4cnk - Revision history

OCA at 12:13, 20 December 2023

OCA — Wed, 20 Dec 2023 12:13:16 GMT

←Older revision		Revision as of 12:13, 20 December 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4cnk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_cristatus Streptococcus cristatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CNK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CNK FirstGlance]. <br>		<table><tr><td colspan='2'>[[4cnk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_cristatus Streptococcus cristatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CNK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CNK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MEU:O-METHYL-GLYCINE'>MEU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MEU:O-METHYL-GLYCINE'>MEU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cnk OCA], [https://pdbe.org/4cnk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cnk RCSB], [https://www.ebi.ac.uk/pdbsum/4cnk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cnk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cnk OCA], [https://pdbe.org/4cnk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cnk RCSB], [https://www.ebi.ac.uk/pdbsum/4cnk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cnk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/B1PUC6_STRCR B1PUC6_STRCR]]	+	[https://www.uniprot.org/uniprot/B1PUC6_STRCR B1PUC6_STRCR]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:23, 14 September 2022

OCA — Wed, 14 Sep 2022 07:23:38 GMT

←Older revision		Revision as of 07:23, 14 September 2022
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	<StructureSection load='4cnk' size='340' side='right'caption='[[4cnk]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4cnk' size='340' side='right'caption='[[4cnk]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4cnk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CNK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4CNK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4cnk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_cristatus Streptococcus cristatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CNK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CNK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MEU:O-METHYL-GLYCINE'>MEU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MEU:O-METHYL-GLYCINE'>MEU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cnj\|4cnj]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cnk OCA], [https://pdbe.org/4cnk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cnk RCSB], [https://www.ebi.ac.uk/pdbsum/4cnk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cnk ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lactate_2-monooxygenase Lactate 2-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.12.4 1.13.12.4] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4cnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cnk OCA], [~~http~~://pdbe.org/4cnk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4cnk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4cnk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4cnk ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/B1PUC6_STRCR B1PUC6_STRCR]]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Lactate 2-monooxygenase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Arrigo, P D~~]]	+	[[Category: Streptococcus cristatus]]
-	[[Category: Bolognesi, M]]	+	[[Category: Bolognesi M]]
-	[[Category: Molla, G]]	+	[[Category: D'Arrigo P]]
-	[[Category: Motta, P]]	+	[[Category: Molla G]]
-	[[Category: Nardini, M]]	+	[[Category: Motta P]]
-	[[Category: Pollegioni, L]]	+	[[Category: Nardini M]]
-	~~[[Category: Flavoprotein]]~~	+	[[Category: Pollegioni L]]
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 09:45, 20 March 2019

OCA — Wed, 20 Mar 2019 09:45:22 GMT

←Older revision		Revision as of 09:45, 20 March 2019
Line 1:		Line 1:

	==L-Aminoacetone oxidase from Streptococcus oligofermentans belongs to a new 3-domain family of bacterial flavoproteins==		==L-Aminoacetone oxidase from Streptococcus oligofermentans belongs to a new 3-domain family of bacterial flavoproteins==
-	<StructureSection load='4cnk' size='340' side='right' caption='[[4cnk]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='4cnk' size='340' side='right'caption='[[4cnk]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4cnk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CNK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CNK FirstGlance]. <br>		<table><tr><td colspan='2'>[[4cnk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CNK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CNK FirstGlance]. <br>
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Amino acid oxidase\|Amino acid oxidase]]	+	*[[Amino acid oxidase 3D structures\|Amino acid oxidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Lactate 2-monooxygenase]]		[[Category: Lactate 2-monooxygenase]]
		+	[[Category: Large Structures]]
	[[Category: Arrigo, P D]]		[[Category: Arrigo, P D]]
	[[Category: Bolognesi, M]]		[[Category: Bolognesi, M]]

OCA at 00:52, 5 August 2016

OCA — Fri, 05 Aug 2016 00:52:42 GMT

←Older revision		Revision as of 00:52, 5 August 2016
Line 1:		Line 1:
		+
	==L-Aminoacetone oxidase from Streptococcus oligofermentans belongs to a new 3-domain family of bacterial flavoproteins==		==L-Aminoacetone oxidase from Streptococcus oligofermentans belongs to a new 3-domain family of bacterial flavoproteins==
	<StructureSection load='4cnk' size='340' side='right' caption='[[4cnk]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4cnk' size='340' side='right' caption='[[4cnk]], [[Resolution\|resolution]] 2.00Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cnj\|4cnj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cnj\|4cnj]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lactate_2-monooxygenase Lactate 2-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.12.4 1.13.12.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lactate_2-monooxygenase Lactate 2-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.12.4 1.13.12.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cnk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cnk RCSB], [http://www.ebi.ac.uk/pdbsum/4cnk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cnk OCA], [http://pdbe.org/4cnk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cnk RCSB], [http://www.ebi.ac.uk/pdbsum/4cnk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cnk ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4cnk" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Amino acid oxidase\|Amino acid oxidase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:43, 17 December 2014

OCA — Wed, 17 Dec 2014 09:43:16 GMT

←Older revision		Revision as of 09:43, 17 December 2014
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	</StructureSection>		</StructureSection>
	[[Category: Lactate 2-monooxygenase]]		[[Category: Lactate 2-monooxygenase]]
-	[[Category: Arrigo, P D.]]	+	[[Category: Arrigo, P D]]
-	[[Category: Bolognesi, M.]]	+	[[Category: Bolognesi, M]]
-	[[Category: Molla, G.]]	+	[[Category: Molla, G]]
-	[[Category: Motta, P.]]	+	[[Category: Motta, P]]
-	[[Category: Nardini, M.]]	+	[[Category: Nardini, M]]
-	[[Category: Pollegioni, L.]]	+	[[Category: Pollegioni, L]]
	[[Category: Flavoprotein]]		[[Category: Flavoprotein]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 10:37, 20 October 2014

OCA — Mon, 20 Oct 2014 10:37:43 GMT

←Older revision		Revision as of 10:37, 20 October 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==L-Aminoacetone oxidase from Streptococcus oligofermentans belongs to a new 3-domain family of bacterial flavoproteins==
		+	<StructureSection load='4cnk' size='340' side='right' caption='[[4cnk]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4cnk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CNK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CNK FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MEU:O-METHYL-GLYCINE'>MEU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cnj\|4cnj]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lactate_2-monooxygenase Lactate 2-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.12.4 1.13.12.4] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cnk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cnk RCSB], [http://www.ebi.ac.uk/pdbsum/4cnk PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The aaoso gene from Streptococcus oligofermentas encodes for a 43 kDa flavoprotein (SoAAO), which was reported to possess a low catalytic activity versus several different L-amino acids: accordingly, it was classified as an L-amino acid oxidase. Subsequently, SoAAO was demonstrated to oxidize aminoacetone (a prooxidant metabolite), with an activity about 25-folds higher than the activity displayed on L-lysine this yielding support to the assumption of aminoacetone as the preferred substrate. In this work we present a characterization of the SoAAO structure-function relationships. SoAAO is a FAD-containing enzyme that does not possess the classical properties of oxidase/dehydrogenase class of flavoproteins (i.e., no flavin semiquinone formation is observed during anaerobic photoreduction as well as no reaction with sulfite) and does not show a true L-amino acid oxidase activity. From a structural point of view, SoAAO belongs to a novel protein family composed of three domains: an alpha/beta domain corresponding to the FAD-binding domain, a beta-domain partially modulating accessibility to the coenzyme, and an additional alpha-domain. Analysis of the reaction products of SoAAO on aminoacetone showed 2,5-dimethylpyrazine as the main product: we propose that condensation of two aminoacetone molecules yields 3,6-dimethyl-2,5-dihydropyrazine that is subsequently oxidized to 2,5-dimethylpyrazine. The ability of SoAAO to bind two molecules of the substrate-analogue O-methylglycine ligand is held to facilitate the condensation reaction. A specialized role for SoAAO in the microbial defence mechanism related to aminoacetone catabolism through a mechanism yielding dimethylpyrazine derivatives instead of methylglyoxal can be proposed.

-	~~The entry 4cnk is ON HOLD~~	+	Aminoacetone oxidase from Streptococcus oligofermentas belongs to a new three-domain family of bacterial flavoproteins.,Molla G, Nardini M, Motta P, D'Arrigo P, Panzeri W, Pollegioni L Biochem J. 2014 Sep 30. PMID:25269103<ref>PMID:25269103</ref>

-	~~Authors~~: ~~Molla~~, G.~~, Nardini~~, M., Motta, P.~~, D'Arrigo, P., Bolognesi~~, M., Pollegioni, L.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~L-Aminoacetone oxidase from Streptococcus oligofermentans belongs to a new 3-domain family of bacterial flavoproteins~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Lactate 2-monooxygenase]]
		+	[[Category: Arrigo, P D.]]
		+	[[Category: Bolognesi, M.]]
		+	[[Category: Molla, G.]]
		+	[[Category: Motta, P.]]
		+	[[Category: Nardini, M.]]
		+	[[Category: Pollegioni, L.]]
		+	[[Category: Flavoprotein]]
		+	[[Category: Oxidoreductase]]

OCA: Protected "4cnk" [edit=sysop:move=sysop]

OCA — Wed, 29 Jan 2014 06:47:04 GMT

Protected "4cnk" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:47, 29 January 2014

OCA: New page: '''Unreleased structure''' The entry 4cnk is ON HOLD Authors: Molla, G., Nardini, M., Motta, P., D'Arrigo, P., Bolognesi, M., Pollegioni, L. Description: L-Aminoacetone oxidase from St...

OCA — Wed, 29 Jan 2014 06:47:02 GMT

New page: '''Unreleased structure''' The entry 4cnk is ON HOLD Authors: Molla, G., Nardini, M., Motta, P., D'Arrigo, P., Bolognesi, M., Pollegioni, L. Description: L-Aminoacetone oxidase from St...

New page

'''Unreleased structure'''

The entry 4cnk is ON HOLD

Authors: Molla, G., Nardini, M., Motta, P., D'Arrigo, P., Bolognesi, M., Pollegioni, L.

Description: L-Aminoacetone oxidase from Streptococcus oligofermentans belongs to a new 3-domain family of bacterial flavoproteins