4d4q - Revision history

OCA at 07:47, 14 September 2022

OCA — Wed, 14 Sep 2022 07:47:22 GMT

←Older revision		Revision as of 07:47, 14 September 2022
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	<StructureSection load='4d4q' size='340' side='right'caption='[[4d4q]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='4d4q' size='340' side='right'caption='[[4d4q]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4d4q]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D4Q OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4D4Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4d4q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D4Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D4Q FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d4o\|4d4o]], [[4d4p\|4d4p]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d4q OCA], [https://pdbe.org/4d4q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d4q RCSB], [https://www.ebi.ac.uk/pdbsum/4d4q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d4q ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4d4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d4q OCA], [~~http~~://pdbe.org/4d4q PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4d4q RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4d4q PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4d4q ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ATS1_YEAST ATS1_YEAST]] May participate in regulatory interactions between microtubules and the cell cycle.	+	[[https://www.uniprot.org/uniprot/ATS1_YEAST ATS1_YEAST]] May participate in regulatory interactions between microtubules and the cell cycle.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Glatt, S~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: ~~Mueller, C W~~]]	+	[[Category: Glatt S]]
-	[[Category: ~~Diphthamide modification]]~~	+	[[Category: Mueller CW]]
-	~~[[Category: Translation]]~~	+
-	~~[[Category: Trna modification~~]]	+

OCA at 09:49, 20 March 2019

OCA — Wed, 20 Mar 2019 09:49:34 GMT

←Older revision		Revision as of 09:49, 20 March 2019
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	==Crystal Structure of Kti13/AtS1==		==Crystal Structure of Kti13/AtS1==
-	<StructureSection load='4d4q' size='340' side='right' caption='[[4d4q]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='4d4q' size='340' side='right'caption='[[4d4q]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4d4q]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D4Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D4Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4d4q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D4Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D4Q FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d4o\|4d4o]], [[4d4p\|4d4p]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d4o\|4d4o]], [[4d4p\|4d4p]]</td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Glatt, S]]		[[Category: Glatt, S]]
	[[Category: Mueller, C W]]		[[Category: Mueller, C W]]

OCA at 07:09, 29 March 2017

OCA — Wed, 29 Mar 2017 07:09:47 GMT

←Older revision		Revision as of 07:09, 29 March 2017
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-	==Structure of ~~the Kti11~~ Kti13 ~~heterodimer and its double role in modifications of tRNA and eukaryotic Elongation Factor 2~~==	+	==Crystal Structure of Kti13/AtS1==
	<StructureSection load='4d4q' size='340' side='right' caption='[[4d4q]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='4d4q' size='340' side='right' caption='[[4d4q]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 12:15, 11 August 2016

OCA — Thu, 11 Aug 2016 12:15:27 GMT

←Older revision		Revision as of 12:15, 11 August 2016
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		+
	==Structure of the Kti11 Kti13 heterodimer and its double role in modifications of tRNA and eukaryotic Elongation Factor 2==		==Structure of the Kti11 Kti13 heterodimer and its double role in modifications of tRNA and eukaryotic Elongation Factor 2==
	<StructureSection load='4d4q' size='340' side='right' caption='[[4d4q]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='4d4q' size='340' side='right' caption='[[4d4q]], [[Resolution\|resolution]] 2.40Å' scene=''>
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	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d4o\|4d4o]], [[4d4p\|4d4p]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d4o\|4d4o]], [[4d4p\|4d4p]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d4q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d4q RCSB], [http://www.ebi.ac.uk/pdbsum/4d4q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d4q OCA], [http://pdbe.org/4d4q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d4q RCSB], [http://www.ebi.ac.uk/pdbsum/4d4q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4d4q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4d4q" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:31, 14 January 2015

OCA — Wed, 14 Jan 2015 13:31:05 GMT

←Older revision		Revision as of 13:31, 14 January 2015
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-	'''~~Unreleased~~ structure'''	+	==Structure of the Kti11 Kti13 heterodimer and its double role in modifications of tRNA and eukaryotic Elongation Factor 2==
		+	<StructureSection load='4d4q' size='340' side='right' caption='[[4d4q]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4d4q]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D4Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D4Q FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d4o\|4d4o]], [[4d4p\|4d4p]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d4q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d4q RCSB], [http://www.ebi.ac.uk/pdbsum/4d4q PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ATS1_YEAST ATS1_YEAST]] May participate in regulatory interactions between microtubules and the cell cycle.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The small, highly conserved Kti11 alias Dph3 protein encoded by the Kluyveromyces lactis killer toxin insensitive gene KTI11/DPH3 is involved in the diphthamide modification of eukaryotic elongation factor 2 and, together with Kti13, in Elongator-dependent tRNA wobble base modifications, thereby affecting the speed and accuracy of protein biosynthesis through two distinct mechanisms. We have solved the crystal structures of Saccharomyces cerevisiae Kti13 and the Kti11/Kti13 heterodimer at 2.4 and 2.9 A resolution, respectively, and validated interacting residues through mutational analysis in vitro and in vivo. We show that metal coordination by Kti11 and its heterodimerization with Kti13 are essential for both translational control mechanisms. Our structural and functional analyses identify Kti13 as an additional component of the diphthamide modification pathway and provide insight into the molecular mechanisms that allow the Kti11/Kti13 heterodimer to coregulate two consecutive steps in ribosomal protein synthesis.

-	~~The entry 4d4q is ON HOLD until Paper Publication~~	+	Structure of the Kti11/Kti13 Heterodimer and Its Double Role in Modifications of tRNA and Eukaryotic Elongation Factor 2.,Glatt S, Zabel R, Vonkova I, Kumar A, Netz DJ, Pierik AJ, Rybin V, Lill R, Gavin AC, Balbach J, Breunig KD, Muller CW Structure. 2015 Jan 6;23(1):149-60. doi: 10.1016/j.str.2014.11.008. Epub 2014 Dec, 24. PMID:25543256<ref>PMID:25543256</ref>

-	~~Authors: Glatt~~, S.~~, Mueller, C.W~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: Structure of the Kti11 Kti13 heterodimer and its double role in modifications of tRNA and eukaryotic Elongation Factor 2~~	+	== References ==
-	~~[[Category: Unreleased Structures]]~~	+	<references/>
-	~~[[Category: Mueller, C.W]]~~	+	__TOC__
		+	</StructureSection>
	[[Category: Glatt, S]]		[[Category: Glatt, S]]
		+	[[Category: Mueller, C W]]
		+	[[Category: Diphthamide modification]]
		+	[[Category: Translation]]
		+	[[Category: Trna modification]]

OCA at 13:48, 24 December 2014

OCA — Wed, 24 Dec 2014 13:48:09 GMT

←Older revision		Revision as of 13:48, 24 December 2014
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	Description: Structure of the Kti11 Kti13 heterodimer and its double role in modifications of tRNA and eukaryotic Elongation Factor 2		Description: Structure of the Kti11 Kti13 heterodimer and its double role in modifications of tRNA and eukaryotic Elongation Factor 2
		+	[[Category: Unreleased Structures]]
		+	[[Category: Mueller, C.W]]
		+	[[Category: Glatt, S]]

OCA at 11:06, 19 November 2014

OCA — Wed, 19 Nov 2014 11:06:22 GMT

←Older revision		Revision as of 11:06, 19 November 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4d4q is ON HOLD	+	The entry 4d4q is ON HOLD until Paper Publication

	Authors: Glatt, S., Mueller, C.W.		Authors: Glatt, S., Mueller, C.W.

	Description: Structure of the Kti11 Kti13 heterodimer and its double role in modifications of tRNA and eukaryotic Elongation Factor 2		Description: Structure of the Kti11 Kti13 heterodimer and its double role in modifications of tRNA and eukaryotic Elongation Factor 2

OCA: Protected "4d4q" [edit=sysop:move=sysop]

OCA — Wed, 05 Nov 2014 07:20:39 GMT

Protected "4d4q" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:20, 5 November 2014

OCA: New page: '''Unreleased structure''' The entry 4d4q is ON HOLD Authors: Glatt, S., Mueller, C.W. Description: Structure of the Kti11 Kti13 heterodimer and its double role in modifications of tRN...

OCA — Wed, 05 Nov 2014 07:20:38 GMT

New page: '''Unreleased structure''' The entry 4d4q is ON HOLD Authors: Glatt, S., Mueller, C.W. Description: Structure of the Kti11 Kti13 heterodimer and its double role in modifications of tRN...

New page

'''Unreleased structure'''

The entry 4d4q is ON HOLD

Authors: Glatt, S., Mueller, C.W.

Description: Structure of the Kti11 Kti13 heterodimer and its double role in modifications of tRNA and eukaryotic Elongation Factor 2