4bq7 - Revision history

OCA at 07:21, 31 August 2022

OCA — Wed, 31 Aug 2022 07:21:45 GMT

←Older revision		Revision as of 07:21, 31 August 2022
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	<StructureSection load='4bq7' size='340' side='right'caption='[[4bq7]], [[Resolution\|resolution]] 6.60Å' scene=''>		<StructureSection load='4bq7' size='340' side='right'caption='[[4bq7]], [[Resolution\|resolution]] 6.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bq7]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human] and [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQ7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4BQ7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bq7]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human] and [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BQ7 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bq6\|4bq6]], [[4bq8\|4bq8]], [[4bq9\|4bq9]], [[4bqb\|4bqb]], [[4bqc\|4bqc]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4bq6\|4bq6]], [[4bq8\|4bq8]], [[4bq9\|4bq9]], [[4bqb\|4bqb]], [[4bqc\|4bqc]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4bq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bq7 OCA], [~~http~~://pdbe.org/4bq7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4bq7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4bq7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4bq7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bq7 OCA], [https://pdbe.org/4bq7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bq7 RCSB], [https://www.ebi.ac.uk/pdbsum/4bq7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bq7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NEO1_MOUSE NEO1_MOUSE]] May be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. May also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues. [[~~http~~://www.uniprot.org/uniprot/RGMB_HUMAN RGMB_HUMAN]] Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth.	+	[[https://www.uniprot.org/uniprot/NEO1_MOUSE NEO1_MOUSE]] May be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. May also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues. [[https://www.uniprot.org/uniprot/RGMB_HUMAN RGMB_HUMAN]] Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:46, 13 March 2019

OCA — Wed, 13 Mar 2019 13:46:21 GMT

←Older revision		Revision as of 13:46, 13 March 2019
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	==Crystal structure of the RGMB-Neo1 complex form 2==		==Crystal structure of the RGMB-Neo1 complex form 2==
-	<StructureSection load='4bq7' size='340' side='right' caption='[[4bq7]], [[Resolution\|resolution]] 6.60Å' scene=''>	+	<StructureSection load='4bq7' size='340' side='right'caption='[[4bq7]], [[Resolution\|resolution]] 6.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bq7]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BQ7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bq7]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BQ7 FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Aricescu, A R]]		[[Category: Aricescu, A R]]

OCA at 12:39, 5 August 2016

OCA — Fri, 05 Aug 2016 12:39:49 GMT

←Older revision		Revision as of 12:39, 5 August 2016
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		+
	==Crystal structure of the RGMB-Neo1 complex form 2==		==Crystal structure of the RGMB-Neo1 complex form 2==
	<StructureSection load='4bq7' size='340' side='right' caption='[[4bq7]], [[Resolution\|resolution]] 6.60Å' scene=''>		<StructureSection load='4bq7' size='340' side='right' caption='[[4bq7]], [[Resolution\|resolution]] 6.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bq7]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~] and [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BQ7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bq7]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BQ7 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bq6\|4bq6]], [[4bq8\|4bq8]], [[4bq9\|4bq9]], [[4bqb\|4bqb]], [[4bqc\|4bqc]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bq6\|4bq6]], [[4bq8\|4bq8]], [[4bq9\|4bq9]], [[4bqb\|4bqb]], [[4bqc\|4bqc]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bq7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bq7 RCSB], [http://www.ebi.ac.uk/pdbsum/4bq7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bq7 OCA], [http://pdbe.org/4bq7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bq7 RCSB], [http://www.ebi.ac.uk/pdbsum/4bq7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bq7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4bq7" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Aricescu, A R]]		[[Category: Aricescu, A R]]
	[[Category: Bell, C H]]		[[Category: Bell, C H]]

OCA at 02:31, 25 December 2014

OCA — Thu, 25 Dec 2014 02:31:34 GMT

←Older revision		Revision as of 02:31, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bq7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bq7 RCSB], [http://www.ebi.ac.uk/pdbsum/4bq7 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bq7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bq7 RCSB], [http://www.ebi.ac.uk/pdbsum/4bq7 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NEO1_MOUSE NEO1_MOUSE]] May be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. May also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues. [[http://www.uniprot.org/uniprot/RGMB_HUMAN RGMB_HUMAN]] Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:55, 21 December 2014

OCA — Sun, 21 Dec 2014 09:55:18 GMT

←Older revision		Revision as of 09:55, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4bq7\| PDB=4bq7 \| SCENE= }}~~	+	==Crystal structure of the RGMB-Neo1 complex form 2==
-	===Crystal structure of the RGMB-Neo1 complex form 2===	+	<StructureSection load='4bq7' size='340' side='right' caption='[[4bq7]], [[Resolution\|resolution]] 6.60Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23744777}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4bq7]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BQ7 FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bq6\|4bq6]], [[4bq8\|4bq8]], [[4bq9\|4bq9]], [[4bqb\|4bqb]], [[4bqc\|4bqc]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bq7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bq7 RCSB], [http://www.ebi.ac.uk/pdbsum/4bq7 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Repulsive guidance molecule family members (RGMs) control fundamental and diverse cellular processes including motility and adhesion, immune cell regulation and systemic iron metabolism. However, it is not known how RGMs initiate signaling through their common cell surface receptor, neogenin (NEO1). Here, we present crystal structures of the NEO1 RGM-binding region and its complex with human RGMB (also called Dragon). The RGMB structure reveals a novel protein fold, a functionally important autocatalytic cleavage mechanism and provides a framework to explain numerous disease-linked mutations in RGMs. In the complex, two RGMB ectodomains conformationally stabilize the juxtamembrane regions of two NEO1 receptors, in a pH-dependent manner. We demonstrate that all RGM-NEO1 complexes share this architecture, which therefore represents the core of multiple signaling pathways.

-	~~==Function==~~	+	Structure of the Repulsive Guidance Molecule (RGM)-Neogenin Signaling Hub.,Bell CH, Healey E, van Erp S, Bishop B, Tang C, Gilbert RJ, Aricescu AR, Pasterkamp RJ, Siebold C Science. 2013 Jun 6. PMID:23744777<ref>PMID:23744777</ref>
-	[[http://www.uniprot.org/uniprot/NEO1_MOUSE NEO1_MOUSE]] May be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. May also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues. [[http://www.uniprot.org/uniprot/RGMB_HUMAN RGMB_HUMAN]] Member of the ~~repulsive guidance molecule~~ (RGM) ~~family that contributes to the patterning of the developing nervous system (By similarity)~~. ~~Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity)~~. ~~Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4bq7]] is~~ a ~~6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens] and [http://en~~.~~wikipedia.org~~/~~wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQ7 OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:023744777</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Aricescu, A R.]]	+	[[Category: Aricescu, A R]]
-	[[Category: Bell, C H.]]	+	[[Category: Bell, C H]]
-	[[Category: Bishop, B.]]	+	[[Category: Bishop, B]]
-	[[Category: Erp, S van.]]	+	[[Category: Erp, S van]]
-	[[Category: Gilbert, R J.C.]]	+	[[Category: Gilbert, R J.C]]
-	[[Category: Healey, E.]]	+	[[Category: Healey, E]]
-	[[Category: Pasterkamp, R J.]]	+	[[Category: Pasterkamp, R J]]
-	[[Category: Siebold, C.]]	+	[[Category: Siebold, C]]
-	[[Category: Tang, C.]]	+	[[Category: Tang, C]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]

OCA: Protected "4bq7" [edit=sysop:move=sysop]

OCA — Wed, 19 Jun 2013 09:15:43 GMT

Protected "4bq7" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:15, 19 June 2013

OCA: New page: {{STRUCTURE_4bq7| PDB=4bq7 | SCENE= }} ===Crystal structure of the RGMB-Neo1 complex form 2=== {{ABSTRACT_PUBMED_23744777}} ==Function== [[http://www.uniprot.org/uniprot/NEO1_MOUSE N...

OCA — Wed, 19 Jun 2013 09:15:40 GMT

New page: {{STRUCTURE_4bq7| PDB=4bq7 | SCENE= }} ===Crystal structure of the RGMB-Neo1 complex form 2=== {{ABSTRACT_PUBMED_23744777}} ==Function== [[http://www.uniprot.org/uniprot/NEO1_MOUSE N...

New page

{{STRUCTURE_4bq7| PDB=4bq7 | SCENE= }}
===Crystal structure of the RGMB-Neo1 complex form 2===
{{ABSTRACT_PUBMED_23744777}}

==Function==
[[http://www.uniprot.org/uniprot/NEO1_MOUSE NEO1_MOUSE]] May be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. May also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues. [[http://www.uniprot.org/uniprot/RGMB_HUMAN RGMB_HUMAN]] Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth.

==About this Structure==
[[4bq7]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQ7 OCA].

==Reference==
<ref group="xtra">PMID:023744777</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Mus musculus]]
[[Category: Aricescu, A R.]]
[[Category: Bell, C H.]]
[[Category: Bishop, B.]]
[[Category: Erp, S van.]]
[[Category: Gilbert, R J.C.]]
[[Category: Healey, E.]]
[[Category: Pasterkamp, R J.]]
[[Category: Siebold, C.]]
[[Category: Tang, C.]]
[[Category: Cell adhesion]]