4csy - Revision history

OCA at 12:16, 20 December 2023

OCA — Wed, 20 Dec 2023 12:16:04 GMT

←Older revision		Revision as of 12:16, 20 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4csy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CSY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CSY FirstGlance]. <br>		<table><tr><td colspan='2'>[[4csy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CSY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CSY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAG:BETA-METHYL-N-ACETYL-D-GLUCOSAMINE'>MAG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.41Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAG:BETA-METHYL-N-ACETYL-D-GLUCOSAMINE'>MAG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4csy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4csy OCA], [https://pdbe.org/4csy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4csy RCSB], [https://www.ebi.ac.uk/pdbsum/4csy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4csy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4csy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4csy OCA], [https://pdbe.org/4csy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4csy RCSB], [https://www.ebi.ac.uk/pdbsum/4csy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4csy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/LYAM2_HUMAN LYAM2_HUMAN]] Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.<ref>PMID:1689848</ref>	+	[https://www.uniprot.org/uniprot/LYAM2_HUMAN LYAM2_HUMAN] Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.<ref>PMID:1689848</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:31, 14 September 2022

OCA — Wed, 14 Sep 2022 07:31:53 GMT

←Older revision		Revision as of 07:31, 14 September 2022
Line 3:		Line 3:
	<StructureSection load='4csy' size='340' side='right'caption='[[4csy]], [[Resolution\|resolution]] 2.41Å' scene=''>		<StructureSection load='4csy' size='340' side='right'caption='[[4csy]], [[Resolution\|resolution]] 2.41Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4csy]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CSY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4CSY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4csy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CSY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CSY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAG:BETA-METHYL-N-ACETYL-D-GLUCOSAMINE'>MAG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAG:BETA-METHYL-N-ACETYL-D-GLUCOSAMINE'>MAG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4css\|4css]], [[4cst\|4cst]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4csy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4csy OCA], [https://pdbe.org/4csy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4csy RCSB], [https://www.ebi.ac.uk/pdbsum/4csy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4csy ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4csy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4csy OCA], [~~http~~://pdbe.org/4csy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4csy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4csy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4csy ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LYAM2_HUMAN LYAM2_HUMAN]] Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.<ref>PMID:1689848</ref>	+	[[https://www.uniprot.org/uniprot/LYAM2_HUMAN LYAM2_HUMAN]] Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.<ref>PMID:1689848</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Binder~~, F P.C~~]]	+	[[Category: Binder FPC]]
-	[[Category: Ernst, B]]	+	[[Category: Ernst B]]
-	[[Category: Jakob~~, R P~~]]	+	[[Category: Jakob RP]]
-	[[Category: Maier, T]]	+	[[Category: Maier T]]
-	[[Category: Preston~~, R C~~]]	+	[[Category: Preston RC]]
-	[[Category: Sager~~, C P]]~~	+	[[Category: Sager CP]]
-	~~[[Category: C-type lectin]]~~	+
-	~~[[Category: Catch- bond]]~~	+
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Cell-adhesion]]~~	+
-	~~[[Category: Human lectin]]~~	+
-	~~[[Category: Inflammation]]~~	+
-	~~[[Category: Leukocyte]]~~	+
-	~~[[Category: Ligand-induced conformational change]]~~	+
-	~~[[Category: Protein conformation]]~~	+
-	~~[[Category: Sialyl lewis x]]~~	+
-	~~[[Category: Slex~~]]	+

OCA at 09:34, 20 March 2019

OCA — Wed, 20 Mar 2019 09:34:51 GMT

←Older revision		Revision as of 09:34, 20 March 2019
Line 1:		Line 1:
		+
	==E-selectin lectin, EGF-like and two SCR domains complexed with Sialyl Lewis X==		==E-selectin lectin, EGF-like and two SCR domains complexed with Sialyl Lewis X==
-	<StructureSection load='4csy' size='340' side='right' caption='[[4csy]], [[Resolution\|resolution]] 2.41Å' scene=''>	+	<StructureSection load='4csy' size='340' side='right'caption='[[4csy]], [[Resolution\|resolution]] 2.41Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4csy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CSY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CSY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4csy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CSY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CSY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA~~</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG~~</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAG:BETA-METHYL-N-ACETYL-D-GLUCOSAMINE'>MAG</scene><~~/td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAG:BETA-METHYL-N-ACETYL-D-GLUCOSAMINE'>MAG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	~~<tr id~~='~~NonStdRes'><td class~~=~~"sblockLbl"><b>[[Non~~-~~Standard_Residue\|NonStd Res:]]</b~~></~~td><td class="sblockDat"~~><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>	+
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4css\|4css]], [[4cst\|4cst]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4css\|4css]], [[4cst\|4cst]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4csy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4csy OCA], [http://pdbe.org/4csy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4csy RCSB], [http://www.ebi.ac.uk/pdbsum/4csy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4csy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4csy OCA], [http://pdbe.org/4csy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4csy RCSB], [http://www.ebi.ac.uk/pdbsum/4csy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4csy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Binder, F P.C]]		[[Category: Binder, F P.C]]
	[[Category: Ernst, B]]		[[Category: Ernst, B]]
Line 34:		Line 36:
	[[Category: C-type lectin]]		[[Category: C-type lectin]]
	[[Category: Catch- bond]]		[[Category: Catch- bond]]
		+	[[Category: Cell adhesion]]
	[[Category: Cell-adhesion]]		[[Category: Cell-adhesion]]
	[[Category: Human lectin]]		[[Category: Human lectin]]

OCA at 18:26, 27 January 2016

OCA — Wed, 27 Jan 2016 18:26:58 GMT

←Older revision		Revision as of 18:26, 27 January 2016
Line 6:		Line 6:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4css\|4css]], [[4cst\|4cst]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4css\|4css]], [[4cst\|4cst]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4csy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4csy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4csy RCSB], [http://www.ebi.ac.uk/pdbsum/4csy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4csy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4csy OCA], [http://pdbe.org/4csy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4csy RCSB], [http://www.ebi.ac.uk/pdbsum/4csy PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4csy" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 08:22, 8 July 2015

OCA — Wed, 08 Jul 2015 08:22:28 GMT

←Older revision		Revision as of 08:22, 8 July 2015
Line 10:		Line 10:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/LYAM2_HUMAN LYAM2_HUMAN]] Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.<ref>PMID:1689848</ref>		[[http://www.uniprot.org/uniprot/LYAM2_HUMAN LYAM2_HUMAN]] Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.<ref>PMID:1689848</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	E-selectin is a cell-adhesion molecule of the vascular endothelium that promotes essential leukocyte rolling in the early inflammatory response by binding to glycoproteins containing the tetrasaccharide sialyl Lewisx (sLex). Efficient leukocyte recruitment under vascular flow conditions depends on an increased lifetime of E-selectin/ligand complexes under tensile force in a so-called catch-bond binding mode. Co-crystal structures of a representative fragment of the extracellular E-selectin region with sLex and a glycomimetic antagonist thereof reveal an extended E-selectin conformation, which is identified as a high-affinity binding state of E-selectin by molecular dynamics simulations. Small-angle X-ray scattering experiments demonstrate a direct link between ligand binding and E-selectin conformational transition under static conditions in solution. This permits tracing a series of concerted structural changes connecting ligand binding to conformational stretching as the structural basis of E-selectin catch-bond-mediated leukocyte recruitment. The detailed molecular view of the binding site paves the way for the design of a new generation of selectin antagonists. This is of special interest, since their therapeutic potential was recently demonstrated with the pan-selectin antagonists GMI-1070 (Rivipansel).
		+
		+	E-selectin ligand complexes adopt an extended high-affinity conformation.,Preston RC, Jakob RP, Binder FP, Sager CP, Ernst B, Maier T J Mol Cell Biol. 2015 Jun 27. pii: mjv046. PMID:26117840<ref>PMID:26117840</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+
		+	==See Also==
		+	*[[Selectin\|Selectin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 21:18, 24 December 2014

OCA — Wed, 24 Dec 2014 21:18:03 GMT

←Older revision		Revision as of 21:18, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4csy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CSY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CSY FirstGlance]. <br>		<table><tr><td colspan='2'>[[4csy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CSY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CSY FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAG:BETA-METHYL-N-ACETYL-D-GLUCOSAMINE'>MAG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAG:BETA-METHYL-N-ACETYL-D-GLUCOSAMINE'>MAG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4css\|4css]], [[4cst\|4cst]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4css\|4css]], [[4cst\|4cst]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4csy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4csy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4csy RCSB], [http://www.ebi.ac.uk/pdbsum/4csy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4csy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4csy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4csy RCSB], [http://www.ebi.ac.uk/pdbsum/4csy PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LYAM2_HUMAN LYAM2_HUMAN]] Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.<ref>PMID:1689848</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Binder, F P.C.]]	+	[[Category: Binder, F P.C]]
-	[[Category: Ernst, B.]]	+	[[Category: Ernst, B]]
-	[[Category: Jakob, R P.]]	+	[[Category: Jakob, R P]]
-	[[Category: Maier, T.]]	+	[[Category: Maier, T]]
-	[[Category: Preston, R C.]]	+	[[Category: Preston, R C]]
-	[[Category: Sager, C P.]]	+	[[Category: Sager, C P]]
	[[Category: C-type lectin]]		[[Category: C-type lectin]]
	[[Category: Catch- bond]]		[[Category: Catch- bond]]

OCA at 10:39, 24 September 2014

OCA — Wed, 24 Sep 2014 10:39:39 GMT

←Older revision		Revision as of 10:39, 24 September 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==E-selectin lectin, EGF-like and two SCR domains complexed with Sialyl Lewis X==
-		+	<StructureSection load='4csy' size='340' side='right' caption='[[4csy]], [[Resolution\|resolution]] 2.41Å' scene=''>
-	~~The entry~~ 4csy is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4csy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CSY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CSY FirstGlance]. <br>
-	~~Authors~~: ~~Preston~~, R.C., ~~Jakob~~, R.P., Binder, F.P.C.~~, Sager, C.P.,~~ Ernst, B., Maier, T.	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAG:BETA-METHYL-N-ACETYL-D-GLUCOSAMINE'>MAG</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	~~Description~~: E-~~selectin~~ lectin~~, EGF~~-~~like and two SCR domains complexed with~~ Sialyl ~~Lewis X~~	+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4css\|4css]], [[4cst\|4cst]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4csy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4csy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4csy RCSB], [http://www.ebi.ac.uk/pdbsum/4csy PDBsum]</span></td></tr>
		+	<table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Binder, F P.C.]]
		+	[[Category: Ernst, B.]]
		+	[[Category: Jakob, R P.]]
		+	[[Category: Maier, T.]]
		+	[[Category: Preston, R C.]]
		+	[[Category: Sager, C P.]]
		+	[[Category: C-type lectin]]
		+	[[Category: Catch- bond]]
		+	[[Category: Cell-adhesion]]
		+	[[Category: Human lectin]]
		+	[[Category: Inflammation]]
		+	[[Category: Leukocyte]]
		+	[[Category: Ligand-induced conformational change]]
		+	[[Category: Protein conformation]]
		+	[[Category: Sialyl lewis x]]
		+	[[Category: Slex]]

OCA at 08:12, 2 April 2014

OCA — Wed, 02 Apr 2014 08:12:18 GMT

←Older revision		Revision as of 08:12, 2 April 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4csy is ON HOLD	+	The entry 4csy is ON HOLD until Paper Publication

	Authors: Preston, R.C., Jakob, R.P., Binder, F.P.C., Sager, C.P., Ernst, B., Maier, T.		Authors: Preston, R.C., Jakob, R.P., Binder, F.P.C., Sager, C.P., Ernst, B., Maier, T.

	Description: E-selectin lectin, EGF-like and two SCR domains complexed with Sialyl Lewis X		Description: E-selectin lectin, EGF-like and two SCR domains complexed with Sialyl Lewis X

OCA: Protected "4csy" [edit=sysop:move=sysop]

OCA — Wed, 19 Mar 2014 06:51:57 GMT

Protected "4csy" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:51, 19 March 2014

OCA: New page: '''Unreleased structure''' The entry 4csy is ON HOLD Authors: Preston, R.C., Jakob, R.P., Binder, F.P.C., Sager, C.P., Ernst, B., Maier, T. Description: E-selectin lectin, EGF-like and...

OCA — Wed, 19 Mar 2014 06:51:55 GMT

New page: '''Unreleased structure''' The entry 4csy is ON HOLD Authors: Preston, R.C., Jakob, R.P., Binder, F.P.C., Sager, C.P., Ernst, B., Maier, T. Description: E-selectin lectin, EGF-like and...

New page

'''Unreleased structure'''

The entry 4csy is ON HOLD

Authors: Preston, R.C., Jakob, R.P., Binder, F.P.C., Sager, C.P., Ernst, B., Maier, T.

Description: E-selectin lectin, EGF-like and two SCR domains complexed with Sialyl Lewis X