4c79 - Revision history

OCA at 12:05, 20 December 2023

OCA — Wed, 20 Dec 2023 12:05:21 GMT

←Older revision		Revision as of 12:05, 20 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4c79]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C79 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C79 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4c79]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C79 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C79 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.604Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c79 OCA], [https://pdbe.org/4c79 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c79 RCSB], [https://www.ebi.ac.uk/pdbsum/4c79 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c79 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c79 OCA], [https://pdbe.org/4c79 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c79 RCSB], [https://www.ebi.ac.uk/pdbsum/4c79 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c79 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/Q90X26_DANRE Q90X26_DANRE]]	+	[https://www.uniprot.org/uniprot/Q90X26_DANRE Q90X26_DANRE]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Hedgehog (Hh) signal is transduced across the membrane by the heptahelical protein Smoothened (Smo), a developmental regulator, oncoprotein and drug target in oncology. We present the 2.3 A crystal structure of the extracellular cysteine rich domain (CRD) of vertebrate Smo and show that it binds to oxysterols, endogenous lipids that activate Hh signaling. The oxysterol-binding groove in the Smo CRD is analogous to that used by Frizzled 8 to bind to the palmitoleyl group of Wnt ligands and to similar pockets used by other Frizzled-like CRDs to bind hydrophobic ligands. The CRD is required for signaling in response to native Hh ligands, showing that it is an important regulatory module for Smo activation. Indeed, targeting of the Smo CRD by oxysterol-inspired small molecules can block signaling by all known classes of Hh activators and by clinically relevant Smo mutants. DOI:http://dx.doi.org/10.7554/eLife.01340.001.
		+
		+	Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling.,Nachtergaele S, Whalen DM, Mydock LK, Zhao Z, Malinauskas T, Krishnan K, Ingham PW, Covey DF, Siebold C, Rohatgi R Elife. 2013 Oct 29;2:e01340. doi: 10.7554/eLife.01340. PMID:24171105<ref>PMID:24171105</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4c79" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 17:30, 7 September 2022

OCA — Wed, 07 Sep 2022 17:30:21 GMT

←Older revision		Revision as of 17:30, 7 September 2022
Line 3:		Line 3:
	<StructureSection load='4c79' size='340' side='right'caption='[[4c79]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='4c79' size='340' side='right'caption='[[4c79]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4c79]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Brachidanio_rerio Brachidanio~~ rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C79 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4C79 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4c79]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C79 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C79 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c7a\|4c7a]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c79 OCA], [https://pdbe.org/4c79 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c79 RCSB], [https://www.ebi.ac.uk/pdbsum/4c79 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c79 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4c79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c79 OCA], [~~http~~://pdbe.org/4c79 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4c79 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4c79 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4c79 ProSAT]</span></td></tr>	+
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[[https://www.uniprot.org/uniprot/Q90X26_DANRE Q90X26_DANRE]]
-	The Hedgehog (Hh) signal is transduced across the membrane by the heptahelical protein Smoothened (Smo), a developmental regulator, oncoprotein and drug target in oncology. We present the 2.3 A crystal structure of the extracellular cysteine rich domain (CRD) of vertebrate Smo and show that it binds to oxysterols, endogenous lipids that activate Hh signaling. The oxysterol-binding groove in the Smo CRD is analogous to that used by Frizzled 8 to bind to the palmitoleyl group of Wnt ligands and to similar pockets used by other Frizzled-like CRDs to bind hydrophobic ligands. The CRD is required for signaling in response to native Hh ligands, showing that it is an important regulatory module for Smo activation. Indeed, targeting of the Smo CRD by oxysterol-inspired small molecules can block signaling by all known classes of Hh activators and by clinically relevant Smo mutants. DOI:http://dx.~~doi~~.org/~~10.7554/eLife.01340.001.~~	+
-		+
-	Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling.,Nachtergaele S, Whalen DM, Mydock LK, Zhao Z, Malinauskas T, Krishnan K, Ingham PW, Covey DF, Siebold C, Rohatgi R Elife. 2013 Oct 29;2:e01340. doi: 10.7554/eLife.01340. PMID:24171105<ref>PMID:24171105</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 4c79" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references~~/>	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Brachidanio~~ rerio]]	+	[[Category: Danio rerio]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Covey~~, D F~~]]	+	[[Category: Covey DF]]
-	[[Category: Ingham~~, P W~~]]	+	[[Category: Ingham PW]]
-	[[Category: Krishnan, K]]	+	[[Category: Krishnan K]]
-	[[Category: Malinauskas, T]]	+	[[Category: Malinauskas T]]
-	[[Category: Mydock~~, L K~~]]	+	[[Category: Mydock LK]]
-	[[Category: Nachtergaele, S]]	+	[[Category: Nachtergaele S]]
-	[[Category: Rohatgi, R]]	+	[[Category: Rohatgi R]]
-	[[Category: Siebold, C]]	+	[[Category: Siebold C]]
-	[[Category: Whalen~~, D M~~]]	+	[[Category: Whalen DM]]
-	[[Category: Zhao, Z]]	+	[[Category: Zhao Z]]
-	~~[[Category: Signaling protein~~]]	+

OCA at 08:55, 20 March 2019

OCA — Wed, 20 Mar 2019 08:55:10 GMT

←Older revision		Revision as of 08:55, 20 March 2019
Line 1:		Line 1:

	==Crystal structure of the Smoothened CRD, native==		==Crystal structure of the Smoothened CRD, native==
-	<StructureSection load='4c79' size='340' side='right' caption='[[4c79]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='4c79' size='340' side='right'caption='[[4c79]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4c79]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C79 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C79 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4c79]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C79 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C79 FirstGlance]. <br>
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Brachidanio rerio]]		[[Category: Brachidanio rerio]]
		+	[[Category: Large Structures]]
	[[Category: Covey, D F]]		[[Category: Covey, D F]]
	[[Category: Ingham, P W]]		[[Category: Ingham, P W]]

OCA at 09:04, 11 August 2016

OCA — Thu, 11 Aug 2016 09:04:32 GMT

←Older revision		Revision as of 09:04, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the Smoothened CRD, native==		==Crystal structure of the Smoothened CRD, native==
	<StructureSection load='4c79' size='340' side='right' caption='[[4c79]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='4c79' size='340' side='right' caption='[[4c79]], [[Resolution\|resolution]] 2.60Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c7a\|4c7a]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c7a\|4c7a]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c79 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c79 RCSB], [http://www.ebi.ac.uk/pdbsum/4c79 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c79 OCA], [http://pdbe.org/4c79 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c79 RCSB], [http://www.ebi.ac.uk/pdbsum/4c79 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4c79 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4c79" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:25, 4 January 2015

OCA — Sun, 04 Jan 2015 12:25:11 GMT

←Older revision		Revision as of 12:25, 4 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_4c79\| PDB~~=4c79 \| ~~SCENE~~= }}	+	==Crystal structure of the Smoothened CRD, native==
-	===~~Crystal~~ structure of the ~~Smoothened CRD~~, ~~native~~===	+	<StructureSection load='4c79' size='340' side='right' caption='[[4c79]], [[Resolution\|resolution]] 2.60Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24171105}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4c79]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C79 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C79 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c7a\|4c7a]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c79 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c79 RCSB], [http://www.ebi.ac.uk/pdbsum/4c79 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Hedgehog (Hh) signal is transduced across the membrane by the heptahelical protein Smoothened (Smo), a developmental regulator, oncoprotein and drug target in oncology. We present the 2.3 A crystal structure of the extracellular cysteine rich domain (CRD) of vertebrate Smo and show that it binds to oxysterols, endogenous lipids that activate Hh signaling. The oxysterol-binding groove in the Smo CRD is analogous to that used by Frizzled 8 to bind to the palmitoleyl group of Wnt ligands and to similar pockets used by other Frizzled-like CRDs to bind hydrophobic ligands. The CRD is required for signaling in response to native Hh ligands, showing that it is an important regulatory module for Smo activation. Indeed, targeting of the Smo CRD by oxysterol-inspired small molecules can block signaling by all known classes of Hh activators and by clinically relevant Smo mutants. DOI:http://dx.doi.org/10.7554/eLife.01340.001.

-	~~==About this~~ Structure==	+	Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling.,Nachtergaele S, Whalen DM, Mydock LK, Zhao Z, Malinauskas T, Krishnan K, Ingham PW, Covey DF, Siebold C, Rohatgi R Elife. 2013 Oct 29;2:e01340. doi: 10.7554/eLife.01340. PMID:24171105<ref>PMID:24171105</ref>
-	~~[[4c79]] is a~~ 2 ~~chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org~~/~~wiki/Brachidanio_rerio Brachidanio rerio]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4C79 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024171105</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Brachidanio rerio]]		[[Category: Brachidanio rerio]]
-	[[Category: Covey, D F.]]	+	[[Category: Covey, D F]]
-	[[Category: Ingham, P W.]]	+	[[Category: Ingham, P W]]
-	[[Category: Krishnan, K.]]	+	[[Category: Krishnan, K]]
-	[[Category: Malinauskas, T.]]	+	[[Category: Malinauskas, T]]
-	[[Category: Mydock, L K.]]	+	[[Category: Mydock, L K]]
-	[[Category: Nachtergaele, S.]]	+	[[Category: Nachtergaele, S]]
-	[[Category: Rohatgi, R.]]	+	[[Category: Rohatgi, R]]
-	[[Category: Siebold, C.]]	+	[[Category: Siebold, C]]
-	[[Category: Whalen, D M.]]	+	[[Category: Whalen, D M]]
-	[[Category: Zhao, Z.]]	+	[[Category: Zhao, Z]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

OCA at 06:40, 13 November 2013

OCA — Wed, 13 Nov 2013 06:40:22 GMT

←Older revision		Revision as of 06:40, 13 November 2013
Line 1:		Line 1:
	{{STRUCTURE_4c79\| PDB=4c79 \| SCENE= }}		{{STRUCTURE_4c79\| PDB=4c79 \| SCENE= }}
	===Crystal structure of the Smoothened CRD, native===		===Crystal structure of the Smoothened CRD, native===
		+	{{ABSTRACT_PUBMED_24171105}}

	==About this Structure==		==About this Structure==
-	[[4c79]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Danio_rerio Danio~~ rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C79 OCA].	+	[[4c79]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C79 OCA].
-	[[Category: ~~Danio~~ rerio]]	+
		+	==Reference==
		+	<ref group="xtra">PMID:024171105</ref><references group="xtra"/><references/>
		+	[[Category: Brachidanio rerio]]
	[[Category: Covey, D F.]]		[[Category: Covey, D F.]]
	[[Category: Ingham, P W.]]		[[Category: Ingham, P W.]]

OCA at 07:38, 6 November 2013

OCA — Wed, 06 Nov 2013 07:38:39 GMT

←Older revision		Revision as of 07:38, 6 November 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4c79\| PDB=4c79 \| SCENE= }}
		+	===Crystal structure of the Smoothened CRD, native===

-	~~The entry~~ 4c79 is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
-		+	[[4c79]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C79 OCA].
-	~~Authors~~: ~~Nachtergaele, S~~.~~, Whalen, D~~.M.~~, Mydock, L~~.K.~~, Zhao, Z~~.~~, Malinauskas, T~~., ~~Krishnan, K~~., Ingham, P.W., ~~Covey~~, D.F., Rohatgi, R., Siebold, C.	+	[[Category: Danio rerio]]
-		+	[[Category: Covey, D F.]]
-	~~Description~~: ~~Crystal structure of the Smoothened CRD~~, ~~native~~	+	[[Category: Ingham, P W.]]
		+	[[Category: Krishnan, K.]]
		+	[[Category: Malinauskas, T.]]
		+	[[Category: Mydock, L K.]]
		+	[[Category: Nachtergaele, S.]]
		+	[[Category: Rohatgi, R.]]
		+	[[Category: Siebold, C.]]
		+	[[Category: Whalen, D M.]]
		+	[[Category: Zhao, Z.]]
		+	[[Category: Signaling protein]]

OCA at 06:33, 2 October 2013

OCA — Wed, 02 Oct 2013 06:33:15 GMT

←Older revision		Revision as of 06:33, 2 October 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4c79 is ON HOLD	+	The entry 4c79 is ON HOLD until Paper Publication

	Authors: Nachtergaele, S., Whalen, D.M., Mydock, L.K., Zhao, Z., Malinauskas, T., Krishnan, K., Ingham, P.W., Covey, D.F., Rohatgi, R., Siebold, C.		Authors: Nachtergaele, S., Whalen, D.M., Mydock, L.K., Zhao, Z., Malinauskas, T., Krishnan, K., Ingham, P.W., Covey, D.F., Rohatgi, R., Siebold, C.

	Description: Crystal structure of the Smoothened CRD, native		Description: Crystal structure of the Smoothened CRD, native

OCA: Protected "4c79" [edit=sysop:move=sysop]

OCA — Sun, 29 Sep 2013 07:17:07 GMT

Protected "4c79" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:17, 29 September 2013

OCA: New page: '''Unreleased structure''' The entry 4c79 is ON HOLD Authors: Nachtergaele, S., Whalen, D.M., Mydock, L.K., Zhao, Z., Malinauskas, T., Krishnan, K., Ingham, P.W., Covey, D.F., Rohatgi, ...

OCA — Sun, 29 Sep 2013 07:17:06 GMT

New page: '''Unreleased structure''' The entry 4c79 is ON HOLD Authors: Nachtergaele, S., Whalen, D.M., Mydock, L.K., Zhao, Z., Malinauskas, T., Krishnan, K., Ingham, P.W., Covey, D.F., Rohatgi, ...

New page

'''Unreleased structure'''

The entry 4c79 is ON HOLD

Authors: Nachtergaele, S., Whalen, D.M., Mydock, L.K., Zhao, Z., Malinauskas, T., Krishnan, K., Ingham, P.W., Covey, D.F., Rohatgi, R., Siebold, C.

Description: Crystal structure of the Smoothened CRD, native