4czt - Revision history

OCA at 12:18, 20 December 2023

OCA — Wed, 20 Dec 2023 12:18:32 GMT

←Older revision		Revision as of 12:18, 20 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4czt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CZT FirstGlance]. <br>		<table><tr><td colspan='2'>[[4czt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CZT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4czt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czt OCA], [https://pdbe.org/4czt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4czt RCSB], [https://www.ebi.ac.uk/pdbsum/4czt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4czt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4czt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czt OCA], [https://pdbe.org/4czt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4czt RCSB], [https://www.ebi.ac.uk/pdbsum/4czt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4czt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CIPKN_ARATH CIPKN_ARATH]] CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein leads to activation of the kinase in a calcium-dependent manner. Downstream of CBL1, CBL2, CBL3 and CBL9, regulates by phosphorylation the K(+) conductance and uptake of AKT1 in low K(+) condition, in response to calcium signaling and during the stomatal opening regulation by monitoring the turgor pressure in guard cells. In response to low nitrate concentration, phosphorylates NRT1.1, switching it from a low-affinity nitrate transporter to a high-affinity transporter. Confers tolerance to low potassium conditions. Involved in drought sensitivity and leaf transpiration.<ref>PMID:16814720</ref> <ref>PMID:16895985</ref> <ref>PMID:17898163</ref> <ref>PMID:17922773</ref> <ref>PMID:19766570</ref> <ref>PMID:22253446</ref>	+	[https://www.uniprot.org/uniprot/CIPKN_ARATH CIPKN_ARATH] CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein leads to activation of the kinase in a calcium-dependent manner. Downstream of CBL1, CBL2, CBL3 and CBL9, regulates by phosphorylation the K(+) conductance and uptake of AKT1 in low K(+) condition, in response to calcium signaling and during the stomatal opening regulation by monitoring the turgor pressure in guard cells. In response to low nitrate concentration, phosphorylates NRT1.1, switching it from a low-affinity nitrate transporter to a high-affinity transporter. Confers tolerance to low potassium conditions. Involved in drought sensitivity and leaf transpiration.<ref>PMID:16814720</ref> <ref>PMID:16895985</ref> <ref>PMID:17898163</ref> <ref>PMID:17922773</ref> <ref>PMID:19766570</ref> <ref>PMID:22253446</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:40, 14 September 2022

OCA — Wed, 14 Sep 2022 07:40:17 GMT

←Older revision		Revision as of 07:40, 14 September 2022
Line 3:		Line 3:
	<StructureSection load='4czt' size='340' side='right'caption='[[4czt]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4czt' size='340' side='right'caption='[[4czt]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4czt]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Arath Arath~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CZT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4CZT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4czt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CZT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4czu\|4czu]], [[4d28\|4d28]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4czt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czt OCA], [https://pdbe.org/4czt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4czt RCSB], [https://www.ebi.ac.uk/pdbsum/4czt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4czt ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4czt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czt OCA], [~~http~~://pdbe.org/4czt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4czt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4czt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4czt ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CIPKN_ARATH CIPKN_ARATH]] CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein leads to activation of the kinase in a calcium-dependent manner. Downstream of CBL1, CBL2, CBL3 and CBL9, regulates by phosphorylation the K(+) conductance and uptake of AKT1 in low K(+) condition, in response to calcium signaling and during the stomatal opening regulation by monitoring the turgor pressure in guard cells. In response to low nitrate concentration, phosphorylates NRT1.1, switching it from a low-affinity nitrate transporter to a high-affinity transporter. Confers tolerance to low potassium conditions. Involved in drought sensitivity and leaf transpiration.<ref>PMID:16814720</ref> <ref>PMID:16895985</ref> <ref>PMID:17898163</ref> <ref>PMID:17922773</ref> <ref>PMID:19766570</ref> <ref>PMID:22253446</ref>	+	[[https://www.uniprot.org/uniprot/CIPKN_ARATH CIPKN_ARATH]] CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein leads to activation of the kinase in a calcium-dependent manner. Downstream of CBL1, CBL2, CBL3 and CBL9, regulates by phosphorylation the K(+) conductance and uptake of AKT1 in low K(+) condition, in response to calcium signaling and during the stomatal opening regulation by monitoring the turgor pressure in guard cells. In response to low nitrate concentration, phosphorylates NRT1.1, switching it from a low-affinity nitrate transporter to a high-affinity transporter. Confers tolerance to low potassium conditions. Involved in drought sensitivity and leaf transpiration.<ref>PMID:16814720</ref> <ref>PMID:16895985</ref> <ref>PMID:17898163</ref> <ref>PMID:17922773</ref> <ref>PMID:19766570</ref> <ref>PMID:22253446</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arath~~]]	+	[[Category: Arabidopsis thaliana]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Non-specific serine/threonine protein kinase]]~~	+	[[Category: Albert A]]
-	[[Category: Albert, A]]	+	[[Category: Chaves-Sanjuan A]]
-	[[Category: Chaves-Sanjuan, A]]	+	[[Category: Sanchez-Barrena MJ]]
-	[[Category: Sanchez-Barrena~~, M J]]~~	+
-	~~[[Category: Potassium transport]]~~	+
-	~~[[Category: Snrk3]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 12:52, 10 May 2019

OCA — Fri, 10 May 2019 12:52:00 GMT

←Older revision		Revision as of 12:52, 10 May 2019
Line 1:		Line 1:

	==Crystal structure of the kinase domain of CIPK23==		==Crystal structure of the kinase domain of CIPK23==
-	<StructureSection load='4czt' size='340' side='right' caption='[[4czt]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='4czt' size='340' side='right'caption='[[4czt]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4czt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CZT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CZT FirstGlance]. <br>		<table><tr><td colspan='2'>[[4czt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CZT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CZT FirstGlance]. <br>
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Arath]]		[[Category: Arath]]
		+	[[Category: Large Structures]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Albert, A]]		[[Category: Albert, A]]

OCA at 07:29, 6 December 2017

OCA — Wed, 06 Dec 2017 07:29:17 GMT

←Older revision		Revision as of 07:29, 6 December 2017
Line 1:		Line 1:

-	==Crystal structure of the kinase domain of ~~SnRK3.23 At1g30270~~==	+	==Crystal structure of the kinase domain of CIPK23==
	<StructureSection load='4czt' size='340' side='right' caption='[[4czt]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4czt' size='340' side='right' caption='[[4czt]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4czt]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CZT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CZT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4czt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CZT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CZT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4czu\|4czu]], [[4d28\|4d28]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4czu\|4czu]], [[4d28\|4d28]]</td></tr>
Line 24:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Arath]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Albert, A]]		[[Category: Albert, A]]

OCA at 18:36, 4 August 2016

OCA — Thu, 04 Aug 2016 18:36:45 GMT

←Older revision		Revision as of 18:36, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the kinase domain of SnRK3.23 At1g30270==		==Crystal structure of the kinase domain of SnRK3.23 At1g30270==
	<StructureSection load='4czt' size='340' side='right' caption='[[4czt]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4czt' size='340' side='right' caption='[[4czt]], [[Resolution\|resolution]] 2.30Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4czu\|4czu]], [[4d28\|4d28]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4czu\|4czu]], [[4d28\|4d28]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4czt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4czt RCSB], [http://www.ebi.ac.uk/pdbsum/4czt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4czt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czt OCA], [http://pdbe.org/4czt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4czt RCSB], [http://www.ebi.ac.uk/pdbsum/4czt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4czt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4czt" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:58, 25 December 2014

OCA — Thu, 25 Dec 2014 11:58:41 GMT

←Older revision		Revision as of 11:58, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4czt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4czt RCSB], [http://www.ebi.ac.uk/pdbsum/4czt PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4czt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4czt RCSB], [http://www.ebi.ac.uk/pdbsum/4czt PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CIPKN_ARATH CIPKN_ARATH]] CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein leads to activation of the kinase in a calcium-dependent manner. Downstream of CBL1, CBL2, CBL3 and CBL9, regulates by phosphorylation the K(+) conductance and uptake of AKT1 in low K(+) condition, in response to calcium signaling and during the stomatal opening regulation by monitoring the turgor pressure in guard cells. In response to low nitrate concentration, phosphorylates NRT1.1, switching it from a low-affinity nitrate transporter to a high-affinity transporter. Confers tolerance to low potassium conditions. Involved in drought sensitivity and leaf transpiration.<ref>PMID:16814720</ref> <ref>PMID:16895985</ref> <ref>PMID:17898163</ref> <ref>PMID:17922773</ref> <ref>PMID:19766570</ref> <ref>PMID:22253446</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
-	[[Category: Albert, A.]]	+	[[Category: Albert, A]]
-	[[Category: Chaves-Sanjuan, A.]]	+	[[Category: Chaves-Sanjuan, A]]
-	[[Category: Sanchez-Barrena, M J.]]	+	[[Category: Sanchez-Barrena, M J]]
	[[Category: Potassium transport]]		[[Category: Potassium transport]]
	[[Category: Snrk3]]		[[Category: Snrk3]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 10:41, 20 October 2014

OCA — Mon, 20 Oct 2014 10:41:50 GMT

←Older revision		Revision as of 10:41, 20 October 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of the kinase domain of SnRK3.23 At1g30270==
		+	<StructureSection load='4czt' size='340' side='right' caption='[[4czt]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4czt]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CZT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CZT FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4czu\|4czu]], [[4d28\|4d28]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4czt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4czt RCSB], [http://www.ebi.ac.uk/pdbsum/4czt PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Plant cells have developed specific protective molecular machinery against environmental stresses. The family of CBL-interacting protein kinases (CIPK) and their interacting activators, the calcium sensors calcineurin B-like (CBLs), work together to decode calcium signals elicited by stress situations. The molecular basis of biological activation of CIPKs relies on the calcium-dependent interaction of a self-inhibitory NAF motif with a particular CBL, the phosphorylation of the activation loop by upstream kinases, and the subsequent phosphorylation of the CBL by the CIPK. We present the crystal structures of the NAF-truncated and pseudophosphorylated kinase domains of CIPK23 and CIPK24/SOS2. In addition, we provide biochemical data showing that although CIPK23 is intrinsically inactive and requires an external stimulation, CIPK24/SOS2 displays basal activity. This data correlates well with the observed conformation of the respective activation loops: Although the loop of CIPK23 is folded into a well-ordered structure that blocks the active site access to substrates, the loop of CIPK24/SOS2 protrudes out of the active site and allows catalysis. These structures together with biochemical and biophysical data show that CIPK kinase activity necessarily requires the coordinated releases of the activation loop from the active site and of the NAF motif from the nucleotide-binding site. Taken all together, we postulate the basis for a conserved calcium-dependent NAF-mediated regulation of CIPKs and a variable regulation by upstream kinases.

-	~~The entry 4czt is ON HOLD until Paper Publication~~	+	Structural basis of the regulatory mechanism of the plant CIPK family of protein kinases controlling ion homeostasis and abiotic stress.,Chaves-Sanjuan A, Sanchez-Barrena MJ, Gonzalez-Rubio JM, Moreno M, Ragel P, Jimenez M, Pardo JM, Martinez-Ripoll M, Quintero FJ, Albert A Proc Natl Acad Sci U S A. 2014 Oct 6. pii: 201407610. PMID:25288725<ref>PMID:25288725</ref>

-	~~Authors~~: Chaves-Sanjuan, A., Sanchez-Barrena, M.J.~~, Albert, A.~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of the kinase domain of SnRK3.23 At1g30270~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Non-specific serine/threonine protein kinase]]
		+	[[Category: Albert, A.]]
		+	[[Category: Chaves-Sanjuan, A.]]
		+	[[Category: Sanchez-Barrena, M J.]]
		+	[[Category: Potassium transport]]
		+	[[Category: Snrk3]]
		+	[[Category: Transferase]]

OCA at 07:01, 14 May 2014

OCA — Wed, 14 May 2014 07:01:56 GMT

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-	The entry 4czt is ON HOLD	+	The entry 4czt is ON HOLD until Paper Publication

	Authors: Chaves-Sanjuan, A., Sanchez-Barrena, M.J., Albert, A.		Authors: Chaves-Sanjuan, A., Sanchez-Barrena, M.J., Albert, A.

	Description: Crystal structure of the kinase domain of SnRK3.23 At1g30270		Description: Crystal structure of the kinase domain of SnRK3.23 At1g30270

OCA: Protected "4czt" [edit=sysop:move=sysop]

OCA — Wed, 30 Apr 2014 05:51:40 GMT

Protected "4czt" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:51, 30 April 2014

OCA: New page: '''Unreleased structure''' The entry 4czt is ON HOLD Authors: Chaves-Sanjuan, A., Sanchez-Barrena, M.J., Albert, A. Description: Crystal structure of the kinase domain of SnRK3.23 At1g...

OCA — Wed, 30 Apr 2014 05:51:39 GMT

New page: '''Unreleased structure''' The entry 4czt is ON HOLD Authors: Chaves-Sanjuan, A., Sanchez-Barrena, M.J., Albert, A. Description: Crystal structure of the kinase domain of SnRK3.23 At1g...

New page

'''Unreleased structure'''

The entry 4czt is ON HOLD

Authors: Chaves-Sanjuan, A., Sanchez-Barrena, M.J., Albert, A.

Description: Crystal structure of the kinase domain of SnRK3.23 At1g30270