4chh - Revision history

OCA at 07:18, 1 May 2024

OCA — Wed, 01 May 2024 07:18:31 GMT

←Older revision		Revision as of 07:18, 1 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4chh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CHH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CHH FirstGlance]. <br>		<table><tr><td colspan='2'>[[4chh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CHH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CHH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.03Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4chh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4chh OCA], [https://pdbe.org/4chh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4chh RCSB], [https://www.ebi.ac.uk/pdbsum/4chh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4chh ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4chh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4chh OCA], [https://pdbe.org/4chh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4chh RCSB], [https://www.ebi.ac.uk/pdbsum/4chh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4chh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PIH1_YEAST PIH1_YEAST]] Involved in pre-rRNA processing and required for the NOP58-snoRNA interaction.<ref>PMID:15670595</ref>	+	[https://www.uniprot.org/uniprot/PIH1_YEAST PIH1_YEAST] Involved in pre-rRNA processing and required for the NOP58-snoRNA interaction.<ref>PMID:15670595</ref>
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:46, 7 September 2022

OCA — Wed, 07 Sep 2022 17:46:15 GMT

←Older revision		Revision as of 17:46, 7 September 2022
Line 3:		Line 3:
	<StructureSection load='4chh' size='340' side='right'caption='[[4chh]], [[Resolution\|resolution]] 2.03Å' scene=''>		<StructureSection load='4chh' size='340' side='right'caption='[[4chh]], [[Resolution\|resolution]] 2.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4chh]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CHH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4CHH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4chh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CHH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CHH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cgq\|4cgq]], [[4cgu\|4cgu]], [[4cgv\|4cgv]], [[4cgw\|4cgw]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4chh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4chh OCA], [https://pdbe.org/4chh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4chh RCSB], [https://www.ebi.ac.uk/pdbsum/4chh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4chh ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4chh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4chh OCA], [~~http~~://pdbe.org/4chh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4chh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4chh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4chh ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PIH1_YEAST PIH1_YEAST]] Involved in pre-rRNA processing and required for the NOP58-snoRNA interaction.<ref>PMID:15670595</ref>	+	[[https://www.uniprot.org/uniprot/PIH1_YEAST PIH1_YEAST]] Involved in pre-rRNA processing and required for the NOP58-snoRNA interaction.<ref>PMID:15670595</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Client protein recruitment to the Hsp90 system depends on cochaperones that bind the client and Hsp90 simultaneously and facilitate their interaction. Hsp90 involvement in the assembly of snoRNPs, RNA polymerases, PI3-kinase-like kinases, and chromatin remodeling complexes depends on the TTT (Tel2-Tti1-Tti2), and R2TP complexes-consisting of the AAA-ATPases Rvb1 and Rvb2, Tah1 (Spagh/RPAP3 in metazoa), and Pih1 (Pih1D1 in humans)-that together provide the connection to Hsp90. The biochemistry underlying R2TP function is still poorly understood. Pih1 in particular, at the heart of the complex, has not been described at a structural level, nor have the multiple protein-protein interactions it mediates been characterized. Here we present a structural and biochemical analysis of Hsp90-Tah1-Pih1, Hsp90-Spagh, and Pih1D1-Tel2 complexes that reveal a domain in Pih1D1 specific for binding CK2 phosphorylation sites, and together define the structural basis by which the R2TP complex connects the Hsp90 chaperone system to the TTT complex.	+
-		+
-	Structural Basis for Phosphorylation-Dependent Recruitment of Tel2 to Hsp90 by Pih1.,Pal M, Morgan M, Phelps SE, Roe SM, Parry-Morris S, Downs JA, Polier S, Pearl LH, Prodromou C Structure. 2014 Apr 30. pii: S0969-2126(14)00105-1. doi:, 10.1016/j.str.2014.04.001. PMID:24794838<ref>PMID:24794838</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 4chh" style="background-color:#fffaf0;"></div~~>	+
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Pal, M~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: ~~Roe, S~~ M]]	+	[[Category: Pal M]]
-	[[Category: ~~Chaperone]]~~	+	[[Category: Roe SM]]
-	~~[[Category: R2tp]]~~	+
-	~~[[Category: Tah1~~]]	+

OCA at 08:52, 20 March 2019

OCA — Wed, 20 Mar 2019 08:52:18 GMT

←Older revision		Revision as of 08:52, 20 March 2019
Line 1:		Line 1:

	==N-terminal domain of yeast PIH1p==		==N-terminal domain of yeast PIH1p==
-	<StructureSection load='4chh' size='340' side='right' caption='[[4chh]], [[Resolution\|resolution]] 2.03Å' scene=''>	+	<StructureSection load='4chh' size='340' side='right'caption='[[4chh]], [[Resolution\|resolution]] 2.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4chh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CHH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CHH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4chh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CHH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CHH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cgq\|4cgq]], [[4cgu\|4cgu]], [[4cgv\|4cgv]], [[4cgw\|4cgw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cgq\|4cgq]], [[4cgu\|4cgu]], [[4cgv\|4cgv]], [[4cgw\|4cgw]]</td></tr>
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Pal, M]]		[[Category: Pal, M]]
	[[Category: Roe, S M]]		[[Category: Roe, S M]]

OCA at 13:05, 5 August 2016

OCA — Fri, 05 Aug 2016 13:05:49 GMT

←Older revision		Revision as of 13:05, 5 August 2016
Line 1:		Line 1:
		+
	==N-terminal domain of yeast PIH1p==		==N-terminal domain of yeast PIH1p==
	<StructureSection load='4chh' size='340' side='right' caption='[[4chh]], [[Resolution\|resolution]] 2.03Å' scene=''>		<StructureSection load='4chh' size='340' side='right' caption='[[4chh]], [[Resolution\|resolution]] 2.03Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cgq\|4cgq]], [[4cgu\|4cgu]], [[4cgv\|4cgv]], [[4cgw\|4cgw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cgq\|4cgq]], [[4cgu\|4cgu]], [[4cgv\|4cgv]], [[4cgw\|4cgw]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4chh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4chh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4chh RCSB], [http://www.ebi.ac.uk/pdbsum/4chh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4chh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4chh OCA], [http://pdbe.org/4chh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4chh RCSB], [http://www.ebi.ac.uk/pdbsum/4chh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4chh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4chh" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 02:42, 25 December 2014

OCA — Thu, 25 Dec 2014 02:42:49 GMT

←Older revision		Revision as of 02:42, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4chh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CHH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CHH FirstGlance]. <br>		<table><tr><td colspan='2'>[[4chh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CHH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CHH FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cgq\|4cgq]], [[4cgu\|4cgu]], [[4cgv\|4cgv]], [[4cgw\|4cgw]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cgq\|4cgq]], [[4cgu\|4cgu]], [[4cgv\|4cgv]], [[4cgw\|4cgw]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4chh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4chh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4chh RCSB], [http://www.ebi.ac.uk/pdbsum/4chh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4chh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4chh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4chh RCSB], [http://www.ebi.ac.uk/pdbsum/4chh PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PIH1_YEAST PIH1_YEAST]] Involved in pre-rRNA processing and required for the NOP58-snoRNA interaction.<ref>PMID:15670595</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Pal, M.]]	+	[[Category: Pal, M]]
-	[[Category: Roe, S M.]]	+	[[Category: Roe, S M]]
	[[Category: Chaperone]]		[[Category: Chaperone]]
	[[Category: R2tp]]		[[Category: R2tp]]
	[[Category: Tah1]]		[[Category: Tah1]]

OCA at 05:18, 25 June 2014

OCA — Wed, 25 Jun 2014 05:18:11 GMT

←Older revision		Revision as of 05:18, 25 June 2014
Line 2:		Line 2:
	<StructureSection load='4chh' size='340' side='right' caption='[[4chh]], [[Resolution\|resolution]] 2.03Å' scene=''>		<StructureSection load='4chh' size='340' side='right' caption='[[4chh]], [[Resolution\|resolution]] 2.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4chh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CHH OCA]. <br>	+	<table><tr><td colspan='2'>[[4chh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CHH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CHH FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>		</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cgq\|4cgq]], [[4cgu\|4cgu]], [[4cgv\|4cgv]], [[4cgw\|4cgw]]</td></tr>		<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cgq\|4cgq]], [[4cgu\|4cgu]], [[4cgv\|4cgv]], [[4cgw\|4cgw]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4chh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4chh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4chh RCSB], [http://www.ebi.ac.uk/pdbsum/4chh PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4chh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4chh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4chh RCSB], [http://www.ebi.ac.uk/pdbsum/4chh PDBsum]</span></td></tr>
	<table>		<table>
Line 14:		Line 13:
	Structural Basis for Phosphorylation-Dependent Recruitment of Tel2 to Hsp90 by Pih1.,Pal M, Morgan M, Phelps SE, Roe SM, Parry-Morris S, Downs JA, Polier S, Pearl LH, Prodromou C Structure. 2014 Apr 30. pii: S0969-2126(14)00105-1. doi:, 10.1016/j.str.2014.04.001. PMID:24794838<ref>PMID:24794838</ref>		Structural Basis for Phosphorylation-Dependent Recruitment of Tel2 to Hsp90 by Pih1.,Pal M, Morgan M, Phelps SE, Roe SM, Parry-Morris S, Downs JA, Polier S, Pearl LH, Prodromou C Structure. 2014 Apr 30. pii: S0969-2126(14)00105-1. doi:, 10.1016/j.str.2014.04.001. PMID:24794838<ref>PMID:24794838</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==

OCA at 07:19, 14 May 2014

OCA — Wed, 14 May 2014 07:19:15 GMT

←Older revision		Revision as of 07:19, 14 May 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==N-terminal domain of yeast PIH1p==
		+	<StructureSection load='4chh' size='340' side='right' caption='[[4chh]], [[Resolution\|resolution]] 2.03Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4chh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CHH OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cgq\|4cgq]], [[4cgu\|4cgu]], [[4cgv\|4cgv]], [[4cgw\|4cgw]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4chh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4chh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4chh RCSB], [http://www.ebi.ac.uk/pdbsum/4chh PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Client protein recruitment to the Hsp90 system depends on cochaperones that bind the client and Hsp90 simultaneously and facilitate their interaction. Hsp90 involvement in the assembly of snoRNPs, RNA polymerases, PI3-kinase-like kinases, and chromatin remodeling complexes depends on the TTT (Tel2-Tti1-Tti2), and R2TP complexes-consisting of the AAA-ATPases Rvb1 and Rvb2, Tah1 (Spagh/RPAP3 in metazoa), and Pih1 (Pih1D1 in humans)-that together provide the connection to Hsp90. The biochemistry underlying R2TP function is still poorly understood. Pih1 in particular, at the heart of the complex, has not been described at a structural level, nor have the multiple protein-protein interactions it mediates been characterized. Here we present a structural and biochemical analysis of Hsp90-Tah1-Pih1, Hsp90-Spagh, and Pih1D1-Tel2 complexes that reveal a domain in Pih1D1 specific for binding CK2 phosphorylation sites, and together define the structural basis by which the R2TP complex connects the Hsp90 chaperone system to the TTT complex.

-	~~The entry 4chh is ON HOLD~~	+	Structural Basis for Phosphorylation-Dependent Recruitment of Tel2 to Hsp90 by Pih1.,Pal M, Morgan M, Phelps SE, Roe SM, Parry-Morris S, Downs JA, Polier S, Pearl LH, Prodromou C Structure. 2014 Apr 30. pii: S0969-2126(14)00105-1. doi:, 10.1016/j.str.2014.04.001. PMID:24794838<ref>PMID:24794838</ref>

-	~~Authors: Roe~~, S.M., Pal, M.	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~N-terminal domain of yeast PIH1p~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Pal, M.]]
		+	[[Category: Roe, S M.]]
		+	[[Category: Chaperone]]
		+	[[Category: R2tp]]
		+	[[Category: Tah1]]

OCA: Protected "4chh" [edit=sysop:move=sysop]

OCA — Wed, 11 Dec 2013 12:47:39 GMT

Protected "4chh" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:47, 11 December 2013

OCA: New page: '''Unreleased structure''' The entry 4chh is ON HOLD Authors: Roe, S.M., Pal, M. Description: N-terminal domain of yeast PIH1p

OCA — Wed, 11 Dec 2013 12:47:39 GMT

New page: '''Unreleased structure''' The entry 4chh is ON HOLD Authors: Roe, S.M., Pal, M. Description: N-terminal domain of yeast PIH1p

New page

'''Unreleased structure'''

The entry 4chh is ON HOLD

Authors: Roe, S.M., Pal, M.

Description: N-terminal domain of yeast PIH1p