4d62 - Revision history

OCA at 11:17, 9 May 2024

OCA — Thu, 09 May 2024 11:17:57 GMT

←Older revision		Revision as of 11:17, 9 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4d62]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Avirulent_turkey_hemorrhagic_enteritis_virus Avirulent turkey hemorrhagic enteritis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D62 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D62 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4d62]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Avirulent_turkey_hemorrhagic_enteritis_virus Avirulent turkey hemorrhagic enteritis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D62 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D62 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d62 OCA], [https://pdbe.org/4d62 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d62 RCSB], [https://www.ebi.ac.uk/pdbsum/4d62 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d62 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d62 OCA], [https://pdbe.org/4d62 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d62 RCSB], [https://www.ebi.ac.uk/pdbsum/4d62 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d62 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/Q2TLC1_9ADEN Q2TLC1_9ADEN]]	+	[https://www.uniprot.org/uniprot/Q2TLC1_9ADEN Q2TLC1_9ADEN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:48, 14 September 2022

OCA — Wed, 14 Sep 2022 07:48:53 GMT

←Older revision		Revision as of 07:48, 14 September 2022
Line 3:		Line 3:
	<StructureSection load='4d62' size='340' side='right'caption='[[4d62]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4d62' size='340' side='right'caption='[[4d62]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4d62]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Avirulent_turkey_hemorrhagic_enteritis_virus Avirulent turkey hemorrhagic enteritis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D62 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4D62 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4d62]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Avirulent_turkey_hemorrhagic_enteritis_virus Avirulent turkey hemorrhagic enteritis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D62 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D62 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d63\|4d63]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d62 OCA], [https://pdbe.org/4d62 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d62 RCSB], [https://www.ebi.ac.uk/pdbsum/4d62 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d62 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4d62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d62 OCA], [~~http~~://pdbe.org/4d62 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4d62 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4d62 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4d62 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/Q2TLC1_9ADEN Q2TLC1_9ADEN]]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 24:
	[[Category: Avirulent turkey hemorrhagic enteritis virus]]		[[Category: Avirulent turkey hemorrhagic enteritis virus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Raaij, M J.van]]~~	+	[[Category: Singh AK]]
-	[[Category: Singh~~, A K~~]]	+	[[Category: Van Raaij MJ]]
-	[[Category: ~~Viral protein~~]]	+

OCA at 09:57, 5 February 2020

OCA — Wed, 05 Feb 2020 09:57:54 GMT

←Older revision		Revision as of 09:57, 5 February 2020
Line 1:		Line 1:

	==Structure of the carboxy-terminal domain of the turkey type 3 siadenovirus fibre, avirulent form complexed with 3-sialyllactose.==		==Structure of the carboxy-terminal domain of the turkey type 3 siadenovirus fibre, avirulent form complexed with 3-sialyllactose.==
-	<StructureSection load='4d62' size='340' side='right' caption='[[4d62]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='4d62' size='340' side='right'caption='[[4d62]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4d62]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Avirulent_turkey_hemorrhagic_enteritis_virus Avirulent turkey hemorrhagic enteritis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D62 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D62 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4d62]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Avirulent_turkey_hemorrhagic_enteritis_virus Avirulent turkey hemorrhagic enteritis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D62 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D62 FirstGlance]. <br>
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Avirulent turkey hemorrhagic enteritis virus]]		[[Category: Avirulent turkey hemorrhagic enteritis virus]]
		+	[[Category: Large Structures]]
	[[Category: Raaij, M J.van]]		[[Category: Raaij, M J.van]]
	[[Category: Singh, A K]]		[[Category: Singh, A K]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 07:52, 17 January 2018

OCA — Wed, 17 Jan 2018 07:52:50 GMT

←Older revision		Revision as of 07:52, 17 January 2018
Line 1:		Line 1:
		+
	==Structure of the carboxy-terminal domain of the turkey type 3 siadenovirus fibre, avirulent form complexed with 3-sialyllactose.==		==Structure of the carboxy-terminal domain of the turkey type 3 siadenovirus fibre, avirulent form complexed with 3-sialyllactose.==
	<StructureSection load='4d62' size='340' side='right' caption='[[4d62]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4d62' size='340' side='right' caption='[[4d62]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4d62]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D62 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D62 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4d62]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Avirulent_turkey_hemorrhagic_enteritis_virus Avirulent turkey hemorrhagic enteritis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D62 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D62 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d63\|4d63]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d63\|4d63]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d62 OCA], [http://pdbe.org/4d62 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d62 RCSB], [http://www.ebi.ac.uk/pdbsum/4d62 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d62 OCA], [http://pdbe.org/4d62 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d62 RCSB], [http://www.ebi.ac.uk/pdbsum/4d62 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4d62 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Avirulent turkey hemorrhagic enteritis virus]]
	[[Category: Raaij, M J.van]]		[[Category: Raaij, M J.van]]
	[[Category: Singh, A K]]		[[Category: Singh, A K]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 03:54, 16 October 2015

OCA — Fri, 16 Oct 2015 03:54:22 GMT

←Older revision		Revision as of 03:54, 16 October 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Structure of the carboxy-terminal domain of the turkey type 3 siadenovirus fibre, avirulent form complexed with 3-sialyllactose.==
		+	<StructureSection load='4d62' size='340' side='right' caption='[[4d62]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4d62]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D62 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D62 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d63\|4d63]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d62 OCA], [http://pdbe.org/4d62 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d62 RCSB], [http://www.ebi.ac.uk/pdbsum/4d62 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The virulent form of turkey adenovirus 3 (TAdV-3), also known as turkey hemorrhagic enteritis virus (THEV), is an economically important poultry pathogen, while the avirulent form is used as a vaccine. TAdV-3 belongs to the genus Siadenovirus. The carboxy-terminal region of its fibre does not have significant sequence similarity to any other adenovirus fibre heads of known structure. Two amino acid sequence differences between virulent and avirulent TAdV-3 map on the fibre head: where virulent TAdV-3 contains Ile354 and Thr376, avirulent TAdV-3 contains Met354 and Met376. We determined the crystal structures of the trimeric virulent and avirulent TAdV-3 fibre head domains at 2.2 A resolution. Each monomer contains a beta-sandwich, which, surprisingly, resembles reovirus fibre head more than other adenovirus fibres, although the ABCJ-GHID topology is conserved in all. A beta-hairpin insertion in the C-strand of each trimer subunit embraces its neighbouring monomer. The avirulent and virulent TAdV-3 fibre heads are identical apart from the exact orientation of the beta-hairpin insertion. In vitro, sialyllactose was identified as a ligand by glycan microarray analysis, nuclear magnetic resonance spectroscopy, and crystallography. Its dissociation constant was measured to be in the mM range by isothermal titration calorimetry. The ligand binds to the side of the fibre head, involving amino acids Glu392, Thr419, Val420, Lys421, Asn422, and Gly423 binding to the sialic acid group. It binds slightly more strongly to the avirulent form. We propose that, in vivo, the TAdV-3 fibre may bind a sialic acid-containing cell surface component.

-	~~The entry 4d62 is ON HOLD until Paper Publication~~	+	Structure and Sialyllactose Binding of the Carboxy-Terminal Head Domain of the Fibre from a Siadenovirus, Turkey Adenovirus 3.,Singh AK, Berbis MA, Ballmann MZ, Kilcoyne M, Menendez M, Nguyen TH, Joshi L, Canada FJ, Jimenez-Barbero J, Benko M, Harrach B, van Raaij MJ PLoS One. 2015 Sep 29;10(9):e0139339. doi: 10.1371/journal.pone.0139339., eCollection 2015. PMID:26418008<ref>PMID:26418008</ref>

-	~~Authors: Singh~~, A.K.~~, van Raaij, M.J~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: Structure of the carboxy~~-~~terminal domain of the turkey type 3 siadenovirus fibre, avirulent form complexed with 3~~-~~sialyllactose.~~	+	<div class="pdbe-citations 4d62" style="background-color:#fffaf0;"></div>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	== References ==
-	[[Category: ~~Van~~ Raaij, M.J]]	+	<references/>
-	[[Category: Singh, A.K]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Raaij, M J.van]]
		+	[[Category: Singh, A K]]
		+	[[Category: Viral protein]]

OCA at 13:52, 24 December 2014

OCA — Wed, 24 Dec 2014 13:52:54 GMT

←Older revision		Revision as of 13:52, 24 December 2014
Line 6:		Line 6:

	Description: Structure of the carboxy-terminal domain of the turkey type 3 siadenovirus fibre, avirulent form complexed with 3-sialyllactose.		Description: Structure of the carboxy-terminal domain of the turkey type 3 siadenovirus fibre, avirulent form complexed with 3-sialyllactose.
		+	[[Category: Unreleased Structures]]
		+	[[Category: Van Raaij, M.J]]
		+	[[Category: Singh, A.K]]

OCA: Protected "4d62" [edit=sysop:move=sysop]

OCA — Wed, 19 Nov 2014 11:08:21 GMT

Protected "4d62" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:08, 19 November 2014

OCA: New page: '''Unreleased structure''' The entry 4d62 is ON HOLD until Paper Publication Authors: Singh, A.K., van Raaij, M.J. Description: Structure of the carboxy-terminal domain of the turkey t...

OCA — Wed, 19 Nov 2014 11:08:20 GMT

New page: '''Unreleased structure''' The entry 4d62 is ON HOLD until Paper Publication Authors: Singh, A.K., van Raaij, M.J. Description: Structure of the carboxy-terminal domain of the turkey t...

New page

'''Unreleased structure'''

The entry 4d62 is ON HOLD until Paper Publication

Authors: Singh, A.K., van Raaij, M.J.

Description: Structure of the carboxy-terminal domain of the turkey type 3 siadenovirus fibre, avirulent form complexed with 3-sialyllactose.