4d3g - Revision history

OCA at 12:19, 20 December 2023

OCA — Wed, 20 Dec 2023 12:19:59 GMT

←Older revision		Revision as of 12:19, 20 December 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4d3g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D3G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D3G FirstGlance]. <br>		<table><tr><td colspan='2'>[[4d3g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D3G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D3G FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d3g OCA], [https://pdbe.org/4d3g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d3g RCSB], [https://www.ebi.ac.uk/pdbsum/4d3g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d3g ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d3g OCA], [https://pdbe.org/4d3g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d3g RCSB], [https://www.ebi.ac.uk/pdbsum/4d3g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d3g ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/Q2G229_STAA8 Q2G229_STAA8]]	+	[https://www.uniprot.org/uniprot/Q2G229_STAA8 Q2G229_STAA8]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:45, 14 September 2022

OCA — Wed, 14 Sep 2022 07:45:27 GMT

←Older revision		Revision as of 07:45, 14 September 2022
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	<StructureSection load='4d3g' size='340' side='right'caption='[[4d3g]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4d3g' size='340' side='right'caption='[[4d3g]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4d3g]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus~~ aureus~~" (rosenbach 1884) zopf 1885~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D3G OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4D3G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4d3g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D3G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D3G FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d3h\|4d3h]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d3g OCA], [https://pdbe.org/4d3g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d3g RCSB], [https://www.ebi.ac.uk/pdbsum/4d3g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d3g ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4d3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d3g OCA], [~~http~~://pdbe.org/4d3g PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4d3g RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4d3g PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4d3g ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/Q2G229_STAA8 Q2G229_STAA8]]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Campeotto, I~~]]	+	[[Category: Staphylococcus aureus]]
-	[[Category: ~~Freemont, P~~]]	+	[[Category: Campeotto I]]
-	[[Category: ~~Grundling, A~~]]	+	[[Category: Freemont P]]
-	[[Category: ~~C-di-amp]]~~	+	[[Category: Grundling A]]
-	~~[[Category: Gram-positive]]~~	+
-	~~[[Category: Psta]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 09:03, 20 March 2019

OCA — Wed, 20 Mar 2019 09:03:20 GMT

←Older revision		Revision as of 09:03, 20 March 2019
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	==Structure of PstA==		==Structure of PstA==
-	<StructureSection load='4d3g' size='340' side='right' caption='[[4d3g]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='4d3g' size='340' side='right'caption='[[4d3g]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4d3g]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D3G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D3G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4d3g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D3G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D3G FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d3h\|4d3h]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d3h\|4d3h]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d3g OCA], [http://pdbe.org/4d3g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d3g RCSB], [http://www.ebi.ac.uk/pdbsum/4d3g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4d3g ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d3g OCA], [http://pdbe.org/4d3g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d3g RCSB], [http://www.ebi.ac.uk/pdbsum/4d3g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4d3g ProSAT]</span></td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Campeotto, I]]		[[Category: Campeotto, I]]
	[[Category: Freemont, P]]		[[Category: Freemont, P]]

OCA at 02:47, 11 December 2016

OCA — Sun, 11 Dec 2016 02:47:36 GMT

←Older revision		Revision as of 02:47, 11 December 2016
Line 1:		Line 1:
		+
	==Structure of PstA==		==Structure of PstA==
	<StructureSection load='4d3g' size='340' side='right' caption='[[4d3g]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4d3g' size='340' side='right' caption='[[4d3g]], [[Resolution\|resolution]] 3.00Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4d3g]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D3G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D3G FirstGlance]. <br>		<table><tr><td colspan='2'>[[4d3g]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D3G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D3G FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d3h\|4d3h]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d3h\|4d3h]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d3g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d3g RCSB], [http://www.ebi.ac.uk/pdbsum/4d3g PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d3g OCA], [http://pdbe.org/4d3g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d3g RCSB], [http://www.ebi.ac.uk/pdbsum/4d3g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4d3g ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4d3g" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:20, 31 December 2014

OCA — Wed, 31 Dec 2014 09:20:30 GMT

←Older revision		Revision as of 09:20, 31 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d3g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d3g RCSB], [http://www.ebi.ac.uk/pdbsum/4d3g PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d3g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d3g RCSB], [http://www.ebi.ac.uk/pdbsum/4d3g PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Signaling nucleotides are integral parts of signal transduction systems allowing bacteria to cope with and rapidly respond to changes in the environment. The Staphylococcus aureus PII-like signal transduction protein PstA was recently identified as a cyclic diadenylate monophosphate (c-di-AMP) binding protein. Here, we present the crystal structures of the apo and c-di-AMP bound PstA protein, which is trimeric in solution as well as in the crystals. The structures combined with a detailed bioinformatics analysis revealed that the protein belongs to a new family of proteins with a similar core fold but with distinct features to classical PII proteins, which usually function in nitrogen metabolism pathways in bacteria. The complex structure revealed three identical c-di-AMP binding sites per trimer with each binding site at a monomer-monomer interface. While distinctly different from other cyclic-di-nucleotide binding sites, as the half binding sites are not symmetrical, the complex structure also highlighted common features for c-di-AMP binding sites. A comparison between the apo and complex structures reveal a series of conformational changes that result in the ordering of two anti-parallel beta-strands that protrude from each monomer and allowed us to propose a mechanism on how the PstA protein functions as a signaling transduction protein.
		+
		+	Complex Structure and Biochemical Characterization of the Staphylococcus aureus cyclic di-AMP binding Protein PstA, the Founding Member of a New Signal Transduction Protein Family.,Campeotto I, Zhang Y, Mladenov MG, Freemont PS, Grundling A J Biol Chem. 2014 Dec 11. pii: jbc.M114.621789. PMID:25505271<ref>PMID:25505271</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:04, 24 December 2014

OCA — Wed, 24 Dec 2014 11:04:51 GMT

←Older revision		Revision as of 11:04, 24 December 2014
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-	'''~~Unreleased structure~~'''	+	==Structure of PstA==
-		+	<StructureSection load='4d3g' size='340' side='right' caption='[[4d3g]], [[Resolution\|resolution]] 3.00Å' scene=''>
-	~~The entry~~ 4d3g is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4d3g]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D3G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D3G FirstGlance]. <br>
-	~~Authors~~: ~~Campeotto~~, I., ~~Freemont~~, P., Grundling, A.	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d3h\|4d3h]]</td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d3g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d3g RCSB], [http://www.ebi.ac.uk/pdbsum/4d3g PDBsum]</span></td></tr>
-	~~Description~~: ~~Structure of PstA~~	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Campeotto, I]]
		+	[[Category: Freemont, P]]
		+	[[Category: Grundling, A]]
		+	[[Category: C-di-amp]]
		+	[[Category: Gram-positive]]
		+	[[Category: Psta]]
		+	[[Category: Signaling protein]]

OCA: Protected "4d3g" [edit=sysop:move=sysop]

OCA — Wed, 29 Oct 2014 09:46:18 GMT

Protected "4d3g" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:46, 29 October 2014

OCA: New page: '''Unreleased structure''' The entry 4d3g is ON HOLD until Paper Publication Authors: Campeotto, I., Freemont, P., Grundling, A. Description: Structure of PstA

OCA — Wed, 29 Oct 2014 09:46:17 GMT

New page: '''Unreleased structure''' The entry 4d3g is ON HOLD until Paper Publication Authors: Campeotto, I., Freemont, P., Grundling, A. Description: Structure of PstA

New page

'''Unreleased structure'''

The entry 4d3g is ON HOLD until Paper Publication

Authors: Campeotto, I., Freemont, P., Grundling, A.

Description: Structure of PstA