4czg - Revision history

OCA at 12:18, 20 December 2023

OCA — Wed, 20 Dec 2023 12:18:20 GMT

←Older revision		Revision as of 12:18, 20 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4czg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caulobacter_vibrioides Caulobacter vibrioides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CZG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CZG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4czg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caulobacter_vibrioides Caulobacter vibrioides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CZG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CZG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=QH3:3,4-DICHLOROBENZYL+CARBAMIMIDOTHIOATE'>QH3</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=QH3:3,4-DICHLOROBENZYL+CARBAMIMIDOTHIOATE'>QH3</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4czg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czg OCA], [https://pdbe.org/4czg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4czg RCSB], [https://www.ebi.ac.uk/pdbsum/4czg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4czg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4czg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czg OCA], [https://pdbe.org/4czg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4czg RCSB], [https://www.ebi.ac.uk/pdbsum/4czg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4czg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MREB_CAUVN MREB_CAUVN]] Forms membrane-associated dynamic filaments that are essential for cell shape determination (PubMed:14982627, PubMed:17880425, PubMed:24843005). Acts by regulating cell wall synthesis and cell elongation, and thus cell shape (PubMed:14982627, PubMed:17880425). A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature (By similarity). Required for mid-cell peptidoglycan synthesis and cell division. Directs the localization of the cytosolic peptidoglycan precursor-synthesizing enzyme MurG (PubMed:17880425). Also required for proper chromosome segregation (PubMed:15707892). Directs the segregation of origin-proximal but not origin-distal loci (PubMed:15707892).[UniProtKB:P0A9X4]<ref>PMID:14982627</ref> <ref>PMID:15707892</ref> <ref>PMID:17880425</ref> <ref>PMID:24843005</ref> <ref>PMID:14982627</ref>	+	[https://www.uniprot.org/uniprot/MREB_CAUVN MREB_CAUVN] Forms membrane-associated dynamic filaments that are essential for cell shape determination (PubMed:14982627, PubMed:17880425, PubMed:24843005). Acts by regulating cell wall synthesis and cell elongation, and thus cell shape (PubMed:14982627, PubMed:17880425). A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature (By similarity). Required for mid-cell peptidoglycan synthesis and cell division. Directs the localization of the cytosolic peptidoglycan precursor-synthesizing enzyme MurG (PubMed:17880425). Also required for proper chromosome segregation (PubMed:15707892). Directs the segregation of origin-proximal but not origin-distal loci (PubMed:15707892).[UniProtKB:P0A9X4]<ref>PMID:14982627</ref> <ref>PMID:15707892</ref> <ref>PMID:17880425</ref> <ref>PMID:24843005</ref> <ref>PMID:14982627</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:39, 14 September 2022

OCA — Wed, 14 Sep 2022 07:39:56 GMT

←Older revision		Revision as of 07:39, 14 September 2022
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	<StructureSection load='4czg' size='340' side='right'caption='[[4czg]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='4czg' size='340' side='right'caption='[[4czg]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4czg]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Cauvi Cauvi~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CZG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4CZG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4czg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caulobacter_vibrioides Caulobacter vibrioides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CZG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CZG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=QH3:3,4-DICHLOROBENZYL+CARBAMIMIDOTHIOATE'>QH3</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=QH3:3,4-DICHLOROBENZYL+CARBAMIMIDOTHIOATE'>QH3</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cze\|4cze]], [[4czf\|4czf]], [[4czh\|4czh]], [[4czi\|4czi]], [[4czj\|4czj]], [[4czk\|4czk]], [[4czl\|4czl]], [[4czm\|4czm]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4czg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czg OCA], [https://pdbe.org/4czg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4czg RCSB], [https://www.ebi.ac.uk/pdbsum/4czg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4czg ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4czg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czg OCA], [~~http~~://pdbe.org/4czg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4czg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4czg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4czg ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/MREB_CAUVN MREB_CAUVN]] Forms membrane-associated dynamic filaments that are essential for cell shape determination (PubMed:14982627, PubMed:17880425, PubMed:24843005). Acts by regulating cell wall synthesis and cell elongation, and thus cell shape (PubMed:14982627, PubMed:17880425). A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature (By similarity). Required for mid-cell peptidoglycan synthesis and cell division. Directs the localization of the cytosolic peptidoglycan precursor-synthesizing enzyme MurG (PubMed:17880425). Also required for proper chromosome segregation (PubMed:15707892). Directs the segregation of origin-proximal but not origin-distal loci (PubMed:15707892).[UniProtKB:P0A9X4]<ref>PMID:14982627</ref> <ref>PMID:15707892</ref> <ref>PMID:17880425</ref> <ref>PMID:24843005</ref> <ref>PMID:14982627</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cauvi~~]]	+	[[Category: Caulobacter vibrioides]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Ent, F van den]]~~	+	[[Category: Lowe J]]
-	[[Category: Lowe, J]]	+	[[Category: Van den Ent F]]
-	[[Category: ~~Bacterial actin]]~~	+
-	~~[[Category: Bacterial cytoskeleton]]~~	+
-	~~[[Category: Structural protein~~]]	+

OCA at 08:52, 20 March 2019

OCA — Wed, 20 Mar 2019 08:52:09 GMT

←Older revision		Revision as of 08:52, 20 March 2019
Line 1:		Line 1:

	==C. crescentus MreB, single filament, ADP, A22 inhibitor==		==C. crescentus MreB, single filament, ADP, A22 inhibitor==
-	<StructureSection load='4czg' size='340' side='right' caption='[[4czg]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='4czg' size='340' side='right'caption='[[4czg]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4czg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CZG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CZG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4czg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cauvi Cauvi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CZG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CZG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=QH3:3,4-DICHLOROBENZYL+CARBAMIMIDOTHIOATE'>QH3</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=QH3:3,4-DICHLOROBENZYL+CARBAMIMIDOTHIOATE'>QH3</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cze\|4cze]], [[4czf\|4czf]], [[4czh\|4czh]], [[4czi\|4czi]], [[4czj\|4czj]], [[4czk\|4czk]], [[4czl\|4czl]], [[4czm\|4czm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cze\|4cze]], [[4czf\|4czf]], [[4czh\|4czh]], [[4czi\|4czi]], [[4czj\|4czj]], [[4czk\|4czk]], [[4czl\|4czl]], [[4czm\|4czm]]</td></tr>
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Cauvi]]
		+	[[Category: Large Structures]]
	[[Category: Ent, F van den]]		[[Category: Ent, F van den]]
	[[Category: Lowe, J]]		[[Category: Lowe, J]]

OCA at 18:43, 11 August 2016

OCA — Thu, 11 Aug 2016 18:43:33 GMT

←Older revision		Revision as of 18:43, 11 August 2016
Line 1:		Line 1:
		+
	==C. crescentus MreB, single filament, ADP, A22 inhibitor==		==C. crescentus MreB, single filament, ADP, A22 inhibitor==
	<StructureSection load='4czg' size='340' side='right' caption='[[4czg]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='4czg' size='340' side='right' caption='[[4czg]], [[Resolution\|resolution]] 1.50Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=QH3:3,4-DICHLOROBENZYL+CARBAMIMIDOTHIOATE'>QH3</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=QH3:3,4-DICHLOROBENZYL+CARBAMIMIDOTHIOATE'>QH3</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cze\|4cze]], [[4czf\|4czf]], [[4czh\|4czh]], [[4czi\|4czi]], [[4czj\|4czj]], [[4czk\|4czk]], [[4czl\|4czl]], [[4czm\|4czm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cze\|4cze]], [[4czf\|4czf]], [[4czh\|4czh]], [[4czi\|4czi]], [[4czj\|4czj]], [[4czk\|4czk]], [[4czl\|4czl]], [[4czm\|4czm]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4czg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4czg RCSB], [http://www.ebi.ac.uk/pdbsum/4czg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4czg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czg OCA], [http://pdbe.org/4czg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4czg RCSB], [http://www.ebi.ac.uk/pdbsum/4czg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4czg ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4czg" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:39, 4 January 2015

OCA — Sun, 04 Jan 2015 13:39:22 GMT

←Older revision		Revision as of 13:39, 4 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4czg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CZG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CZG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4czg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CZG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CZG FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=QH3:3,4-DICHLOROBENZYL+CARBAMIMIDOTHIOATE'>QH3</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=QH3:3,4-DICHLOROBENZYL+CARBAMIMIDOTHIOATE'>QH3</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cze\|4cze]], [[4czf\|4czf]], [[4czh\|4czh]], [[4czi\|4czi]], [[4czj\|4czj]], [[4czk\|4czk]], [[4czl\|4czl]], [[4czm\|4czm]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cze\|4cze]], [[4czf\|4czf]], [[4czh\|4czh]], [[4czi\|4czi]], [[4czj\|4czj]], [[4czk\|4czk]], [[4czl\|4czl]], [[4czm\|4czm]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4czg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4czg RCSB], [http://www.ebi.ac.uk/pdbsum/4czg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4czg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4czg RCSB], [http://www.ebi.ac.uk/pdbsum/4czg PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Ent, F van den.]]	+	[[Category: Ent, F van den]]
-	[[Category: Lowe, J.]]	+	[[Category: Lowe, J]]
	[[Category: Bacterial actin]]		[[Category: Bacterial actin]]
	[[Category: Bacterial cytoskeleton]]		[[Category: Bacterial cytoskeleton]]
	[[Category: Structural protein]]		[[Category: Structural protein]]

OCA at 08:46, 11 June 2014

OCA — Wed, 11 Jun 2014 08:46:58 GMT

←Older revision		Revision as of 08:46, 11 June 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==C. crescentus MreB, single filament, ADP, A22 inhibitor==
		+	<StructureSection load='4czg' size='340' side='right' caption='[[4czg]], [[Resolution\|resolution]] 1.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4czg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CZG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CZG FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=QH3:3,4-DICHLOROBENZYL+CARBAMIMIDOTHIOATE'>QH3</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cze\|4cze]], [[4czf\|4czf]], [[4czh\|4czh]], [[4czi\|4czi]], [[4czj\|4czj]], [[4czk\|4czk]], [[4czl\|4czl]], [[4czm\|4czm]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4czg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4czg RCSB], [http://www.ebi.ac.uk/pdbsum/4czg PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Filaments of all actin-like proteins known to date are assembled from pairs of protofilaments that are arranged in a parallel fashion, generating polarity. Here we show that the prokaryotic actin homologue MreB forms pairs of protofilaments that adopt an antiparallel arrangement in vitro and in vivo. We provide an atomic view of antiparallel protofilaments of Caulobacter MreB as apparent from crystal structures. We show that a protofilament doublet is essential for MreB's function in cell shape maintenance and demonstrate by in vivo site-specific cross-linking the antiparallel orientation of MreB protofilaments in E. coli. 3D cryo-EM shows that pairs of protofilaments of Caulobacter MreB tightly bind to membranes. Crystal structures of different nucleotide and polymerisation states of Caulobacter MreB reveal conserved conformational changes accompanying antiparallel filament formation. Finally, the antimicrobial agents A22/MP265 are shown to bind close to the bound nucleotide of MreB, presumably preventing nucleotide hydrolysis and destabilising double protofilaments.

-	~~The entry 4czg is ON HOLD~~	+	Bacterial actin MreB forms antiparallel double filaments.,Van den Ent F, Izore T, Bharat TA, Johnson CM, Lowe J Elife. 2014 May 2:e02634. doi: 10.7554/eLife.02634. PMID:24843005<ref>PMID:24843005</ref>

-	~~Authors: Lowe~~, J.~~, vandenEnt, F~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: C. ~~crescentus MreB~~, ~~single filament, ADP, A22 inhibitor~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ent, F van den.]]
		+	[[Category: Lowe, J.]]
		+	[[Category: Bacterial actin]]
		+	[[Category: Bacterial cytoskeleton]]
		+	[[Category: Structural protein]]

OCA: Protected "4czg" [edit=sysop:move=sysop]

OCA — Wed, 30 Apr 2014 05:50:54 GMT

Protected "4czg" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:50, 30 April 2014

OCA: New page: '''Unreleased structure''' The entry 4czg is ON HOLD Authors: Lowe, J., vandenEnt, F. Description: C. crescentus MreB, single filament, ADP, A22 inhibitor

OCA — Wed, 30 Apr 2014 05:50:53 GMT

New page: '''Unreleased structure''' The entry 4czg is ON HOLD Authors: Lowe, J., vandenEnt, F. Description: C. crescentus MreB, single filament, ADP, A22 inhibitor

New page

'''Unreleased structure'''

The entry 4czg is ON HOLD

Authors: Lowe, J., vandenEnt, F.

Description: C. crescentus MreB, single filament, ADP, A22 inhibitor