4boq - Revision history

OCA at 11:55, 20 December 2023

OCA — Wed, 20 Dec 2023 11:55:58 GMT

←Older revision		Revision as of 11:55, 20 December 2023
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	<StructureSection load='4boq' size='340' side='right'caption='[[4boq]], [[Resolution\|resolution]] 1.47Å' scene=''>		<StructureSection load='4boq' size='340' side='right'caption='[[4boq]], [[Resolution\|resolution]] 1.47Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4boq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BOQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BOQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4boq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BOQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BOQ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.47Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[4bop\|4bop]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4boq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4boq OCA], [https://pdbe.org/4boq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4boq RCSB], [https://www.ebi.ac.uk/pdbsum/4boq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4boq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4boq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4boq OCA], [https://pdbe.org/4boq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4boq RCSB], [https://www.ebi.ac.uk/pdbsum/4boq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4boq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/OTU1_HUMAN OTU1_HUMAN]] Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Able to cleave both polyubiquitin and di-ubiquitin.	+	[https://www.uniprot.org/uniprot/OTU1_HUMAN OTU1_HUMAN] Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Able to cleave both polyubiquitin and di-ubiquitin.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Ubiquitinyl hydrolase 1~~]]	+	[[Category: Akutsu M]]
-	[[Category: ~~Akutsu, M~~]]	+	[[Category: Arnaudo N]]
-	[[Category: ~~Arnaudo, N~~]]	+	[[Category: Ekkebus R]]
-	[[Category: ~~Ekkebus, R~~]]	+	[[Category: El Oualid F]]
-	[[Category: Elliott~~, P R~~]]	+	[[Category: Elliott PR]]
-	[[Category: Freund~~, S M.V~~]]	+	[[Category: Freund SMV]]
-	[[Category: Geurink~~, P P~~]]	+	[[Category: Geurink PP]]
-	[[Category: Hospenthal~~, M K~~]]	+	[[Category: Hospenthal MK]]
-	[[Category: Komander, D]]	+	[[Category: Komander D]]
-	[[Category: Kulathu, Y]]	+	[[Category: Kulathu Y]]
-	[[Category: Mevissen~~, T E.T]]~~	+	[[Category: Mevissen TET]]
-	~~[[Category: Oualid, F El~~]]	+	[[Category: Ovaa H]]
-	[[Category: Ovaa, H]]	+	[[Category: Wauer T]]
-	[[Category: Wauer, T]]	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 07:20, 31 August 2022

OCA — Wed, 31 Aug 2022 07:20:33 GMT

←Older revision		Revision as of 07:20, 31 August 2022
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	<StructureSection load='4boq' size='340' side='right'caption='[[4boq]], [[Resolution\|resolution]] 1.47Å' scene=''>		<StructureSection load='4boq' size='340' side='right'caption='[[4boq]], [[Resolution\|resolution]] 1.47Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4boq]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BOQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4BOQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4boq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BOQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BOQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bop\|4bop]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4bop\|4bop]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4boq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4boq OCA], [~~http~~://pdbe.org/4boq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4boq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4boq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4boq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4boq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4boq OCA], [https://pdbe.org/4boq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4boq RCSB], [https://www.ebi.ac.uk/pdbsum/4boq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4boq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/OTU1_HUMAN OTU1_HUMAN]] Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Able to cleave both polyubiquitin and di-ubiquitin.	+	[[https://www.uniprot.org/uniprot/OTU1_HUMAN OTU1_HUMAN]] Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Able to cleave both polyubiquitin and di-ubiquitin.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Thioesterase\|Thioesterase]]	+	*[[Thioesterase 3D structures\|Thioesterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:49, 13 March 2019

OCA — Wed, 13 Mar 2019 13:49:42 GMT

←Older revision		Revision as of 13:49, 13 March 2019
Line 1:		Line 1:

	==Structure of OTUD2 OTU domain==		==Structure of OTUD2 OTU domain==
-	<StructureSection load='4boq' size='340' side='right' caption='[[4boq]], [[Resolution\|resolution]] 1.47Å' scene=''>	+	<StructureSection load='4boq' size='340' side='right'caption='[[4boq]], [[Resolution\|resolution]] 1.47Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4boq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BOQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BOQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4boq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BOQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BOQ FirstGlance]. <br>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Ubiquitinyl hydrolase 1]]		[[Category: Ubiquitinyl hydrolase 1]]
	[[Category: Akutsu, M]]		[[Category: Akutsu, M]]

OCA at 16:36, 4 August 2016

OCA — Thu, 04 Aug 2016 16:36:59 GMT

←Older revision		Revision as of 16:36, 4 August 2016
Line 1:		Line 1:
		+
	==Structure of OTUD2 OTU domain==		==Structure of OTUD2 OTU domain==
	<StructureSection load='4boq' size='340' side='right' caption='[[4boq]], [[Resolution\|resolution]] 1.47Å' scene=''>		<StructureSection load='4boq' size='340' side='right' caption='[[4boq]], [[Resolution\|resolution]] 1.47Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4boq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BOQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BOQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4boq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BOQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BOQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bop\|4bop]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bop\|4bop]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4boq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4boq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4boq RCSB], [http://www.ebi.ac.uk/pdbsum/4boq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4boq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4boq OCA], [http://pdbe.org/4boq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4boq RCSB], [http://www.ebi.ac.uk/pdbsum/4boq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4boq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4boq" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Ubiquitinyl hydrolase 1]]		[[Category: Ubiquitinyl hydrolase 1]]
	[[Category: Akutsu, M]]		[[Category: Akutsu, M]]

OCA at 17:06, 24 December 2014

OCA — Wed, 24 Dec 2014 17:06:13 GMT

←Older revision		Revision as of 17:06, 24 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4boq~~\| ~~PDB~~=4boq \| ~~SCENE~~= }}	+	==Structure of OTUD2 OTU domain==
-	===~~Structure of OTUD2 OTU domain~~===	+	<StructureSection load='4boq' size='340' side='right' caption='[[4boq]], [[Resolution\|resolution]] 1.47Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23827681}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4boq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BOQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BOQ FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bop\|4bop]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4boq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4boq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4boq RCSB], [http://www.ebi.ac.uk/pdbsum/4boq PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/OTU1_HUMAN OTU1_HUMAN]] Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Able to cleave both polyubiquitin and di-ubiquitin.		[[http://www.uniprot.org/uniprot/OTU1_HUMAN OTU1_HUMAN]] Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Able to cleave both polyubiquitin and di-ubiquitin.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Sixteen ovarian tumor (OTU) family deubiquitinases (DUBs) exist in humans, and most members regulate cell-signaling cascades. Several OTU DUBs were reported to be ubiquitin (Ub) chain linkage specific, but comprehensive analyses are missing, and the underlying mechanisms of linkage specificity are unclear. Using Ub chains of all eight linkage types, we reveal that most human OTU enzymes are linkage specific, preferring one, two, or a defined subset of linkage types, including unstudied atypical Ub chains. Biochemical analysis and five crystal structures of OTU DUBs with or without Ub substrates reveal four mechanisms of linkage specificity. Additional Ub-binding domains, the ubiquitinated sequence in the substrate, and defined S1' and S2 Ub-binding sites on the OTU domain enable OTU DUBs to distinguish linkage types. We introduce Ub chain restriction analysis, in which OTU DUBs are used as restriction enzymes to reveal linkage type and the relative abundance of Ub chains on substrates.
		+
		+	OTU Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis.,Mevissen TE, Hospenthal MK, Geurink PP, Elliott PR, Akutsu M, Arnaudo N, Ekkebus R, Kulathu Y, Wauer T, El Oualid F, Freund SM, Ovaa H, Komander D Cell. 2013 Jul 3;154(1):169-84. doi: 10.1016/j.cell.2013.05.046. PMID:23827681<ref>PMID:23827681</ref>

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4boq]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4BOQ OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:023827681</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Thioesterase\|Thioesterase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ubiquitinyl hydrolase 1]]		[[Category: Ubiquitinyl hydrolase 1]]
-	[[Category: Akutsu, M.]]	+	[[Category: Akutsu, M]]
-	[[Category: Arnaudo, N.]]	+	[[Category: Arnaudo, N]]
-	[[Category: Ekkebus, R.]]	+	[[Category: Ekkebus, R]]
-	[[Category: Elliott, P R.]]	+	[[Category: Elliott, P R]]
-	[[Category: Freund, S M.V.]]	+	[[Category: Freund, S M.V]]
-	[[Category: Geurink, P P.]]	+	[[Category: Geurink, P P]]
-	[[Category: Hospenthal, M K.]]	+	[[Category: Hospenthal, M K]]
-	[[Category: Komander, D.]]	+	[[Category: Komander, D]]
-	[[Category: Kulathu, Y.]]	+	[[Category: Kulathu, Y]]
-	[[Category: Mevissen, T E.T.]]	+	[[Category: Mevissen, T E.T]]
-	[[Category: Oualid, F El.]]	+	[[Category: Oualid, F El]]
-	[[Category: Ovaa, H.]]	+	[[Category: Ovaa, H]]
-	[[Category: Wauer, T.]]	+	[[Category: Wauer, T]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 04:58, 18 July 2013

OCA — Thu, 18 Jul 2013 04:58:42 GMT

←Older revision		Revision as of 04:58, 18 July 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4boq\| PDB=4boq \| SCENE= }}
		+	===Structure of OTUD2 OTU domain===
		+	{{ABSTRACT_PUBMED_23827681}}

-	~~The entry 4boq~~ is ~~ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/OTU1_HUMAN OTU1_HUMAN]] Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Able to cleave both polyubiquitin and di-ubiquitin.

-	~~Authors~~: ~~Mevissen, T~~.E.T.~~, Hospenthal, M.K., Geurink, P.P., Elliott, P.R., Akutsu, M., Arnaudo, N., Ekkebus, R., Kulathu, Y., Wauer, T., El Oualid, F., Freund, S.M~~.V.~~, Ovaa, H~~.~~, Komander, D~~.	+	==About this Structure==
		+	[[4boq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BOQ OCA].

-	~~Description~~: ~~Structure of OTUD2 OTU domain~~	+	==Reference==
		+	<ref group="xtra">PMID:023827681</ref><references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Ubiquitinyl hydrolase 1]]
		+	[[Category: Akutsu, M.]]
		+	[[Category: Arnaudo, N.]]
		+	[[Category: Ekkebus, R.]]
		+	[[Category: Elliott, P R.]]
		+	[[Category: Freund, S M.V.]]
		+	[[Category: Geurink, P P.]]
		+	[[Category: Hospenthal, M K.]]
		+	[[Category: Komander, D.]]
		+	[[Category: Kulathu, Y.]]
		+	[[Category: Mevissen, T E.T.]]
		+	[[Category: Oualid, F El.]]
		+	[[Category: Ovaa, H.]]
		+	[[Category: Wauer, T.]]
		+	[[Category: Hydrolase]]

OCA: Protected "4boq" [edit=sysop:move=sysop]

OCA — Wed, 19 Jun 2013 10:51:04 GMT

Protected "4boq" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:51, 19 June 2013

OCA: New page: '''Unreleased structure''' The entry 4boq is ON HOLD until Paper Publication Authors: Mevissen, T.E.T., Hospenthal, M.K., Geurink, P.P., Elliott, P.R., Akutsu, M., Arnaudo, N., Ekkebus,...

OCA — Wed, 19 Jun 2013 10:51:03 GMT

New page: '''Unreleased structure''' The entry 4boq is ON HOLD until Paper Publication Authors: Mevissen, T.E.T., Hospenthal, M.K., Geurink, P.P., Elliott, P.R., Akutsu, M., Arnaudo, N., Ekkebus,...

New page

'''Unreleased structure'''

The entry 4boq is ON HOLD until Paper Publication

Authors: Mevissen, T.E.T., Hospenthal, M.K., Geurink, P.P., Elliott, P.R., Akutsu, M., Arnaudo, N., Ekkebus, R., Kulathu, Y., Wauer, T., El Oualid, F., Freund, S.M.V., Ovaa, H., Komander, D.

Description: Structure of OTUD2 OTU domain