4bqt - Revision history

OCA at 11:56, 20 December 2023

OCA — Wed, 20 Dec 2023 11:56:49 GMT

←Older revision		Revision as of 11:56, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='4bqt' size='340' side='right'caption='[[4bqt]], [[Resolution\|resolution]] 2.88Å' scene=''>		<StructureSection load='4bqt' size='340' side='right'caption='[[4bqt]], [[Resolution\|resolution]] 2.88Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bqt]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Aplca Aplca~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4afo 4afo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BQT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bqt]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4afo 4afo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BQT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C5E:(1R,5S)-1,2,3,4,5,6-HEXAHYDRO-8H-1,5-METHANOPYRIDO[1,2-A][1,5]DIAZOCIN-8-ONE'>C5E</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.88Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C5E:(1R,5S)-1,2,3,4,5,6-HEXAHYDRO-8H-1,5-METHANOPYRIDO[1,2-A][1,5]DIAZOCIN-8-ONE'>C5E</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bqt OCA], [https://pdbe.org/4bqt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bqt RCSB], [https://www.ebi.ac.uk/pdbsum/4bqt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bqt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bqt OCA], [https://pdbe.org/4bqt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bqt RCSB], [https://www.ebi.ac.uk/pdbsum/4bqt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bqt ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8WSF8_APLCA Q8WSF8_APLCA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Aplca~~]]	+	[[Category: Aplysia californica]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gallagher, T]]	+	[[Category: Gallagher T]]
-	[[Category: Haseler~~, C A~~]]	+	[[Category: Haseler CA]]
-	[[Category: Rucktooa, P]]	+	[[Category: Rucktooa P]]
-	[[Category: Sixma~~, T K~~]]	+	[[Category: Sixma TK]]
-	[[Category: Smit~~, A B~~]]	+	[[Category: Smit AB]]
-	[[Category: VanElke, R]]	+	[[Category: VanElke R]]
-	~~[[Category: Receptor~~]]	+

OCA at 07:22, 31 August 2022

OCA — Wed, 31 Aug 2022 07:22:25 GMT

←Older revision		Revision as of 07:22, 31 August 2022
Line 3:		Line 3:
	<StructureSection load='4bqt' size='340' side='right'caption='[[4bqt]], [[Resolution\|resolution]] 2.88Å' scene=''>		<StructureSection load='4bqt' size='340' side='right'caption='[[4bqt]], [[Resolution\|resolution]] 2.88Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bqt]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Aplca Aplca]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4afo 4afo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4BQT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bqt]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Aplca Aplca]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4afo 4afo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BQT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C5E:(1R,5S)-1,2,3,4,5,6-HEXAHYDRO-8H-1,5-METHANOPYRIDO[1,2-A][1,5]DIAZOCIN-8-ONE'>C5E</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C5E:(1R,5S)-1,2,3,4,5,6-HEXAHYDRO-8H-1,5-METHANOPYRIDO[1,2-A][1,5]DIAZOCIN-8-ONE'>C5E</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4bqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bqt OCA], [~~http~~://pdbe.org/4bqt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4bqt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4bqt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4bqt ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bqt OCA], [https://pdbe.org/4bqt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bqt RCSB], [https://www.ebi.ac.uk/pdbsum/4bqt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bqt ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:10, 13 March 2019

OCA — Wed, 13 Mar 2019 13:10:13 GMT

←Older revision		Revision as of 13:10, 13 March 2019
Line 1:		Line 1:

	==Aplysia californica AChBP in complex with Cytisine==		==Aplysia californica AChBP in complex with Cytisine==
-	<StructureSection load='4bqt' size='340' side='right' caption='[[4bqt]], [[Resolution\|resolution]] 2.88Å' scene=''>	+	<StructureSection load='4bqt' size='340' side='right'caption='[[4bqt]], [[Resolution\|resolution]] 2.88Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bqt]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplca Aplca]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4afo 4afo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BQT FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bqt]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplca Aplca]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4afo 4afo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BQT FirstGlance]. <br>
Line 18:		Line 18:

	==See Also==		==See Also==
-	*[[Acetylcholine binding protein\|Acetylcholine binding protein]]	+	*[[Acetylcholine binding protein 3D structures\|Acetylcholine binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Aplca]]		[[Category: Aplca]]
		+	[[Category: Large Structures]]
	[[Category: Gallagher, T]]		[[Category: Gallagher, T]]
	[[Category: Haseler, C A]]		[[Category: Haseler, C A]]

OCA at 08:18, 11 August 2016

OCA — Thu, 11 Aug 2016 08:18:14 GMT

←Older revision		Revision as of 08:18, 11 August 2016
Line 1:		Line 1:
		+
	==Aplysia californica AChBP in complex with Cytisine==		==Aplysia californica AChBP in complex with Cytisine==
	<StructureSection load='4bqt' size='340' side='right' caption='[[4bqt]], [[Resolution\|resolution]] 2.88Å' scene=''>		<StructureSection load='4bqt' size='340' side='right' caption='[[4bqt]], [[Resolution\|resolution]] 2.88Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bqt]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Aplysia_californica Aplysia californica~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4afo 4afo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BQT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bqt]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplca Aplca]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4afo 4afo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BQT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C5E:(1R,5S)-1,2,3,4,5,6-HEXAHYDRO-8H-1,5-METHANOPYRIDO[1,2-A][1,5]DIAZOCIN-8-ONE'>C5E</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C5E:(1R,5S)-1,2,3,4,5,6-HEXAHYDRO-8H-1,5-METHANOPYRIDO[1,2-A][1,5]DIAZOCIN-8-ONE'>C5E</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bqt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bqt RCSB], [http://www.ebi.ac.uk/pdbsum/4bqt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bqt OCA], [http://pdbe.org/4bqt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bqt RCSB], [http://www.ebi.ac.uk/pdbsum/4bqt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bqt ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4bqt" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 21:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Aplysia californica~~]]	+	[[Category: Aplca]]
	[[Category: Gallagher, T]]		[[Category: Gallagher, T]]
	[[Category: Haseler, C A]]		[[Category: Haseler, C A]]

OCA at 13:45, 4 January 2015

OCA — Sun, 04 Jan 2015 13:45:42 GMT

←Older revision		Revision as of 13:45, 4 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_4bqt\| PDB~~=4bqt \| ~~SCENE~~= }}	+	==Aplysia californica AChBP in complex with Cytisine==
-	===Aplysia californica ~~AChBP in complex with Cytisine~~===	+	<StructureSection load='4bqt' size='340' side='right' caption='[[4bqt]], [[Resolution\|resolution]] 2.88Å' scene=''>
-	~~{{ABSTRACT_PUBMED_22553201}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4bqt]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4afo 4afo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BQT FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C5E:(1R,5S)-1,2,3,4,5,6-HEXAHYDRO-8H-1,5-METHANOPYRIDO[1,2-A][1,5]DIAZOCIN-8-ONE'>C5E</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bqt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bqt RCSB], [http://www.ebi.ac.uk/pdbsum/4bqt PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Smoking cessation is an important aim in public health worldwide as tobacco smoking causes many preventable deaths. Addiction to tobacco smoking results from the binding of nicotine to nicotinic acetylcholine receptors (nAChRs) in the brain, in particular the alpha4beta2 receptor. One way to aid smoking cessation is by the use of nicotine replacement therapies or partial nAChR agonists like cytisine or varenicline. Here we present the co-crystal structures of cytisine and varenicline in complex with Aplysia californica acetylcholine-binding protein and use these as models to investigate binding of these ligands binding to nAChRs. This analysis of the binding properties of these two partial agonists provides insight into differences with nicotine binding to nAChRs. A mutational analysis reveals that the residues conveying subtype selectivity in nAChRs reside on the binding site complementary face and include features extending beyond the first shell of contacting residues.

-	~~==About this Structure==~~	+	Structural Characterization of Binding Mode of Smoking Cessation Drugs to Nicotinic Acetylcholine Receptors through Study of Ligand Complexes with Acetylcholine-binding Protein.,Rucktooa P, Haseler CA, van Elk R, Smit AB, Gallagher T, Sixma TK J Biol Chem. 2012 Jul 6;287(28):23283-93. Epub 2012 May 2. PMID:22553201<ref>PMID:22553201</ref>
-	~~[[4bqt]] is a 5 chain structure~~ with ~~sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Aplysia_californica Aplysia californica]. This structure supersedes the now removed PDB entry [http~~:~~//oca~~.~~weizmann~~.~~ac.il/oca-bin/send-pdb?obs=1&id=4afo 4afo]. Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4BQT OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group~~=~~"xtra">PMID:022553201</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+
		+	==See Also==
		+	*[[Acetylcholine binding protein\|Acetylcholine binding protein]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Aplysia californica]]		[[Category: Aplysia californica]]
-	[[Category: Gallagher, T.]]	+	[[Category: Gallagher, T]]
-	[[Category: Haseler, C A.]]	+	[[Category: Haseler, C A]]
-	[[Category: Rucktooa, P.]]	+	[[Category: Rucktooa, P]]
-	[[Category: Sixma, T K.]]	+	[[Category: Sixma, T K]]
-	[[Category: Smit, A B.]]	+	[[Category: Smit, A B]]
-	[[Category: VanElke, R.]]	+	[[Category: VanElke, R]]
	[[Category: Receptor]]		[[Category: Receptor]]

OCA: Protected "4bqt" [edit=sysop:move=sysop]

OCA — Wed, 19 Jun 2013 13:18:42 GMT

Protected "4bqt" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:18, 19 June 2013

OCA: New page: {{STRUCTURE_4bqt| PDB=4bqt | SCENE= }} ===Aplysia californica AChBP in complex with Cytisine=== {{ABSTRACT_PUBMED_22553201}} ==About this Structure== 4bqt is a 5 chain structure ...

OCA — Wed, 19 Jun 2013 13:18:40 GMT

New page: {{STRUCTURE_4bqt| PDB=4bqt | SCENE= }} ===Aplysia californica AChBP in complex with Cytisine=== {{ABSTRACT_PUBMED_22553201}} ==About this Structure== 4bqt is a 5 chain structure ...

New page

{{STRUCTURE_4bqt| PDB=4bqt | SCENE= }}
===Aplysia californica AChBP in complex with Cytisine===
{{ABSTRACT_PUBMED_22553201}}

==About this Structure==
[[4bqt]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4afo 4afo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQT OCA].

==Reference==
<ref group="xtra">PMID:022553201</ref><references group="xtra"/><references/>
[[Category: Aplysia californica]]
[[Category: Gallagher, T.]]
[[Category: Haseler, C A.]]
[[Category: Rucktooa, P.]]
[[Category: Sixma, T K.]]
[[Category: Smit, A B.]]
[[Category: VanElke, R.]]
[[Category: Receptor]]