4cb5 - Revision history

OCA at 12:06, 20 December 2023

OCA — Wed, 20 Dec 2023 12:06:54 GMT

←Older revision		Revision as of 12:06, 20 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4cb5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/duck/Shantou/4610/2003(H5N1)) Influenza A virus (A/duck/Shantou/4610/2003(H5N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CB5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4cb5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/duck/Shantou/4610/2003(H5N1)) Influenza A virus (A/duck/Shantou/4610/2003(H5N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CB5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=93G:9-N-(3-CARBOXY-4-HYDROXYPHENYL)KETOMETHYL-7-N-METHYLGUANINE'>93G</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=93G:9-N-(3-CARBOXY-4-HYDROXYPHENYL)KETOMETHYL-7-N-METHYLGUANINE'>93G</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cb5 OCA], [https://pdbe.org/4cb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cb5 RCSB], [https://www.ebi.ac.uk/pdbsum/4cb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cb5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cb5 OCA], [https://pdbe.org/4cb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cb5 RCSB], [https://www.ebi.ac.uk/pdbsum/4cb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cb5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/Q2LG68_9INFA Q2LG68_9INFA]]	+	[https://www.uniprot.org/uniprot/Q2LG68_9INFA Q2LG68_9INFA]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The heterotrimeric influenza virus polymerase performs replication and transcription of viral RNA in the nucleus of infected cells. Transcription by 'cap-snatching' requires that host-cell pre-mRNAs are bound via their 5' cap to the PB2 subunit. Thus, the PB2 cap binding site is potentially a good target for new antiviral drugs that will directly inhibit viral replication. Docking studies using the structure of the PB2 cap binding domain suggested that 7-alkylguanine derivatives substituted at position N-9 and N-2 could be good candidates. Four series of 7,9-di- and 2,7,9-tri-alkyl guanine derivatives were synthesized and evaluated by an AlphaScreen assay in competition with a biotinylated cap analogue. Three synthesised compounds display potent in vitro activity with IC50 lower than 10 M. High-resolution X-ray structures of three inhibitors in complex with the H5N1 PB2 cap-binding domain confirmed the binding mode and provide detailed information for further compound optimization.
		+
		+	New 7-methyl-guanosine derivatives targeting the influenza polymerase PB2 cap-binding domain.,Pautus S, Sehr P, Lewis J, Fortune A, Wolkerstorfer A, Szolar O, Guilligay D, Lunardi T, Decout JL, Cusack S J Med Chem. 2013 Oct 18. PMID:24134208<ref>PMID:24134208</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4cb5" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 17:36, 7 September 2022

OCA — Wed, 07 Sep 2022 17:36:07 GMT

←Older revision		Revision as of 17:36, 7 September 2022
Line 3:		Line 3:
	<StructureSection load='4cb5' size='340' side='right'caption='[[4cb5]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='4cb5' size='340' side='right'caption='[[4cb5]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4cb5]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Influenza_a_virus_~~(a/duck/~~shantou~~/4610/2003(~~h5n1~~)) Influenza a virus (a/duck/~~shantou~~/4610/2003(~~h5n1~~))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CB5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4CB5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4cb5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/duck/Shantou/4610/2003(H5N1)) Influenza A virus (A/duck/Shantou/4610/2003(H5N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CB5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=93G:9-N-(3-CARBOXY-4-HYDROXYPHENYL)KETOMETHYL-7-N-METHYLGUANINE'>93G</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=93G:9-N-(3-CARBOXY-4-HYDROXYPHENYL)KETOMETHYL-7-N-METHYLGUANINE'>93G</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cb4\|4cb4]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cb5 OCA], [https://pdbe.org/4cb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cb5 RCSB], [https://www.ebi.ac.uk/pdbsum/4cb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cb5 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4cb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cb5 OCA], [~~http~~://pdbe.org/4cb5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4cb5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4cb5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4cb5 ProSAT]</span></td></tr>	+
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[[https://www.uniprot.org/uniprot/Q2LG68_9INFA Q2LG68_9INFA]]
-	The heterotrimeric influenza virus polymerase performs replication and transcription of viral RNA in the nucleus of infected cells. Transcription by 'cap-snatching' requires that host-cell pre-mRNAs are bound via their 5' cap to the PB2 subunit. Thus, the PB2 cap binding site is potentially a good target for new antiviral drugs that will directly inhibit viral replication. Docking studies using the structure of the PB2 cap binding domain suggested that 7-alkylguanine derivatives substituted at position N-9 and N-2 could be good candidates. Four series of 7,9-di- and 2,7,9-tri-alkyl guanine derivatives were synthesized and evaluated by an AlphaScreen assay in competition with a biotinylated cap analogue. Three synthesised compounds display potent in vitro activity with IC50 lower than 10 M. High-resolution X-ray structures of three inhibitors in complex with the H5N1 PB2 cap-binding domain confirmed the binding mode and provide detailed information for further compound optimization.	+
-		+
-	New 7-methyl-guanosine derivatives targeting the influenza polymerase PB2 cap-binding domain.,Pautus S, Sehr P, Lewis J, Fortune A, Wolkerstorfer A, Szolar O, Guilligay D, Lunardi T, Decout JL, Cusack S J Med Chem. 2013 Oct 18. PMID:~~24134208<ref>PMID:24134208<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®~~/~~PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 4cb5" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references~~/>	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cusack, S]]	+	[[Category: Cusack S]]
-	[[Category: Decout~~, J L~~]]	+	[[Category: Decout JL]]
-	[[Category: Fortune, A]]	+	[[Category: Fortune A]]
-	[[Category: Gulligay, D]]	+	[[Category: Gulligay D]]
-	[[Category: Lewis, J]]	+	[[Category: Lewis J]]
-	[[Category: Lunardi, T]]	+	[[Category: Lunardi T]]
-	[[Category: Pautus, S]]	+	[[Category: Pautus S]]
-	[[Category: Sehr, P]]	+	[[Category: Sehr P]]
-	[[Category: Szolar, O]]	+	[[Category: Szolar O]]
-	[[Category: Wolkerstorfer, A]]	+	[[Category: Wolkerstorfer A]]
-	~~[[Category: Cap-binding inhibitor]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 09:57, 5 February 2020

OCA — Wed, 05 Feb 2020 09:57:28 GMT

←Older revision		Revision as of 09:57, 5 February 2020
Line 1:		Line 1:

	==Structure of Influenza A H5N1 PB2 cap-binding domain with bound cap analogue (compound 8f)==		==Structure of Influenza A H5N1 PB2 cap-binding domain with bound cap analogue (compound 8f)==
-	<StructureSection load='4cb5' size='340' side='right' caption='[[4cb5]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='4cb5' size='340' side='right'caption='[[4cb5]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4cb5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/duck/shantou/4610/2003(h5n1)) Influenza a virus (a/duck/shantou/4610/2003(h5n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CB5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CB5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4cb5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/duck/shantou/4610/2003(h5n1)) Influenza a virus (a/duck/shantou/4610/2003(h5n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CB5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CB5 FirstGlance]. <br>
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Cusack, S]]		[[Category: Cusack, S]]
	[[Category: Decout, J L]]		[[Category: Decout, J L]]

OCA at 14:53, 11 August 2016

OCA — Thu, 11 Aug 2016 14:53:12 GMT

←Older revision		Revision as of 14:53, 11 August 2016
Line 1:		Line 1:
		+
	==Structure of Influenza A H5N1 PB2 cap-binding domain with bound cap analogue (compound 8f)==		==Structure of Influenza A H5N1 PB2 cap-binding domain with bound cap analogue (compound 8f)==
	<StructureSection load='4cb5' size='340' side='right' caption='[[4cb5]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='4cb5' size='340' side='right' caption='[[4cb5]], [[Resolution\|resolution]] 1.50Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=93G:9-N-(3-CARBOXY-4-HYDROXYPHENYL)KETOMETHYL-7-N-METHYLGUANINE'>93G</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=93G:9-N-(3-CARBOXY-4-HYDROXYPHENYL)KETOMETHYL-7-N-METHYLGUANINE'>93G</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cb4\|4cb4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cb4\|4cb4]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cb5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cb5 RCSB], [http://www.ebi.ac.uk/pdbsum/4cb5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cb5 OCA], [http://pdbe.org/4cb5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cb5 RCSB], [http://www.ebi.ac.uk/pdbsum/4cb5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cb5 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4cb5" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:19, 4 January 2015

OCA — Sun, 04 Jan 2015 13:19:54 GMT

←Older revision		Revision as of 13:19, 4 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_4cb5\| PDB=4cb5 \| SCENE= }}~~	+	==Structure of Influenza A H5N1 PB2 cap-binding domain with bound cap analogue (compound 8f)==
-	===Structure of Influenza A H5N1 PB2 cap-binding domain with bound cap analogue (compound 8f)===	+	<StructureSection load='4cb5' size='340' side='right' caption='[[4cb5]], [[Resolution\|resolution]] 1.50Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24134208}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4cb5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/duck/shantou/4610/2003(h5n1)) Influenza a virus (a/duck/shantou/4610/2003(h5n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CB5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CB5 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=93G:9-N-(3-CARBOXY-4-HYDROXYPHENYL)KETOMETHYL-7-N-METHYLGUANINE'>93G</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cb4\|4cb4]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cb5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cb5 RCSB], [http://www.ebi.ac.uk/pdbsum/4cb5 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The heterotrimeric influenza virus polymerase performs replication and transcription of viral RNA in the nucleus of infected cells. Transcription by 'cap-snatching' requires that host-cell pre-mRNAs are bound via their 5' cap to the PB2 subunit. Thus, the PB2 cap binding site is potentially a good target for new antiviral drugs that will directly inhibit viral replication. Docking studies using the structure of the PB2 cap binding domain suggested that 7-alkylguanine derivatives substituted at position N-9 and N-2 could be good candidates. Four series of 7,9-di- and 2,7,9-tri-alkyl guanine derivatives were synthesized and evaluated by an AlphaScreen assay in competition with a biotinylated cap analogue. Three synthesised compounds display potent in vitro activity with IC50 lower than 10 M. High-resolution X-ray structures of three inhibitors in complex with the H5N1 PB2 cap-binding domain confirmed the binding mode and provide detailed information for further compound optimization.

-	~~==About this Structure==~~	+	New 7-methyl-guanosine derivatives targeting the influenza polymerase PB2 cap-binding domain.,Pautus S, Sehr P, Lewis J, Fortune A, Wolkerstorfer A, Szolar O, Guilligay D, Lunardi T, Decout JL, Cusack S J Med Chem. 2013 Oct 18. PMID:24134208<ref>PMID:24134208</ref>
-	~~[[4cb5]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Influenza_a_virus_(a/duck/shantou/4610/2003(h5n1)) Influenza a virus (a/duck/shantou/4610/2003(h5n1))]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4CB5 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024134208</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
-	[[Category: Cusack, S.]]	+	== References ==
-	[[Category: Decout, J L.]]	+	<references/>
-	[[Category: Fortune, A.]]	+	__TOC__
-	[[Category: Gulligay, D.]]	+	</StructureSection>
-	[[Category: Lewis, J.]]	+	[[Category: Cusack, S]]
-	[[Category: Lunardi, T.]]	+	[[Category: Decout, J L]]
-	[[Category: Pautus, S.]]	+	[[Category: Fortune, A]]
-	[[Category: Sehr, P.]]	+	[[Category: Gulligay, D]]
-	[[Category: Szolar, O.]]	+	[[Category: Lewis, J]]
-	[[Category: Wolkerstorfer, A.]]	+	[[Category: Lunardi, T]]
		+	[[Category: Pautus, S]]
		+	[[Category: Sehr, P]]
		+	[[Category: Szolar, O]]
		+	[[Category: Wolkerstorfer, A]]
	[[Category: Cap-binding inhibitor]]		[[Category: Cap-binding inhibitor]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 09:40, 30 October 2013

OCA — Wed, 30 Oct 2013 09:40:17 GMT

←Older revision		Revision as of 09:40, 30 October 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4cb5\| PDB=4cb5 \| SCENE= }}
		+	===Structure of Influenza A H5N1 PB2 cap-binding domain with bound cap analogue (compound 8f)===
		+	{{ABSTRACT_PUBMED_24134208}}

-	~~The entry~~ 4cb5 is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
		+	[[4cb5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/duck/shantou/4610/2003(h5n1)) Influenza a virus (a/duck/shantou/4610/2003(h5n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CB5 OCA].

-	~~Authors~~: ~~Pautus~~, S.~~, Sehr, P., Lewis~~, J., Fortune, A.~~, Wolkerstorfer, A., Szolar, O.,~~ Gulligay, D., Lunardi, T., ~~Decout~~, ~~J.L~~., ~~Cusack, S~~.	+	==Reference==
-		+	<ref group="xtra">PMID:024134208</ref><references group="xtra"/><references/>
-	~~Description~~: ~~Structure of Influenza~~ A ~~H5N1 PB2 cap~~-binding ~~domain with bound cap analogue (compound 8f)~~	+	[[Category: Cusack, S.]]
		+	[[Category: Decout, J L.]]
		+	[[Category: Fortune, A.]]
		+	[[Category: Gulligay, D.]]
		+	[[Category: Lewis, J.]]
		+	[[Category: Lunardi, T.]]
		+	[[Category: Pautus, S.]]
		+	[[Category: Sehr, P.]]
		+	[[Category: Szolar, O.]]
		+	[[Category: Wolkerstorfer, A.]]
		+	[[Category: Cap-binding inhibitor]]
		+	[[Category: Transferase]]

OCA at 05:39, 23 October 2013

OCA — Wed, 23 Oct 2013 05:39:36 GMT

←Older revision		Revision as of 05:39, 23 October 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4cb5 is ON HOLD	+	The entry 4cb5 is ON HOLD until Paper Publication

	Authors: Pautus, S., Sehr, P., Lewis, J., Fortune, A., Wolkerstorfer, A., Szolar, O., Gulligay, D., Lunardi, T., Decout, J.L., Cusack, S.		Authors: Pautus, S., Sehr, P., Lewis, J., Fortune, A., Wolkerstorfer, A., Szolar, O., Gulligay, D., Lunardi, T., Decout, J.L., Cusack, S.

	Description: Structure of Influenza A H5N1 PB2 cap-binding domain with bound cap analogue (compound 8f)		Description: Structure of Influenza A H5N1 PB2 cap-binding domain with bound cap analogue (compound 8f)

OCA: Protected "4cb5" [edit=sysop:move=sysop]

OCA — Wed, 16 Oct 2013 07:10:07 GMT

Protected "4cb5" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:10, 16 October 2013

OCA: New page: '''Unreleased structure''' The entry 4cb5 is ON HOLD Authors: Pautus, S., Sehr, P., Lewis, J., Fortune, A., Wolkerstorfer, A., Szolar, O., Gulligay, D., Lunardi, T., Decout, J.L., Cusac...

OCA — Wed, 16 Oct 2013 07:10:06 GMT

New page: '''Unreleased structure''' The entry 4cb5 is ON HOLD Authors: Pautus, S., Sehr, P., Lewis, J., Fortune, A., Wolkerstorfer, A., Szolar, O., Gulligay, D., Lunardi, T., Decout, J.L., Cusac...

New page

'''Unreleased structure'''

The entry 4cb5 is ON HOLD

Authors: Pautus, S., Sehr, P., Lewis, J., Fortune, A., Wolkerstorfer, A., Szolar, O., Gulligay, D., Lunardi, T., Decout, J.L., Cusack, S.

Description: Structure of Influenza A H5N1 PB2 cap-binding domain with bound cap analogue (compound 8f)