4cpk - Revision history

OCA at 12:14, 20 December 2023

OCA — Wed, 20 Dec 2023 12:14:25 GMT

←Older revision		Revision as of 12:14, 20 December 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4cpk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_Mu50 Staphylococcus aureus subsp. aureus Mu50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CPK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CPK FirstGlance]. <br>		<table><tr><td colspan='2'>[[4cpk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_Mu50 Staphylococcus aureus subsp. aureus Mu50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CPK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CPK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MUR:MURAMIC+ACID'>MUR</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.35Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MUR:MURAMIC+ACID'>MUR</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cpk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cpk OCA], [https://pdbe.org/4cpk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cpk RCSB], [https://www.ebi.ac.uk/pdbsum/4cpk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cpk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cpk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cpk OCA], [https://pdbe.org/4cpk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cpk RCSB], [https://www.ebi.ac.uk/pdbsum/4cpk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cpk ProSAT]</span></td></tr>
	</table>		</table>

OCA at 06:52, 7 April 2023

OCA — Fri, 07 Apr 2023 06:52:11 GMT

←Older revision		Revision as of 06:52, 7 April 2023
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	<StructureSection load='4cpk' size='340' side='right'caption='[[4cpk]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='4cpk' size='340' side='right'caption='[[4cpk]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4cpk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Staam Staam~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CPK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CPK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4cpk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_Mu50 Staphylococcus aureus subsp. aureus Mu50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CPK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CPK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MUR:MURAMIC+ACID'>MUR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MUR:MURAMIC+ACID'>MUR</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mecA, SAV0041 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=158878 STAAM])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cpk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cpk OCA], [https://pdbe.org/4cpk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cpk RCSB], [https://www.ebi.ac.uk/pdbsum/4cpk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cpk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cpk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cpk OCA], [https://pdbe.org/4cpk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cpk RCSB], [https://www.ebi.ac.uk/pdbsum/4cpk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cpk ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0H3JPA5_STAAM A0A0H3JPA5_STAAM]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Staam~~]]	+	[[Category: Staphylococcus aureus subsp. aureus Mu50]]
-	[[Category: Hermoso~~, J A~~]]	+	[[Category: Hermoso JA]]
-	[[Category: Otero~~, L H~~]]	+	[[Category: Otero LH]]
-	[[Category: Rojas-Altuve, A]]	+	[[Category: Rojas-Altuve A]]
-	~~[[Category: Allosteric site]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Mrsa]]~~	+
-	~~[[Category: Penicillin-binding protein~~]]	+

OCA at 03:37, 2 July 2021

OCA — Fri, 02 Jul 2021 03:37:33 GMT

←Older revision		Revision as of 03:37, 2 July 2021
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	<table><tr><td colspan='2'>[[4cpk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staam Staam]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CPK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CPK FirstGlance]. <br>		<table><tr><td colspan='2'>[[4cpk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staam Staam]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CPK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CPK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MUR:MURAMIC+ACID'>MUR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MUR:MURAMIC+ACID'>MUR</scene></td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat">~~<span class='plainlinks'>[https://en.wikipedia.org/wiki/Serine-type_D-Ala-D-Ala_carboxypeptidase Serine-type D-Ala-D-Ala carboxypeptidase]~~, ~~with EC number~~ [https://www.~~brenda-enzymes~~.~~info~~/~~php~~/~~result_flat~~.~~php4~~?~~ecno~~=~~3.4.16.4 3.4.16.4~~] ~~</span>~~</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mecA, SAV0041 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=158878 STAAM])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cpk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cpk OCA], [https://pdbe.org/4cpk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cpk RCSB], [https://www.ebi.ac.uk/pdbsum/4cpk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cpk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cpk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cpk OCA], [https://pdbe.org/4cpk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cpk RCSB], [https://www.ebi.ac.uk/pdbsum/4cpk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cpk ProSAT]</span></td></tr>
	</table>		</table>
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Serine-type D-Ala-D-Ala carboxypeptidase]]
	[[Category: Staam]]		[[Category: Staam]]
	[[Category: Hermoso, J A]]		[[Category: Hermoso, J A]]

OCA at 14:49, 17 June 2021

OCA — Thu, 17 Jun 2021 14:49:01 GMT

←Older revision		Revision as of 14:49, 17 June 2021
Line 3:		Line 3:
	<StructureSection load='4cpk' size='340' side='right'caption='[[4cpk]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='4cpk' size='340' side='right'caption='[[4cpk]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4cpk]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Staam Staam]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CPK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4CPK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4cpk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staam Staam]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CPK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CPK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MUR:MURAMIC+ACID'>MUR</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MUR:MURAMIC+ACID'>MUR</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Serine-type_D-Ala-D-Ala_carboxypeptidase Serine-type D-Ala-D-Ala carboxypeptidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.16.4 3.4.16.4] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Serine-type_D-Ala-D-Ala_carboxypeptidase Serine-type D-Ala-D-Ala carboxypeptidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.16.4 3.4.16.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4cpk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cpk OCA], [~~http~~://pdbe.org/4cpk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4cpk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4cpk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4cpk ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cpk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cpk OCA], [https://pdbe.org/4cpk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cpk RCSB], [https://www.ebi.ac.uk/pdbsum/4cpk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cpk ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 19:		Line 19:

	==See Also==		==See Also==
-	*[[Penicillin-binding protein\|Penicillin-binding protein]]	+	*[[Penicillin-binding protein 3D structures\|Penicillin-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:33, 20 March 2019

OCA — Wed, 20 Mar 2019 09:33:04 GMT

←Older revision		Revision as of 09:33, 20 March 2019
Line 1:		Line 1:

	==Crystal structure of PBP2a double clinical mutant N146K-E150K from MRSA==		==Crystal structure of PBP2a double clinical mutant N146K-E150K from MRSA==
-	<StructureSection load='4cpk' size='340' side='right' caption='[[4cpk]], [[Resolution\|resolution]] 2.35Å' scene=''>	+	<StructureSection load='4cpk' size='340' side='right'caption='[[4cpk]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4cpk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CPK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CPK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4cpk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staam Staam]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CPK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CPK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MUR:MURAMIC+ACID'>MUR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MUR:MURAMIC+ACID'>MUR</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Serine-type_D-Ala-D-Ala_carboxypeptidase Serine-type D-Ala-D-Ala carboxypeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.16.4 3.4.16.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Serine-type_D-Ala-D-Ala_carboxypeptidase Serine-type D-Ala-D-Ala carboxypeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.16.4 3.4.16.4] </span></td></tr>
Line 17:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 4cpk" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4cpk" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Penicillin-binding protein\|Penicillin-binding protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Serine-type D-Ala-D-Ala carboxypeptidase]]		[[Category: Serine-type D-Ala-D-Ala carboxypeptidase]]
		+	[[Category: Staam]]
	[[Category: Hermoso, J A]]		[[Category: Hermoso, J A]]
	[[Category: Otero, L H]]		[[Category: Otero, L H]]

OCA at 19:12, 11 August 2016

OCA — Thu, 11 Aug 2016 19:12:56 GMT

←Older revision		Revision as of 19:12, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of PBP2a double clinical mutant N146K-E150K from MRSA==		==Crystal structure of PBP2a double clinical mutant N146K-E150K from MRSA==
	<StructureSection load='4cpk' size='340' side='right' caption='[[4cpk]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='4cpk' size='340' side='right' caption='[[4cpk]], [[Resolution\|resolution]] 2.35Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MUR:MURAMIC+ACID'>MUR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MUR:MURAMIC+ACID'>MUR</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Serine-type_D-Ala-D-Ala_carboxypeptidase Serine-type D-Ala-D-Ala carboxypeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.16.4 3.4.16.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Serine-type_D-Ala-D-Ala_carboxypeptidase Serine-type D-Ala-D-Ala carboxypeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.16.4 3.4.16.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cpk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cpk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cpk RCSB], [http://www.ebi.ac.uk/pdbsum/4cpk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cpk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cpk OCA], [http://pdbe.org/4cpk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cpk RCSB], [http://www.ebi.ac.uk/pdbsum/4cpk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cpk ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4cpk" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:33, 20 January 2015

OCA — Tue, 20 Jan 2015 09:33:45 GMT

←Older revision		Revision as of 09:33, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4cpk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CPK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CPK FirstGlance]. <br>		<table><tr><td colspan='2'>[[4cpk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CPK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CPK FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MUR:MURAMIC+ACID'>MUR</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MUR:MURAMIC+ACID'>MUR</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Serine-type_D-Ala-D-Ala_carboxypeptidase Serine-type D-Ala-D-Ala carboxypeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.16.4 3.4.16.4] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Serine-type_D-Ala-D-Ala_carboxypeptidase Serine-type D-Ala-D-Ala carboxypeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.16.4 3.4.16.4] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cpk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cpk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cpk RCSB], [http://www.ebi.ac.uk/pdbsum/4cpk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cpk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cpk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cpk RCSB], [http://www.ebi.ac.uk/pdbsum/4cpk PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Serine-type D-Ala-D-Ala carboxypeptidase]]		[[Category: Serine-type D-Ala-D-Ala carboxypeptidase]]
-	[[Category: Hermoso, J A.]]	+	[[Category: Hermoso, J A]]
-	[[Category: Otero, L H.]]	+	[[Category: Otero, L H]]
-	[[Category: Rojas-Altuve, A.]]	+	[[Category: Rojas-Altuve, A]]
	[[Category: Allosteric site]]		[[Category: Allosteric site]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Mrsa]]		[[Category: Mrsa]]
	[[Category: Penicillin-binding protein]]		[[Category: Penicillin-binding protein]]

OCA at 09:55, 10 September 2014

OCA — Wed, 10 Sep 2014 09:55:59 GMT

←Older revision		Revision as of 09:55, 10 September 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of PBP2a double clinical mutant N146K-E150K from MRSA==
		+	<StructureSection load='4cpk' size='340' side='right' caption='[[4cpk]], [[Resolution\|resolution]] 2.35Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4cpk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CPK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CPK FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MUR:MURAMIC+ACID'>MUR</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Serine-type_D-Ala-D-Ala_carboxypeptidase Serine-type D-Ala-D-Ala carboxypeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.16.4 3.4.16.4] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cpk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cpk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cpk RCSB], [http://www.ebi.ac.uk/pdbsum/4cpk PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ceftaroline, a recently approved beta-lactam antibiotic for treatment of infections by methicillin-resistant Staphylococcus aureus (MRSA), is able to inhibit penicillin-binding protein 2a (PBP2a) by triggering an allosteric conformational change that leads to the opening of the active site. The opened active site is now vulnerable to inhibition by a second molecule of ceftaroline, an event that impairs cell-wall biosynthesis and leads to bacterial death. The triggering of the allosteric effect takes place by binding of the first antibiotic molecule 60 A away from the active site of PBP2a within the core of the allosteric site. We document, by kinetic studies and by determination of three X-ray structures of the mutant variants of PBP2a that result in resistance to ceftaroline, that the effect of these clinical mutants is the disruption of the allosteric trigger in this important protein in MRSA. This is an unprecedented mechanism for antibiotic resistance.

-	~~The entry 4cpk is ON HOLD until Paper Publication~~	+	Disruption of allosteric response as an unprecedented mechanism of resistance to antibiotics.,Fishovitz J, Rojas-Altuve A, Otero LH, Dawley M, Carrasco-Lopez C, Chang M, Hermoso JA, Mobashery S J Am Chem Soc. 2014 Jul 16;136(28):9814-7. doi: 10.1021/ja5030657. Epub 2014 Jul , 2. PMID:24955778<ref>PMID:24955778</ref>

-	~~Authors~~: Otero, L.H., Rojas-Altuve, A.~~, Hermoso, J.A.~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of PBP2a double clinical mutant N146K~~-~~E150K from MRSA~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Serine-type D-Ala-D-Ala carboxypeptidase]]
		+	[[Category: Hermoso, J A.]]
		+	[[Category: Otero, L H.]]
		+	[[Category: Rojas-Altuve, A.]]
		+	[[Category: Allosteric site]]
		+	[[Category: Hydrolase]]
		+	[[Category: Mrsa]]
		+	[[Category: Penicillin-binding protein]]

OCA at 11:45, 12 March 2014

OCA — Wed, 12 Mar 2014 11:45:45 GMT

←Older revision		Revision as of 11:45, 12 March 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4cpk is ON HOLD	+	The entry 4cpk is ON HOLD until Paper Publication

	Authors: Otero, L.H., Rojas-Altuve, A., Hermoso, J.A.		Authors: Otero, L.H., Rojas-Altuve, A., Hermoso, J.A.

	Description: Crystal structure of PBP2a double clinical mutant N146K-E150K from MRSA		Description: Crystal structure of PBP2a double clinical mutant N146K-E150K from MRSA

OCA: Protected "4cpk" [edit=sysop:move=sysop]

OCA — Wed, 19 Feb 2014 15:48:17 GMT

Protected "4cpk" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:48, 19 February 2014