4d6g - Revision history

OCA at 12:21, 20 December 2023

OCA — Wed, 20 Dec 2023 12:21:30 GMT

←Older revision		Revision as of 12:21, 20 December 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4d6g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_SP3-BS71 Streptococcus pneumoniae SP3-BS71]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D6G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D6G FirstGlance]. <br>		<table><tr><td colspan='2'>[[4d6g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_SP3-BS71 Streptococcus pneumoniae SP3-BS71]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D6G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D6G FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.24Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d6g OCA], [https://pdbe.org/4d6g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d6g RCSB], [https://www.ebi.ac.uk/pdbsum/4d6g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d6g ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d6g OCA], [https://pdbe.org/4d6g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d6g RCSB], [https://www.ebi.ac.uk/pdbsum/4d6g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d6g ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:49, 14 September 2022

OCA — Wed, 14 Sep 2022 07:49:27 GMT

←Older revision		Revision as of 07:49, 14 September 2022
Line 3:		Line 3:
	<StructureSection load='4d6g' size='340' side='right'caption='[[4d6g]], [[Resolution\|resolution]] 1.24Å' scene=''>		<StructureSection load='4d6g' size='340' side='right'caption='[[4d6g]], [[Resolution\|resolution]] 1.24Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4d6g]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Streptococcus_pneumoniae_sp3~~-~~bs71~~ Streptococcus pneumoniae ~~sp3~~-~~bs71~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D6G OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4D6G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4d6g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_SP3-BS71 Streptococcus pneumoniae SP3-BS71]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D6G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D6G FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d6c\|4d6c]], [[4d6d\|4d6d]], [[4d6e\|4d6e]], [[4d6f\|4d6f]], [[4d6h\|4d6h]], [[4d6i\|4d6i]], [[4d6j\|4d6j]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d6g OCA], [https://pdbe.org/4d6g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d6g RCSB], [https://www.ebi.ac.uk/pdbsum/4d6g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d6g ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Blood-group-substance_endo-1,4-beta-galactosidase Blood-group-substance endo-1,4-beta-galactosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.102 3.2.1.102] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4d6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d6g OCA], [~~http~~://pdbe.org/4d6g PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4d6g RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4d6g PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4d6g ProSAT]</span></td></tr>	+
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 22:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Blood-group-substance endo-1,4-beta-galactosidase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Streptococcus pneumoniae ~~sp3~~-~~bs71~~]]	+	[[Category: Streptococcus pneumoniae SP3-BS71]]
-	[[Category: Boraston~~, A B~~]]	+	[[Category: Boraston AB]]
-	[[Category: Chapanian, R]]	+	[[Category: Chapanian R]]
-	[[Category: Constantinescu, I]]	+	[[Category: Constantinescu I]]
-	[[Category: Higgins~~, M A~~]]	+	[[Category: Higgins MA]]
-	[[Category: Kizhakkedathu~~, J N~~]]	+	[[Category: Kizhakkedathu JN]]
-	[[Category: Kwan~~, D H~~]]	+	[[Category: Kwan DH]]
-	[[Category: Samain, E]]	+	[[Category: Samain E]]
-	[[Category: Withers~~, S G]]~~	+	[[Category: Withers SG]]
-	~~[[Category: Blood group antigen]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 09:38, 5 February 2020

OCA — Wed, 05 Feb 2020 09:38:29 GMT

←Older revision		Revision as of 09:38, 5 February 2020
Line 1:		Line 1:

	==Crystal structure of a family 98 glycoside hydrolase catalytic module (Sp3GH98) in complex with the blood group A-trisaccharide (L19 mutant)==		==Crystal structure of a family 98 glycoside hydrolase catalytic module (Sp3GH98) in complex with the blood group A-trisaccharide (L19 mutant)==
-	<StructureSection load='4d6g' size='340' side='right' caption='[[4d6g]], [[Resolution\|resolution]] 1.24Å' scene=''>	+	<StructureSection load='4d6g' size='340' side='right'caption='[[4d6g]], [[Resolution\|resolution]] 1.24Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4d6g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae_sp3-bs71 Streptococcus pneumoniae sp3-bs71]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D6G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D6G FirstGlance]. <br>		<table><tr><td colspan='2'>[[4d6g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae_sp3-bs71 Streptococcus pneumoniae sp3-bs71]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D6G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D6G FirstGlance]. <br>
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Blood-group-substance endo-1,4-beta-galactosidase]]		[[Category: Blood-group-substance endo-1,4-beta-galactosidase]]
		+	[[Category: Large Structures]]
	[[Category: Streptococcus pneumoniae sp3-bs71]]		[[Category: Streptococcus pneumoniae sp3-bs71]]
	[[Category: Boraston, A B]]		[[Category: Boraston, A B]]

OCA at 06:07, 18 April 2018

OCA — Wed, 18 Apr 2018 06:07:16 GMT

←Older revision		Revision as of 06:07, 18 April 2018
Line 3:		Line 3:
	<StructureSection load='4d6g' size='340' side='right' caption='[[4d6g]], [[Resolution\|resolution]] 1.24Å' scene=''>		<StructureSection load='4d6g' size='340' side='right' caption='[[4d6g]], [[Resolution\|resolution]] 1.24Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4d6g]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D6G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D6G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4d6g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae_sp3-bs71 Streptococcus pneumoniae sp3-bs71]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D6G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D6G FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~EDO~~:1,2-~~ETHANEDIOL~~'>~~EDO~~</scene>, <scene name='pdbligand=~~A2G~~:~~N-ACETYL-~~2-~~DEOXY-2-AMINO-GALACTOSE~~'>~~A2G~~</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d6c\|4d6c]], [[4d6d\|4d6d]], [[4d6e\|4d6e]], [[4d6f\|4d6f]], [[4d6h\|4d6h]], [[4d6i\|4d6i]], [[4d6j\|4d6j]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d6c\|4d6c]], [[4d6d\|4d6d]], [[4d6e\|4d6e]], [[4d6f\|4d6f]], [[4d6h\|4d6h]], [[4d6i\|4d6i]], [[4d6j\|4d6j]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Blood-group-substance_endo-1,4-beta-galactosidase Blood-group-substance endo-1,4-beta-galactosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.102 3.2.1.102] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Blood-group-substance_endo-1,4-beta-galactosidase Blood-group-substance endo-1,4-beta-galactosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.102 3.2.1.102] </span></td></tr>
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Blood-group-substance endo-1,4-beta-galactosidase]]		[[Category: Blood-group-substance endo-1,4-beta-galactosidase]]
		+	[[Category: Streptococcus pneumoniae sp3-bs71]]
	[[Category: Boraston, A B]]		[[Category: Boraston, A B]]
	[[Category: Chapanian, R]]		[[Category: Chapanian, R]]

OCA at 17:37, 9 March 2017

OCA — Thu, 09 Mar 2017 17:37:26 GMT

←Older revision		Revision as of 17:37, 9 March 2017
Line 1:		Line 1:
		+
	==Crystal structure of a family 98 glycoside hydrolase catalytic module (Sp3GH98) in complex with the blood group A-trisaccharide (L19 mutant)==		==Crystal structure of a family 98 glycoside hydrolase catalytic module (Sp3GH98) in complex with the blood group A-trisaccharide (L19 mutant)==
	<StructureSection load='4d6g' size='340' side='right' caption='[[4d6g]], [[Resolution\|resolution]] 1.24Å' scene=''>		<StructureSection load='4d6g' size='340' side='right' caption='[[4d6g]], [[Resolution\|resolution]] 1.24Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d6c\|4d6c]], [[4d6d\|4d6d]], [[4d6e\|4d6e]], [[4d6f\|4d6f]], [[4d6h\|4d6h]], [[4d6i\|4d6i]], [[4d6j\|4d6j]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d6c\|4d6c]], [[4d6d\|4d6d]], [[4d6e\|4d6e]], [[4d6f\|4d6f]], [[4d6h\|4d6h]], [[4d6i\|4d6i]], [[4d6j\|4d6j]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Blood-group-substance_endo-1,4-beta-galactosidase Blood-group-substance endo-1,4-beta-galactosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.102 3.2.1.102] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Blood-group-substance_endo-1,4-beta-galactosidase Blood-group-substance endo-1,4-beta-galactosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.102 3.2.1.102] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d6g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d6g RCSB], [http://www.ebi.ac.uk/pdbsum/4d6g PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d6g OCA], [http://pdbe.org/4d6g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d6g RCSB], [http://www.ebi.ac.uk/pdbsum/4d6g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4d6g ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4d6g" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:49, 30 April 2015

OCA — Thu, 30 Apr 2015 05:49:14 GMT

←Older revision		Revision as of 05:49, 30 April 2015
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d6g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d6g RCSB], [http://www.ebi.ac.uk/pdbsum/4d6g PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d6g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d6g RCSB], [http://www.ebi.ac.uk/pdbsum/4d6g PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Blood transfusions are critically important in many medical procedures, but the presence of antigens on red blood cells (RBCs, erythrocytes) means that careful blood-typing must be carried out prior to transfusion to avoid adverse and sometimes fatal reactions following transfusion. Enzymatic removal of the terminal N-acetylgalactosamine or galactose of A- or B-antigens, respectively, yields universal O-type blood, but is inefficient. Starting with the family 98 glycoside hydrolase from Streptococcus pneumoniae SP3-BS71 (Sp3GH98), which cleaves the entire terminal trisaccharide antigenic determinants of both A- and B-antigens from some of the linkages on RBC surface glycans, through several rounds of evolution, we developed variants with vastly improved activity toward some of the linkages that are resistant to cleavage by the wild-type enzyme. The resulting enzyme effects more complete removal of blood group antigens from cell surfaces, demonstrating the potential for engineering enzymes to generate antigen-null blood from donors of various types.
		+
		+	Toward Efficient Enzymes for the Generation of Universal Blood through Structure-Guided Directed Evolution.,Kwan DH, Constantinescu I, Chapanian R, Higgins MA, Kotzler MP, Samain E, Boraston AB, Kizhakkedathu JN, Withers SG J Am Chem Soc. 2015 Apr 24. PMID:25870881<ref>PMID:25870881</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:07, 26 November 2014

OCA — Wed, 26 Nov 2014 08:07:47 GMT

←Older revision		Revision as of 08:07, 26 November 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of a family 98 glycoside hydrolase catalytic module (Sp3GH98) in complex with the blood group A-trisaccharide (L19 mutant)==
-		+	<StructureSection load='4d6g' size='340' side='right' caption='[[4d6g]], [[Resolution\|resolution]] 1.24Å' scene=''>
-	~~The entry~~ 4d6g is ~~ON HOLD~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4d6g]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D6G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D6G FirstGlance]. <br>
-	~~Authors~~: ~~Kwan~~, D~~.H.~~, ~~Constantinescu~~, I., ~~Chapanian~~, R., ~~Higgins~~, M.A., ~~Samain~~, E., Boraston, A.B., Kizhakkedathu, J.N., Withers, S.G.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d6c\|4d6c]], [[4d6d\|4d6d]], [[4d6e\|4d6e]], [[4d6f\|4d6f]], [[4d6h\|4d6h]], [[4d6i\|4d6i]], [[4d6j\|4d6j]]</td></tr>
-	~~Description~~: ~~Crystal structure of a family 98 glycoside hydrolase catalytic module (Sp3GH98) in complex with the blood~~ group ~~A-trisaccharide (L19 mutant)~~	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Blood-group-substance_endo-1,4-beta-galactosidase Blood-group-substance endo-1,4-beta-galactosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.102 3.2.1.102] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d6g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d6g RCSB], [http://www.ebi.ac.uk/pdbsum/4d6g PDBsum]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Blood-group-substance endo-1,4-beta-galactosidase]]
		+	[[Category: Boraston, A B]]
		+	[[Category: Chapanian, R]]
		+	[[Category: Constantinescu, I]]
		+	[[Category: Higgins, M A]]
		+	[[Category: Kizhakkedathu, J N]]
		+	[[Category: Kwan, D H]]
		+	[[Category: Samain, E]]
		+	[[Category: Withers, S G]]
		+	[[Category: Blood group antigen]]
		+	[[Category: Hydrolase]]

OCA: Protected "4d6g" [edit=sysop:move=sysop]

OCA — Wed, 19 Nov 2014 11:08:47 GMT

Protected "4d6g" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:08, 19 November 2014

OCA: New page: '''Unreleased structure''' The entry 4d6g is ON HOLD Authors: Kwan, D.H., Constantinescu, I., Chapanian, R., Higgins, M.A., Samain, E., Boraston, A.B., Kizhakkedathu, J.N., Withers, S.G...

OCA — Wed, 19 Nov 2014 11:08:45 GMT

New page: '''Unreleased structure''' The entry 4d6g is ON HOLD Authors: Kwan, D.H., Constantinescu, I., Chapanian, R., Higgins, M.A., Samain, E., Boraston, A.B., Kizhakkedathu, J.N., Withers, S.G...

New page

'''Unreleased structure'''

The entry 4d6g is ON HOLD

Authors: Kwan, D.H., Constantinescu, I., Chapanian, R., Higgins, M.A., Samain, E., Boraston, A.B., Kizhakkedathu, J.N., Withers, S.G.

Description: Crystal structure of a family 98 glycoside hydrolase catalytic module (Sp3GH98) in complex with the blood group A-trisaccharide (L19 mutant)