4byn - Revision history

OCA: Redirecting to 4v8y

OCA — Wed, 10 Dec 2014 15:41:11 GMT

Redirecting to 4v8y

←Older revision		Revision as of 15:41, 10 December 2014
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-	~~{{STRUCTURE_4byn\| PDB=4byn \| SCENE= }}~~	+	#REDIRECT [[4v8y]] This PDB entry is obsolete and replaced by 4v8y
-	~~===Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex===~~	+
-	~~{{ABSTRACT_PUBMED_24200810}}~~	+
-		+
-	~~==Function==~~	+
-	[[~~http://www.uniprot.org/uniprot/RL25_YEAST RL25_YEAST~~]] This protein binds to a specific region on the 26S rRNA. [[http://www.uniprot.org/uniprot/RL11A_YEAST RL11A_YEAST]] Binds to 5S ribosomal RNA. [[http://www.uniprot.org/uniprot/RLA0_YEAST RLA0_YEAST]] Ribosomal protein P0 is the functional equivalent of E.coli protein L10. [[http://www.uniprot.org/uniprot/RL401_YEAST RL401_YEAST]] Ubiquitin: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, and DNA-damage responses. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).<ref>PMID:23169626</ref> 60S ribosomal protein L40: component of the 60S subunit of the ribosome. Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, including stress response transcripts, such as DDR2.<ref>PMID:23169626</ref> [[http://www.uniprot.org/uniprot/RL4A_YEAST RL4A_YEAST]] Participates in the regulation of the accumulation of its own mRNA.<ref>PMID:2065661</ref> [[http://www.uniprot.org/uniprot/RL37A_YEAST RL37A_YEAST]] Binds to the 23S rRNA (By similarity). [[http://www.uniprot.org/uniprot/RL5_YEAST RL5_YEAST]] Binds 5S RNA and is required for 60S subunit assembly.	+
-		+
-	~~==About this Structure==~~	+
-	[[4byn]] is a 45 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BYN OCA].	+
-		+
-	~~==Reference==~~	+
-	~~<ref group="xtra">PMID:024200810</ref><references group="xtra"/><references/>~~	+
-	~~[[Category: Saccharomyces cerevisiae]]~~	+
-	~~[[Category: Bai, X C.]]~~	+
-	~~[[Category: Fernandez, I S.]]~~	+
-	~~[[Category: Hussain, T.]]~~	+
-	~~[[Category: Kelley, A C.]]~~	+
-	~~[[Category: Lorsch, J R.]]~~	+
-	~~[[Category: Ramakrishnan, V.]]~~	+
-	~~[[Category: Scheres, S H.W.]]~~	+
-	~~[[Category: Cryo em]]~~	+
-	~~[[Category: Initiator factor eif5b]]~~	+
-	~~[[Category: Ribosome]]~~	+
-	~~[[Category: Ribosome initiation complex]]~~	+
-	~~[[Category: Single particle analysis]]~~	+

OCA at 13:33, 20 November 2013

OCA — Wed, 20 Nov 2013 13:33:44 GMT

←Older revision		Revision as of 13:33, 20 November 2013
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-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4byn\| PDB=4byn \| SCENE= }}
		+	===Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex===
		+	{{ABSTRACT_PUBMED_24200810}}

-	~~The entry 4byn~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/RL25_YEAST RL25_YEAST]] This protein binds to a specific region on the 26S rRNA. [[http://www.uniprot.org/uniprot/RL11A_YEAST RL11A_YEAST]] Binds to 5S ribosomal RNA. [[http://www.uniprot.org/uniprot/RLA0_YEAST RLA0_YEAST]] Ribosomal protein P0 is the functional equivalent of E.coli protein L10. [[http://www.uniprot.org/uniprot/RL401_YEAST RL401_YEAST]] Ubiquitin: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, and DNA-damage responses. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).<ref>PMID:23169626</ref> 60S ribosomal protein L40: component of the 60S subunit of the ribosome. Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, including stress response transcripts, such as DDR2.<ref>PMID:23169626</ref> [[http://www.uniprot.org/uniprot/RL4A_YEAST RL4A_YEAST]] Participates in the regulation of the accumulation of its own mRNA.<ref>PMID:2065661</ref> [[http://www.uniprot.org/uniprot/RL37A_YEAST RL37A_YEAST]] Binds to the 23S rRNA (By similarity). [[http://www.uniprot.org/uniprot/RL5_YEAST RL5_YEAST]] Binds 5S RNA and is required for 60S subunit assembly.

-	~~Authors~~: ~~Fernandez, I~~.S.~~, Bai, X~~.~~C., Hussain, T., Kelley, A.C., Lorsch, J.R., Ramakrishnan, V~~.~~, Scheres, S~~.H.W.	+	==About this Structure==
		+	[[4byn]] is a 45 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BYN OCA].

-	~~Description~~: Cryo~~-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex~~	+	==Reference==
		+	<ref group="xtra">PMID:024200810</ref><references group="xtra"/><references/>
		+	[[Category: Saccharomyces cerevisiae]]
		+	[[Category: Bai, X C.]]
		+	[[Category: Fernandez, I S.]]
		+	[[Category: Hussain, T.]]
		+	[[Category: Kelley, A C.]]
		+	[[Category: Lorsch, J R.]]
		+	[[Category: Ramakrishnan, V.]]
		+	[[Category: Scheres, S H.W.]]
		+	[[Category: Cryo em]]
		+	[[Category: Initiator factor eif5b]]
		+	[[Category: Ribosome]]
		+	[[Category: Ribosome initiation complex]]
		+	[[Category: Single particle analysis]]

OCA at 04:29, 12 September 2013

OCA — Thu, 12 Sep 2013 04:29:32 GMT

←Older revision		Revision as of 04:29, 12 September 2013
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4byn is ON HOLD until ~~sometime in the future~~	+	The entry 4byn is ON HOLD until Paper Publication

	Authors: Fernandez, I.S., Bai, X.C., Hussain, T., Kelley, A.C., Lorsch, J.R., Ramakrishnan, V., Scheres, S.H.W.		Authors: Fernandez, I.S., Bai, X.C., Hussain, T., Kelley, A.C., Lorsch, J.R., Ramakrishnan, V., Scheres, S.H.W.

	Description: Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex		Description: Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex

OCA: Protected "4byn" [edit=sysop:move=sysop]

OCA — Thu, 01 Aug 2013 04:00:09 GMT

Protected "4byn" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:00, 1 August 2013

OCA: New page: '''Unreleased structure''' The entry 4byn is ON HOLD until sometime in the future Authors: Fernandez, I.S., Bai, X.C., Hussain, T., Kelley, A.C., Lorsch, J.R., Ramakrishnan, V., Scheres...

OCA — Thu, 01 Aug 2013 04:00:08 GMT

New page: '''Unreleased structure''' The entry 4byn is ON HOLD until sometime in the future Authors: Fernandez, I.S., Bai, X.C., Hussain, T., Kelley, A.C., Lorsch, J.R., Ramakrishnan, V., Scheres...

New page

'''Unreleased structure'''

The entry 4byn is ON HOLD until sometime in the future

Authors: Fernandez, I.S., Bai, X.C., Hussain, T., Kelley, A.C., Lorsch, J.R., Ramakrishnan, V., Scheres, S.H.W.

Description: Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex