4cm7 - Revision history

OCA at 12:12, 20 December 2023

OCA — Wed, 20 Dec 2023 12:12:29 GMT

←Older revision		Revision as of 12:12, 20 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4cm7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CM7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CM7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4cm7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CM7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CM7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=H0V:5-PHENETHYL-7H-PYRROLO[2,3-D]PYRIMIDINE-2,4-DIAMINE'>H0V</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=H0V:5-PHENETHYL-7H-PYRROLO[2,3-D]PYRIMIDINE-2,4-DIAMINE'>H0V</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cm7 OCA], [https://pdbe.org/4cm7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cm7 RCSB], [https://www.ebi.ac.uk/pdbsum/4cm7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cm7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cm7 OCA], [https://pdbe.org/4cm7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cm7 RCSB], [https://www.ebi.ac.uk/pdbsum/4cm7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cm7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/O76290_TRYBB O76290_TRYBB]]	+	[https://www.uniprot.org/uniprot/O76290_TRYBB O76290_TRYBB]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:21, 14 September 2022

OCA — Wed, 14 Sep 2022 07:21:19 GMT

←Older revision		Revision as of 07:21, 14 September 2022
Line 3:		Line 3:
	<StructureSection load='4cm7' size='340' side='right'caption='[[4cm7]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4cm7' size='340' side='right'caption='[[4cm7]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4cm7]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Trybb Trybb~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CM7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4CM7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4cm7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CM7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CM7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=H0V:5-PHENETHYL-7H-PYRROLO[2,3-D]PYRIMIDINE-2,4-DIAMINE'>H0V</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=H0V:5-PHENETHYL-7H-PYRROLO[2,3-D]PYRIMIDINE-2,4-DIAMINE'>H0V</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cl8\|4cl8]], [[4cld\|4cld]], [[4cle\|4cle]], [[4clh\|4clh]], [[4clo\|4clo]], [[4clr\|4clr]], [[4clx\|4clx]], [[4cm1\|4cm1]], [[4cm3\|4cm3]], [[4cm4\|4cm4]], [[4cm5\|4cm5]], [[4cm6\|4cm6]], [[4cm8\|4cm8]], [[4cm9\|4cm9]], [[4cma\|4cma]], [[4cmb\|4cmb]], [[4cmc\|4cmc]], [[4cme\|4cme]], [[4cmg\|4cmg]], [[4cmi\|4cmi]], [[4cmj\|4cmj]], [[4cmk\|4cmk]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cm7 OCA], [https://pdbe.org/4cm7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cm7 RCSB], [https://www.ebi.ac.uk/pdbsum/4cm7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cm7 ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pteridine_reductase Pteridine reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.33 1.5.1.33] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4cm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cm7 OCA], [~~http~~://pdbe.org/4cm7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4cm7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4cm7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4cm7 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/O76290_TRYBB O76290_TRYBB]]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Pteridine reductase]]~~	+	[[Category: Trypanosoma brucei brucei]]
-	~~[[Category: Trybb~~]]	+	[[Category: Barrack KL]]
-	[[Category: Barrack~~, K L~~]]	+	[[Category: Hunter WN]]
-	[[Category: Hunter~~, W N]]~~	+
-	~~[[Category: Ptr1]]~~	+
-	~~[[Category: Short-chain dehydrogenase/reductase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 16:22, 28 August 2019

OCA — Wed, 28 Aug 2019 16:22:04 GMT

←Older revision		Revision as of 16:22, 28 August 2019
Line 1:		Line 1:

	==Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor==		==Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor==
-	<StructureSection load='4cm7' size='340' side='right' caption='[[4cm7]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='4cm7' size='340' side='right'caption='[[4cm7]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4cm7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trybb Trybb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CM7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CM7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4cm7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trybb Trybb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CM7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CM7 FirstGlance]. <br>
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4cm7" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4cm7" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Pteridine reductase\|Pteridine reductase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Pteridine reductase]]		[[Category: Pteridine reductase]]
	[[Category: Trybb]]		[[Category: Trybb]]

OCA at 07:48, 16 November 2017

OCA — Thu, 16 Nov 2017 07:48:22 GMT

←Older revision		Revision as of 07:48, 16 November 2017
Line 3:		Line 3:
	<StructureSection load='4cm7' size='340' side='right' caption='[[4cm7]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4cm7' size='340' side='right' caption='[[4cm7]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4cm7]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CM7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CM7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4cm7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trybb Trybb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CM7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CM7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=H0V:5-PHENETHYL-7H-PYRROLO[2,3-D]PYRIMIDINE-2,4-DIAMINE'>H0V</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=H0V:5-PHENETHYL-7H-PYRROLO[2,3-D]PYRIMIDINE-2,4-DIAMINE'>H0V</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cl8\|4cl8]], [[4cld\|4cld]], [[4cle\|4cle]], [[4clh\|4clh]], [[4clo\|4clo]], [[4clr\|4clr]], [[4clx\|4clx]], [[4cm1\|4cm1]], [[4cm3\|4cm3]], [[4cm4\|4cm4]], [[4cm5\|4cm5]], [[4cm6\|4cm6]], [[4cm8\|4cm8]], [[4cm9\|4cm9]], [[4cma\|4cma]], [[4cmb\|4cmb]], [[4cmc\|4cmc]], [[4cme\|4cme]], [[4cmg\|4cmg]], [[4cmi\|4cmi]], [[4cmj\|4cmj]], [[4cmk\|4cmk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cl8\|4cl8]], [[4cld\|4cld]], [[4cle\|4cle]], [[4clh\|4clh]], [[4clo\|4clo]], [[4clr\|4clr]], [[4clx\|4clx]], [[4cm1\|4cm1]], [[4cm3\|4cm3]], [[4cm4\|4cm4]], [[4cm5\|4cm5]], [[4cm6\|4cm6]], [[4cm8\|4cm8]], [[4cm9\|4cm9]], [[4cma\|4cma]], [[4cmb\|4cmb]], [[4cmc\|4cmc]], [[4cme\|4cme]], [[4cmg\|4cmg]], [[4cmi\|4cmi]], [[4cmj\|4cmj]], [[4cmk\|4cmk]]</td></tr>
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4cm7" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4cm7" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Pteridine reductase\|Pteridine reductase]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Pteridine reductase]]		[[Category: Pteridine reductase]]
		+	[[Category: Trybb]]
	[[Category: Barrack, K L]]		[[Category: Barrack, K L]]
	[[Category: Hunter, W N]]		[[Category: Hunter, W N]]

OCA at 10:48, 11 August 2016

OCA — Thu, 11 Aug 2016 10:48:49 GMT

←Older revision		Revision as of 10:48, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor==		==Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor==
	<StructureSection load='4cm7' size='340' side='right' caption='[[4cm7]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4cm7' size='340' side='right' caption='[[4cm7]], [[Resolution\|resolution]] 1.90Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cl8\|4cl8]], [[4cld\|4cld]], [[4cle\|4cle]], [[4clh\|4clh]], [[4clo\|4clo]], [[4clr\|4clr]], [[4clx\|4clx]], [[4cm1\|4cm1]], [[4cm3\|4cm3]], [[4cm4\|4cm4]], [[4cm5\|4cm5]], [[4cm6\|4cm6]], [[4cm8\|4cm8]], [[4cm9\|4cm9]], [[4cma\|4cma]], [[4cmb\|4cmb]], [[4cmc\|4cmc]], [[4cme\|4cme]], [[4cmg\|4cmg]], [[4cmi\|4cmi]], [[4cmj\|4cmj]], [[4cmk\|4cmk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cl8\|4cl8]], [[4cld\|4cld]], [[4cle\|4cle]], [[4clh\|4clh]], [[4clo\|4clo]], [[4clr\|4clr]], [[4clx\|4clx]], [[4cm1\|4cm1]], [[4cm3\|4cm3]], [[4cm4\|4cm4]], [[4cm5\|4cm5]], [[4cm6\|4cm6]], [[4cm8\|4cm8]], [[4cm9\|4cm9]], [[4cma\|4cma]], [[4cmb\|4cmb]], [[4cmc\|4cmc]], [[4cme\|4cme]], [[4cmg\|4cmg]], [[4cmi\|4cmi]], [[4cmj\|4cmj]], [[4cmk\|4cmk]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pteridine_reductase Pteridine reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.33 1.5.1.33] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pteridine_reductase Pteridine reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.33 1.5.1.33] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cm7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cm7 RCSB], [http://www.ebi.ac.uk/pdbsum/4cm7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cm7 OCA], [http://pdbe.org/4cm7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cm7 RCSB], [http://www.ebi.ac.uk/pdbsum/4cm7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cm7 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4cm7" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Pteridine reductase\|Pteridine reductase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:50, 21 January 2015

OCA — Wed, 21 Jan 2015 16:50:57 GMT

←Older revision		Revision as of 16:50, 21 January 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor==
		+	<StructureSection load='4cm7' size='340' side='right' caption='[[4cm7]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4cm7]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CM7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CM7 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=H0V:5-PHENETHYL-7H-PYRROLO[2,3-D]PYRIMIDINE-2,4-DIAMINE'>H0V</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cl8\|4cl8]], [[4cld\|4cld]], [[4cle\|4cle]], [[4clh\|4clh]], [[4clo\|4clo]], [[4clr\|4clr]], [[4clx\|4clx]], [[4cm1\|4cm1]], [[4cm3\|4cm3]], [[4cm4\|4cm4]], [[4cm5\|4cm5]], [[4cm6\|4cm6]], [[4cm8\|4cm8]], [[4cm9\|4cm9]], [[4cma\|4cma]], [[4cmb\|4cmb]], [[4cmc\|4cmc]], [[4cme\|4cme]], [[4cmg\|4cmg]], [[4cmi\|4cmi]], [[4cmj\|4cmj]], [[4cmk\|4cmk]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pteridine_reductase Pteridine reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.33 1.5.1.33] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cm7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cm7 RCSB], [http://www.ebi.ac.uk/pdbsum/4cm7 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The treatment of Human African trypanosomiasis remains a major unmet health need in sub-Saharan Africa. Approaches involving new molecular targets are important; pteridine reductase 1 (PTR1), an enzyme that reduces dihydrobiopterin in Trypanosoma spp., has been identified as a candidate target, and it has been shown previously that substituted pyrrolo[2,3-d]pyrimidines are inhibitors of PTR1 from Trypanosoma brucei (J. Med. Chem. 2010, 53, 221-229). In this study, 61 new pyrrolo[2,3-d]pyrimidines have been prepared, designed with input from new crystal structures of 23 of these compounds complexed with PTR1, and evaluated in screens for enzyme inhibitory activity against PTR1 and in vitro antitrypanosomal activity. Eight compounds were sufficiently active in both screens to take forward to in vivo evaluation. Thus, although evidence for trypanocidal activity in a stage I disease model in mice was obtained, the compounds were too toxic to mice for further development.

-	~~The entry 4cm7 is ON HOLD until Paper Publication~~	+	Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1.,Khalaf AI, Huggan JK, Suckling CJ, Gibson CL, Stewart K, Giordani F, Barrett MP, Wong PE, Barrack KL, Hunter WN J Med Chem. 2014 Aug 14;57(15):6479-94. doi: 10.1021/jm500483b. Epub 2014 Jul 29. PMID:25007262<ref>PMID:25007262</ref>

-	~~Authors: Barrack~~, K.L.~~, Hunter, W.N~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of pteridine~~ reductase ~~1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor~~	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
-	[[Category: Hunter, W.N]]	+	__TOC__
-	[[Category: ~~Barrack, K.L~~]]	+	</StructureSection>
		+	[[Category: Pteridine reductase]]
		+	[[Category: Barrack, K L]]
		+	[[Category: Hunter, W N]]
		+	[[Category: Ptr1]]
		+	[[Category: Short-chain dehydrogenase/reductase]]
		+	[[Category: Transferase]]

OCA at 13:23, 24 December 2014

OCA — Wed, 24 Dec 2014 13:23:07 GMT

←Older revision		Revision as of 13:23, 24 December 2014
Line 6:		Line 6:

	Description: Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor		Description: Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor
		+	[[Category: Unreleased Structures]]
		+	[[Category: Hunter, W.N]]
		+	[[Category: Barrack, K.L]]

OCA at 06:45, 29 January 2014

OCA — Wed, 29 Jan 2014 06:45:08 GMT

←Older revision		Revision as of 06:45, 29 January 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4cm7 is ON HOLD	+	The entry 4cm7 is ON HOLD until Paper Publication

	Authors: Barrack, K.L., Hunter, W.N.		Authors: Barrack, K.L., Hunter, W.N.

	Description: Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor		Description: Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor

OCA: Protected "4cm7" [edit=sysop:move=sysop]

OCA — Wed, 22 Jan 2014 06:40:05 GMT

Protected "4cm7" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:40, 22 January 2014

OCA: New page: '''Unreleased structure''' The entry 4cm7 is ON HOLD Authors: Barrack, K.L., Hunter, W.N. Description: Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in tern...

OCA — Wed, 22 Jan 2014 06:40:04 GMT

New page: '''Unreleased structure''' The entry 4cm7 is ON HOLD Authors: Barrack, K.L., Hunter, W.N. Description: Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in tern...

New page

'''Unreleased structure'''

The entry 4cm7 is ON HOLD

Authors: Barrack, K.L., Hunter, W.N.

Description: Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor