4c1n - Revision history

OCA at 11:07, 9 May 2024

OCA — Thu, 09 May 2024 11:07:42 GMT

←Older revision		Revision as of 11:07, 9 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4c1n]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Carboxydothermus_hydrogenoformans Carboxydothermus hydrogenoformans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C1N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C1N FirstGlance]. <br>		<table><tr><td colspan='2'>[[4c1n]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Carboxydothermus_hydrogenoformans Carboxydothermus hydrogenoformans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C1N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C1N FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B12:COBALAMIN'>B12</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.53Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B12:COBALAMIN'>B12</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c1n OCA], [https://pdbe.org/4c1n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c1n RCSB], [https://www.ebi.ac.uk/pdbsum/4c1n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c1n ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c1n OCA], [https://pdbe.org/4c1n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c1n RCSB], [https://www.ebi.ac.uk/pdbsum/4c1n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c1n ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/Q3ACS3_CARHZ Q3ACS3_CARHZ]]	+	[https://www.uniprot.org/uniprot/Q3ACS3_CARHZ Q3ACS3_CARHZ]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Thermodynamically unfavourable electron transfers are enabled by coupling to an energy-supplying reaction. How the energy is transduced from the exergonic to the endergonic process is largely unknown. Here we provide the structural basis for an energy transduction process in the reductive activation of B12-dependent methyltransferases. The transfer of one electron from an activating enzyme to the cobalamin cofactor is energetically uphill and relies on coupling to an ATPase reaction. Our results demonstrate that the key to coupling is, besides the oxidation state-dependent complex formation, the conformational gating of the electron transfer. Complex formation induces a substitution of the ligand at the electron-accepting Co ion. Addition of ATP initiates electron transfer by provoking conformational changes that destabilize the complex. We show how remodelling of the electron-accepting Co(2+) promotes ATP-dependent electron transfer; an efficient strategy not seen in other electron-transferring ATPases.
		+
		+	ATP-induced electron transfer by redox-selective partner recognition.,Hennig SE, Goetzl S, Jeoung JH, Bommer M, Lendzian F, Hildebrandt P, Dobbek H Nat Commun. 2014 Aug 11;5:4626. doi: 10.1038/ncomms5626. PMID:25109607<ref>PMID:25109607</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4c1n" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Acetyl-CoA synthase 3D structures\|Acetyl-CoA synthase 3D structures]]		*[[Acetyl-CoA synthase 3D structures\|Acetyl-CoA synthase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 17:20, 7 September 2022

OCA — Wed, 07 Sep 2022 17:20:46 GMT

←Older revision		Revision as of 17:20, 7 September 2022
Line 3:		Line 3:
	<StructureSection load='4c1n' size='340' side='right'caption='[[4c1n]], [[Resolution\|resolution]] 2.53Å' scene=''>		<StructureSection load='4c1n' size='340' side='right'caption='[[4c1n]], [[Resolution\|resolution]] 2.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4c1n]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_baa-161 Atcc baa-161~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C1N OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4C1N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4c1n]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Carboxydothermus_hydrogenoformans Carboxydothermus hydrogenoformans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C1N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C1N FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B12:COBALAMIN'>B12</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B12:COBALAMIN'>B12</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4c1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c1n OCA], [~~http~~://pdbe.org/4c1n PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4c1n RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4c1n PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4c1n ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c1n OCA], [https://pdbe.org/4c1n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c1n RCSB], [https://www.ebi.ac.uk/pdbsum/4c1n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c1n ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[[https://www.uniprot.org/uniprot/Q3ACS3_CARHZ Q3ACS3_CARHZ]]
-	Thermodynamically unfavourable electron transfers are enabled by coupling to an energy-supplying reaction. How the energy is transduced from the exergonic to the endergonic process is largely unknown. Here we provide the structural basis for an energy transduction process in the reductive activation of B12-dependent methyltransferases. The transfer of one electron from an activating enzyme to the cobalamin cofactor is energetically uphill and relies on coupling to an ATPase reaction. Our results demonstrate that the key to coupling is, besides the oxidation state-dependent complex formation, the conformational gating of the electron transfer. Complex formation induces a substitution of the ligand at the electron-accepting Co ion. Addition of ATP initiates electron transfer by provoking conformational changes that destabilize the complex. We show how remodelling of the electron-accepting Co(2+) promotes ATP-dependent electron transfer; an efficient strategy not seen in other electron-transferring ATPases.	+
-		+
-	~~ATP-induced electron transfer by redox-selective partner recognition.,Hennig SE, Goetzl S, Jeoung JH, Bommer M, Lendzian F, Hildebrandt P, Dobbek H Nat Commun. 2014 Aug 11;5~~:~~4626. doi: 10.1038~~/~~ncomms5626. PMID:25109607<ref>PMID:25109607<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 4c1n" style="background-color:#fffaf0;"><~~/~~div>~~	+

	==See Also==		==See Also==
	*[[Acetyl-CoA synthase 3D structures\|Acetyl-CoA synthase 3D structures]]		*[[Acetyl-CoA synthase 3D structures\|Acetyl-CoA synthase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc baa-161~~]]	+	[[Category: Carboxydothermus hydrogenoformans]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bommer, M]]	+	[[Category: Bommer M]]
-	[[Category: Dobbek, H]]	+	[[Category: Dobbek H]]
-	[[Category: Goetzl, S]]	+	[[Category: Goetzl S]]
-	[[Category: Hennig~~, S E~~]]	+	[[Category: Hennig SE]]
-	[[Category: Hildebrandt, P]]	+	[[Category: Hildebrandt P]]
-	[[Category: Jeoung~~, J H~~]]	+	[[Category: Jeoung JH]]
-	[[Category: Lendzian, F]]	+	[[Category: Lendzian F]]
-	~~[[Category: Oxidoreductase-metal binding protein complex~~]]	+

OCA at 13:34, 13 March 2019

OCA — Wed, 13 Mar 2019 13:34:49 GMT

←Older revision		Revision as of 13:34, 13 March 2019
Line 1:		Line 1:

	==Corrinoid protein reactivation complex with activator==		==Corrinoid protein reactivation complex with activator==
-	<StructureSection load='4c1n' size='340' side='right' caption='[[4c1n]], [[Resolution\|resolution]] 2.53Å' scene=''>	+	<StructureSection load='4c1n' size='340' side='right'caption='[[4c1n]], [[Resolution\|resolution]] 2.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4c1n]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C1N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C1N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4c1n]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_baa-161 Atcc baa-161]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C1N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C1N FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B12:COBALAMIN'>B12</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B12:COBALAMIN'>B12</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c1n OCA], [http://pdbe.org/4c1n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c1n RCSB], [http://www.ebi.ac.uk/pdbsum/4c1n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4c1n ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c1n OCA], [http://pdbe.org/4c1n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c1n RCSB], [http://www.ebi.ac.uk/pdbsum/4c1n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4c1n ProSAT]</span></td></tr>
Line 16:		Line 16:
	</div>		</div>
	<div class="pdbe-citations 4c1n" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4c1n" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Acetyl-CoA synthase 3D structures\|Acetyl-CoA synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc baa-161]]
		+	[[Category: Large Structures]]
	[[Category: Bommer, M]]		[[Category: Bommer, M]]
	[[Category: Dobbek, H]]		[[Category: Dobbek, H]]

OCA at 14:40, 11 August 2016

OCA — Thu, 11 Aug 2016 14:40:01 GMT

←Older revision		Revision as of 14:40, 11 August 2016
Line 1:		Line 1:
		+
	==Corrinoid protein reactivation complex with activator==		==Corrinoid protein reactivation complex with activator==
	<StructureSection load='4c1n' size='340' side='right' caption='[[4c1n]], [[Resolution\|resolution]] 2.53Å' scene=''>		<StructureSection load='4c1n' size='340' side='right' caption='[[4c1n]], [[Resolution\|resolution]] 2.53Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4c1n]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C1N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C1N FirstGlance]. <br>		<table><tr><td colspan='2'>[[4c1n]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C1N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C1N FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B12:COBALAMIN'>B12</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B12:COBALAMIN'>B12</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c1n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c1n RCSB], [http://www.ebi.ac.uk/pdbsum/4c1n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c1n OCA], [http://pdbe.org/4c1n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c1n RCSB], [http://www.ebi.ac.uk/pdbsum/4c1n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4c1n ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4c1n" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:43, 5 January 2015

OCA — Mon, 05 Jan 2015 14:43:04 GMT

←Older revision		Revision as of 14:43, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4c1n]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C1N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C1N FirstGlance]. <br>		<table><tr><td colspan='2'>[[4c1n]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C1N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C1N FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B12:COBALAMIN'>B12</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B12:COBALAMIN'>B12</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c1n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c1n RCSB], [http://www.ebi.ac.uk/pdbsum/4c1n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c1n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c1n RCSB], [http://www.ebi.ac.uk/pdbsum/4c1n PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bommer, M.]]	+	[[Category: Bommer, M]]
-	[[Category: Dobbek, H.]]	+	[[Category: Dobbek, H]]
-	[[Category: Goetzl, S.]]	+	[[Category: Goetzl, S]]
-	[[Category: Hennig, S E.]]	+	[[Category: Hennig, S E]]
-	[[Category: Hildebrandt, P.]]	+	[[Category: Hildebrandt, P]]
-	[[Category: Jeoung, J H.]]	+	[[Category: Jeoung, J H]]
-	[[Category: Lendzian, F.]]	+	[[Category: Lendzian, F]]
	[[Category: Oxidoreductase-metal binding protein complex]]		[[Category: Oxidoreductase-metal binding protein complex]]

OCA at 13:31, 20 August 2014

OCA — Wed, 20 Aug 2014 13:31:49 GMT

←Older revision		Revision as of 13:31, 20 August 2014
Line 6:		Line 6:
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c1n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c1n RCSB], [http://www.ebi.ac.uk/pdbsum/4c1n PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c1n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c1n RCSB], [http://www.ebi.ac.uk/pdbsum/4c1n PDBsum]</span></td></tr>
	<table>		<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Thermodynamically unfavourable electron transfers are enabled by coupling to an energy-supplying reaction. How the energy is transduced from the exergonic to the endergonic process is largely unknown. Here we provide the structural basis for an energy transduction process in the reductive activation of B12-dependent methyltransferases. The transfer of one electron from an activating enzyme to the cobalamin cofactor is energetically uphill and relies on coupling to an ATPase reaction. Our results demonstrate that the key to coupling is, besides the oxidation state-dependent complex formation, the conformational gating of the electron transfer. Complex formation induces a substitution of the ligand at the electron-accepting Co ion. Addition of ATP initiates electron transfer by provoking conformational changes that destabilize the complex. We show how remodelling of the electron-accepting Co(2+) promotes ATP-dependent electron transfer; an efficient strategy not seen in other electron-transferring ATPases.
		+
		+	ATP-induced electron transfer by redox-selective partner recognition.,Hennig SE, Goetzl S, Jeoung JH, Bommer M, Lendzian F, Hildebrandt P, Dobbek H Nat Commun. 2014 Aug 11;5:4626. doi: 10.1038/ncomms5626. PMID:25109607<ref>PMID:25109607</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 09:12, 13 August 2014

OCA — Wed, 13 Aug 2014 09:12:01 GMT

←Older revision		Revision as of 09:12, 13 August 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Corrinoid protein reactivation complex with activator==
-		+	<StructureSection load='4c1n' size='340' side='right' caption='[[4c1n]], [[Resolution\|resolution]] 2.53Å' scene=''>
-	~~The entry~~ 4c1n is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4c1n]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C1N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C1N FirstGlance]. <br>
-	~~Authors~~: ~~Hennig~~, S.E., ~~Goetzl, S~~., ~~Jeoung, J~~.H., Bommer, M., ~~Lendzian~~, F., Hildebrandt, P., ~~Dobbek,~~ H.	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B12:COBALAMIN'>B12</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene><br>
-		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c1n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c1n RCSB], [http://www.ebi.ac.uk/pdbsum/4c1n PDBsum]</span></td></tr>
-	~~Description~~: ~~Corrinoid~~ protein ~~reactivation~~ complex ~~with activator~~	+	<table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bommer, M.]]
		+	[[Category: Dobbek, H.]]
		+	[[Category: Goetzl, S.]]
		+	[[Category: Hennig, S E.]]
		+	[[Category: Hildebrandt, P.]]
		+	[[Category: Jeoung, J H.]]
		+	[[Category: Lendzian, F.]]
		+	[[Category: Oxidoreductase-metal binding protein complex]]

OCA at 07:18, 7 May 2014

OCA — Wed, 07 May 2014 07:18:30 GMT

←Older revision		Revision as of 07:18, 7 May 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4c1n is ON HOLD until ~~sometime in the future~~	+	The entry 4c1n is ON HOLD until Paper Publication

	Authors: Hennig, S.E., Goetzl, S., Jeoung, J.H., Bommer, M., Lendzian, F., Hildebrandt, P., Dobbek, H.		Authors: Hennig, S.E., Goetzl, S., Jeoung, J.H., Bommer, M., Lendzian, F., Hildebrandt, P., Dobbek, H.

	Description: Corrinoid protein reactivation complex with activator		Description: Corrinoid protein reactivation complex with activator

OCA at 08:23, 26 March 2014

OCA — Wed, 26 Mar 2014 08:23:29 GMT

←Older revision		Revision as of 08:23, 26 March 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4c1n is ON HOLD	+	The entry 4c1n is ON HOLD until sometime in the future

	Authors: Hennig, S.E., Goetzl, S., Jeoung, J.H., Bommer, M., Lendzian, F., Hildebrandt, P., Dobbek, H.		Authors: Hennig, S.E., Goetzl, S., Jeoung, J.H., Bommer, M., Lendzian, F., Hildebrandt, P., Dobbek, H.

	Description: Corrinoid protein reactivation complex with activator		Description: Corrinoid protein reactivation complex with activator

OCA: Protected "4c1n" [edit=sysop:move=sysop]

OCA — Wed, 21 Aug 2013 07:37:26 GMT

Protected "4c1n" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:37, 21 August 2013