4cxy - Revision history

OCA at 12:17, 20 December 2023

OCA — Wed, 20 Dec 2023 12:17:42 GMT

←Older revision		Revision as of 12:17, 20 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4cxy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CXY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CXY FirstGlance]. <br>		<table><tr><td colspan='2'>[[4cxy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CXY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CXY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DGR:(E)-4-(2-NICOTINOYLHYDRAZINYL)-4-OXOBUT-2-ENOIC+ACID'>DGR</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.65Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DGR:(E)-4-(2-NICOTINOYLHYDRAZINYL)-4-OXOBUT-2-ENOIC+ACID'>DGR</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cxy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cxy OCA], [https://pdbe.org/4cxy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cxy RCSB], [https://www.ebi.ac.uk/pdbsum/4cxy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cxy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cxy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cxy OCA], [https://pdbe.org/4cxy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cxy RCSB], [https://www.ebi.ac.uk/pdbsum/4cxy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cxy ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/FTO_HUMAN FTO_HUMAN]] Defects in FTO are the cause of growth retardation developmental delay coarse facies and early death (GDFD) [MIM:[https://omim.org/entry/612938 612938]]. A severe polymalformation syndrome characterized by postnatal growth retardation, microcephaly, severe psychomotor delay, functional brain deficits and characteristic facial dysmorphism. In some patients, structural brain malformations, cardiac defects, genital anomalies, and cleft palate are observed. Early death occurs by the age of 3 years.<ref>PMID:19559399</ref>	+	[https://www.uniprot.org/uniprot/FTO_HUMAN FTO_HUMAN] Defects in FTO are the cause of growth retardation developmental delay coarse facies and early death (GDFD) [MIM:[https://omim.org/entry/612938 612938]. A severe polymalformation syndrome characterized by postnatal growth retardation, microcephaly, severe psychomotor delay, functional brain deficits and characteristic facial dysmorphism. In some patients, structural brain malformations, cardiac defects, genital anomalies, and cleft palate are observed. Early death occurs by the age of 3 years.<ref>PMID:19559399</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FTO_HUMAN FTO_HUMAN]] Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation.<ref>PMID:18775698</ref> <ref>PMID:20376003</ref>	+	[https://www.uniprot.org/uniprot/FTO_HUMAN FTO_HUMAN] Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation.<ref>PMID:18775698</ref> <ref>PMID:20376003</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:38, 14 September 2022

OCA — Wed, 14 Sep 2022 07:38:10 GMT

←Older revision		Revision as of 07:38, 14 September 2022
Line 3:		Line 3:
	<StructureSection load='4cxy' size='340' side='right'caption='[[4cxy]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='4cxy' size='340' side='right'caption='[[4cxy]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4cxy]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CXY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4CXY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4cxy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CXY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CXY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DGR:(E)-4-(2-NICOTINOYLHYDRAZINYL)-4-OXOBUT-2-ENOIC+ACID'>DGR</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DGR:(E)-4-(2-NICOTINOYLHYDRAZINYL)-4-OXOBUT-2-ENOIC+ACID'>DGR</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cxw\|4cxw]], [[4cxx\|4cxx]], [[4cxz\|4cxz]], [[4cy0\|4cy0]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cxy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cxy OCA], [https://pdbe.org/4cxy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cxy RCSB], [https://www.ebi.ac.uk/pdbsum/4cxy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cxy ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4cxy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cxy OCA], [~~http~~://pdbe.org/4cxy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4cxy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4cxy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4cxy ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/FTO_HUMAN FTO_HUMAN]] Defects in FTO are the cause of growth retardation developmental delay coarse facies and early death (GDFD) [MIM:[~~http~~://omim.org/entry/612938 612938]]. A severe polymalformation syndrome characterized by postnatal growth retardation, microcephaly, severe psychomotor delay, functional brain deficits and characteristic facial dysmorphism. In some patients, structural brain malformations, cardiac defects, genital anomalies, and cleft palate are observed. Early death occurs by the age of 3 years.<ref>PMID:19559399</ref>	+	[[https://www.uniprot.org/uniprot/FTO_HUMAN FTO_HUMAN]] Defects in FTO are the cause of growth retardation developmental delay coarse facies and early death (GDFD) [MIM:[https://omim.org/entry/612938 612938]]. A severe polymalformation syndrome characterized by postnatal growth retardation, microcephaly, severe psychomotor delay, functional brain deficits and characteristic facial dysmorphism. In some patients, structural brain malformations, cardiac defects, genital anomalies, and cleft palate are observed. Early death occurs by the age of 3 years.<ref>PMID:19559399</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FTO_HUMAN FTO_HUMAN]] Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation.<ref>PMID:18775698</ref> <ref>PMID:20376003</ref>	+	[[https://www.uniprot.org/uniprot/FTO_HUMAN FTO_HUMAN]] Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation.<ref>PMID:18775698</ref> <ref>PMID:20376003</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen, Y]]	+	[[Category: Chen Y]]
-	[[Category: Gao~~, Y G~~]]	+	[[Category: Gao YG]]
-	[[Category: Hong, W]]	+	[[Category: Hong W]]
-	[[Category: Lau~~, L Z.M~~]]	+	[[Category: Lau LZM]]
-	[[Category: Sun, L]]	+	[[Category: Sun L]]
-	[[Category: Tan, J]]	+	[[Category: Tan J]]
-	[[Category: Toh~~, D W~~]]	+	[[Category: Toh DW]]
-	[[Category: Woon~~, E C.Y]]~~	+	[[Category: Woon ECY]]
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Small molecular probe~~]]	+

OCA at 09:59, 5 February 2020

OCA — Wed, 05 Feb 2020 09:59:09 GMT

←Older revision		Revision as of 09:59, 5 February 2020
Line 1:		Line 1:

	==Crystal structure of human FTO in complex with acylhydrazine inhibitor 21==		==Crystal structure of human FTO in complex with acylhydrazine inhibitor 21==
-	<StructureSection load='4cxy' size='340' side='right' caption='[[4cxy]], [[Resolution\|resolution]] 2.65Å' scene=''>	+	<StructureSection load='4cxy' size='340' side='right'caption='[[4cxy]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4cxy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CXY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CXY FirstGlance]. <br>		<table><tr><td colspan='2'>[[4cxy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CXY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CXY FirstGlance]. <br>
Line 23:		Line 23:

	==See Also==		==See Also==
-	*[[Dioxygenase\|Dioxygenase]]	+	*[[Dioxygenase 3D structures\|Dioxygenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Chen, Y]]		[[Category: Chen, Y]]
	[[Category: Gao, Y G]]		[[Category: Gao, Y G]]

OCA at 06:07, 18 April 2018

OCA — Wed, 18 Apr 2018 06:07:06 GMT

←Older revision		Revision as of 06:07, 18 April 2018
Line 3:		Line 3:
	<StructureSection load='4cxy' size='340' side='right' caption='[[4cxy]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='4cxy' size='340' side='right' caption='[[4cxy]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4cxy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CXY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CXY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4cxy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CXY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CXY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DGR:(E)-4-(2-NICOTINOYLHYDRAZINYL)-4-OXOBUT-2-ENOIC+ACID'>DGR</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DGR:(E)-4-(2-NICOTINOYLHYDRAZINYL)-4-OXOBUT-2-ENOIC+ACID'>DGR</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cxw\|4cxw]], [[4cxx\|4cxx]], [[4cxz\|4cxz]], [[4cy0\|4cy0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cxw\|4cxw]], [[4cxx\|4cxx]], [[4cxz\|4cxz]], [[4cy0\|4cy0]]</td></tr>
Line 12:		Line 12:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/FTO_HUMAN FTO_HUMAN]] Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation.<ref>PMID:18775698</ref> <ref>PMID:20376003</ref>		[[http://www.uniprot.org/uniprot/FTO_HUMAN FTO_HUMAN]] Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation.<ref>PMID:18775698</ref> <ref>PMID:20376003</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The AlkB family of nucleic acid demethylases are of intense biological and medical interest because of their roles in nucleic acid repair and epigenetic modification. However their functional and molecular mechanisms are unclear, hence, there is strong interest in developing selective inhibitors for them. Here we report the identification of key residues within the nucleotide-binding sites of the AlkB subfamilies that likely determine their substrate specificity. We further provide proof of principle that a strategy exploiting these inherent structural differences can enable selective and potent inhibition of the AlkB subfamilies. This is demonstrated by the first report of a subfamily-selective and cell-active FTO inhibitor 12. The distinct selectivity of 12 for FTO against other AlkB subfamilies and 2OG oxygenases shall be of considerable interest with regards to its potential use as a functional probe. The strategy outlined here is likely applicable to other AlkB subfamilies, and, more widely, to other 2OG oxygenases.
		+
		+	A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N(6)-methyladenosine demethylase FTO.,Toh JDW, Sun L, Lau LZM, Tan J, Low JJA, Tang CWQ, Cheong EJY, Tan MJH, Chen Y, Hong W, Gao YG, Woon ECY Chem Sci. 2015 Jan 1;6(1):112-122. doi: 10.1039/c4sc02554g. Epub 2014 Sep 22. PMID:28553460<ref>PMID:28553460</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4cxy" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 19:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Chen, Y]]		[[Category: Chen, Y]]
	[[Category: Gao, Y G]]		[[Category: Gao, Y G]]

OCA at 16:41, 11 August 2016

OCA — Thu, 11 Aug 2016 16:41:28 GMT

←Older revision		Revision as of 16:41, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of human FTO in complex with acylhydrazine inhibitor 21==		==Crystal structure of human FTO in complex with acylhydrazine inhibitor 21==
	<StructureSection load='4cxy' size='340' side='right' caption='[[4cxy]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='4cxy' size='340' side='right' caption='[[4cxy]], [[Resolution\|resolution]] 2.65Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DGR:(E)-4-(2-NICOTINOYLHYDRAZINYL)-4-OXOBUT-2-ENOIC+ACID'>DGR</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DGR:(E)-4-(2-NICOTINOYLHYDRAZINYL)-4-OXOBUT-2-ENOIC+ACID'>DGR</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cxw\|4cxw]], [[4cxx\|4cxx]], [[4cxz\|4cxz]], [[4cy0\|4cy0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cxw\|4cxw]], [[4cxx\|4cxx]], [[4cxz\|4cxz]], [[4cy0\|4cy0]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cxy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cxy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cxy RCSB], [http://www.ebi.ac.uk/pdbsum/4cxy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cxy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cxy OCA], [http://pdbe.org/4cxy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cxy RCSB], [http://www.ebi.ac.uk/pdbsum/4cxy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cxy ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 11:		Line 12:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/FTO_HUMAN FTO_HUMAN]] Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation.<ref>PMID:18775698</ref> <ref>PMID:20376003</ref>		[[http://www.uniprot.org/uniprot/FTO_HUMAN FTO_HUMAN]] Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation.<ref>PMID:18775698</ref> <ref>PMID:20376003</ref>
		+
		+	==See Also==
		+	*[[Dioxygenase\|Dioxygenase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:54, 20 January 2015

OCA — Tue, 20 Jan 2015 10:54:01 GMT

←Older revision		Revision as of 10:54, 20 January 2015
Line 15:		Line 15:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Chen, Y.]]	+	[[Category: Chen, Y]]
-	[[Category: Gao, Y G.]]	+	[[Category: Gao, Y G]]
-	[[Category: Hong, W.]]	+	[[Category: Hong, W]]
-	[[Category: Lau, L Z.M.]]	+	[[Category: Lau, L Z.M]]
-	[[Category: Sun, L.]]	+	[[Category: Sun, L]]
-	[[Category: Tan, J.]]	+	[[Category: Tan, J]]
-	[[Category: Toh, D W.]]	+	[[Category: Toh, D W]]
-	[[Category: Woon, E C.Y.]]	+	[[Category: Woon, E C.Y]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Small molecular probe]]		[[Category: Small molecular probe]]

OCA at 05:47, 8 October 2014

OCA — Wed, 08 Oct 2014 05:47:50 GMT

←Older revision		Revision as of 05:47, 8 October 2014
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-	==~~Oxidoreductase~~ complex 3==	+	==Crystal structure of human FTO in complex with acylhydrazine inhibitor 21==
	<StructureSection load='4cxy' size='340' side='right' caption='[[4cxy]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='4cxy' size='340' side='right' caption='[[4cxy]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4cxy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CXY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CXY FirstGlance]. <br>		<table><tr><td colspan='2'>[[4cxy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CXY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CXY FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DGR:4-(2-NICOTINOYLHYDRAZINYL)-4-~~OXOBUTANOIC~~+ACID'>DGR</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DGR:(E)-4-(2-NICOTINOYLHYDRAZINYL)-4-OXOBUT-2-ENOIC+ACID'>DGR</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cxw\|4cxw]], [[4cxx\|4cxx]], [[4cxz\|4cxz]], [[4cy0\|4cy0]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cxw\|4cxw]], [[4cxx\|4cxx]], [[4cxz\|4cxz]], [[4cy0\|4cy0]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cxy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cxy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cxy RCSB], [http://www.ebi.ac.uk/pdbsum/4cxy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cxy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cxy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cxy RCSB], [http://www.ebi.ac.uk/pdbsum/4cxy PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/FTO_HUMAN FTO_HUMAN]] Defects in FTO are the cause of growth retardation developmental delay coarse facies and early death (GDFD) [MIM:[http://omim.org/entry/612938 612938]]. A severe polymalformation syndrome characterized by postnatal growth retardation, microcephaly, severe psychomotor delay, functional brain deficits and characteristic facial dysmorphism. In some patients, structural brain malformations, cardiac defects, genital anomalies, and cleft palate are observed. Early death occurs by the age of 3 years.<ref>PMID:19559399</ref>		[[http://www.uniprot.org/uniprot/FTO_HUMAN FTO_HUMAN]] Defects in FTO are the cause of growth retardation developmental delay coarse facies and early death (GDFD) [MIM:[http://omim.org/entry/612938 612938]]. A severe polymalformation syndrome characterized by postnatal growth retardation, microcephaly, severe psychomotor delay, functional brain deficits and characteristic facial dysmorphism. In some patients, structural brain malformations, cardiac defects, genital anomalies, and cleft palate are observed. Early death occurs by the age of 3 years.<ref>PMID:19559399</ref>

OCA at 00:21, 2 October 2014

OCA — Thu, 02 Oct 2014 00:21:46 GMT

←Older revision		Revision as of 00:21, 2 October 2014
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-	'''~~Unreleased structure~~'''	+	==Oxidoreductase complex 3==
-		+	<StructureSection load='4cxy' size='340' side='right' caption='[[4cxy]], [[Resolution\|resolution]] 2.65Å' scene=''>
-	~~The entry~~ 4cxy is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4cxy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CXY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CXY FirstGlance]. <br>
-	~~Authors~~: ~~Toh~~, D.W., ~~Sun~~, L., ~~Tan~~, J., Chen, Y., Lau, L.Z.M., ~~Hong~~, W., Woon, E.C.Y.~~, Gao, Y.G.~~	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DGR:4-(2-NICOTINOYLHYDRAZINYL)-4-OXOBUTANOIC+ACID'>DGR</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cxw\|4cxw]], [[4cxx\|4cxx]], [[4cxz\|4cxz]], [[4cy0\|4cy0]]</td></tr>
-	~~Description~~: ~~Oxidoreductase complex 3~~	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cxy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cxy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cxy RCSB], [http://www.ebi.ac.uk/pdbsum/4cxy PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/FTO_HUMAN FTO_HUMAN]] Defects in FTO are the cause of growth retardation developmental delay coarse facies and early death (GDFD) [MIM:[http://omim.org/entry/612938 612938]]. A severe polymalformation syndrome characterized by postnatal growth retardation, microcephaly, severe psychomotor delay, functional brain deficits and characteristic facial dysmorphism. In some patients, structural brain malformations, cardiac defects, genital anomalies, and cleft palate are observed. Early death occurs by the age of 3 years.<ref>PMID:19559399</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FTO_HUMAN FTO_HUMAN]] Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation.<ref>PMID:18775698</ref> <ref>PMID:20376003</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Chen, Y.]]
		+	[[Category: Gao, Y G.]]
		+	[[Category: Hong, W.]]
		+	[[Category: Lau, L Z.M.]]
		+	[[Category: Sun, L.]]
		+	[[Category: Tan, J.]]
		+	[[Category: Toh, D W.]]
		+	[[Category: Woon, E C.Y.]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Small molecular probe]]

OCA at 07:05, 23 April 2014

OCA — Wed, 23 Apr 2014 07:05:39 GMT

←Older revision		Revision as of 07:05, 23 April 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4cxy is ON HOLD	+	The entry 4cxy is ON HOLD until Paper Publication

	Authors: Toh, D.W., Sun, L., Tan, J., Chen, Y., Lau, L.Z.M., Hong, W., Woon, E.C.Y., Gao, Y.G.		Authors: Toh, D.W., Sun, L., Tan, J., Chen, Y., Lau, L.Z.M., Hong, W., Woon, E.C.Y., Gao, Y.G.

-	Description: ~~Complex~~ 3	+	Description: Oxidoreductase complex 3

OCA: Protected "4cxy" [edit=sysop:move=sysop]

OCA — Wed, 16 Apr 2014 08:47:18 GMT

Protected "4cxy" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:47, 16 April 2014