4c0n - Revision history

OCA at 11:07, 9 May 2024

OCA — Thu, 09 May 2024 11:07:17 GMT

←Older revision		Revision as of 11:07, 9 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4c0n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C0N FirstGlance]. <br>		<table><tr><td colspan='2'>[[4c0n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C0N FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.77Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c0n OCA], [https://pdbe.org/4c0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c0n RCSB], [https://www.ebi.ac.uk/pdbsum/4c0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c0n ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c0n OCA], [https://pdbe.org/4c0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c0n RCSB], [https://www.ebi.ac.uk/pdbsum/4c0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c0n ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GLB3_ARATH GLB3_ARATH]] Hemoglobin-like protein that exhibits an unusual concentration-independent binding of O(2) and CO. May promote shoot organogenesis from root explants in vitro.<ref>PMID:11526234</ref> <ref>PMID:21741261</ref>	+	[https://www.uniprot.org/uniprot/GLB3_ARATH GLB3_ARATH] Hemoglobin-like protein that exhibits an unusual concentration-independent binding of O(2) and CO. May promote shoot organogenesis from root explants in vitro.<ref>PMID:11526234</ref> <ref>PMID:21741261</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Plant nonsymbiotic haemoglobins fall into three classes, each with distinct properties but all with largely unresolved physiological functions. Here, the first crystal structure of a class 3 nonsymbiotic plant haemoglobin, that from Arabidopsis thaliana, is reported to 1.77 A resolution. The protein forms a homodimer, with each monomer containing a two-over-two alpha-helical domain similar to that observed in bacterial truncated haemoglobins. A novel N-terminal extension comprising two alpha-helices plays a major role in the dimer interface, which occupies the periphery of the dimer-dimer face, surrounding an open central cavity. The haem pocket contains a proximal histidine ligand and an open sixth iron-coordination site with potential for a ligand, in this structure hydroxide, to form hydrogen bonds to a tyrosine or a tryptophan residue. The haem pocket appears to be unusually open to the external environment, with another cavity spanning the entrance of the two haem pockets. The final 23 residues of the C-terminal domain are disordered in the structure; however, these domains in the functional dimer are adjacent and include the only two cysteine residues in the protein sequence. It is likely that these residues form disulfide bonds in vitro and it is conceivable that this C-terminal region may act in a putative complex with a partner molecule in vivo.
		+
		+	The structure of a class 3 nonsymbiotic plant haemoglobin from Arabidopsis thaliana reveals a novel N-terminal helical extension.,Reeder BJ, Hough MA Acta Crystallogr D Biol Crystallogr. 2014 May;70(Pt 5):1411-8. doi:, 10.1107/S1399004714004878. Epub 2014 Apr 30. PMID:24816109<ref>PMID:24816109</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4c0n" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 17:19, 7 September 2022

OCA — Wed, 07 Sep 2022 17:19:27 GMT

←Older revision		Revision as of 17:19, 7 September 2022
Line 3:		Line 3:
	<StructureSection load='4c0n' size='340' side='right'caption='[[4c0n]], [[Resolution\|resolution]] 1.77Å' scene=''>		<StructureSection load='4c0n' size='340' side='right'caption='[[4c0n]], [[Resolution\|resolution]] 1.77Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4c0n]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Arath Arath~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0N OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4C0N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4c0n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C0N FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4c0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c0n OCA], [~~http~~://pdbe.org/4c0n PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4c0n RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4c0n PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4c0n ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c0n OCA], [https://pdbe.org/4c0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c0n RCSB], [https://www.ebi.ac.uk/pdbsum/4c0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c0n ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GLB3_ARATH GLB3_ARATH]] Hemoglobin-like protein that exhibits an unusual concentration-independent binding of O(2) and CO. May promote shoot organogenesis from root explants in vitro.<ref>PMID:11526234</ref> <ref>PMID:21741261</ref>	+	[[https://www.uniprot.org/uniprot/GLB3_ARATH GLB3_ARATH]] Hemoglobin-like protein that exhibits an unusual concentration-independent binding of O(2) and CO. May promote shoot organogenesis from root explants in vitro.<ref>PMID:11526234</ref> <ref>PMID:21741261</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Plant nonsymbiotic haemoglobins fall into three classes, each with distinct properties but all with largely unresolved physiological functions. Here, the first crystal structure of a class 3 nonsymbiotic plant haemoglobin, that from Arabidopsis thaliana, is reported to 1.77 A resolution. The protein forms a homodimer, with each monomer containing a two-over-two alpha-helical domain similar to that observed in bacterial truncated haemoglobins. A novel N-terminal extension comprising two alpha-helices plays a major role in the dimer interface, which occupies the periphery of the dimer-dimer face, surrounding an open central cavity. The haem pocket contains a proximal histidine ligand and an open sixth iron-coordination site with potential for a ligand, in this structure hydroxide, to form hydrogen bonds to a tyrosine or a tryptophan residue. The haem pocket appears to be unusually open to the external environment, with another cavity spanning the entrance of the two haem pockets. The final 23 residues of the C-terminal domain are disordered in the structure; however, these domains in the functional dimer are adjacent and include the only two cysteine residues in the protein sequence. It is likely that these residues form disulfide bonds in vitro and it is conceivable that this C-terminal region may act in a putative complex with a partner molecule in vivo.	+
-		+
-	The structure of a class 3 nonsymbiotic plant haemoglobin from Arabidopsis thaliana reveals a novel N-terminal helical extension.,Reeder BJ, Hough MA Acta Crystallogr D Biol Crystallogr. 2014 May;70(Pt 5):1411-8. doi:, 10.1107/S1399004714004878. Epub 2014 Apr 30. PMID:24816109<ref>PMID:24816109</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 4c0n" style="background-color:#fffaf0;"></div~~>	+

	==See Also==		==See Also==
Line 25:		Line 16:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arath~~]]	+	[[Category: Arabidopsis thaliana]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hough~~, M A~~]]	+	[[Category: Hough MA]]
-	[[Category: Reeder~~, B J]]~~	+	[[Category: Reeder BJ]]
-	~~[[Category: 2-over-2 fold]]~~	+
-	~~[[Category: Oxygen transport~~]]	+

OCA at 13:10, 13 March 2019

OCA — Wed, 13 Mar 2019 13:10:06 GMT

←Older revision		Revision as of 13:10, 13 March 2019
Line 1:		Line 1:

	==Crystal structure of non symbiotic plant hemoglobin AHb3 (GLB3) from Arabidopsis thaliana==		==Crystal structure of non symbiotic plant hemoglobin AHb3 (GLB3) from Arabidopsis thaliana==
-	<StructureSection load='4c0n' size='340' side='right' caption='[[4c0n]], [[Resolution\|resolution]] 1.77Å' scene=''>	+	<StructureSection load='4c0n' size='340' side='right'caption='[[4c0n]], [[Resolution\|resolution]] 1.77Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4c0n]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C0N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4c0n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C0N FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c0n OCA], [http://pdbe.org/4c0n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c0n RCSB], [http://www.ebi.ac.uk/pdbsum/4c0n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4c0n ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c0n OCA], [http://pdbe.org/4c0n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c0n RCSB], [http://www.ebi.ac.uk/pdbsum/4c0n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4c0n ProSAT]</span></td></tr>
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4c0n" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4c0n" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Hemoglobin 3D structures\|Hemoglobin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Arath]]
		+	[[Category: Large Structures]]
	[[Category: Hough, M A]]		[[Category: Hough, M A]]
	[[Category: Reeder, B J]]		[[Category: Reeder, B J]]
	[[Category: 2-over-2 fold]]		[[Category: 2-over-2 fold]]
	[[Category: Oxygen transport]]		[[Category: Oxygen transport]]

OCA at 12:01, 5 August 2016

OCA — Fri, 05 Aug 2016 12:01:47 GMT

←Older revision		Revision as of 12:01, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of non symbiotic plant hemoglobin AHb3 (GLB3) from Arabidopsis thaliana==		==Crystal structure of non symbiotic plant hemoglobin AHb3 (GLB3) from Arabidopsis thaliana==
	<StructureSection load='4c0n' size='340' side='right' caption='[[4c0n]], [[Resolution\|resolution]] 1.77Å' scene=''>		<StructureSection load='4c0n' size='340' side='right' caption='[[4c0n]], [[Resolution\|resolution]] 1.77Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4c0n]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C0N FirstGlance]. <br>		<table><tr><td colspan='2'>[[4c0n]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C0N FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c0n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c0n RCSB], [http://www.ebi.ac.uk/pdbsum/4c0n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c0n OCA], [http://pdbe.org/4c0n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c0n RCSB], [http://www.ebi.ac.uk/pdbsum/4c0n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4c0n ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4c0n" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:39, 25 December 2014

OCA — Thu, 25 Dec 2014 18:39:31 GMT

←Older revision		Revision as of 18:39, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4c0n]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C0N FirstGlance]. <br>		<table><tr><td colspan='2'>[[4c0n]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C0N FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c0n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c0n RCSB], [http://www.ebi.ac.uk/pdbsum/4c0n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c0n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c0n RCSB], [http://www.ebi.ac.uk/pdbsum/4c0n PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GLB3_ARATH GLB3_ARATH]] Hemoglobin-like protein that exhibits an unusual concentration-independent binding of O(2) and CO. May promote shoot organogenesis from root explants in vitro.<ref>PMID:11526234</ref> <ref>PMID:21741261</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 12:		Line 14:
	The structure of a class 3 nonsymbiotic plant haemoglobin from Arabidopsis thaliana reveals a novel N-terminal helical extension.,Reeder BJ, Hough MA Acta Crystallogr D Biol Crystallogr. 2014 May;70(Pt 5):1411-8. doi:, 10.1107/S1399004714004878. Epub 2014 Apr 30. PMID:24816109<ref>PMID:24816109</ref>		The structure of a class 3 nonsymbiotic plant haemoglobin from Arabidopsis thaliana reveals a novel N-terminal helical extension.,Reeder BJ, Hough MA Acta Crystallogr D Biol Crystallogr. 2014 May;70(Pt 5):1411-8. doi:, 10.1107/S1399004714004878. Epub 2014 Apr 30. PMID:24816109<ref>PMID:24816109</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 18:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Hough, M A.]]	+	[[Category: Hough, M A]]
-	[[Category: Reeder, B J.]]	+	[[Category: Reeder, B J]]
	[[Category: 2-over-2 fold]]		[[Category: 2-over-2 fold]]
	[[Category: Oxygen transport]]		[[Category: Oxygen transport]]

OCA at 07:06, 21 May 2014

OCA — Wed, 21 May 2014 07:06:38 GMT

←Older revision		Revision as of 07:06, 21 May 2014
Line 2:		Line 2:
	<StructureSection load='4c0n' size='340' side='right' caption='[[4c0n]], [[Resolution\|resolution]] 1.77Å' scene=''>		<StructureSection load='4c0n' size='340' side='right' caption='[[4c0n]], [[Resolution\|resolution]] 1.77Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4c0n]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0N OCA]. <br>	+	<table><tr><td colspan='2'>[[4c0n]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C0N FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene><br>		</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene><br>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c0n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c0n RCSB], [http://www.ebi.ac.uk/pdbsum/4c0n PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c0n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c0n RCSB], [http://www.ebi.ac.uk/pdbsum/4c0n PDBsum]</span></td></tr>
	<table>		<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Plant nonsymbiotic haemoglobins fall into three classes, each with distinct properties but all with largely unresolved physiological functions. Here, the first crystal structure of a class 3 nonsymbiotic plant haemoglobin, that from Arabidopsis thaliana, is reported to 1.77 A resolution. The protein forms a homodimer, with each monomer containing a two-over-two alpha-helical domain similar to that observed in bacterial truncated haemoglobins. A novel N-terminal extension comprising two alpha-helices plays a major role in the dimer interface, which occupies the periphery of the dimer-dimer face, surrounding an open central cavity. The haem pocket contains a proximal histidine ligand and an open sixth iron-coordination site with potential for a ligand, in this structure hydroxide, to form hydrogen bonds to a tyrosine or a tryptophan residue. The haem pocket appears to be unusually open to the external environment, with another cavity spanning the entrance of the two haem pockets. The final 23 residues of the C-terminal domain are disordered in the structure; however, these domains in the functional dimer are adjacent and include the only two cysteine residues in the protein sequence. It is likely that these residues form disulfide bonds in vitro and it is conceivable that this C-terminal region may act in a putative complex with a partner molecule in vivo.
		+
		+	The structure of a class 3 nonsymbiotic plant haemoglobin from Arabidopsis thaliana reveals a novel N-terminal helical extension.,Reeder BJ, Hough MA Acta Crystallogr D Biol Crystallogr. 2014 May;70(Pt 5):1411-8. doi:, 10.1107/S1399004714004878. Epub 2014 Apr 30. PMID:24816109<ref>PMID:24816109</ref>
		+
		+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:23, 14 May 2014

OCA — Wed, 14 May 2014 07:23:17 GMT

←Older revision		Revision as of 07:23, 14 May 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of non symbiotic plant hemoglobin AHb3 (GLB3) from Arabidopsis thaliana==
-		+	<StructureSection load='4c0n' size='340' side='right' caption='[[4c0n]], [[Resolution\|resolution]] 1.77Å' scene=''>
-	~~The entry~~ 4c0n is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4c0n]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0N OCA]. <br>
-	~~Authors~~: ~~HOUGH~~, M.A., ~~REEDER~~, B.J.	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene><br>
-		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
-	~~Description~~: ~~Crystal structure of non symbiotic plant hemoglobin AHb3 (GLB3) from Arabidopsis thaliana~~	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c0n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c0n RCSB], [http://www.ebi.ac.uk/pdbsum/4c0n PDBsum]</span></td></tr>
		+	<table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Hough, M A.]]
		+	[[Category: Reeder, B J.]]
		+	[[Category: 2-over-2 fold]]
		+	[[Category: Oxygen transport]]

OCA at 07:36, 21 August 2013

OCA — Wed, 21 Aug 2013 07:36:34 GMT

←Older revision		Revision as of 07:36, 21 August 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4c0n is ON HOLD	+	The entry 4c0n is ON HOLD until Paper Publication

	Authors: HOUGH, M.A., REEDER, B.J.		Authors: HOUGH, M.A., REEDER, B.J.

	Description: Crystal structure of non symbiotic plant hemoglobin AHb3 (GLB3) from Arabidopsis thaliana		Description: Crystal structure of non symbiotic plant hemoglobin AHb3 (GLB3) from Arabidopsis thaliana

OCA: Protected "4c0n" [edit=sysop:move=sysop]

OCA — Wed, 14 Aug 2013 07:00:50 GMT

Protected "4c0n" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:00, 14 August 2013

OCA: New page: '''Unreleased structure''' The entry 4c0n is ON HOLD Authors: HOUGH, M.A., REEDER, B.J. Description: Crystal structure of non symbiotic plant hemoglobin AHb3 (GLB3) from Arabidopsis th...

OCA — Wed, 14 Aug 2013 07:00:48 GMT

New page: '''Unreleased structure''' The entry 4c0n is ON HOLD Authors: HOUGH, M.A., REEDER, B.J. Description: Crystal structure of non symbiotic plant hemoglobin AHb3 (GLB3) from Arabidopsis th...

New page

'''Unreleased structure'''

The entry 4c0n is ON HOLD

Authors: HOUGH, M.A., REEDER, B.J.

Description: Crystal structure of non symbiotic plant hemoglobin AHb3 (GLB3) from Arabidopsis thaliana