4cse - Revision history

OCA at 12:15, 20 December 2023

OCA — Wed, 20 Dec 2023 12:15:46 GMT

←Older revision		Revision as of 12:15, 20 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4cse]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CSE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CSE FirstGlance]. <br>		<table><tr><td colspan='2'>[[4cse]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CSE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CSE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cse OCA], [https://pdbe.org/4cse PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cse RCSB], [https://www.ebi.ac.uk/pdbsum/4cse PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cse ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cse OCA], [https://pdbe.org/4cse PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cse RCSB], [https://www.ebi.ac.uk/pdbsum/4cse PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cse ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PIHD1_MOUSE PIHD1_MOUSE]]	+	[https://www.uniprot.org/uniprot/PIHD1_MOUSE PIHD1_MOUSE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:30, 14 September 2022

OCA — Wed, 14 Sep 2022 07:30:42 GMT

←Older revision		Revision as of 07:30, 14 September 2022
Line 3:		Line 3:
	<StructureSection load='4cse' size='340' side='right'caption='[[4cse]], [[Resolution\|resolution]] 3.30Å' scene=''>		<StructureSection load='4cse' size='340' side='right'caption='[[4cse]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4cse]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CSE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4CSE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4cse]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CSE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CSE FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cgu\|4cgu]], [[4cgv\|4cgv]], [[4cgw\|4cgw]], [[4chh\|4chh]], [[4ckt\|4ckt]], [[4cv4\|4cv4]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cse OCA], [https://pdbe.org/4cse PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cse RCSB], [https://www.ebi.ac.uk/pdbsum/4cse PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cse ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4cse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cse OCA], [~~http~~://pdbe.org/4cse PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4cse RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4cse PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4cse ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/~~TELO2_MOUSE TELO2_MOUSE~~]] Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation (By similarity).	+	[[https://www.uniprot.org/uniprot/PIHD1_MOUSE PIHD1_MOUSE]]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Morgan~~, R M~~]]	+	[[Category: Morgan RM]]
-	[[Category: Roe~~, S M]]~~	+	[[Category: Roe SM]]
-	~~[[Category: Chaperone]]~~	+
-	~~[[Category: Molecular chaperone]]~~	+
-	~~[[Category: Multiprotein complex]]~~	+
-	~~[[Category: Phosphorylation~~]]	+

OCA at 09:51, 20 March 2019

OCA — Wed, 20 Mar 2019 09:51:21 GMT

←Older revision		Revision as of 09:51, 20 March 2019
Line 1:		Line 1:

	==PIH N-terminal domain==		==PIH N-terminal domain==
-	<StructureSection load='4cse' size='340' side='right' caption='[[4cse]], [[Resolution\|resolution]] 3.30Å' scene=''>	+	<StructureSection load='4cse' size='340' side='right'caption='[[4cse]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4cse]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CSE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CSE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4cse]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CSE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CSE FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cgu\|4cgu]], [[4cgv\|4cgv]], [[4cgw\|4cgw]], [[4chh\|4chh]], [[4ckt\|4ckt]], [[4cv4\|4cv4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cgu\|4cgu]], [[4cgv\|4cgv]], [[4cgw\|4cgw]], [[4chh\|4chh]], [[4ckt\|4ckt]], [[4cv4\|4cv4]]</td></tr>
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Morgan, R M]]		[[Category: Morgan, R M]]
	[[Category: Roe, S M]]		[[Category: Roe, S M]]

OCA at 13:07, 4 August 2016

OCA — Thu, 04 Aug 2016 13:07:51 GMT

←Older revision		Revision as of 13:07, 4 August 2016
Line 1:		Line 1:
		+
	==PIH N-terminal domain==		==PIH N-terminal domain==
	<StructureSection load='4cse' size='340' side='right' caption='[[4cse]], [[Resolution\|resolution]] 3.30Å' scene=''>		<StructureSection load='4cse' size='340' side='right' caption='[[4cse]], [[Resolution\|resolution]] 3.30Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cgu\|4cgu]], [[4cgv\|4cgv]], [[4cgw\|4cgw]], [[4chh\|4chh]], [[4ckt\|4ckt]], [[4cv4\|4cv4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cgu\|4cgu]], [[4cgv\|4cgv]], [[4cgw\|4cgw]], [[4chh\|4chh]], [[4ckt\|4ckt]], [[4cv4\|4cv4]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cse OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cse RCSB], [http://www.ebi.ac.uk/pdbsum/4cse PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cse OCA], [http://pdbe.org/4cse PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cse RCSB], [http://www.ebi.ac.uk/pdbsum/4cse PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cse ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4cse" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:35, 25 December 2014

OCA — Thu, 25 Dec 2014 09:35:17 GMT

←Older revision		Revision as of 09:35, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4cse]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CSE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CSE FirstGlance]. <br>		<table><tr><td colspan='2'>[[4cse]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CSE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CSE FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cgu\|4cgu]], [[4cgv\|4cgv]], [[4cgw\|4cgw]], [[4chh\|4chh]], [[4ckt\|4ckt]], [[4cv4\|4cv4]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cgu\|4cgu]], [[4cgv\|4cgv]], [[4cgw\|4cgw]], [[4chh\|4chh]], [[4ckt\|4ckt]], [[4cv4\|4cv4]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cse OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cse RCSB], [http://www.ebi.ac.uk/pdbsum/4cse PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cse OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cse RCSB], [http://www.ebi.ac.uk/pdbsum/4cse PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TELO2_MOUSE TELO2_MOUSE]] Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Morgan, R M.]]	+	[[Category: Morgan, R M]]
-	[[Category: Roe, S M.]]	+	[[Category: Roe, S M]]
	[[Category: Chaperone]]		[[Category: Chaperone]]
	[[Category: Molecular chaperone]]		[[Category: Molecular chaperone]]
	[[Category: Multiprotein complex]]		[[Category: Multiprotein complex]]
	[[Category: Phosphorylation]]		[[Category: Phosphorylation]]

OCA at 05:16, 25 June 2014

OCA — Wed, 25 Jun 2014 05:16:47 GMT

←Older revision		Revision as of 05:16, 25 June 2014
Line 2:		Line 2:
	<StructureSection load='4cse' size='340' side='right' caption='[[4cse]], [[Resolution\|resolution]] 3.30Å' scene=''>		<StructureSection load='4cse' size='340' side='right' caption='[[4cse]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4cse]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CSE OCA]. <br>	+	<table><tr><td colspan='2'>[[4cse]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CSE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CSE FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>		</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cgu\|4cgu]], [[4cgv\|4cgv]], [[4cgw\|4cgw]], [[4chh\|4chh]], [[4ckt\|4ckt]], [[4cv4\|4cv4]]</td></tr>		<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cgu\|4cgu]], [[4cgv\|4cgv]], [[4cgw\|4cgw]], [[4chh\|4chh]], [[4ckt\|4ckt]], [[4cv4\|4cv4]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cse OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cse RCSB], [http://www.ebi.ac.uk/pdbsum/4cse PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cse OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cse RCSB], [http://www.ebi.ac.uk/pdbsum/4cse PDBsum]</span></td></tr>
	<table>		<table>
Line 14:		Line 13:
	Structural Basis for Phosphorylation-Dependent Recruitment of Tel2 to Hsp90 by Pih1.,Pal M, Morgan M, Phelps SE, Roe SM, Parry-Morris S, Downs JA, Polier S, Pearl LH, Prodromou C Structure. 2014 Apr 30. pii: S0969-2126(14)00105-1. doi:, 10.1016/j.str.2014.04.001. PMID:24794838<ref>PMID:24794838</ref>		Structural Basis for Phosphorylation-Dependent Recruitment of Tel2 to Hsp90 by Pih1.,Pal M, Morgan M, Phelps SE, Roe SM, Parry-Morris S, Downs JA, Polier S, Pearl LH, Prodromou C Structure. 2014 Apr 30. pii: S0969-2126(14)00105-1. doi:, 10.1016/j.str.2014.04.001. PMID:24794838<ref>PMID:24794838</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==

OCA at 07:18, 14 May 2014

OCA — Wed, 14 May 2014 07:18:41 GMT

←Older revision		Revision as of 07:18, 14 May 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==PIH N-terminal domain==
		+	<StructureSection load='4cse' size='340' side='right' caption='[[4cse]], [[Resolution\|resolution]] 3.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4cse]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CSE OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cgu\|4cgu]], [[4cgv\|4cgv]], [[4cgw\|4cgw]], [[4chh\|4chh]], [[4ckt\|4ckt]], [[4cv4\|4cv4]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cse OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cse RCSB], [http://www.ebi.ac.uk/pdbsum/4cse PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Client protein recruitment to the Hsp90 system depends on cochaperones that bind the client and Hsp90 simultaneously and facilitate their interaction. Hsp90 involvement in the assembly of snoRNPs, RNA polymerases, PI3-kinase-like kinases, and chromatin remodeling complexes depends on the TTT (Tel2-Tti1-Tti2), and R2TP complexes-consisting of the AAA-ATPases Rvb1 and Rvb2, Tah1 (Spagh/RPAP3 in metazoa), and Pih1 (Pih1D1 in humans)-that together provide the connection to Hsp90. The biochemistry underlying R2TP function is still poorly understood. Pih1 in particular, at the heart of the complex, has not been described at a structural level, nor have the multiple protein-protein interactions it mediates been characterized. Here we present a structural and biochemical analysis of Hsp90-Tah1-Pih1, Hsp90-Spagh, and Pih1D1-Tel2 complexes that reveal a domain in Pih1D1 specific for binding CK2 phosphorylation sites, and together define the structural basis by which the R2TP complex connects the Hsp90 chaperone system to the TTT complex.

-	~~The entry 4cse is ON HOLD~~	+	Structural Basis for Phosphorylation-Dependent Recruitment of Tel2 to Hsp90 by Pih1.,Pal M, Morgan M, Phelps SE, Roe SM, Parry-Morris S, Downs JA, Polier S, Pearl LH, Prodromou C Structure. 2014 Apr 30. pii: S0969-2126(14)00105-1. doi:, 10.1016/j.str.2014.04.001. PMID:24794838<ref>PMID:24794838</ref>

-	~~Authors~~: Morgan, R.M., Roe, S.M.	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~PIH N-terminal domain~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Morgan, R M.]]
		+	[[Category: Roe, S M.]]
		+	[[Category: Chaperone]]
		+	[[Category: Molecular chaperone]]
		+	[[Category: Multiprotein complex]]
		+	[[Category: Phosphorylation]]

OCA at 06:50, 19 March 2014

OCA — Wed, 19 Mar 2014 06:50:55 GMT

←Older revision		Revision as of 06:50, 19 March 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4cse is ON HOLD ~~until sometime in the future~~	+	The entry 4cse is ON HOLD

	Authors: Morgan, R.M., Roe, S.M.		Authors: Morgan, R.M., Roe, S.M.

	Description: PIH N-terminal domain		Description: PIH N-terminal domain

OCA: Protected "4cse" [edit=sysop:move=sysop]

OCA — Wed, 12 Mar 2014 11:49:33 GMT

Protected "4cse" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:49, 12 March 2014

OCA: New page: '''Unreleased structure''' The entry 4cse is ON HOLD until sometime in the future Authors: Morgan, R.M., Roe, S.M. Description: PIH N-terminal domain

OCA — Wed, 12 Mar 2014 11:49:32 GMT

New page: '''Unreleased structure''' The entry 4cse is ON HOLD until sometime in the future Authors: Morgan, R.M., Roe, S.M. Description: PIH N-terminal domain

New page

'''Unreleased structure'''

The entry 4cse is ON HOLD until sometime in the future

Authors: Morgan, R.M., Roe, S.M.

Description: PIH N-terminal domain