4czz - Revision history

OCA at 12:18, 20 December 2023

OCA — Wed, 20 Dec 2023 12:18:37 GMT

←Older revision		Revision as of 12:18, 20 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4czz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CZZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CZZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4czz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CZZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CZZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4czz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czz OCA], [https://pdbe.org/4czz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4czz RCSB], [https://www.ebi.ac.uk/pdbsum/4czz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4czz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4czz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czz OCA], [https://pdbe.org/4czz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4czz RCSB], [https://www.ebi.ac.uk/pdbsum/4czz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4czz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/KDM1A_HUMAN KDM1A_HUMAN]] Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development.<ref>PMID:12032298</ref> <ref>PMID:15620353</ref> <ref>PMID:16079795</ref> <ref>PMID:17805299</ref> <ref>PMID:20228790</ref>	+	[https://www.uniprot.org/uniprot/KDM1A_HUMAN KDM1A_HUMAN] Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development.<ref>PMID:12032298</ref> <ref>PMID:15620353</ref> <ref>PMID:16079795</ref> <ref>PMID:17805299</ref> <ref>PMID:20228790</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:40, 14 September 2022

OCA — Wed, 14 Sep 2022 07:40:28 GMT

←Older revision		Revision as of 07:40, 14 September 2022
Line 3:		Line 3:
	<StructureSection load='4czz' size='340' side='right'caption='[[4czz]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4czz' size='340' side='right'caption='[[4czz]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4czz]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CZZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4CZZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4czz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CZZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CZZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4czz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czz OCA], [~~http~~://pdbe.org/4czz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4czz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4czz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4czz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4czz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czz OCA], [https://pdbe.org/4czz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4czz RCSB], [https://www.ebi.ac.uk/pdbsum/4czz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4czz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/KDM1A_HUMAN KDM1A_HUMAN]] Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development.<ref>PMID:12032298</ref> <ref>PMID:15620353</ref> <ref>PMID:16079795</ref> <ref>PMID:17805299</ref> <ref>PMID:20228790</ref> ~~[[http://www.uniprot.org/uniprot/RCOR3_HUMAN RCOR3_HUMAN]] May act as a component of a corepressor complex that represses transcription (Potential).~~	+	[[https://www.uniprot.org/uniprot/KDM1A_HUMAN KDM1A_HUMAN]] Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development.<ref>PMID:12032298</ref> <ref>PMID:15620353</ref> <ref>PMID:16079795</ref> <ref>PMID:17805299</ref> <ref>PMID:20228790</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Lysine-specific histone demethylase\|Lysine-specific histone demethylase]]	+	*[[Lysine-specific histone demethylase 3D structures\|Lysine-specific histone demethylase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Andres~~, M E~~]]	+	[[Category: Andres ME]]
-	[[Category: Barrios~~, A P~~]]	+	[[Category: Barrios AP]]
-	[[Category: Battaglioli, E]]	+	[[Category: Battaglioli E]]
-	[[Category: Ciossani, G]]	+	[[Category: Ciossani G]]
-	[[Category: Gomez~~, A V~~]]	+	[[Category: Gomez AV]]
-	[[Category: Mattevi, A]]	+	[[Category: Mattevi A]]
-	[[Category: Saez~~, J E~~]]	+	[[Category: Saez JE]]
-	[[Category: Toffolo, E]]	+	[[Category: Toffolo E]]
-	~~[[Category: Corest]]~~	+
-	~~[[Category: Hdac1/2]]~~	+
-	~~[[Category: Lsd1]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Rcor2]]~~	+
-	~~[[Category: Rcor3~~]]	+

OCA at 09:40, 20 March 2019

OCA — Wed, 20 Mar 2019 09:40:04 GMT

←Older revision		Revision as of 09:40, 20 March 2019
Line 1:		Line 1:

	==Histone demethylase LSD1(KDM1A)-CoREST3 Complex==		==Histone demethylase LSD1(KDM1A)-CoREST3 Complex==
-	<StructureSection load='4czz' size='340' side='right' caption='[[4czz]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='4czz' size='340' side='right'caption='[[4czz]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4czz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CZZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CZZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4czz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CZZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CZZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4czz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czz OCA], [http://pdbe.org/4czz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4czz RCSB], [http://www.ebi.ac.uk/pdbsum/4czz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4czz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4czz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czz OCA], [http://pdbe.org/4czz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4czz RCSB], [http://www.ebi.ac.uk/pdbsum/4czz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4czz ProSAT]</span></td></tr>
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Andres, M E]]		[[Category: Andres, M E]]
	[[Category: Barrios, A P]]		[[Category: Barrios, A P]]

OCA at 08:06, 4 August 2016

OCA — Thu, 04 Aug 2016 08:06:50 GMT

←Older revision		Revision as of 08:06, 4 August 2016
Line 1:		Line 1:
		+
	==Histone demethylase LSD1(KDM1A)-CoREST3 Complex==		==Histone demethylase LSD1(KDM1A)-CoREST3 Complex==
	<StructureSection load='4czz' size='340' side='right' caption='[[4czz]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4czz' size='340' side='right' caption='[[4czz]], [[Resolution\|resolution]] 3.00Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4czz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CZZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CZZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4czz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CZZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CZZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4czz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4czz RCSB], [http://www.ebi.ac.uk/pdbsum/4czz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4czz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czz OCA], [http://pdbe.org/4czz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4czz RCSB], [http://www.ebi.ac.uk/pdbsum/4czz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4czz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4czz" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Lysine-specific histone demethylase\|Lysine-specific histone demethylase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:12, 25 December 2014

OCA — Thu, 25 Dec 2014 07:12:07 GMT

←Older revision		Revision as of 07:12, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4czz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4czz RCSB], [http://www.ebi.ac.uk/pdbsum/4czz PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4czz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4czz RCSB], [http://www.ebi.ac.uk/pdbsum/4czz PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KDM1A_HUMAN KDM1A_HUMAN]] Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development.<ref>PMID:12032298</ref> <ref>PMID:15620353</ref> <ref>PMID:16079795</ref> <ref>PMID:17805299</ref> <ref>PMID:20228790</ref> [[http://www.uniprot.org/uniprot/RCOR3_HUMAN RCOR3_HUMAN]] May act as a component of a corepressor complex that represses transcription (Potential).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Andres, M E.]]	+	[[Category: Andres, M E]]
-	[[Category: Barrios, A P.]]	+	[[Category: Barrios, A P]]
-	[[Category: Battaglioli, E.]]	+	[[Category: Battaglioli, E]]
-	[[Category: Ciossani, G.]]	+	[[Category: Ciossani, G]]
-	[[Category: Gomez, A V.]]	+	[[Category: Gomez, A V]]
-	[[Category: Mattevi, A.]]	+	[[Category: Mattevi, A]]
-	[[Category: Saez, J E.]]	+	[[Category: Saez, J E]]
-	[[Category: Toffolo, E.]]	+	[[Category: Toffolo, E]]
	[[Category: Corest]]		[[Category: Corest]]
	[[Category: Hdac1/2]]		[[Category: Hdac1/2]]

OCA at 08:54, 20 October 2014

OCA — Mon, 20 Oct 2014 08:54:13 GMT

←Older revision		Revision as of 08:54, 20 October 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4czz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CZZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CZZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4czz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CZZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CZZ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4czz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4czz RCSB], [http://www.ebi.ac.uk/pdbsum/4czz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4czz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4czz RCSB], [http://www.ebi.ac.uk/pdbsum/4czz PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 08:48, 11 June 2014

OCA — Wed, 11 Jun 2014 08:48:55 GMT

←Older revision		Revision as of 08:48, 11 June 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Histone demethylase LSD1(KDM1A)-CoREST3 Complex==
		+	<StructureSection load='4czz' size='340' side='right' caption='[[4czz]], [[Resolution\|resolution]] 3.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4czz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CZZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CZZ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4czz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4czz RCSB], [http://www.ebi.ac.uk/pdbsum/4czz PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mammalian genomes harbor three CoREST genes. rcor1 encodes CoREST (CoREST1) and the paralogues rcor2 and rcor3 encode CoREST2 and CoREST3, respectively. Here, we describe specific properties of transcriptional complexes formed by CoREST proteins with the histone demethylase LSD1/KDM1A and histone deacetylases HDAC1/2 and the finding that all three CoRESTs express in the adult rat brain. CoRESTs interact equally strong with LSD1/KDM1A. Structural analysis shows that the overall conformation of CoREST3 is similar to that of CoREST1 complexed with LSD1/KDM1A. Nonetheless, transcriptional repressive capacity of CoREST3 is lower than that of CoREST1, which correlates with the observation that CoREST3 leads to a reduced LSD1/KDM1A catalytic efficiency. Also, CoREST2 shows a lower transcriptional repression than CoREST1, which is resistant to HDAC inhibitors. CoREST2 displays lower interaction with HDAC1/2 which is barely present in LSD1/KDM1A-CoREST2 complexes. A non-conserved Leucine in the first SANT domain of CoREST2 severely weakens its association to HDAC1/2. Furthermore, CoREST2 mutants with either increased or lacking HDAC1/2 interaction feature equivalent transcriptional repression capacities, indicating that CoREST2 represses in a HDAC-independent manner. In conclusion, differences among CoREST proteins are instrumental to the modulation of protein-protein interactions and catalytic activities of LSD1/KDM1A-CoREST-HDAC complexes, fine tuning gene expression regulation.

-	~~The entry 4czz is ON HOLD until Paper Publication~~	+	Differential properties of transcriptional complexes formed by the CoREST family.,Barrios AP, Gomez AV, Saez JE, Ciossani G, Toffolo E, Battaglioli E, Mattevi A, Andres ME Mol Cell Biol. 2014 May 12. PMID:24820421<ref>PMID:24820421</ref>

-	~~Authors: Barrios~~, A.P., ~~Gomez~~, A.V., ~~Saez, J.~~E., Ciossani, G., ~~Toffolo, E~~.~~, Battaglioli, E.,~~ Mattevi, A., ~~Andres, M~~.E.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Histone demethylase LSD1(KDM1A)-CoREST3 Complex~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Andres, M E.]]
		+	[[Category: Barrios, A P.]]
		+	[[Category: Battaglioli, E.]]
		+	[[Category: Ciossani, G.]]
		+	[[Category: Gomez, A V.]]
		+	[[Category: Mattevi, A.]]
		+	[[Category: Saez, J E.]]
		+	[[Category: Toffolo, E.]]
		+	[[Category: Corest]]
		+	[[Category: Hdac1/2]]
		+	[[Category: Lsd1]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Rcor2]]
		+	[[Category: Rcor3]]

OCA: Protected "4czz" [edit=sysop:move=sysop]

OCA — Wed, 30 Apr 2014 05:52:01 GMT

Protected "4czz" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:52, 30 April 2014

OCA: New page: '''Unreleased structure''' The entry 4czz is ON HOLD until Paper Publication Authors: Barrios, A.P., Gomez, A.V., Saez, J.E., Ciossani, G., Toffolo, E., Battaglioli, E., Mattevi, A., An...

OCA — Wed, 30 Apr 2014 05:51:59 GMT

New page: '''Unreleased structure''' The entry 4czz is ON HOLD until Paper Publication Authors: Barrios, A.P., Gomez, A.V., Saez, J.E., Ciossani, G., Toffolo, E., Battaglioli, E., Mattevi, A., An...

New page

'''Unreleased structure'''

The entry 4czz is ON HOLD until Paper Publication

Authors: Barrios, A.P., Gomez, A.V., Saez, J.E., Ciossani, G., Toffolo, E., Battaglioli, E., Mattevi, A., Andres, M.E.

Description: Histone demethylase LSD1(KDM1A)-CoREST3 Complex