4by9 - Revision history

OCA at 10:08, 14 June 2023

OCA — Wed, 14 Jun 2023 10:08:32 GMT

←Older revision		Revision as of 10:08, 14 June 2023
Line 7:		Line 7:
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/Q8U4M1_PYRFU Q8U4M1_PYRFU]]	+	[https://www.uniprot.org/uniprot/Q8U4M1_PYRFU Q8U4M1_PYRFU]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Post-transcriptional modifications are essential to the cell life cycle, as they affect both pre-ribosomal RNA processing and ribosome assembly. The box C/D ribonucleoprotein enzyme that methylates ribosomal RNA at the 2'-O-ribose uses a multitude of guide RNAs as templates for the recognition of rRNA target sites. Two methylation guide sequences are combined on each guide RNA, the significance of which has remained unclear. Here we use a powerful combination of NMR spectroscopy and small-angle neutron scattering to solve the structure of the 390 kDa archaeal RNP enzyme bound to substrate RNA. We show that the two methylation guide sequences are located in different environments in the complex and that the methylation of physiological substrates targeted by the same guide RNA occurs sequentially. This structure provides a means for differential control of methylation levels at the two sites and at the same time offers an unexpected regulatory mechanism for rRNA folding.
		+
		+	The structure of the box C/D enzyme reveals regulation of RNA methylation.,Lapinaite A, Simon B, Skjaerven L, Rakwalska-Bange M, Gabel F, Carlomagno T Nature. 2013 Oct 13. doi: 10.1038/nature12581. PMID:24121435<ref>PMID:24121435</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4by9" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 17:16, 7 September 2022

OCA — Wed, 07 Sep 2022 17:16:15 GMT

←Older revision		Revision as of 17:16, 7 September 2022
Line 1:		Line 1:

	==The structure of the Box CD enzyme reveals regulation of rRNA methylation==		==The structure of the Box CD enzyme reveals regulation of rRNA methylation==
-	<StructureSection load='4by9' size='340' side='right'caption='[[4by9~~]], [[NMR_Ensembles_of_Models \| 1 NMR models~~]]' scene=''>	+	<StructureSection load='4by9' size='340' side='right'caption='[[4by9]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4by9]] is a 18 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_43587 Atcc 43587~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BY9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4BY9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4by9]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BY9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BY9 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4by9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4by9 OCA], [~~http~~://pdbe.org/4by9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4by9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4by9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4by9 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4by9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4by9 OCA], [https://pdbe.org/4by9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4by9 RCSB], [https://www.ebi.ac.uk/pdbsum/4by9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4by9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/~~FLPA_PYRFU FLPA_PYRFU~~]] Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity).[HAMAP-Rule:MF_00351] [[http://www.uniprot.org/uniprot/RL7A_PYRFU RL7A_PYRFU]] Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, box H/ACA, box C/D and box C'/D' sRNAs (By similarity).	+	[[https://www.uniprot.org/uniprot/Q8U4M1_PYRFU Q8U4M1_PYRFU]]
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Post-transcriptional modifications are essential to the cell life cycle, as they affect both pre-ribosomal RNA processing and ribosome assembly. The box C/D ribonucleoprotein enzyme that methylates ribosomal RNA at the 2'-O-ribose uses a multitude of guide RNAs as templates for the recognition of rRNA target sites. Two methylation guide sequences are combined on each guide RNA, the significance of which has remained unclear. Here we use a powerful combination of NMR spectroscopy and small-angle neutron scattering to solve the structure of the 390 kDa archaeal RNP enzyme bound to substrate RNA. We show that the two methylation guide sequences are located in different environments in the complex and that the methylation of physiological substrates targeted by the same guide RNA occurs sequentially. This structure provides a means for differential control of methylation levels at the two sites and at the same time offers an unexpected regulatory mechanism for rRNA folding.	+
-		+
-	The structure of the box C/D enzyme reveals regulation of RNA methylation.,Lapinaite A, Simon B, Skjaerven L, Rakwalska-Bange M, Gabel F, Carlomagno T Nature. 2013 Oct 13. doi: 10.1038/nature12581. PMID:24121435<ref>PMID:24121435</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 4by9" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 43587]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Carlomagno, T]]	+	[[Category: Pyrococcus furiosus]]
-	[[Category: Gabel, F]]	+	[[Category: Carlomagno T]]
-	[[Category: Lapinaite, A]]	+	[[Category: Gabel F]]
-	[[Category: Rakwalska-Bange, M]]	+	[[Category: Lapinaite A]]
-	[[Category: Simon, B]]	+	[[Category: Rakwalska-Bange M]]
-	[[Category: Skjaerven, L]]	+	[[Category: Simon B]]
-	~~[[Category: Rrna modification]]~~	+	[[Category: Skjaerven L]]
-	~~[[Category: Transferase-rna complex~~]]	+

OCA at 13:19, 13 March 2019

OCA — Wed, 13 Mar 2019 13:19:29 GMT

←Older revision		Revision as of 13:19, 13 March 2019
Line 1:		Line 1:

	==The structure of the Box CD enzyme reveals regulation of rRNA methylation==		==The structure of the Box CD enzyme reveals regulation of rRNA methylation==
-	<StructureSection load='4by9' size='340' side='right' caption='[[4by9]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>	+	<StructureSection load='4by9' size='340' side='right'caption='[[4by9]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4by9]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43587 Atcc 43587]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BY9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4by9]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43587 Atcc 43587]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BY9 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4by9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4by9 OCA], [http://pdbe.org/4by9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4by9 RCSB], [http://www.ebi.ac.uk/pdbsum/4by9 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4by9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4by9 OCA], [http://pdbe.org/4by9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4by9 RCSB], [http://www.ebi.ac.uk/pdbsum/4by9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4by9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 43587]]		[[Category: Atcc 43587]]
		+	[[Category: Large Structures]]
	[[Category: Carlomagno, T]]		[[Category: Carlomagno, T]]
	[[Category: Gabel, F]]		[[Category: Gabel, F]]

OCA at 18:20, 10 May 2016

OCA — Tue, 10 May 2016 18:20:22 GMT

←Older revision		Revision as of 18:20, 10 May 2016
Line 1:		Line 1:
		+
	==The structure of the Box CD enzyme reveals regulation of rRNA methylation==		==The structure of the Box CD enzyme reveals regulation of rRNA methylation==
	<StructureSection load='4by9' size='340' side='right' caption='[[4by9]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='4by9' size='340' side='right' caption='[[4by9]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4by9]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pyrococcus_furiosus Pyrococcus furiosus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BY9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4by9]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43587 Atcc 43587]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BY9 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4by9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4by9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4by9 RCSB], [http://www.ebi.ac.uk/pdbsum/4by9 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4by9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4by9 OCA], [http://pdbe.org/4by9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4by9 RCSB], [http://www.ebi.ac.uk/pdbsum/4by9 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4by9" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Pyrococcus furiosus~~]]	+	[[Category: Atcc 43587]]
	[[Category: Carlomagno, T]]		[[Category: Carlomagno, T]]
	[[Category: Gabel, F]]		[[Category: Gabel, F]]

OCA at 22:55, 24 December 2014

OCA — Wed, 24 Dec 2014 22:55:45 GMT

←Older revision		Revision as of 22:55, 24 December 2014
Line 5:		Line 5:
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4by9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4by9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4by9 RCSB], [http://www.ebi.ac.uk/pdbsum/4by9 PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4by9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4by9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4by9 RCSB], [http://www.ebi.ac.uk/pdbsum/4by9 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FLPA_PYRFU FLPA_PYRFU]] Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity).[HAMAP-Rule:MF_00351] [[http://www.uniprot.org/uniprot/RL7A_PYRFU RL7A_PYRFU]] Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, box H/ACA, box C/D and box C'/D' sRNAs (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:18, 21 December 2014

OCA — Sun, 21 Dec 2014 09:18:47 GMT

←Older revision		Revision as of 09:18, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4by9\| PDB=4by9 \| SCENE= }}~~	+	==The structure of the Box CD enzyme reveals regulation of rRNA methylation==
-	===The structure of the Box CD enzyme reveals regulation of rRNA methylation===	+	<StructureSection load='4by9' size='340' side='right' caption='[[4by9]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_24121435}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4by9]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BY9 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4by9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4by9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4by9 RCSB], [http://www.ebi.ac.uk/pdbsum/4by9 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Post-transcriptional modifications are essential to the cell life cycle, as they affect both pre-ribosomal RNA processing and ribosome assembly. The box C/D ribonucleoprotein enzyme that methylates ribosomal RNA at the 2'-O-ribose uses a multitude of guide RNAs as templates for the recognition of rRNA target sites. Two methylation guide sequences are combined on each guide RNA, the significance of which has remained unclear. Here we use a powerful combination of NMR spectroscopy and small-angle neutron scattering to solve the structure of the 390 kDa archaeal RNP enzyme bound to substrate RNA. We show that the two methylation guide sequences are located in different environments in the complex and that the methylation of physiological substrates targeted by the same guide RNA occurs sequentially. This structure provides a means for differential control of methylation levels at the two sites and at the same time offers an unexpected regulatory mechanism for rRNA folding.

-	~~==Function==~~	+	The structure of the box C/D enzyme reveals regulation of RNA methylation.,Lapinaite A, Simon B, Skjaerven L, Rakwalska-Bange M, Gabel F, Carlomagno T Nature. 2013 Oct 13. doi: 10.1038/nature12581. PMID:24121435<ref>PMID:24121435</ref>
-	~~[[http:~~/~~/www~~.~~uniprot.org/uniprot/FLPA_PYRFU FLPA_PYRFU]] Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-~~L-~~methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA~~. ~~Site specificity is provided by a guide RNA that base pairs with the substrate~~. ~~Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity)~~.~~[HAMAP-Rule~~:~~MF_00351] [[http~~:/~~/www.uniprot.org/uniprot/RL7A_PYRFU RL7A_PYRFU]] Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, box H/ACA, box C/D and box C'/D' sRNAs (By similarity).~~	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4by9]] is~~ a ~~18 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4BY9 OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:024121435</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Pyrococcus furiosus]]		[[Category: Pyrococcus furiosus]]
-	[[Category: Carlomagno, T.]]	+	[[Category: Carlomagno, T]]
-	[[Category: Gabel, F.]]	+	[[Category: Gabel, F]]
-	[[Category: Lapinaite, A.]]	+	[[Category: Lapinaite, A]]
-	[[Category: Rakwalska-Bange, M.]]	+	[[Category: Rakwalska-Bange, M]]
-	[[Category: Simon, B.]]	+	[[Category: Simon, B]]
-	[[Category: Skjaerven, L.]]	+	[[Category: Skjaerven, L]]
	[[Category: Rrna modification]]		[[Category: Rrna modification]]
	[[Category: Transferase-rna complex]]		[[Category: Transferase-rna complex]]

OCA at 05:14, 23 October 2013

OCA — Wed, 23 Oct 2013 05:14:25 GMT

←Older revision		Revision as of 05:14, 23 October 2013
Line 1:		Line 1:
	{{STRUCTURE_4by9\| PDB=4by9 \| SCENE= }}		{{STRUCTURE_4by9\| PDB=4by9 \| SCENE= }}
	===The structure of the Box CD enzyme reveals regulation of rRNA methylation===		===The structure of the Box CD enzyme reveals regulation of rRNA methylation===
		+	{{ABSTRACT_PUBMED_24121435}}

	==Function==		==Function==
Line 7:		Line 8:
	==About this Structure==		==About this Structure==
	[[4by9]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BY9 OCA].		[[4by9]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BY9 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:024121435</ref><references group="xtra"/><references/>
	[[Category: Pyrococcus furiosus]]		[[Category: Pyrococcus furiosus]]
	[[Category: Carlomagno, T.]]		[[Category: Carlomagno, T.]]

OCA at 06:34, 10 October 2013

OCA — Thu, 10 Oct 2013 06:34:38 GMT

←Older revision		Revision as of 06:34, 10 October 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4by9\| PDB=4by9 \| SCENE= }}
		+	===The structure of the Box CD enzyme reveals regulation of rRNA methylation===

-	~~The entry 4by9~~ is ~~ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/FLPA_PYRFU FLPA_PYRFU]] Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity).[HAMAP-Rule:MF_00351] [[http://www.uniprot.org/uniprot/RL7A_PYRFU RL7A_PYRFU]] Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, box H/ACA, box C/D and box C'/D' sRNAs (By similarity).

-	~~Authors~~: ~~Lapinaite, A~~., ~~Simon, B~~., ~~Skjaerven, L~~., Rakwalska-Bange, M., ~~Gabel, F~~., ~~Carlomagno, T~~.	+	==About this Structure==
-		+	[[4by9]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BY9 OCA].
-	~~Description~~: ~~The structure of the Box CD enzyme reveals regulation of rRNA methylation~~	+	[[Category: Pyrococcus furiosus]]
		+	[[Category: Carlomagno, T.]]
		+	[[Category: Gabel, F.]]
		+	[[Category: Lapinaite, A.]]
		+	[[Category: Rakwalska-Bange, M.]]
		+	[[Category: Simon, B.]]
		+	[[Category: Skjaerven, L.]]
		+	[[Category: Rrna modification]]
		+	[[Category: Transferase-rna complex]]

OCA at 09:29, 4 September 2013

OCA — Wed, 04 Sep 2013 09:29:29 GMT

←Older revision		Revision as of 09:29, 4 September 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4by9 is ON HOLD	+	The entry 4by9 is ON HOLD until Paper Publication

	Authors: Lapinaite, A., Simon, B., Skjaerven, L., Rakwalska-Bange, M., Gabel, F., Carlomagno, T.		Authors: Lapinaite, A., Simon, B., Skjaerven, L., Rakwalska-Bange, M., Gabel, F., Carlomagno, T.

	Description: The structure of the Box CD enzyme reveals regulation of rRNA methylation		Description: The structure of the Box CD enzyme reveals regulation of rRNA methylation

OCA at 19:42, 7 August 2013

OCA — Wed, 07 Aug 2013 19:42:36 GMT

←Older revision		Revision as of 19:42, 7 August 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4by9 is ON HOLD ~~until sometime in the future~~	+	The entry 4by9 is ON HOLD

	Authors: Lapinaite, A., Simon, B., Skjaerven, L., Rakwalska-Bange, M., Gabel, F., Carlomagno, T.		Authors: Lapinaite, A., Simon, B., Skjaerven, L., Rakwalska-Bange, M., Gabel, F., Carlomagno, T.

	Description: The structure of the Box CD enzyme reveals regulation of rRNA methylation		Description: The structure of the Box CD enzyme reveals regulation of rRNA methylation