4by5 - Revision history

OCA at 12:00, 20 December 2023

OCA — Wed, 20 Dec 2023 12:00:20 GMT

←Older revision		Revision as of 12:00, 20 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4by5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BY5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BY5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4by5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BY5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BY5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.22Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4by5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4by5 OCA], [https://pdbe.org/4by5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4by5 RCSB], [https://www.ebi.ac.uk/pdbsum/4by5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4by5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4by5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4by5 OCA], [https://pdbe.org/4by5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4by5 RCSB], [https://www.ebi.ac.uk/pdbsum/4by5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4by5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/Q9VWX8_DROME Q9VWX8_DROME]]	+	[https://www.uniprot.org/uniprot/Q9VWX8_DROME Q9VWX8_DROME]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The conserved Ca2+-binding protein Frequenin/Neuronal Calcium Sensor 1 (Frq/NCS-1) is involved in pathologies that result from abnormal synapse number and probability of neurotransmitter release per synapse. Both synaptic features are likely co-regulated but the intervening mechanisms remain poorly understood. We show here that Drosophila Ric8a/Synembryn, a receptor-independent activator of G protein complexes, binds Frq2 but not the virtually identical duplicate Frq1. Based on crystallographic data on Frq2 and site directed mutagenesis on Frq1, the differential amino acids R94 and T138 account for this specificity. Human NCS-1 and Ric8a reproduce the binding and maintain the structural requirements at these key positions. Ric8a and Galphas regulate synapse number and neurotransmitter release and both are functionally linked to Frq2. Frq2 negatively regulates Ric8a to control synapse number. However, the regulation of neurotransmitter release by Ric8a is independent from the Frq2 binding. Thus, the antagonistic regulation of these two synaptic properties shares a common pathway, Frq2,Ric8a,Galphas which diverges downstream. These mechanisms expose the Frq2-Ric8a interacting surface as a potential pharmacological target for NCS-1 related diseases and provide key data towards the corresponding drug design.
		+
		+	The guanine-exchange factor Ric8a binds the calcium sensor NCS-1 to regulate synapse number and probability of release.,Romero-Pozuelo J, Dason JS, Mansilla A, Banos-Mateos S, Sardina JL, Chaves-Sanjuan A, Jurado-Gomez J, Santana E, Atwood HL, Hernandez-Hernandez A, Sanchez-Barrena MJ, Ferrus A J Cell Sci. 2014 Jul 29. pii: jcs.152603. PMID:25074811<ref>PMID:25074811</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4by5" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 17:15, 7 September 2022

OCA — Wed, 07 Sep 2022 17:15:58 GMT

←Older revision		Revision as of 17:15, 7 September 2022
Line 3:		Line 3:
	<StructureSection load='4by5' size='340' side='right'caption='[[4by5]], [[Resolution\|resolution]] 2.22Å' scene=''>		<StructureSection load='4by5' size='340' side='right'caption='[[4by5]], [[Resolution\|resolution]] 2.22Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4by5]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Drome Drome~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BY5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4BY5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4by5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BY5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BY5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4by4\|4by4]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4by5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4by5 OCA], [https://pdbe.org/4by5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4by5 RCSB], [https://www.ebi.ac.uk/pdbsum/4by5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4by5 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4by5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4by5 OCA], [~~http~~://pdbe.org/4by5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4by5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4by5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4by5 ProSAT]</span></td></tr>	+
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[[https://www.uniprot.org/uniprot/Q9VWX8_DROME Q9VWX8_DROME]]
-	The conserved Ca2+-binding protein Frequenin/Neuronal Calcium Sensor 1 (Frq/NCS-1) is involved in pathologies that result from abnormal synapse number and probability of neurotransmitter release per synapse. Both synaptic features are likely co-regulated but the intervening mechanisms remain poorly understood. We show here that Drosophila Ric8a/Synembryn, a receptor-independent activator of G protein complexes, binds Frq2 but not the virtually identical duplicate Frq1. Based on crystallographic data on Frq2 and site directed mutagenesis on Frq1, the differential amino acids R94 and T138 account for this specificity. Human NCS-1 and Ric8a reproduce the binding and maintain the structural requirements at these key positions. Ric8a and Galphas regulate synapse number and neurotransmitter release and both are functionally linked to Frq2. Frq2 negatively regulates Ric8a to control synapse number. However, the regulation of neurotransmitter release by Ric8a is independent from the Frq2 binding. Thus, the antagonistic regulation of these two synaptic properties shares a common pathway, Frq2,Ric8a,Galphas which diverges downstream. These mechanisms expose the Frq2-Ric8a interacting surface as a potential pharmacological target for NCS-1 related diseases and provide key data towards the corresponding drug design.	+
-		+
-	The guanine-exchange factor Ric8a binds the calcium sensor NCS-1 to regulate synapse number and probability of release.,Romero-Pozuelo J, Dason JS, Mansilla A, Banos-Mateos S, Sardina JL, Chaves-Sanjuan A, Jurado-Gomez J, Santana E, Atwood HL, Hernandez-Hernandez A, Sanchez-Barrena MJ, Ferrus A J Cell Sci. 2014 Jul 29. pii: ~~jcs.152603. PMID:25074811<ref>PMID:25074811<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®~~/~~PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 4by5" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references~~/>	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Drome~~]]	+	[[Category: Drosophila melanogaster]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Banos-Mateos, S]]	+	[[Category: Banos-Mateos S]]
-	[[Category: Chaves-Sanjuan, A]]	+	[[Category: Chaves-Sanjuan A]]
-	[[Category: Sanchez-Barrena~~, M J]]~~	+	[[Category: Sanchez-Barrena MJ]]
-	~~[[Category: Calcium sensor]]~~	+
-	~~[[Category: Calcium-binding protein~~]]	+

OCA at 14:01, 13 March 2019

OCA — Wed, 13 Mar 2019 14:01:54 GMT

←Older revision		Revision as of 14:01, 13 March 2019
Line 1:		Line 1:

	==Crystal structure of Drosophila Frq2==		==Crystal structure of Drosophila Frq2==
-	<StructureSection load='4by5' size='340' side='right' caption='[[4by5]], [[Resolution\|resolution]] 2.22Å' scene=''>	+	<StructureSection load='4by5' size='340' side='right'caption='[[4by5]], [[Resolution\|resolution]] 2.22Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4by5]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BY5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BY5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4by5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BY5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BY5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4by4\|4by4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4by4\|4by4]]</td></tr>
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Drome]]
		+	[[Category: Large Structures]]
	[[Category: Banos-Mateos, S]]		[[Category: Banos-Mateos, S]]
	[[Category: Chaves-Sanjuan, A]]		[[Category: Chaves-Sanjuan, A]]

OCA at 10:27, 5 August 2016

OCA — Fri, 05 Aug 2016 10:27:17 GMT

←Older revision		Revision as of 10:27, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of Drosophila Frq2==		==Crystal structure of Drosophila Frq2==
	<StructureSection load='4by5' size='340' side='right' caption='[[4by5]], [[Resolution\|resolution]] 2.22Å' scene=''>		<StructureSection load='4by5' size='340' side='right' caption='[[4by5]], [[Resolution\|resolution]] 2.22Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4by4\|4by4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4by4\|4by4]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4by5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4by5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4by5 RCSB], [http://www.ebi.ac.uk/pdbsum/4by5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4by5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4by5 OCA], [http://pdbe.org/4by5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4by5 RCSB], [http://www.ebi.ac.uk/pdbsum/4by5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4by5 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4by5" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:30, 17 December 2014

OCA — Wed, 17 Dec 2014 10:30:08 GMT

←Older revision		Revision as of 10:30, 17 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4by5]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BY5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BY5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4by5]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BY5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BY5 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4by4\|4by4]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4by4\|4by4]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4by5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4by5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4by5 RCSB], [http://www.ebi.ac.uk/pdbsum/4by5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4by5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4by5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4by5 RCSB], [http://www.ebi.ac.uk/pdbsum/4by5 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Banos-Mateos, S.]]	+	[[Category: Banos-Mateos, S]]
-	[[Category: Chaves-Sanjuan, A.]]	+	[[Category: Chaves-Sanjuan, A]]
-	[[Category: Sanchez-Barrena, M J.]]	+	[[Category: Sanchez-Barrena, M J]]
	[[Category: Calcium sensor]]		[[Category: Calcium sensor]]
	[[Category: Calcium-binding protein]]		[[Category: Calcium-binding protein]]

OCA at 09:08, 13 August 2014

OCA — Wed, 13 Aug 2014 09:08:10 GMT

←Older revision		Revision as of 09:08, 13 August 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of Drosophila Frq2==
		+	<StructureSection load='4by5' size='340' side='right' caption='[[4by5]], [[Resolution\|resolution]] 2.22Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4by5]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BY5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BY5 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4by4\|4by4]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4by5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4by5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4by5 RCSB], [http://www.ebi.ac.uk/pdbsum/4by5 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The conserved Ca2+-binding protein Frequenin/Neuronal Calcium Sensor 1 (Frq/NCS-1) is involved in pathologies that result from abnormal synapse number and probability of neurotransmitter release per synapse. Both synaptic features are likely co-regulated but the intervening mechanisms remain poorly understood. We show here that Drosophila Ric8a/Synembryn, a receptor-independent activator of G protein complexes, binds Frq2 but not the virtually identical duplicate Frq1. Based on crystallographic data on Frq2 and site directed mutagenesis on Frq1, the differential amino acids R94 and T138 account for this specificity. Human NCS-1 and Ric8a reproduce the binding and maintain the structural requirements at these key positions. Ric8a and Galphas regulate synapse number and neurotransmitter release and both are functionally linked to Frq2. Frq2 negatively regulates Ric8a to control synapse number. However, the regulation of neurotransmitter release by Ric8a is independent from the Frq2 binding. Thus, the antagonistic regulation of these two synaptic properties shares a common pathway, Frq2,Ric8a,Galphas which diverges downstream. These mechanisms expose the Frq2-Ric8a interacting surface as a potential pharmacological target for NCS-1 related diseases and provide key data towards the corresponding drug design.

-	The ~~entry 4by5 is ON HOLD until Paper Publication~~	+	The guanine-exchange factor Ric8a binds the calcium sensor NCS-1 to regulate synapse number and probability of release.,Romero-Pozuelo J, Dason JS, Mansilla A, Banos-Mateos S, Sardina JL, Chaves-Sanjuan A, Jurado-Gomez J, Santana E, Atwood HL, Hernandez-Hernandez A, Sanchez-Barrena MJ, Ferrus A J Cell Sci. 2014 Jul 29. pii: jcs.152603. PMID:25074811<ref>PMID:25074811</ref>

-	~~Authors~~: Banos-Mateos, S., Chaves-Sanjuan, A., Sanchez-Barrena, M.J.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of Drosophila Frq2~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Banos-Mateos, S.]]
		+	[[Category: Chaves-Sanjuan, A.]]
		+	[[Category: Sanchez-Barrena, M J.]]
		+	[[Category: Calcium sensor]]
		+	[[Category: Calcium-binding protein]]

OCA: Protected "4by5" [edit=sysop:move=sysop]

OCA — Wed, 24 Jul 2013 12:03:54 GMT

Protected "4by5" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:03, 24 July 2013

OCA: New page: '''Unreleased structure''' The entry 4by5 is ON HOLD until Paper Publication Authors: Banos-Mateos, S., Chaves-Sanjuan, A., Sanchez-Barrena, M.J. Description: Crystal structure of Dros...

OCA — Wed, 24 Jul 2013 12:03:53 GMT

New page: '''Unreleased structure''' The entry 4by5 is ON HOLD until Paper Publication Authors: Banos-Mateos, S., Chaves-Sanjuan, A., Sanchez-Barrena, M.J. Description: Crystal structure of Dros...

New page

'''Unreleased structure'''

The entry 4by5 is ON HOLD until Paper Publication

Authors: Banos-Mateos, S., Chaves-Sanjuan, A., Sanchez-Barrena, M.J.

Description: Crystal structure of Drosophila Frq2