4ct0 - Revision history

OCA at 12:16, 20 December 2023

OCA — Wed, 20 Dec 2023 12:16:06 GMT

←Older revision		Revision as of 12:16, 20 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ct0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CT0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CT0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ct0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CT0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CT0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.45Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ct0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ct0 OCA], [https://pdbe.org/4ct0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ct0 RCSB], [https://www.ebi.ac.uk/pdbsum/4ct0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ct0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ct0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ct0 OCA], [https://pdbe.org/4ct0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ct0 RCSB], [https://www.ebi.ac.uk/pdbsum/4ct0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ct0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CRY1_MOUSE CRY1_MOUSE]] Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK\|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK\|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL.<ref>PMID:10428031</ref> <ref>PMID:16628007</ref> <ref>PMID:16478995</ref>	+	[https://www.uniprot.org/uniprot/CRY1_MOUSE CRY1_MOUSE] Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK\|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK\|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL.<ref>PMID:10428031</ref> <ref>PMID:16628007</ref> <ref>PMID:16478995</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:31, 14 September 2022

OCA — Wed, 14 Sep 2022 07:31:59 GMT

←Older revision		Revision as of 07:31, 14 September 2022
Line 3:		Line 3:
	<StructureSection load='4ct0' size='340' side='right'caption='[[4ct0]], [[Resolution\|resolution]] 2.45Å' scene=''>		<StructureSection load='4ct0' size='340' side='right'caption='[[4ct0]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ct0]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CT0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4CT0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ct0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CT0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CT0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ct0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ct0 OCA], [~~http~~://pdbe.org/4ct0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ct0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ct0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ct0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ct0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ct0 OCA], [https://pdbe.org/4ct0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ct0 RCSB], [https://www.ebi.ac.uk/pdbsum/4ct0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ct0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CRY1_MOUSE CRY1_MOUSE]] Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK\|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK\|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL.<ref>PMID:10428031</ref> <ref>PMID:16628007</ref> <ref>PMID:16478995</ref> [[http://www.uniprot.org/uniprot/PER2_MOUSE PER2_MOUSE]] Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK\|NPAS2-BMAL1\|BMAL2-induced transactivation.<ref>PMID:10428031</ref> <ref>PMID:17310242</ref>	+	[[https://www.uniprot.org/uniprot/CRY1_MOUSE CRY1_MOUSE]] Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK\|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK\|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL.<ref>PMID:10428031</ref> <ref>PMID:16628007</ref> <ref>PMID:16478995</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Cryptochrome\|Cryptochrome]]	+	*[[Cryptochrome 3D structures\|Cryptochrome 3D structures]]
	*[[Period circadian protein\|Period circadian protein]]		*[[Period circadian protein\|Period circadian protein]]
	== References ==		== References ==
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Benda, C]]	+	[[Category: Benda C]]
-	[[Category: Prabu, J ~~Rajan~~]]	+	[[Category: Rajan Prabu J]]
-	[[Category: Schmalen, I]]	+	[[Category: Schmalen I]]
-	[[Category: Wolf, E]]	+	[[Category: Wolf E]]
-	~~[[Category: Circadian clock protein]]~~	+
-	~~[[Category: Cryptochrome interaction]]~~	+
-	~~[[Category: Cryptochrome-period complex]]~~	+
-	~~[[Category: Disulfide bond]]~~	+
-	~~[[Category: Redox regulation]]~~	+
-	~~[[Category: Zinc interface~~]]	+

OCA at 09:35, 20 March 2019

OCA — Wed, 20 Mar 2019 09:35:42 GMT

←Older revision		Revision as of 09:35, 20 March 2019
Line 1:		Line 1:

	==Crystal Structure of Mouse Cryptochrome1 in Complex with Period2==		==Crystal Structure of Mouse Cryptochrome1 in Complex with Period2==
-	<StructureSection load='4ct0' size='340' side='right' caption='[[4ct0]], [[Resolution\|resolution]] 2.45Å' scene=''>	+	<StructureSection load='4ct0' size='340' side='right'caption='[[4ct0]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ct0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CT0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CT0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ct0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CT0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CT0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ct0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ct0 OCA], [http://pdbe.org/4ct0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ct0 RCSB], [http://www.ebi.ac.uk/pdbsum/4ct0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ct0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ct0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ct0 OCA], [http://pdbe.org/4ct0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ct0 RCSB], [http://www.ebi.ac.uk/pdbsum/4ct0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ct0 ProSAT]</span></td></tr>
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4ct0" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4ct0" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cryptochrome\|Cryptochrome]]
		+	*[[Period circadian protein\|Period circadian protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Benda, C]]		[[Category: Benda, C]]
	[[Category: Prabu, J Rajan]]		[[Category: Prabu, J Rajan]]

OCA at 11:39, 4 August 2016

OCA — Thu, 04 Aug 2016 11:39:03 GMT

←Older revision		Revision as of 11:39, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of Mouse Cryptochrome1 in Complex with Period2==		==Crystal Structure of Mouse Cryptochrome1 in Complex with Period2==
	<StructureSection load='4ct0' size='340' side='right' caption='[[4ct0]], [[Resolution\|resolution]] 2.45Å' scene=''>		<StructureSection load='4ct0' size='340' side='right' caption='[[4ct0]], [[Resolution\|resolution]] 2.45Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4ct0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CT0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CT0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ct0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CT0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CT0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ct0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ct0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ct0 RCSB], [http://www.ebi.ac.uk/pdbsum/4ct0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ct0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ct0 OCA], [http://pdbe.org/4ct0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ct0 RCSB], [http://www.ebi.ac.uk/pdbsum/4ct0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ct0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ct0" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:01, 24 December 2014

OCA — Wed, 24 Dec 2014 14:01:00 GMT

←Older revision		Revision as of 14:01, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ct0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CT0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CT0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ct0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CT0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CT0 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ct0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ct0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ct0 RCSB], [http://www.ebi.ac.uk/pdbsum/4ct0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ct0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ct0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ct0 RCSB], [http://www.ebi.ac.uk/pdbsum/4ct0 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CRY1_MOUSE CRY1_MOUSE]] Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK\|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK\|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL.<ref>PMID:10428031</ref> <ref>PMID:16628007</ref> <ref>PMID:16478995</ref> [[http://www.uniprot.org/uniprot/PER2_MOUSE PER2_MOUSE]] Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK\|NPAS2-BMAL1\|BMAL2-induced transactivation.<ref>PMID:10428031</ref> <ref>PMID:17310242</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 12:		Line 14:
	Interaction of Circadian Clock Proteins CRY1 and PER2 Is Modulated by Zinc Binding and Disulfide Bond Formation.,Schmalen I, Reischl S, Wallach T, Klemz R, Grudziecki A, Prabu JR, Benda C, Kramer A, Wolf E Cell. 2014 May 22;157(5):1203-15. doi: 10.1016/j.cell.2014.03.057. PMID:24855952<ref>PMID:24855952</ref>		Interaction of Circadian Clock Proteins CRY1 and PER2 Is Modulated by Zinc Binding and Disulfide Bond Formation.,Schmalen I, Reischl S, Wallach T, Klemz R, Grudziecki A, Prabu JR, Benda C, Kramer A, Wolf E Cell. 2014 May 22;157(5):1203-15. doi: 10.1016/j.cell.2014.03.057. PMID:24855952<ref>PMID:24855952</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 18:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Benda, C.]]	+	[[Category: Benda, C]]
-	[[Category: Prabu, J Rajan.]]	+	[[Category: Prabu, J Rajan]]
-	[[Category: Schmalen, I.]]	+	[[Category: Schmalen, I]]
-	[[Category: Wolf, E.]]	+	[[Category: Wolf, E]]
	[[Category: Circadian clock protein]]		[[Category: Circadian clock protein]]
	[[Category: Cryptochrome interaction]]		[[Category: Cryptochrome interaction]]

OCA at 05:06, 4 June 2014

OCA — Wed, 04 Jun 2014 05:06:36 GMT

←Older revision		Revision as of 05:06, 4 June 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal Structure of Mouse Cryptochrome1 in Complex with Period2==
		+	<StructureSection load='4ct0' size='340' side='right' caption='[[4ct0]], [[Resolution\|resolution]] 2.45Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4ct0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CT0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CT0 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ct0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ct0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ct0 RCSB], [http://www.ebi.ac.uk/pdbsum/4ct0 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Period (PER) proteins are essential components of the mammalian circadian clock. They form complexes with cryptochromes (CRY), which negatively regulate CLOCK/BMAL1-dependent transactivation of clock and clock-controlled genes. To define the roles of mammalian CRY/PER complexes in the circadian clock, we have determined the crystal structure of a complex comprising the photolyase homology region of mouse CRY1 (mCRY1) and a C-terminal mouse PER2 (mPER2) fragment. mPER2 winds around the helical mCRY1 domain covering the binding sites of FBXL3 and CLOCK/BMAL1, but not the FAD binding pocket. Our structure revealed an unexpected zinc ion in one interface, which stabilizes mCRY1-mPER2 interactions in vivo. We provide evidence that mCRY1/mPER2 complex formation is modulated by an interplay of zinc binding and mCRY1 disulfide bond formation, which may be influenced by the redox state of the cell. Our studies may allow for the development of circadian and metabolic modulators.

-	~~The entry 4ct0 is ON HOLD until Paper Publication~~	+	Interaction of Circadian Clock Proteins CRY1 and PER2 Is Modulated by Zinc Binding and Disulfide Bond Formation.,Schmalen I, Reischl S, Wallach T, Klemz R, Grudziecki A, Prabu JR, Benda C, Kramer A, Wolf E Cell. 2014 May 22;157(5):1203-15. doi: 10.1016/j.cell.2014.03.057. PMID:24855952<ref>PMID:24855952</ref>

-	~~Authors: Schmalen~~, I., ~~Rajan~~ Prabu, J., ~~Benda, C~~., Wolf, E.	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal Structure of Mouse Cryptochrome1 in Complex with Period2~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Benda, C.]]
		+	[[Category: Prabu, J Rajan.]]
		+	[[Category: Schmalen, I.]]
		+	[[Category: Wolf, E.]]
		+	[[Category: Circadian clock protein]]
		+	[[Category: Cryptochrome interaction]]
		+	[[Category: Cryptochrome-period complex]]
		+	[[Category: Disulfide bond]]
		+	[[Category: Redox regulation]]
		+	[[Category: Zinc interface]]

OCA at 08:27, 26 March 2014

OCA — Wed, 26 Mar 2014 08:27:22 GMT

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-	The entry 4ct0 is ON HOLD	+	The entry 4ct0 is ON HOLD until Paper Publication

	Authors: Schmalen, I., Rajan Prabu, J., Benda, C., Wolf, E.		Authors: Schmalen, I., Rajan Prabu, J., Benda, C., Wolf, E.

	Description: Crystal Structure of Mouse Cryptochrome1 in Complex with Period2		Description: Crystal Structure of Mouse Cryptochrome1 in Complex with Period2

OCA: Protected "4ct0" [edit=sysop:move=sysop]

OCA — Wed, 19 Mar 2014 06:52:04 GMT

Protected "4ct0" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:52, 19 March 2014

OCA: New page: '''Unreleased structure''' The entry 4ct0 is ON HOLD Authors: Schmalen, I., Rajan Prabu, J., Benda, C., Wolf, E. Description: Crystal Structure of Mouse Cryptochrome1 in Complex with P...

OCA — Wed, 19 Mar 2014 06:52:03 GMT

New page: '''Unreleased structure''' The entry 4ct0 is ON HOLD Authors: Schmalen, I., Rajan Prabu, J., Benda, C., Wolf, E. Description: Crystal Structure of Mouse Cryptochrome1 in Complex with P...

New page

'''Unreleased structure'''

The entry 4ct0 is ON HOLD

Authors: Schmalen, I., Rajan Prabu, J., Benda, C., Wolf, E.

Description: Crystal Structure of Mouse Cryptochrome1 in Complex with Period2