4bqj - Revision history

OCA at 11:04, 9 May 2024

OCA — Thu, 09 May 2024 11:04:10 GMT

←Older revision		Revision as of 11:04, 9 May 2024
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	<StructureSection load='4bqj' size='340' side='right'caption='[[4bqj]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4bqj' size='340' side='right'caption='[[4bqj]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bqj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BQJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bqj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BQJ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=XKL:5~~-[2,~~4-DIHYDROXY-6-(4-NITROPHENOXY)PHENYL~~]~~-N-ETHYL-1,~~2~~-OXAZOLE-3-CARBOXAMIDE'>XKL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;'>~~[~~[4bqg\|4bqg]~~]</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XKL:5-[2,4-DIHYDROXY-6-(4-NITROPHENOXY)PHENYL]-N-ETHYL-1,2-OXAZOLE-3-CARBOXAMIDE'>XKL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bqj OCA], [https://pdbe.org/4bqj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bqj RCSB], [https://www.ebi.ac.uk/pdbsum/4bqj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bqj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bqj OCA], [https://pdbe.org/4bqj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bqj RCSB], [https://www.ebi.ac.uk/pdbsum/4bqj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bqj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>	+	[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Amboldi, N]]	+	[[Category: Amboldi N]]
-	[[Category: Bindi, S]]	+	[[Category: Bindi S]]
-	[[Category: Brasca~~, M G~~]]	+	[[Category: Brasca MG]]
-	[[Category: Caronni, D]]	+	[[Category: Caronni D]]
-	[[Category: Casale, E]]	+	[[Category: Casale E]]
-	[[Category: Ceccarelli, W]]	+	[[Category: Ceccarelli W]]
-	[[Category: Colombo, N]]	+	[[Category: Colombo N]]
-	[[Category: DePonti, A]]	+	[[Category: DePonti A]]
-	[[Category: Donati, D]]	+	[[Category: Donati D]]
-	[[Category: Ermoli, A]]	+	[[Category: Ermoli A]]
-	[[Category: Fachin, G]]	+	[[Category: Fachin G]]
-	[[Category: Felder~~, E R~~]]	+	[[Category: Felder ER]]
-	[[Category: Ferguson~~, R D~~]]	+	[[Category: Ferguson RD]]
-	[[Category: Fiorelli, C]]	+	[[Category: Fiorelli C]]
-	[[Category: Fogliatto, G]]	+	[[Category: Fogliatto G]]
-	[[Category: Guanci, M]]	+	[[Category: Guanci M]]
-	[[Category: Isacchi, A]]	+	[[Category: Isacchi A]]
-	[[Category: Mantegani, S]]	+	[[Category: Mantegani S]]
-	[[Category: Pesenti, E]]	+	[[Category: Pesenti E]]
-	[[Category: Polucci, P]]	+	[[Category: Polucci P]]
-	[[Category: Riceputi, L]]	+	[[Category: Riceputi L]]
-	[[Category: Sola, F]]	+	[[Category: Sola F]]
-	[[Category: Visco, C]]	+	[[Category: Visco C]]
-	[[Category: Zuccotto, F]]	+	[[Category: Zuccotto F]]
-	~~[[Category: Hydrolase~~]]	+

OCA at 07:22, 31 August 2022

OCA — Wed, 31 Aug 2022 07:22:08 GMT

←Older revision		Revision as of 07:22, 31 August 2022
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	<StructureSection load='4bqj' size='340' side='right'caption='[[4bqj]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4bqj' size='340' side='right'caption='[[4bqj]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bqj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4BQJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bqj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BQJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=XKL:5-[2,4-DIHYDROXY-6-(4-NITROPHENOXY)PHENYL]-N-ETHYL-1,2-OXAZOLE-3-CARBOXAMIDE'>XKL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XKL:5-[2,4-DIHYDROXY-6-(4-NITROPHENOXY)PHENYL]-N-ETHYL-1,2-OXAZOLE-3-CARBOXAMIDE'>XKL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bqg\|4bqg]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4bqg\|4bqg]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4bqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bqj OCA], [~~http~~://pdbe.org/4bqj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4bqj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4bqj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4bqj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bqj OCA], [https://pdbe.org/4bqj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bqj RCSB], [https://www.ebi.ac.uk/pdbsum/4bqj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bqj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>	+	[[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 17:57, 14 August 2019

OCA — Wed, 14 Aug 2019 17:57:50 GMT

←Older revision		Revision as of 17:57, 14 August 2019
Line 1:		Line 1:

	==structure of HSP90 with an inhibitor bound==		==structure of HSP90 with an inhibitor bound==
-	<StructureSection load='4bqj' size='340' side='right' caption='[[4bqj]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='4bqj' size='340' side='right'caption='[[4bqj]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bqj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BQJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bqj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BQJ FirstGlance]. <br>
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4bqj" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4bqj" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Amboldi, N]]		[[Category: Amboldi, N]]
	[[Category: Bindi, S]]		[[Category: Bindi, S]]

OCA at 12:30, 6 November 2017

OCA — Mon, 06 Nov 2017 12:30:56 GMT

←Older revision		Revision as of 12:30, 6 November 2017
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4bqj" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4bqj" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Heat Shock Proteins\|Heat Shock Proteins]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:59, 3 August 2017

OCA — Thu, 03 Aug 2017 08:59:06 GMT

←Older revision		Revision as of 08:59, 3 August 2017
Line 3:		Line 3:
	<StructureSection load='4bqj' size='340' side='right' caption='[[4bqj]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4bqj' size='340' side='right' caption='[[4bqj]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bqj]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Human Human]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BQJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bqj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BQJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=XKL:5-[2,4-DIHYDROXY-6-(4-NITROPHENOXY)PHENYL]-N-ETHYL-1,2-OXAZOLE-3-CARBOXAMIDE'>XKL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=XKL:5-[2,4-DIHYDROXY-6-(4-NITROPHENOXY)PHENYL]-N-ETHYL-1,2-OXAZOLE-3-CARBOXAMIDE'>XKL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bqg\|4bqg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bqg\|4bqg]]</td></tr>
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human]]
	[[Category: Amboldi, N]]		[[Category: Amboldi, N]]
	[[Category: Bindi, S]]		[[Category: Bindi, S]]

OCA at 18:45, 5 August 2016

OCA — Fri, 05 Aug 2016 18:45:13 GMT

←Older revision		Revision as of 18:45, 5 August 2016
Line 1:		Line 1:
		+
	==structure of HSP90 with an inhibitor bound==		==structure of HSP90 with an inhibitor bound==
	<StructureSection load='4bqj' size='340' side='right' caption='[[4bqj]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4bqj' size='340' side='right' caption='[[4bqj]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bqj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BQJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bqj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BQJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=XKL:5-[2,4-DIHYDROXY-6-(4-NITROPHENOXY)PHENYL]-N-ETHYL-1,2-OXAZOLE-3-CARBOXAMIDE'>XKL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=XKL:5-[2,4-DIHYDROXY-6-(4-NITROPHENOXY)PHENYL]-N-ETHYL-1,2-OXAZOLE-3-CARBOXAMIDE'>XKL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bqg\|4bqg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bqg\|4bqg]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bqj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bqj RCSB], [http://www.ebi.ac.uk/pdbsum/4bqj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bqj OCA], [http://pdbe.org/4bqj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bqj RCSB], [http://www.ebi.ac.uk/pdbsum/4bqj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bqj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4bqj" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Heat Shock Proteins\|Heat Shock Proteins]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Amboldi, N]]		[[Category: Amboldi, N]]
	[[Category: Bindi, S]]		[[Category: Bindi, S]]

OCA at 21:04, 25 December 2014

OCA — Thu, 25 Dec 2014 21:04:56 GMT

←Older revision		Revision as of 21:04, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4bqj\| PDB~~=4bqj \| ~~SCENE~~= }}	+	==structure of HSP90 with an inhibitor bound==
-	===structure ~~of HSP90~~ with ~~an inhibitor bound~~===	+	<StructureSection load='4bqj' size='340' side='right' caption='[[4bqj]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24100158}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4bqj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BQJ FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=XKL:5-[2,4-DIHYDROXY-6-(4-NITROPHENOXY)PHENYL]-N-ETHYL-1,2-OXAZOLE-3-CARBOXAMIDE'>XKL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bqg\|4bqg]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bqj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bqj RCSB], [http://www.ebi.ac.uk/pdbsum/4bqj PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>		[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Novel small molecule inhibitors of heat shock protein 90 (Hsp90) were discovered with the help of a fragment based drug discovery approach (FBDD) and subsequent optimization with a combination of structure guided design, parallel synthesis and application of medicinal chemistry principles. These efforts led to the identification of compound 18 (NMS-E973), which displayed significant efficacy in a human ovarian A2780 xenograft tumor model, with a mechanism of action confirmed in vivo by typical modulation of known Hsp90 client proteins, and with a favorable pharmacokinetic and safety profile.

-	~~==About this Structure==~~	+	Discovery of NMS-E973 as novel, selective and potent inhibitor of heat shock protein 90 (Hsp90).,Brasca MG, Mantegani S, Amboldi N, Bindi S, Caronni D, Casale E, Ceccarelli W, Colombo N, De Ponti A, Donati D, Ermoli A, Fachin G, Felder ER, Ferguson RD, Fiorelli C, Guanci M, Isacchi A, Pesenti E, Polucci P, Riceputi L, Sola F, Visco C, Zuccotto F, Fogliatto G Bioorg Med Chem. 2013 Nov 15;21(22):7047-63. doi: 10.1016/j.bmc.2013.09.018. Epub, 2013 Sep 19. PMID:24100158<ref>PMID:24100158</ref>
-	~~[[4bqj]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.~~il/oca-bin/ocashort?id=4BQJ OCA]~~.	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024100158</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Amboldi, N.]]	+	[[Category: Amboldi, N]]
-	[[Category: Bindi, S.]]	+	[[Category: Bindi, S]]
-	[[Category: Brasca, M G.]]	+	[[Category: Brasca, M G]]
-	[[Category: Caronni, D.]]	+	[[Category: Caronni, D]]
-	[[Category: Casale, E.]]	+	[[Category: Casale, E]]
-	[[Category: Ceccarelli, W.]]	+	[[Category: Ceccarelli, W]]
-	[[Category: Colombo, N.]]	+	[[Category: Colombo, N]]
-	[[Category: DePonti, A.]]	+	[[Category: DePonti, A]]
-	[[Category: Donati, D.]]	+	[[Category: Donati, D]]
-	[[Category: Ermoli, A.]]	+	[[Category: Ermoli, A]]
-	[[Category: Fachin, G.]]	+	[[Category: Fachin, G]]
-	[[Category: Felder, E R.]]	+	[[Category: Felder, E R]]
-	[[Category: Ferguson, R D.]]	+	[[Category: Ferguson, R D]]
-	[[Category: Fiorelli, C.]]	+	[[Category: Fiorelli, C]]
-	[[Category: Fogliatto, G.]]	+	[[Category: Fogliatto, G]]
-	[[Category: Guanci, M.]]	+	[[Category: Guanci, M]]
-	[[Category: Isacchi, A.]]	+	[[Category: Isacchi, A]]
-	[[Category: Mantegani, S.]]	+	[[Category: Mantegani, S]]
-	[[Category: Pesenti, E.]]	+	[[Category: Pesenti, E]]
-	[[Category: Polucci, P.]]	+	[[Category: Polucci, P]]
-	[[Category: Riceputi, L.]]	+	[[Category: Riceputi, L]]
-	[[Category: Sola, F.]]	+	[[Category: Sola, F]]
-	[[Category: Visco, C.]]	+	[[Category: Visco, C]]
-	[[Category: Zuccotto, F.]]	+	[[Category: Zuccotto, F]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 06:46, 23 October 2013

OCA — Wed, 23 Oct 2013 06:46:10 GMT

←Older revision		Revision as of 06:46, 23 October 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4bqj\| PDB=4bqj \| SCENE= }}
		+	===structure of HSP90 with an inhibitor bound===
		+	{{ABSTRACT_PUBMED_24100158}}

-	~~The entry 4bqj~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>

-	~~Authors~~: ~~Casale, E~~.~~, Brasca, M~~.G., Mantegani, S., Amboldi, N., Bindi, S., Caronni, D., Ceccarelli, W., Colombo, N., DePonti, A., Donati, D., Ermoli, A., Fachin, G., Felder, E.R., Ferguson, R.D., Fiorelli, C., Guanci, M., Isacchi, A., Pesenti, E., Polucci, P., Riceputi, L., Sola, F.~~, Visco, C~~.~~, Zuccotto, F~~.~~, Fogliatto, G~~.	+	==About this Structure==
		+	[[4bqj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQJ OCA].

-	~~Description~~: ~~structure of HSP90 with an inhibitor bound~~	+	==Reference==
		+	<ref group="xtra">PMID:024100158</ref><references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Amboldi, N.]]
		+	[[Category: Bindi, S.]]
		+	[[Category: Brasca, M G.]]
		+	[[Category: Caronni, D.]]
		+	[[Category: Casale, E.]]
		+	[[Category: Ceccarelli, W.]]
		+	[[Category: Colombo, N.]]
		+	[[Category: DePonti, A.]]
		+	[[Category: Donati, D.]]
		+	[[Category: Ermoli, A.]]
		+	[[Category: Fachin, G.]]
		+	[[Category: Felder, E R.]]
		+	[[Category: Ferguson, R D.]]
		+	[[Category: Fiorelli, C.]]
		+	[[Category: Fogliatto, G.]]
		+	[[Category: Guanci, M.]]
		+	[[Category: Isacchi, A.]]
		+	[[Category: Mantegani, S.]]
		+	[[Category: Pesenti, E.]]
		+	[[Category: Polucci, P.]]
		+	[[Category: Riceputi, L.]]
		+	[[Category: Sola, F.]]
		+	[[Category: Visco, C.]]
		+	[[Category: Zuccotto, F.]]
		+	[[Category: Hydrolase]]

OCA: Protected "4bqj" [edit=sysop:move=sysop]

OCA — Wed, 19 Jun 2013 10:54:03 GMT

Protected "4bqj" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:54, 19 June 2013

OCA: New page: '''Unreleased structure''' The entry 4bqj is ON HOLD until Paper Publication Authors: Casale, E., Brasca, M.G., Mantegani, S., Amboldi, N., Bindi, S., Caronni, D., Ceccarelli, W., Colom...

OCA — Wed, 19 Jun 2013 10:54:00 GMT

New page: '''Unreleased structure''' The entry 4bqj is ON HOLD until Paper Publication Authors: Casale, E., Brasca, M.G., Mantegani, S., Amboldi, N., Bindi, S., Caronni, D., Ceccarelli, W., Colom...

New page

'''Unreleased structure'''

The entry 4bqj is ON HOLD until Paper Publication

Authors: Casale, E., Brasca, M.G., Mantegani, S., Amboldi, N., Bindi, S., Caronni, D., Ceccarelli, W., Colombo, N., DePonti, A., Donati, D., Ermoli, A., Fachin, G., Felder, E.R., Ferguson, R.D., Fiorelli, C., Guanci, M., Isacchi, A., Pesenti, E., Polucci, P., Riceputi, L., Sola, F., Visco, C., Zuccotto, F., Fogliatto, G.

Description: structure of HSP90 with an inhibitor bound