4cwv - Revision history

OCA at 07:36, 14 September 2022

OCA — Wed, 14 Sep 2022 07:36:38 GMT

←Older revision		Revision as of 07:36, 14 September 2022
Line 3:		Line 3:
	<StructureSection load='4cwv' size='340' side='right'caption='[[4cwv]], [[Resolution\|resolution]] 2.34Å' scene=''>		<StructureSection load='4cwv' size='340' side='right'caption='[[4cwv]], [[Resolution\|resolution]] 2.34Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4cwv]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Bovin Bovin~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CWV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4CWV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4cwv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CWV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CWV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=HW8:4-METHYL-6-{[(3R,4R)-4-{[5-(PYRIDIN-2-YL)PENTYL]OXY}PYRROLIDIN-3-YL]METHYL}PYRIDIN-2-AMINE'>HW8</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=HW8:4-METHYL-6-{[(3R,4R)-4-{[5-(PYRIDIN-2-YL)PENTYL]OXY}PYRROLIDIN-3-YL]METHYL}PYRIDIN-2-AMINE'>HW8</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cwv OCA], [https://pdbe.org/4cwv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cwv RCSB], [https://www.ebi.ac.uk/pdbsum/4cwv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cwv ProSAT]</span></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cww\|4cww]], [[4cwx\|4cwx]], [[4cwy\|4cwy]], [[4cwz\|4cwz]], [[4cx0\|4cx0]], [[4cx1\|4cx1]], [[4cx2\|4cx2]], [[4cx3\|4cx3]], [[4cx4\|4cx4]], [[4cx5\|4cx5]], [[4cx6\|4cx6]], [[4cx7\|4cx7]]</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4cwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cwv OCA], [~~http~~://pdbe.org/4cwv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4cwv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4cwv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4cwv ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NOS3_BOVIN NOS3_BOVIN]] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.	+	[[https://www.uniprot.org/uniprot/NOS3_BOVIN NOS3_BOVIN]] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 20:

	==See Also==		==See Also==
-	*[[Nitric Oxide Synthase\|Nitric Oxide Synthase]]	+	*[[Nitric Oxide Synthase 3D structures\|Nitric Oxide Synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bovin~~]]	+	[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Li, H]]	+	[[Category: Li H]]
-	[[Category: Poulos~~, T L]]~~	+	[[Category: Poulos TL]]
-	~~[[Category: Inhibitor complex]]~~	+
-	~~[[Category: Nitric oxide synthase]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 09:25, 20 March 2019

OCA — Wed, 20 Mar 2019 09:25:30 GMT

←Older revision		Revision as of 09:25, 20 March 2019
Line 1:		Line 1:

	==Structure of bovine endothelial nitric oxide synthase heme domain in complex with 4-METHYL-6-(((3R,4R)-4-((5-(PYRIDIN-2-YL)PENTYL)OXY) PYRROLIDIN-3-YL)METHYL)PYRIDIN-2-AMINE==		==Structure of bovine endothelial nitric oxide synthase heme domain in complex with 4-METHYL-6-(((3R,4R)-4-((5-(PYRIDIN-2-YL)PENTYL)OXY) PYRROLIDIN-3-YL)METHYL)PYRIDIN-2-AMINE==
-	<StructureSection load='4cwv' size='340' side='right' caption='[[4cwv]], [[Resolution\|resolution]] 2.34Å' scene=''>	+	<StructureSection load='4cwv' size='340' side='right'caption='[[4cwv]], [[Resolution\|resolution]] 2.34Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4cwv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CWV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CWV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4cwv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CWV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CWV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=HW8:4-METHYL-6-{[(3R,4R)-4-{[5-(PYRIDIN-2-YL)PENTYL]OXY}PYRROLIDIN-3-YL]METHYL}PYRIDIN-2-AMINE'>HW8</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=HW8:4-METHYL-6-{[(3R,4R)-4-{[5-(PYRIDIN-2-YL)PENTYL]OXY}PYRROLIDIN-3-YL]METHYL}PYRIDIN-2-AMINE'>HW8</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene></td></tr>
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4cwv" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4cwv" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Nitric Oxide Synthase\|Nitric Oxide Synthase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bovin]]
		+	[[Category: Large Structures]]
	[[Category: Li, H]]		[[Category: Li, H]]
	[[Category: Poulos, T L]]		[[Category: Poulos, T L]]

OCA at 23:18, 4 August 2016

OCA — Thu, 04 Aug 2016 23:18:44 GMT

←Older revision		Revision as of 23:18, 4 August 2016
Line 1:		Line 1:
		+
	==Structure of bovine endothelial nitric oxide synthase heme domain in complex with 4-METHYL-6-(((3R,4R)-4-((5-(PYRIDIN-2-YL)PENTYL)OXY) PYRROLIDIN-3-YL)METHYL)PYRIDIN-2-AMINE==		==Structure of bovine endothelial nitric oxide synthase heme domain in complex with 4-METHYL-6-(((3R,4R)-4-((5-(PYRIDIN-2-YL)PENTYL)OXY) PYRROLIDIN-3-YL)METHYL)PYRIDIN-2-AMINE==
	<StructureSection load='4cwv' size='340' side='right' caption='[[4cwv]], [[Resolution\|resolution]] 2.34Å' scene=''>		<StructureSection load='4cwv' size='340' side='right' caption='[[4cwv]], [[Resolution\|resolution]] 2.34Å' scene=''>
Line 7:		Line 8:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cww\|4cww]], [[4cwx\|4cwx]], [[4cwy\|4cwy]], [[4cwz\|4cwz]], [[4cx0\|4cx0]], [[4cx1\|4cx1]], [[4cx2\|4cx2]], [[4cx3\|4cx3]], [[4cx4\|4cx4]], [[4cx5\|4cx5]], [[4cx6\|4cx6]], [[4cx7\|4cx7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cww\|4cww]], [[4cwx\|4cwx]], [[4cwy\|4cwy]], [[4cwz\|4cwz]], [[4cx0\|4cx0]], [[4cx1\|4cx1]], [[4cx2\|4cx2]], [[4cx3\|4cx3]], [[4cx4\|4cx4]], [[4cx5\|4cx5]], [[4cx6\|4cx6]], [[4cx7\|4cx7]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cwv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cwv RCSB], [http://www.ebi.ac.uk/pdbsum/4cwv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cwv OCA], [http://pdbe.org/4cwv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cwv RCSB], [http://www.ebi.ac.uk/pdbsum/4cwv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cwv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4cwv" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:56, 25 December 2014

OCA — Thu, 25 Dec 2014 13:56:22 GMT

←Older revision		Revision as of 13:56, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4cwv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CWV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CWV FirstGlance]. <br>		<table><tr><td colspan='2'>[[4cwv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CWV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CWV FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=HW8:4-METHYL-6-{[(3R,4R)-4-{[5-(PYRIDIN-2-YL)PENTYL]OXY}PYRROLIDIN-3-YL]METHYL}PYRIDIN-2-AMINE'>HW8</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=HW8:4-METHYL-6-{[(3R,4R)-4-{[5-(PYRIDIN-2-YL)PENTYL]OXY}PYRROLIDIN-3-YL]METHYL}PYRIDIN-2-AMINE'>HW8</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cww\|4cww]], [[4cwx\|4cwx]], [[4cwy\|4cwy]], [[4cwz\|4cwz]], [[4cx0\|4cx0]], [[4cx1\|4cx1]], [[4cx2\|4cx2]], [[4cx3\|4cx3]], [[4cx4\|4cx4]], [[4cx5\|4cx5]], [[4cx6\|4cx6]], [[4cx7\|4cx7]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cww\|4cww]], [[4cwx\|4cwx]], [[4cwy\|4cwy]], [[4cwz\|4cwz]], [[4cx0\|4cx0]], [[4cx1\|4cx1]], [[4cx2\|4cx2]], [[4cx3\|4cx3]], [[4cx4\|4cx4]], [[4cx5\|4cx5]], [[4cx6\|4cx6]], [[4cx7\|4cx7]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cwv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cwv RCSB], [http://www.ebi.ac.uk/pdbsum/4cwv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cwv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cwv RCSB], [http://www.ebi.ac.uk/pdbsum/4cwv PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NOS3_BOVIN NOS3_BOVIN]] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Li, H.]]	+	[[Category: Li, H]]
-	[[Category: Poulos, T L.]]	+	[[Category: Poulos, T L]]
	[[Category: Inhibitor complex]]		[[Category: Inhibitor complex]]
	[[Category: Nitric oxide synthase]]		[[Category: Nitric oxide synthase]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 08:59, 13 August 2014

OCA — Wed, 13 Aug 2014 08:59:24 GMT

←Older revision		Revision as of 08:59, 13 August 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Structure of bovine endothelial nitric oxide synthase heme domain in complex with 4-METHYL-6-(((3R,4R)-4-((5-(PYRIDIN-2-YL)PENTYL)OXY) PYRROLIDIN-3-YL)METHYL)PYRIDIN-2-AMINE==
		+	<StructureSection load='4cwv' size='340' side='right' caption='[[4cwv]], [[Resolution\|resolution]] 2.34Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4cwv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CWV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CWV FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=HW8:4-METHYL-6-{[(3R,4R)-4-{[5-(PYRIDIN-2-YL)PENTYL]OXY}PYRROLIDIN-3-YL]METHYL}PYRIDIN-2-AMINE'>HW8</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cww\|4cww]], [[4cwx\|4cwx]], [[4cwy\|4cwy]], [[4cwz\|4cwz]], [[4cx0\|4cx0]], [[4cx1\|4cx1]], [[4cx2\|4cx2]], [[4cx3\|4cx3]], [[4cx4\|4cx4]], [[4cx5\|4cx5]], [[4cx6\|4cx6]], [[4cx7\|4cx7]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cwv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cwv RCSB], [http://www.ebi.ac.uk/pdbsum/4cwv PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Many pyrrolidine-based inhibitors highly selective for neuronal nitric oxide synthase (nNOS) over endothelial NOS (eNOS) exhibit dramatically different binding modes. In some cases, the inhibitor binds in a 180 degrees flipped orientation in nNOS relative to eNOS. From the several crystal structures we have determined, we know that isoform selectivity correlates with the rotamer position of a conserved tyrosine residue that H-bonds with a heme propionate. In nNOS, this Tyr more readily adopts the out-rotamer conformation, while in eNOS, the Tyr tends to remain fixed in the original in-rotamer conformation. In the out-rotamer conformation, inhibitors are able to form better H-bonds with the protein and heme, thus increasing inhibitor potency. A segment of polypeptide that runs along the surface near the conserved Tyr has long been thought to be the reason for the difference in Tyr mobility. Although this segment is usually disordered in both eNOS and nNOS, sequence comparisons and modeling from a few structures show that this segment is structured quite differently in eNOS and nNOS. In this study, we have probed the importance of this surface segment near the Tyr by making a few mutants in the region followed by crystal structure determinations. In addition, because the segment near the conserved Tyr is highly ordered in iNOS, we also determined the structure of an iNOS-inhibitor complex. This new structure provides further insight into the critical role that mobility plays in isoform selectivity.

-	The ~~entry 4cwv is ON HOLD until Paper Publication~~	+	The Mobility of a Conserved Tyrosine Residue Controls Isoform-Dependent Enzyme-Inhibitor Interactions in Nitric Oxide Synthases.,Li H, Jamal J, Delker S, Plaza C, Ji H, Jing Q, Huang H, Kang S, Silverman RB, Poulos TL Biochemistry. 2014 Aug 11. PMID:25089924<ref>PMID:25089924</ref>

-	~~Authors~~: Li, H., Poulos, T.L.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Structure of bovine endothelial nitric~~ oxide synthase ~~heme domain in complex with 4-METHYL-6-(((3R,4R)-4-((5-(PYRIDIN-2-YL)PENTYL)OXY) PYRROLIDIN-3-YL)METHYL)PYRIDIN-2-AMINE~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Li, H.]]
		+	[[Category: Poulos, T L.]]
		+	[[Category: Inhibitor complex]]
		+	[[Category: Nitric oxide synthase]]
		+	[[Category: Oxidoreductase]]

OCA at 08:45, 16 April 2014

OCA — Wed, 16 Apr 2014 08:45:55 GMT

←Older revision		Revision as of 08:45, 16 April 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4cwv is ON HOLD until ~~sometime in the future~~	+	The entry 4cwv is ON HOLD until Paper Publication

	Authors: Li, H., Poulos, T.L.		Authors: Li, H., Poulos, T.L.

	Description: Structure of bovine endothelial nitric oxide synthase heme domain in complex with 4-METHYL-6-(((3R,4R)-4-((5-(PYRIDIN-2-YL)PENTYL)OXY) PYRROLIDIN-3-YL)METHYL)PYRIDIN-2-AMINE		Description: Structure of bovine endothelial nitric oxide synthase heme domain in complex with 4-METHYL-6-(((3R,4R)-4-((5-(PYRIDIN-2-YL)PENTYL)OXY) PYRROLIDIN-3-YL)METHYL)PYRIDIN-2-AMINE

OCA: Protected "4cwv" [edit=sysop:move=sysop]

OCA — Wed, 09 Apr 2014 05:37:42 GMT

Protected "4cwv" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:37, 9 April 2014

OCA: New page: '''Unreleased structure''' The entry 4cwv is ON HOLD until sometime in the future Authors: Li, H., Poulos, T.L. Description: Structure of bovine endothelial nitric oxide synthase heme ...

OCA — Wed, 09 Apr 2014 05:37:41 GMT

New page: '''Unreleased structure''' The entry 4cwv is ON HOLD until sometime in the future Authors: Li, H., Poulos, T.L. Description: Structure of bovine endothelial nitric oxide synthase heme ...

New page

'''Unreleased structure'''

The entry 4cwv is ON HOLD until sometime in the future

Authors: Li, H., Poulos, T.L.

Description: Structure of bovine endothelial nitric oxide synthase heme domain in complex with 4-METHYL-6-(((3R,4R)-4-((5-(PYRIDIN-2-YL)PENTYL)OXY) PYRROLIDIN-3-YL)METHYL)PYRIDIN-2-AMINE