4c1w - Revision history

OCA at 11:07, 9 May 2024

OCA — Thu, 09 May 2024 11:07:48 GMT

←Older revision		Revision as of 11:07, 9 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4c1w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C1W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C1W FirstGlance]. <br>		<table><tr><td colspan='2'>[[4c1w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C1W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C1W FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900025:3-sialyl-alpha-lactose'>PRD_900025</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.84Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900025:3-sialyl-alpha-lactose'>PRD_900025</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c1w OCA], [https://pdbe.org/4c1w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c1w RCSB], [https://www.ebi.ac.uk/pdbsum/4c1w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c1w ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c1w OCA], [https://pdbe.org/4c1w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c1w RCSB], [https://www.ebi.ac.uk/pdbsum/4c1w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c1w ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/Q4LB86_STREE Q4LB86_STREE]]	+	[https://www.uniprot.org/uniprot/Q4LB86_STREE Q4LB86_STREE]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	There is a need for new approaches for the control of influenza given the burden caused by annual seasonal outbreaks, the emergence of viruses with pandemic potential, and the development of resistance to current antiviral drugs. We show that multivalent biologics, engineered using carbohydrate-binding modules specific for sialic acid, mask the cell-surface receptor recognized by the influenza virus and protect mice from a lethal challenge with 2009 pandemic H1N1 influenza virus. The most promising biologic protects mice when given as a single 1-mug intranasal dose 7 d in advance of viral challenge. There also is sufficient virus replication to establish an immune response, potentially protecting the animal from future exposure to the virus. Furthermore, the biologics appear to stimulate inflammatory mediators, and this stimulation may contribute to their protective ability. Our results suggest that this host-targeted approach could provide a front-line prophylactic that has the potential to protect against any current and future influenza virus and possibly against other respiratory pathogens that use sialic acid as a receptor.
		+
		+	Prevention of influenza by targeting host receptors using engineered proteins.,Connaris H, Govorkova EA, Ligertwood Y, Dutia BM, Yang L, Tauber S, Taylor MA, Alias N, Hagan R, Nash AA, Webster RG, Taylor GL Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):6401-6. doi:, 10.1073/pnas.1404205111. Epub 2014 Apr 14. PMID:24733924<ref>PMID:24733924</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4c1w" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Neuraminidase 3D structures\|Neuraminidase 3D structures]]		*[[Neuraminidase 3D structures\|Neuraminidase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 17:21, 7 September 2022

OCA — Wed, 07 Sep 2022 17:21:19 GMT

←Older revision		Revision as of 17:21, 7 September 2022
Line 3:		Line 3:
	<StructureSection load='4c1w' size='340' side='right'caption='[[4c1w]], [[Resolution\|resolution]] 1.84Å' scene=''>		<StructureSection load='4c1w' size='340' side='right'caption='[[4c1w]], [[Resolution\|resolution]] 1.84Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4c1w]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus~~ pneumoniae~~" (klein 1884) weichselbaum 1886~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C1W OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4C1W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4c1w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C1W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C1W FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~SLT~~:5-~~(ACETYLAMINO)~~-3,5-~~DIDEOXYNON-2-ULOPYRANONOSYL-(2~~- 3)-~~BETA~~-D-~~LYXO-HEXOPYRANOSYL-(1~~- ~~4)HEXOPYRANOSE~~'>~~SLT~~</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900025:3-sialyl-alpha-lactose'>PRD_900025</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c1x\|4c1x]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c1w OCA], [https://pdbe.org/4c1w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c1w RCSB], [https://www.ebi.ac.uk/pdbsum/4c1w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c1w ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4c1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c1w OCA], [~~http~~://pdbe.org/4c1w PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4c1w RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4c1w PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4c1w ProSAT]</span></td></tr>	+
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[[https://www.uniprot.org/uniprot/Q4LB86_STREE Q4LB86_STREE]]
-	There is a need for new approaches for the control of influenza given the burden caused by annual seasonal outbreaks, the emergence of viruses with pandemic potential, and the development of resistance to current antiviral drugs. We show that multivalent biologics, engineered using carbohydrate-binding modules specific for sialic acid, mask the cell-surface receptor recognized by the influenza virus and protect mice from a lethal challenge with 2009 pandemic H1N1 influenza virus. The most promising biologic protects mice when given as a single 1-mug intranasal dose 7 d in advance of viral challenge. There also is sufficient virus replication to establish an immune response, potentially protecting the animal from future exposure to the virus. Furthermore, the biologics appear to stimulate inflammatory mediators, and this stimulation may contribute to their protective ability. Our results suggest that this host-targeted approach could provide a front-line prophylactic that has the potential to protect against any current and future influenza virus and possibly against other respiratory pathogens that use sialic acid as a receptor.	+
-		+
-	Prevention of influenza by targeting host receptors using engineered proteins.,Connaris H, Govorkova EA, Ligertwood Y, Dutia BM, Yang L, Tauber S, Taylor MA, Alias N, Hagan R, Nash AA, Webster RG, Taylor GL Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):~~6401-6. doi:, 10.1073~~/~~pnas.1404205111. Epub 2014 Apr 14. PMID:24733924<ref>PMID:24733924<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 4c1w" style="background-color:#fffaf0;"><~~/~~div>~~	+

	==See Also==		==See Also==
-	*[[~~Carbohydrate binding domain from Streptococcus pneumoniae NanA sialidase complexed with 3'-sialyllactose~~\|~~Carbohydrate binding domain from Streptococcus pneumoniae NanA sialidase complexed with 3'-sialyllactose~~]]	+	*[[Neuraminidase 3D structures\|Neuraminidase 3D structures]]
-	*[[Sialidase\|Sialidase]]	+
-	~~== References ==~~	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Connaris, H~~]]	+	[[Category: Streptococcus pneumoniae]]
-	[[Category: ~~Potter, J A~~]]	+	[[Category: Connaris H]]
-	[[Category: ~~Taylor, G L~~]]	+	[[Category: Potter JA]]
-	[[Category: ~~Yang, L~~]]	+	[[Category: Taylor GL]]
-	[[Category: ~~Carbohydrate-binding module]]~~	+	[[Category: Yang L]]
-	~~[[Category: Sialic acid binding]]~~	+
-	~~[[Category: Sugar binding protein~~]]	+

OCA at 14:02, 13 March 2019

OCA — Wed, 13 Mar 2019 14:02:51 GMT

←Older revision		Revision as of 14:02, 13 March 2019
Line 1:		Line 1:

	==Carbohydrate binding domain from Streptococcus pneumoniae NanA sialidase complexed with 3'-sialyllactose==		==Carbohydrate binding domain from Streptococcus pneumoniae NanA sialidase complexed with 3'-sialyllactose==
-	<StructureSection load='4c1w' size='340' side='right' caption='[[4c1w]], [[Resolution\|resolution]] 1.84Å' scene=''>	+	<StructureSection load='4c1w' size='340' side='right'caption='[[4c1w]], [[Resolution\|resolution]] 1.84Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4c1w]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C1W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C1W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4c1w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C1W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C1W FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SLT:5-(ACETYLAMINO)-3,5-DIDEOXYNON-2-ULOPYRANONOSYL-(2- 3)-BETA-D-LYXO-HEXOPYRANOSYL-(1- 4)HEXOPYRANOSE'>SLT</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SLT:5-(ACETYLAMINO)-3,5-DIDEOXYNON-2-ULOPYRANONOSYL-(2- 3)-BETA-D-LYXO-HEXOPYRANOSYL-(1- 4)HEXOPYRANOSE'>SLT</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c1x\|4c1x]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c1x\|4c1x]]</td></tr>
Line 20:		Line 20:
	==See Also==		==See Also==
	*[[Carbohydrate binding domain from Streptococcus pneumoniae NanA sialidase complexed with 3'-sialyllactose\|Carbohydrate binding domain from Streptococcus pneumoniae NanA sialidase complexed with 3'-sialyllactose]]		*[[Carbohydrate binding domain from Streptococcus pneumoniae NanA sialidase complexed with 3'-sialyllactose\|Carbohydrate binding domain from Streptococcus pneumoniae NanA sialidase complexed with 3'-sialyllactose]]
-	*[[~~Neuraminidase~~\|~~Neuraminidase~~]]	+	*[[Sialidase\|Sialidase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Connaris, H]]		[[Category: Connaris, H]]
	[[Category: Potter, J A]]		[[Category: Potter, J A]]

OCA at 16:46, 11 August 2016

OCA — Thu, 11 Aug 2016 16:46:14 GMT

←Older revision		Revision as of 16:46, 11 August 2016
Line 1:		Line 1:
		+
	==Carbohydrate binding domain from Streptococcus pneumoniae NanA sialidase complexed with 3'-sialyllactose==		==Carbohydrate binding domain from Streptococcus pneumoniae NanA sialidase complexed with 3'-sialyllactose==
	<StructureSection load='4c1w' size='340' side='right' caption='[[4c1w]], [[Resolution\|resolution]] 1.84Å' scene=''>		<StructureSection load='4c1w' size='340' side='right' caption='[[4c1w]], [[Resolution\|resolution]] 1.84Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SLT:5-(ACETYLAMINO)-3,5-DIDEOXYNON-2-ULOPYRANONOSYL-(2- 3)-BETA-D-LYXO-HEXOPYRANOSYL-(1- 4)HEXOPYRANOSE'>SLT</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SLT:5-(ACETYLAMINO)-3,5-DIDEOXYNON-2-ULOPYRANONOSYL-(2- 3)-BETA-D-LYXO-HEXOPYRANOSYL-(1- 4)HEXOPYRANOSE'>SLT</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c1x\|4c1x]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c1x\|4c1x]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c1w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c1w RCSB], [http://www.ebi.ac.uk/pdbsum/4c1w PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c1w OCA], [http://pdbe.org/4c1w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c1w RCSB], [http://www.ebi.ac.uk/pdbsum/4c1w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4c1w ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4c1w" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Carbohydrate binding domain from Streptococcus pneumoniae NanA sialidase complexed with 3'-sialyllactose\|Carbohydrate binding domain from Streptococcus pneumoniae NanA sialidase complexed with 3'-sialyllactose]]
		+	*[[Neuraminidase\|Neuraminidase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:03, 5 January 2015

OCA — Mon, 05 Jan 2015 15:03:55 GMT

←Older revision		Revision as of 15:03, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4c1w]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C1W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C1W FirstGlance]. <br>		<table><tr><td colspan='2'>[[4c1w]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C1W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C1W FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SLT:5-(ACETYLAMINO)-3,5-DIDEOXYNON-2-ULOPYRANONOSYL-(2- 3)-BETA-D-LYXO-HEXOPYRANOSYL-(1- 4)HEXOPYRANOSE'>SLT</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SLT:5-(ACETYLAMINO)-3,5-DIDEOXYNON-2-ULOPYRANONOSYL-(2- 3)-BETA-D-LYXO-HEXOPYRANOSYL-(1- 4)HEXOPYRANOSE'>SLT</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c1x\|4c1x]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c1x\|4c1x]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c1w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c1w RCSB], [http://www.ebi.ac.uk/pdbsum/4c1w PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c1w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c1w RCSB], [http://www.ebi.ac.uk/pdbsum/4c1w PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Connaris, H.]]	+	[[Category: Connaris, H]]
-	[[Category: Potter, J A.]]	+	[[Category: Potter, J A]]
-	[[Category: Taylor, G L.]]	+	[[Category: Taylor, G L]]
-	[[Category: Yang, L.]]	+	[[Category: Yang, L]]
	[[Category: Carbohydrate-binding module]]		[[Category: Carbohydrate-binding module]]
	[[Category: Sialic acid binding]]		[[Category: Sialic acid binding]]
	[[Category: Sugar binding protein]]		[[Category: Sugar binding protein]]

OCA at 08:46, 27 August 2014

OCA — Wed, 27 Aug 2014 08:46:00 GMT

←Older revision		Revision as of 08:46, 27 August 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Carbohydrate binding domain from Streptococcus pneumoniae NanA sialidase complexed with 3'-sialyllactose==
		+	<StructureSection load='4c1w' size='340' side='right' caption='[[4c1w]], [[Resolution\|resolution]] 1.84Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4c1w]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C1W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C1W FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SLT:5-(ACETYLAMINO)-3,5-DIDEOXYNON-2-ULOPYRANONOSYL-(2- 3)-BETA-D-LYXO-HEXOPYRANOSYL-(1- 4)HEXOPYRANOSE'>SLT</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c1x\|4c1x]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c1w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c1w RCSB], [http://www.ebi.ac.uk/pdbsum/4c1w PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	There is a need for new approaches for the control of influenza given the burden caused by annual seasonal outbreaks, the emergence of viruses with pandemic potential, and the development of resistance to current antiviral drugs. We show that multivalent biologics, engineered using carbohydrate-binding modules specific for sialic acid, mask the cell-surface receptor recognized by the influenza virus and protect mice from a lethal challenge with 2009 pandemic H1N1 influenza virus. The most promising biologic protects mice when given as a single 1-mug intranasal dose 7 d in advance of viral challenge. There also is sufficient virus replication to establish an immune response, potentially protecting the animal from future exposure to the virus. Furthermore, the biologics appear to stimulate inflammatory mediators, and this stimulation may contribute to their protective ability. Our results suggest that this host-targeted approach could provide a front-line prophylactic that has the potential to protect against any current and future influenza virus and possibly against other respiratory pathogens that use sialic acid as a receptor.

-	~~The entry 4c1w is ON HOLD until Paper Publication~~	+	Prevention of influenza by targeting host receptors using engineered proteins.,Connaris H, Govorkova EA, Ligertwood Y, Dutia BM, Yang L, Tauber S, Taylor MA, Alias N, Hagan R, Nash AA, Webster RG, Taylor GL Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):6401-6. doi:, 10.1073/pnas.1404205111. Epub 2014 Apr 14. PMID:24733924<ref>PMID:24733924</ref>

-	~~Authors: Yang~~, L., Connaris, H., Potter, J.A., Taylor, G.L.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: Carbohydrate ~~binding domain from Streptococcus pneumoniae NanA sialidase complexed with 3'~~-~~sialyllactose~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Connaris, H.]]
		+	[[Category: Potter, J A.]]
		+	[[Category: Taylor, G L.]]
		+	[[Category: Yang, L.]]
		+	[[Category: Carbohydrate-binding module]]
		+	[[Category: Sialic acid binding]]
		+	[[Category: Sugar binding protein]]

OCA at 06:38, 22 January 2014

OCA — Wed, 22 Jan 2014 06:38:54 GMT

←Older revision		Revision as of 06:38, 22 January 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4c1w is ON HOLD	+	The entry 4c1w is ON HOLD until Paper Publication

	Authors: Yang, L., Connaris, H., Potter, J.A., Taylor, G.L.		Authors: Yang, L., Connaris, H., Potter, J.A., Taylor, G.L.

	Description: Carbohydrate binding domain from Streptococcus pneumoniae NanA sialidase complexed with 3'-sialyllactose		Description: Carbohydrate binding domain from Streptococcus pneumoniae NanA sialidase complexed with 3'-sialyllactose

OCA: Protected "4c1w" [edit=sysop:move=sysop]

OCA — Wed, 21 Aug 2013 07:37:48 GMT

Protected "4c1w" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:37, 21 August 2013

OCA: New page: '''Unreleased structure''' The entry 4c1w is ON HOLD Authors: Yang, L., Connaris, H., Potter, J.A., Taylor, G.L. Description: Carbohydrate binding domain from Streptococcus pneumoniae ...

OCA — Wed, 21 Aug 2013 07:37:47 GMT

New page: '''Unreleased structure''' The entry 4c1w is ON HOLD Authors: Yang, L., Connaris, H., Potter, J.A., Taylor, G.L. Description: Carbohydrate binding domain from Streptococcus pneumoniae ...

New page

'''Unreleased structure'''

The entry 4c1w is ON HOLD

Authors: Yang, L., Connaris, H., Potter, J.A., Taylor, G.L.

Description: Carbohydrate binding domain from Streptococcus pneumoniae NanA sialidase complexed with 3'-sialyllactose