4d5h - Revision history

OCA at 12:21, 20 December 2023

OCA — Wed, 20 Dec 2023 12:21:04 GMT

←Older revision		Revision as of 12:21, 20 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4d5h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D5H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D5H FirstGlance]. <br>		<table><tr><td colspan='2'>[[4d5h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D5H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D5H FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9RM:6-METHYL-5-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}-1,2,4-TRIAZIN-3(4H)-ONE'>9RM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.75Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9RM:6-METHYL-5-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}-1,2,4-TRIAZIN-3(4H)-ONE'>9RM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d5h OCA], [https://pdbe.org/4d5h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d5h RCSB], [https://www.ebi.ac.uk/pdbsum/4d5h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d5h ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d5h OCA], [https://pdbe.org/4d5h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d5h RCSB], [https://www.ebi.ac.uk/pdbsum/4d5h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d5h ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FAK1_CHICK FAK1_CHICK]] Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development, embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), ephrin receptors, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Regulates P53/TP53 activity and stability. Phosphorylates SRC; this increases SRC kinase activity. Isoform 2 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling.<ref>PMID:15494733</ref> <ref>PMID:15494734</ref> <ref>PMID:15494732</ref> <ref>PMID:20705914</ref> <ref>PMID:21852560</ref> <ref>PMID:21937583</ref>	+	[https://www.uniprot.org/uniprot/FAK1_CHICK FAK1_CHICK] Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development, embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), ephrin receptors, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Regulates P53/TP53 activity and stability. Phosphorylates SRC; this increases SRC kinase activity. Isoform 2 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling.<ref>PMID:15494733</ref> <ref>PMID:15494734</ref> <ref>PMID:15494732</ref> <ref>PMID:20705914</ref> <ref>PMID:21852560</ref> <ref>PMID:21937583</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:48, 14 September 2022

OCA — Wed, 14 Sep 2022 07:48:06 GMT

←Older revision		Revision as of 07:48, 14 September 2022
Line 3:		Line 3:
	<StructureSection load='4d5h' size='340' side='right'caption='[[4d5h]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='4d5h' size='340' side='right'caption='[[4d5h]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4d5h]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Chick Chick~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D5H OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4D5H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4d5h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D5H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D5H FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9RM:6-METHYL-5-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}-1,2,4-TRIAZIN-3(4H)-ONE'>9RM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9RM:6-METHYL-5-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}-1,2,4-TRIAZIN-3(4H)-ONE'>9RM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d4r\|4d4r]], [[4d4s\|4d4s]], [[4d4v\|4d4v]], [[4d4y\|4d4y]], [[4d55\|4d55]], [[4d58\|4d58]], [[4d5k\|4d5k]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d5h OCA], [https://pdbe.org/4d5h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d5h RCSB], [https://www.ebi.ac.uk/pdbsum/4d5h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d5h ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4d5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d5h OCA], [~~http~~://pdbe.org/4d5h PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4d5h RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4d5h PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4d5h ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FAK1_CHICK FAK1_CHICK]] Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development, embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), ephrin receptors, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Regulates P53/TP53 activity and stability. Phosphorylates SRC; this increases SRC kinase activity. Isoform 2 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling.<ref>PMID:15494733</ref> <ref>PMID:15494734</ref> <ref>PMID:15494732</ref> <ref>PMID:20705914</ref> <ref>PMID:21852560</ref> <ref>PMID:21937583</ref>	+	[[https://www.uniprot.org/uniprot/FAK1_CHICK FAK1_CHICK]] Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development, embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), ephrin receptors, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Regulates P53/TP53 activity and stability. Phosphorylates SRC; this increases SRC kinase activity. Isoform 2 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling.<ref>PMID:15494733</ref> <ref>PMID:15494734</ref> <ref>PMID:15494732</ref> <ref>PMID:20705914</ref> <ref>PMID:21852560</ref> <ref>PMID:21937583</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:

	==See Also==		==See Also==
-	*[[Focal adhesion kinase\|Focal adhesion kinase]]	+	*[[Focal adhesion kinase 3D structures\|Focal adhesion kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Chick~~]]	+	[[Category: Gallus gallus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Non-specific protein-tyrosine kinase]]~~	+	[[Category: Le Coq J]]
-	~~[[Category:~~ Coq, J Le]]	+	[[Category: Lietha D]]
-	[[Category: Lietha, D]]	+	[[Category: Lin A]]
-	[[Category: Lin, A]]	+
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Integrin signaling]]~~	+
-	~~[[Category: Kinase inhibitor]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 07:38, 27 March 2019

OCA — Wed, 27 Mar 2019 07:38:07 GMT

←Older revision		Revision as of 07:38, 27 March 2019
Line 1:		Line 1:

	==Focal Adhesion Kinase catalytic domain==		==Focal Adhesion Kinase catalytic domain==
-	<StructureSection load='4d5h' size='340' side='right' caption='[[4d5h]], [[Resolution\|resolution]] 1.75Å' scene=''>	+	<StructureSection load='4d5h' size='340' side='right'caption='[[4d5h]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4d5h]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D5H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D5H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4d5h]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D5H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D5H FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9RM:6-METHYL-5-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}-1,2,4-TRIAZIN-3(4H)-ONE'>9RM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9RM:6-METHYL-5-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}-1,2,4-TRIAZIN-3(4H)-ONE'>9RM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d4r\|4d4r]], [[4d4s\|4d4s]], [[4d4v\|4d4v]], [[4d4y\|4d4y]], [[4d55\|4d55]], [[4d58\|4d58]], [[4d5k\|4d5k]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d4r\|4d4r]], [[4d4s\|4d4s]], [[4d4v\|4d4v]], [[4d4y\|4d4y]], [[4d55\|4d55]], [[4d58\|4d58]], [[4d5k\|4d5k]]</td></tr>
Line 27:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Chick]]
		+	[[Category: Large Structures]]
	[[Category: Non-specific protein-tyrosine kinase]]		[[Category: Non-specific protein-tyrosine kinase]]
	[[Category: Coq, J Le]]		[[Category: Coq, J Le]]

OCA at 02:49, 11 December 2016

OCA — Sun, 11 Dec 2016 02:49:13 GMT

←Older revision		Revision as of 02:49, 11 December 2016
Line 1:		Line 1:
		+
	==Focal Adhesion Kinase catalytic domain==		==Focal Adhesion Kinase catalytic domain==
	<StructureSection load='4d5h' size='340' side='right' caption='[[4d5h]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='4d5h' size='340' side='right' caption='[[4d5h]], [[Resolution\|resolution]] 1.75Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d4r\|4d4r]], [[4d4s\|4d4s]], [[4d4v\|4d4v]], [[4d4y\|4d4y]], [[4d55\|4d55]], [[4d58\|4d58]], [[4d5k\|4d5k]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d4r\|4d4r]], [[4d4s\|4d4s]], [[4d4v\|4d4v]], [[4d4y\|4d4y]], [[4d55\|4d55]], [[4d58\|4d58]], [[4d5k\|4d5k]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d5h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d5h RCSB], [http://www.ebi.ac.uk/pdbsum/4d5h PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d5h OCA], [http://pdbe.org/4d5h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d5h RCSB], [http://www.ebi.ac.uk/pdbsum/4d5h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4d5h ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4d5h" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Focal adhesion kinase\|Focal adhesion kinase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:55, 18 February 2015

OCA — Wed, 18 Feb 2015 12:55:51 GMT

←Older revision		Revision as of 12:55, 18 February 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Focal Adhesion Kinase catalytic domain==
		+	<StructureSection load='4d5h' size='340' side='right' caption='[[4d5h]], [[Resolution\|resolution]] 1.75Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4d5h]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D5H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D5H FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9RM:6-METHYL-5-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}-1,2,4-TRIAZIN-3(4H)-ONE'>9RM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d4r\|4d4r]], [[4d4s\|4d4s]], [[4d4v\|4d4v]], [[4d4y\|4d4y]], [[4d55\|4d55]], [[4d58\|4d58]], [[4d5k\|4d5k]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d5h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d5h RCSB], [http://www.ebi.ac.uk/pdbsum/4d5h PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FAK1_CHICK FAK1_CHICK]] Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development, embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), ephrin receptors, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Regulates P53/TP53 activity and stability. Phosphorylates SRC; this increases SRC kinase activity. Isoform 2 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling.<ref>PMID:15494733</ref> <ref>PMID:15494734</ref> <ref>PMID:15494732</ref> <ref>PMID:20705914</ref> <ref>PMID:21852560</ref> <ref>PMID:21937583</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase that regulates cell signaling, proliferation, migration, and development. A major mechanism of regulation of FAK activity is an intramolecular autoinhibitory interaction between two of its domains-the catalytic and FERM domains. Upon cell adhesion to the extracellular matrix, FAK is being translocated toward focal adhesion sites and activated. Interactions of FAK with phosphoinositide phosphatidylinsositol-4,5-bis-phosphate (PIP2) are required to activate FAK. However, the molecular mechanism of the activation remains poorly understood. Recent fluorescence resonance energy transfer experiments revealed a closure of the FERM-kinase interface upon ATP binding, which is reversed upon additional binding of PIP2. Here, we addressed the allosteric regulation of FAK by performing all-atom molecular-dynamics simulations of a FAK fragment containing the catalytic and FERM domains, and comparing the dynamics in the absence or presence of ATP and PIP2. As a major conformational change, we observe a closing and opening motion upon ATP and additional PIP2 binding, respectively, in good agreement with the fluorescence resonance energy transfer experiments. To reveal how the binding of the regulatory PIP2 to the FERM F2 lobe is transduced to the very distant F1/N-lobe interface, we employed force distribution analysis. We identified a network of mainly charged residue-residue interactions spanning from the PIP2 binding site to the distant interface between the kinase and FERM domains, comprising candidate residues for mutagenesis to validate the predicted mechanism of FAK activation.

-	~~The entry 4d5h is ON HOLD until Paper Publication~~	+	Allosteric Regulation of Focal Adhesion Kinase by PIP2 and ATP.,Zhou J, Bronowska A, Le Coq J, Lietha D, Grater F Biophys J. 2015 Feb 3;108(3):698-705. doi: 10.1016/j.bpj.2014.11.3454. PMID:25650936<ref>PMID:25650936</ref>

-	~~Authors: Le Coq~~, J.~~, Lin, A~~.~~, Lietha, D~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: Focal Adhesion Kinase catalytic domain~~	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
-	[[Category: Le Coq, J]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Non-specific protein-tyrosine kinase]]
		+	[[Category: Coq, J Le]]
		+	[[Category: Lietha, D]]
	[[Category: Lin, A]]		[[Category: Lin, A]]
-	[[Category: ~~Lietha, D~~]]	+	[[Category: Atp-binding]]
		+	[[Category: Integrin signaling]]
		+	[[Category: Kinase inhibitor]]
		+	[[Category: Transferase]]

OCA at 13:50, 24 December 2014

OCA — Wed, 24 Dec 2014 13:50:41 GMT

←Older revision		Revision as of 13:50, 24 December 2014
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	Description: Focal Adhesion Kinase catalytic domain		Description: Focal Adhesion Kinase catalytic domain
		+	[[Category: Unreleased Structures]]
		+	[[Category: Le Coq, J]]
		+	[[Category: Lin, A]]
		+	[[Category: Lietha, D]]

OCA at 06:26, 26 November 2014

OCA — Wed, 26 Nov 2014 06:26:17 GMT

←Older revision		Revision as of 06:26, 26 November 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4d5h is ON HOLD	+	The entry 4d5h is ON HOLD until Paper Publication

	Authors: Le Coq, J., Lin, A., Lietha, D.		Authors: Le Coq, J., Lin, A., Lietha, D.

	Description: Focal Adhesion Kinase catalytic domain		Description: Focal Adhesion Kinase catalytic domain

OCA: Protected "4d5h" [edit=sysop:move=sysop]

OCA — Wed, 19 Nov 2014 11:07:31 GMT

Protected "4d5h" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:07, 19 November 2014

OCA: New page: '''Unreleased structure''' The entry 4d5h is ON HOLD Authors: Le Coq, J., Lin, A., Lietha, D. Description: Focal Adhesion Kinase catalytic domain

OCA — Wed, 19 Nov 2014 11:07:30 GMT

New page: '''Unreleased structure''' The entry 4d5h is ON HOLD Authors: Le Coq, J., Lin, A., Lietha, D. Description: Focal Adhesion Kinase catalytic domain

New page

'''Unreleased structure'''

The entry 4d5h is ON HOLD

Authors: Le Coq, J., Lin, A., Lietha, D.

Description: Focal Adhesion Kinase catalytic domain