07:18, 31 August 2022
Line 3:		Line 3:
	<StructureSection load='4bmh' size='340' side='right'caption='[[4bmh]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='4bmh' size='340' side='right'caption='[[4bmh]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bmh]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Streptomyces_sviceus_atcc_29083 Streptomyces sviceus atcc 29083]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BMH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4BMH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bmh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_sviceus_atcc_29083 Streptomyces sviceus atcc 29083]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BMH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BMH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4bmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bmh OCA], [~~http~~://pdbe.org/4bmh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4bmh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4bmh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4bmh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bmh OCA], [https://pdbe.org/4bmh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bmh RCSB], [https://www.ebi.ac.uk/pdbsum/4bmh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bmh ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:57, 13 March 2019

OCA — Wed, 13 Mar 2019 13:57:18 GMT

←Older revision		Revision as of 13:57, 13 March 2019
Line 1:		Line 1:

	==Crystal structure of SsHAT==		==Crystal structure of SsHAT==
-	<StructureSection load='4bmh' size='340' side='right' caption='[[4bmh]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='4bmh' size='340' side='right'caption='[[4bmh]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bmh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_sviceus_atcc_29083 Streptomyces sviceus atcc 29083]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BMH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BMH FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bmh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_sviceus_atcc_29083 Streptomyces sviceus atcc 29083]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BMH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BMH FirstGlance]. <br>
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Streptomyces sviceus atcc 29083]]		[[Category: Streptomyces sviceus atcc 29083]]
	[[Category: Davies, G J]]		[[Category: Davies, G J]]

OCA at 20:51, 5 August 2016

OCA — Fri, 05 Aug 2016 20:51:05 GMT

←Older revision		Revision as of 20:51, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of SsHAT==		==Crystal structure of SsHAT==
	<StructureSection load='4bmh' size='340' side='right' caption='[[4bmh]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='4bmh' size='340' side='right' caption='[[4bmh]], [[Resolution\|resolution]] 1.50Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4bmh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_sviceus_atcc_29083 Streptomyces sviceus atcc 29083]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BMH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BMH FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bmh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_sviceus_atcc_29083 Streptomyces sviceus atcc 29083]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BMH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BMH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bmh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bmh RCSB], [http://www.ebi.ac.uk/pdbsum/4bmh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bmh OCA], [http://pdbe.org/4bmh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bmh RCSB], [http://www.ebi.ac.uk/pdbsum/4bmh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bmh ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4bmh" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:53, 21 December 2014

OCA — Sun, 21 Dec 2014 18:53:33 GMT

←Older revision		Revision as of 18:53, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4bmh\| PDB~~=4bmh \| ~~SCENE~~= }}	+	==Crystal structure of SsHAT==
-	===~~Crystal~~ structure ~~of SsHAT~~===	+	<StructureSection load='4bmh' size='340' side='right' caption='[[4bmh]], [[Resolution\|resolution]] 1.50Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24419391}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4bmh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_sviceus_atcc_29083 Streptomyces sviceus atcc 29083]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BMH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BMH FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bmh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bmh RCSB], [http://www.ebi.ac.uk/pdbsum/4bmh PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The mammalian O-GlcNAc hydrolysing enzyme O-GlcNAcase (OGA) is a multi-domain protein with glycoside hydrolase activity in the N-terminus and with a C-terminal domain that has low sequence similarity to known acetyltransferases, prompting speculation, albeit controversial, that the C-terminal domain may function as a histone acetyltransferase (HAT). There are currently scarce data available regarding the structure and function of this C-terminal region. Here, a bacterial homologue of the human OGA C-terminal domain, an acetyltransferase protein (accession No. ZP_05014886) from Streptomyces sviceus (SsAT), was cloned and its crystal structure was solved to high resolution. The structure reveals a conserved protein core that has considerable structural homology to the acetyl-CoA (AcCoA) binding site of GCN5-related acetyltransferases (GNATs). Calorimetric data further confirm that SsAT is indeed able to bind AcCoA in solution with micromolar affinity. Detailed structural analysis provided insight into the binding of AcCoA. An acceptor-binding cavity was identified, indicating that the physiological substrate of SsAT may be a small molecule. Consistent with recently published work, the SsAT structure further questions a HAT function for the human OGA domain.

-	~~==About this Structure==~~	+	Three-dimensional structure of a Streptomyces sviceus GNAT acetyltransferase with similarity to the C-terminal domain of the human GH84 O-GlcNAcase.,He Y, Roth C, Turkenburg JP, Davies GJ Acta Crystallogr D Biol Crystallogr. 2014 Jan;70(Pt 1):186-95. doi:, 10.1107/S1399004713029155. Epub 2013 Dec 31. PMID:24419391<ref>PMID:24419391</ref>
-	~~[[4bmh]] is~~ a 1 ~~chain structure~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4BMH OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024419391</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
-	[[Category: Davies, G J.]]	+	== References ==
-	[[Category: He, Y.]]	+	<references/>
-	[[Category: Turkenburg, J P.]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Streptomyces sviceus atcc 29083]]
		+	[[Category: Davies, G J]]
		+	[[Category: He, Y]]
		+	[[Category: Turkenburg, J P]]
	[[Category: Hat]]		[[Category: Hat]]
	[[Category: O-glcnacase]]		[[Category: O-glcnacase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 06:26, 22 January 2014

OCA — Wed, 22 Jan 2014 06:26:42 GMT

←Older revision		Revision as of 06:26, 22 January 2014
Line 1:		Line 1:
	{{STRUCTURE_4bmh\| PDB=4bmh \| SCENE= }}		{{STRUCTURE_4bmh\| PDB=4bmh \| SCENE= }}
	===Crystal structure of SsHAT===		===Crystal structure of SsHAT===
		+	{{ABSTRACT_PUBMED_24419391}}

	==About this Structure==		==About this Structure==
	[[4bmh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BMH OCA].		[[4bmh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BMH OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:024419391</ref><references group="xtra"/><references/>
	[[Category: Davies, G J.]]		[[Category: Davies, G J.]]
	[[Category: He, Y.]]		[[Category: He, Y.]]

OCA at 08:21, 15 January 2014

OCA — Wed, 15 Jan 2014 08:21:01 GMT

←Older revision		Revision as of 08:21, 15 January 2014
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4bmh\| PDB=4bmh \| SCENE= }}
		+	===Crystal structure of SsHAT===

-	~~The entry~~ 4bmh is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
-		+	[[4bmh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BMH OCA].
-	~~Authors~~: He, Y., Turkenburg, J.P.~~, Davies, G.J.~~	+	[[Category: Davies, G J.]]
-		+	[[Category: He, Y.]]
-	~~Description~~: ~~Crystal structure of SsHAT~~	+	[[Category: Turkenburg, J P.]]
		+	[[Category: Hat]]
		+	[[Category: O-glcnacase]]
		+	[[Category: Transferase]]

OCA: Protected "4bmh" [edit=sysop:move=sysop]

OCA — Thu, 16 May 2013 06:42:38 GMT

Protected "4bmh" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:42, 16 May 2013

OCA: New page: '''Unreleased structure''' The entry 4bmh is ON HOLD until Paper Publication Authors: He, Y., Turkenburg, J.P., Davies, G.J. Description: Crystal structure of SsHAT

OCA — Thu, 16 May 2013 06:42:37 GMT

New page: '''Unreleased structure''' The entry 4bmh is ON HOLD until Paper Publication Authors: He, Y., Turkenburg, J.P., Davies, G.J. Description: Crystal structure of SsHAT

New page

'''Unreleased structure'''

The entry 4bmh is ON HOLD until Paper Publication

Authors: He, Y., Turkenburg, J.P., Davies, G.J.

Description: Crystal structure of SsHAT