4bo7 - Revision history

OCA at 11:55, 20 December 2023

OCA — Wed, 20 Dec 2023 11:55:47 GMT

←Older revision		Revision as of 11:55, 20 December 2023
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	<StructureSection load='4bo7' size='340' side='right'caption='[[4bo7]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='4bo7' size='340' side='right'caption='[[4bo7]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bo7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Pseae Pseae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BO7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bo7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BO7 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=J2T:N~~-(2,~~3-DIHYDRO-1H-INDEN-5-YL)TETRAZOLO~~[~~1,5-B~~]~~PYRIDAZIN-~~6~~-AMINE'>J2T</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4bnt\|4bnt]], [[4bnu\|4bnu]], [[4bnv\|4bnv]], [[4bnw\|4bnw]], [[4bnx\|4bnx]], [[4bny\|4bny]], [[4bnz\|4bnz]], [[4bo0\|4bo0]], [[4bo1\|4bo1]], [[4bo2\|4bo2]], [[4bo3\|4bo3]], [[4bo4\|4bo4]], [[4bo5\|4bo5]], [[4bo6\|4bo6]], [[4bo8\|4bo8]], [[4bo9\|4bo9]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=J2T:N-(2,3-DIHYDRO-1H-INDEN-5-YL)TETRAZOLO[1,5-B]PYRIDAZIN-6-AMINE'>J2T</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/~~3-~~oxoacyl~~-~~[acyl~~-~~carrier~~-~~protein]_reductase 3-oxoacyl~~-[~~acyl~~-~~carrier-protein~~] ~~reductase], with EC number [https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=1.1.1.100 1.1.1.100]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bo7 OCA], [https://pdbe.org/4bo7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bo7 RCSB], [https://www.ebi.ac.uk/pdbsum/4bo7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bo7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bo7 OCA], [https://pdbe.org/4bo7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bo7 RCSB], [https://www.ebi.ac.uk/pdbsum/4bo7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bo7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FABG_PSEAE FABG_PSEAE]] Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis (By similarity).	+	[https://www.uniprot.org/uniprot/FABG_PSEAE FABG_PSEAE] Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 29:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Pseae~~]]	+	[[Category: Pseudomonas aeruginosa PAO1]]
-	[[Category: Cukier~~, C D~~]]	+	[[Category: Cukier CD]]
-	[[Category: Lindqvist, Y]]	+	[[Category: Lindqvist Y]]
-	[[Category: Schneider, G]]	+	[[Category: Schneider G]]
-	[[Category: Schnell, R]]	+	[[Category: Schnell R]]
-	~~[[Category: Fatty acid biosynthesis]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Rossmann fold~~]]	+

OCA at 07:20, 31 August 2022

OCA — Wed, 31 Aug 2022 07:20:03 GMT

←Older revision		Revision as of 07:20, 31 August 2022
Line 3:		Line 3:
	<StructureSection load='4bo7' size='340' side='right'caption='[[4bo7]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='4bo7' size='340' side='right'caption='[[4bo7]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bo7]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BO7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4BO7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bo7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BO7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=J2T:N-(2,3-DIHYDRO-1H-INDEN-5-YL)TETRAZOLO[1,5-B]PYRIDAZIN-6-AMINE'>J2T</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=J2T:N-(2,3-DIHYDRO-1H-INDEN-5-YL)TETRAZOLO[1,5-B]PYRIDAZIN-6-AMINE'>J2T</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bnt\|4bnt]], [[4bnu\|4bnu]], [[4bnv\|4bnv]], [[4bnw\|4bnw]], [[4bnx\|4bnx]], [[4bny\|4bny]], [[4bnz\|4bnz]], [[4bo0\|4bo0]], [[4bo1\|4bo1]], [[4bo2\|4bo2]], [[4bo3\|4bo3]], [[4bo4\|4bo4]], [[4bo5\|4bo5]], [[4bo6\|4bo6]], [[4bo8\|4bo8]], [[4bo9\|4bo9]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4bnt\|4bnt]], [[4bnu\|4bnu]], [[4bnv\|4bnv]], [[4bnw\|4bnw]], [[4bnx\|4bnx]], [[4bny\|4bny]], [[4bnz\|4bnz]], [[4bo0\|4bo0]], [[4bo1\|4bo1]], [[4bo2\|4bo2]], [[4bo3\|4bo3]], [[4bo4\|4bo4]], [[4bo5\|4bo5]], [[4bo6\|4bo6]], [[4bo8\|4bo8]], [[4bo9\|4bo9]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/3-oxoacyl-[acyl-carrier-protein]_reductase 3-oxoacyl-[acyl-carrier-protein] reductase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.100 1.1.1.100] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/3-oxoacyl-[acyl-carrier-protein]_reductase 3-oxoacyl-[acyl-carrier-protein] reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.100 1.1.1.100] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4bo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bo7 OCA], [~~http~~://pdbe.org/4bo7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4bo7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4bo7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4bo7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bo7 OCA], [https://pdbe.org/4bo7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bo7 RCSB], [https://www.ebi.ac.uk/pdbsum/4bo7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bo7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FABG_PSEAE FABG_PSEAE]] Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis (By similarity).	+	[[https://www.uniprot.org/uniprot/FABG_PSEAE FABG_PSEAE]] Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Beta-~~ketoacyl~~-~~ACP reductase~~\|Beta-ketoacyl-~~ACP~~ reductase]]	+	*[[Beta-hydroxyacyl-acyl carrier protein dehydratase 3D structures\|Beta-hydroxyacyl-acyl carrier protein dehydratase 3D structures]]
		+	*[[Beta-ketoacyl carrier protein reductase 3D structures\|Beta-ketoacyl carrier protein reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:32, 13 March 2019

OCA — Wed, 13 Mar 2019 13:32:41 GMT

←Older revision		Revision as of 13:32, 13 March 2019
Line 1:		Line 1:

	==Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with N-(2,3-dihydro-1H-inden- 5-yl)tetrazolo(1,5-b)pyridazin-6-amine at 2.6A resolution==		==Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with N-(2,3-dihydro-1H-inden- 5-yl)tetrazolo(1,5-b)pyridazin-6-amine at 2.6A resolution==
-	<StructureSection load='4bo7' size='340' side='right' caption='[[4bo7]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='4bo7' size='340' side='right'caption='[[4bo7]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bo7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BO7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bo7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BO7 FirstGlance]. <br>
Line 27:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Pseae]]		[[Category: Pseae]]
	[[Category: Cukier, C D]]		[[Category: Cukier, C D]]

OCA at 22:58, 5 August 2016

OCA — Fri, 05 Aug 2016 22:58:54 GMT

←Older revision		Revision as of 22:58, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with N-(2,3-dihydro-1H-inden- 5-yl)tetrazolo(1,5-b)pyridazin-6-amine at 2.6A resolution==		==Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with N-(2,3-dihydro-1H-inden- 5-yl)tetrazolo(1,5-b)pyridazin-6-amine at 2.6A resolution==
	<StructureSection load='4bo7' size='340' side='right' caption='[[4bo7]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='4bo7' size='340' side='right' caption='[[4bo7]], [[Resolution\|resolution]] 2.60Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bnt\|4bnt]], [[4bnu\|4bnu]], [[4bnv\|4bnv]], [[4bnw\|4bnw]], [[4bnx\|4bnx]], [[4bny\|4bny]], [[4bnz\|4bnz]], [[4bo0\|4bo0]], [[4bo1\|4bo1]], [[4bo2\|4bo2]], [[4bo3\|4bo3]], [[4bo4\|4bo4]], [[4bo5\|4bo5]], [[4bo6\|4bo6]], [[4bo8\|4bo8]], [[4bo9\|4bo9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bnt\|4bnt]], [[4bnu\|4bnu]], [[4bnv\|4bnv]], [[4bnw\|4bnw]], [[4bnx\|4bnx]], [[4bny\|4bny]], [[4bnz\|4bnz]], [[4bo0\|4bo0]], [[4bo1\|4bo1]], [[4bo2\|4bo2]], [[4bo3\|4bo3]], [[4bo4\|4bo4]], [[4bo5\|4bo5]], [[4bo6\|4bo6]], [[4bo8\|4bo8]], [[4bo9\|4bo9]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-oxoacyl-[acyl-carrier-protein]_reductase 3-oxoacyl-[acyl-carrier-protein] reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.100 1.1.1.100] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-oxoacyl-[acyl-carrier-protein]_reductase 3-oxoacyl-[acyl-carrier-protein] reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.100 1.1.1.100] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bo7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bo7 RCSB], [http://www.ebi.ac.uk/pdbsum/4bo7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bo7 OCA], [http://pdbe.org/4bo7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bo7 RCSB], [http://www.ebi.ac.uk/pdbsum/4bo7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bo7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4bo7" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 06:36, 25 December 2014

OCA — Thu, 25 Dec 2014 06:36:18 GMT

←Older revision		Revision as of 06:36, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4bo7\| PDB=4bo7 \| SCENE= }}~~	+	==Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with N-(2,3-dihydro-1H-inden- 5-yl)tetrazolo(1,5-b)pyridazin-6-amine at 2.6A resolution==
-	===Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with N-(2,3-dihydro-1H-inden- 5-yl)tetrazolo(1,5-b)pyridazin-6-amine at 2.6A resolution===	+	<StructureSection load='4bo7' size='340' side='right' caption='[[4bo7]], [[Resolution\|resolution]] 2.60Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24015914}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4bo7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BO7 FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=J2T:N-(2,3-DIHYDRO-1H-INDEN-5-YL)TETRAZOLO[1,5-B]PYRIDAZIN-6-AMINE'>J2T</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bnt\|4bnt]], [[4bnu\|4bnu]], [[4bnv\|4bnv]], [[4bnw\|4bnw]], [[4bnx\|4bnx]], [[4bny\|4bny]], [[4bnz\|4bnz]], [[4bo0\|4bo0]], [[4bo1\|4bo1]], [[4bo2\|4bo2]], [[4bo3\|4bo3]], [[4bo4\|4bo4]], [[4bo5\|4bo5]], [[4bo6\|4bo6]], [[4bo8\|4bo8]], [[4bo9\|4bo9]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-oxoacyl-[acyl-carrier-protein]_reductase 3-oxoacyl-[acyl-carrier-protein] reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.100 1.1.1.100] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bo7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bo7 RCSB], [http://www.ebi.ac.uk/pdbsum/4bo7 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/FABG_PSEAE FABG_PSEAE]] Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis (By similarity).		[[http://www.uniprot.org/uniprot/FABG_PSEAE FABG_PSEAE]] Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	3-oxo-acyl-acyl carrier protein (ACP) reductase (FabG) plays a key role in the bacterial fatty acid synthesis II system in pathogenic microorganisms, which has been recognized as a potential drug target. FabG catalyzes reduction of a 3-oxo-acyl-ACP intermediate during the elongation cycle of fatty acid biosynthesis. Here, we report gene deletion experiments that support the essentiality of this gene in P. aeruginosa and the identification of a number of small molecule FabG inhibitors with IC50 values in the nanomolar to low micromolar range and good physicochemical properties. Structural characterization of sixteen FabG-inhibitor complexes by X-ray crystallography revealed that the compounds bind at a novel allosteric site located at the FabG subunit-subunit interface. Inhibitor binding relies primarily on hydrophobic interactions, but specific hydrogen-bonds are also observed. Importantly, the binding cavity is formed upon complex formation and therefore would not be recognized by virtual screening approaches. The structure analysis further reveals that the inhibitors act by inducing conformational changes that propagate to the active site resulting in a displacement of the catalytic triad and the inability to bind NADPH.
		+
		+	Discovery of an allosteric inhibitor binding site in 3-oxo-acyl-ACP reductase from Pseudomonas aeruginosa.,Cukier CD, Hope AG, Elamin AA, Moynie L, Schnell R, Schach S, Kneuper H, Singh M, Naismith JH, Lindqvist Y, Gray DW, Schneider G ACS Chem Biol. 2013 Sep 9. PMID:24015914<ref>PMID:24015914</ref>

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4bo7]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Pseae Pseae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4BO7 OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:024015914</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Beta-ketoacyl-ACP reductase\|Beta-ketoacyl-ACP reductase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Pseae]]		[[Category: Pseae]]
-	[[Category: Cukier, C D.]]	+	[[Category: Cukier, C D]]
-	[[Category: Lindqvist, Y.]]	+	[[Category: Lindqvist, Y]]
-	[[Category: Schneider, G.]]	+	[[Category: Schneider, G]]
-	[[Category: Schnell, R.]]	+	[[Category: Schnell, R]]
	[[Category: Fatty acid biosynthesis]]		[[Category: Fatty acid biosynthesis]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Rossmann fold]]		[[Category: Rossmann fold]]

OCA at 08:37, 27 November 2013

OCA — Wed, 27 Nov 2013 08:37:09 GMT

←Older revision		Revision as of 08:37, 27 November 2013
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[4bo7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BO7 OCA].	+	[[4bo7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BO7 OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:024015914</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:024015914</ref><references group="xtra"/><references/>
-	[[Category: ~~Pseudomonas aeruginosa pao1~~]]	+	[[Category: Pseae]]
	[[Category: Cukier, C D.]]		[[Category: Cukier, C D.]]
	[[Category: Lindqvist, Y.]]		[[Category: Lindqvist, Y.]]

OCA at 04:08, 20 September 2013

OCA — Fri, 20 Sep 2013 04:08:50 GMT

←Older revision		Revision as of 04:08, 20 September 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4bo7\| PDB=4bo7 \| SCENE= }}
		+	===Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with N-(2,3-dihydro-1H-inden- 5-yl)tetrazolo(1,5-b)pyridazin-6-amine at 2.6A resolution===
		+	{{ABSTRACT_PUBMED_24015914}}

-	~~The entry 4bo7 is ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/FABG_PSEAE FABG_PSEAE]] Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis (By similarity).

-	~~Authors~~: ~~CUKIER, C~~.D.~~, SCHNELL, R~~.~~, LINDQVIST, Y~~.~~, SCHNEIDER, G~~.	+	==About this Structure==
		+	[[4bo7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BO7 OCA].

-	~~Description~~: ~~Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from~~ Pseudomonas aeruginosa ~~in complex with N-(2~~,~~3-dihydro-1H-inden-5-yl)tetrazolo(1~~,~~5-b)pyridazin-6-amine at 2~~.~~6A resolution~~	+	==Reference==
		+	<ref group="xtra">PMID:024015914</ref><references group="xtra"/><references/>
		+	[[Category: Pseudomonas aeruginosa pao1]]
		+	[[Category: Cukier, C D.]]
		+	[[Category: Lindqvist, Y.]]
		+	[[Category: Schneider, G.]]
		+	[[Category: Schnell, R.]]
		+	[[Category: Fatty acid biosynthesis]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Rossmann fold]]

OCA: Protected "4bo7" [edit=sysop:move=sysop]

OCA — Wed, 19 Jun 2013 10:49:48 GMT

Protected "4bo7" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:49, 19 June 2013

OCA: New page: '''Unreleased structure''' The entry 4bo7 is ON HOLD until Paper Publication Authors: CUKIER, C.D., SCHNELL, R., LINDQVIST, Y., SCHNEIDER, G. Description: Crystal structure of 3-oxoacy...

OCA — Wed, 19 Jun 2013 10:49:47 GMT

New page: '''Unreleased structure''' The entry 4bo7 is ON HOLD until Paper Publication Authors: CUKIER, C.D., SCHNELL, R., LINDQVIST, Y., SCHNEIDER, G. Description: Crystal structure of 3-oxoacy...

New page

'''Unreleased structure'''

The entry 4bo7 is ON HOLD until Paper Publication

Authors: CUKIER, C.D., SCHNELL, R., LINDQVIST, Y., SCHNEIDER, G.

Description: Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with N-(2,3-dihydro-1H-inden-5-yl)tetrazolo(1,5-b)pyridazin-6-amine at 2.6A resolution