4d6u - Revision history

OCA at 12:21, 20 December 2023

OCA — Wed, 20 Dec 2023 12:21:41 GMT

←Older revision		Revision as of 12:21, 20 December 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4d6u]] is a 17 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D6U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D6U FirstGlance]. <br>		<table><tr><td colspan='2'>[[4d6u]] is a 17 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D6U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D6U FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=G8U:3-CHLORO-6-(HYDROXYMETHYL)-2-METHYL-5-{4-[3-(TRIFLUOROMETHOXY)PHENOXY]PHENYL}PYRIDIN-4-OL'>G8U</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PEE:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>PEE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 4.09Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=G8U:3-CHLORO-6-(HYDROXYMETHYL)-2-METHYL-5-{4-[3-(TRIFLUOROMETHOXY)PHENOXY]PHENYL}PYRIDIN-4-OL'>G8U</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PEE:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>PEE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d6u OCA], [https://pdbe.org/4d6u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d6u RCSB], [https://www.ebi.ac.uk/pdbsum/4d6u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d6u ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d6u OCA], [https://pdbe.org/4d6u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d6u RCSB], [https://www.ebi.ac.uk/pdbsum/4d6u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d6u ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/QCR2_BOVIN QCR2_BOVIN]] This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex.	+	[https://www.uniprot.org/uniprot/QCR2_BOVIN QCR2_BOVIN] This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 21:

	==See Also==		==See Also==
-	*[[Cytochrome bc1 ~~complex~~\|Cytochrome bc1 ~~complex~~]]	+	*[[Cytochrome bc1 3D structures\|Cytochrome bc1 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:49, 14 September 2022

OCA — Wed, 14 Sep 2022 07:49:51 GMT

←Older revision		Revision as of 07:49, 14 September 2022
Line 3:		Line 3:
	<StructureSection load='4d6u' size='340' side='right'caption='[[4d6u]], [[Resolution\|resolution]] 4.09Å' scene=''>		<StructureSection load='4d6u' size='340' side='right'caption='[[4d6u]], [[Resolution\|resolution]] 4.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4d6u]] is a 20 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D6U OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4D6U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4d6u]] is a 17 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D6U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D6U FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=G8U:3-CHLORO-6-(HYDROXYMETHYL)-2-METHYL-5-{4-[3-(TRIFLUOROMETHOXY)PHENOXY]PHENYL}PYRIDIN-4-OL'>G8U</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PEE:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>PEE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=G8U:3-CHLORO-6-(HYDROXYMETHYL)-2-METHYL-5-{4-[3-(TRIFLUOROMETHOXY)PHENOXY]PHENYL}PYRIDIN-4-OL'>G8U</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PEE:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>PEE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d6t\|4d6t]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d6u OCA], [https://pdbe.org/4d6u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d6u RCSB], [https://www.ebi.ac.uk/pdbsum/4d6u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d6u ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquinol--cytochrome-c_reductase Ubiquinol--cytochrome-c reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.2.2 1.10.2.2] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4d6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d6u OCA], [~~http~~://pdbe.org/4d6u PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4d6u RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4d6u PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4d6u ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/QCR7_BOVIN QCR7_BOVIN]] This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton pumping. [[http://www.uniprot.org/uniprot/QCR2_BOVIN QCR2_BOVIN]] This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex. [[http://www.uniprot.org/uniprot/CYB_BOVIN CYB_BOVIN]] Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. [[http://www.uniprot.org/uniprot/QCR8_BOVIN QCR8_BOVIN]] This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit, together with cytochrome b, binds to ubiquinone. [[http://www.uniprot.org/uniprot/QCR9_BOVIN QCR9_BOVIN]] This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit interacts with cytochrome c1. [[http://www.uniprot.org/uniprot/UCRI_BOVIN UCRI_BOVIN]] Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The transit peptide of the Rieske protein seems to form part of the bc1 complex and is considered to be the subunit 11/IX of that complex. [[http://www.uniprot.org/uniprot/QCR6_BOVIN QCR6_BOVIN]] This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. [[http://www.uniprot.org/uniprot/QCR1_BOVIN QCR1_BOVIN]] This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. [[http://www.uniprot.org/uniprot/CY1_BOVIN CY1_BOVIN]] This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain.	+	[[https://www.uniprot.org/uniprot/QCR2_BOVIN QCR2_BOVIN]] This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 29:		Line 27:
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Ubiquinol--cytochrome-c reductase]]~~	+	[[Category: Antonyuk SV]]
-	[[Category: Antonyuk~~, S V~~]]	+	[[Category: Berry NG]]
-	[[Category: Berry~~, N G~~]]	+	[[Category: Biagini GA]]
-	[[Category: Biagini~~, G A~~]]	+	[[Category: Capper MJ]]
-	[[Category: Capper~~, M J~~]]	+	[[Category: Fisher N]]
-	[[Category: Fisher, N]]	+	[[Category: Hasnain SS]]
-	[[Category: Hasnain~~, S S~~]]	+	[[Category: Lawrenson AS]]
-	[[Category: Lawrenson~~, A S~~]]	+	[[Category: Moss D]]
-	[[Category: Moss, D]]	+	[[Category: ONeill PM]]
-	[[Category: ONeill~~, P M~~]]	+	[[Category: Strange RW]]
-	[[Category: Strange~~, R W~~]]	+	[[Category: Ward SA]]
-	[[Category: Ward~~, S A]]~~	+
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 07:59, 27 March 2019

OCA — Wed, 27 Mar 2019 07:59:19 GMT

←Older revision		Revision as of 07:59, 27 March 2019
Line 1:		Line 1:

	==Cytochrome bc1 bound to the 4(1H)-pyridone GSK932121==		==Cytochrome bc1 bound to the 4(1H)-pyridone GSK932121==
-	<StructureSection load='4d6u' size='340' side='right' caption='[[4d6u]], [[Resolution\|resolution]] 4.09Å' scene=''>	+	<StructureSection load='4d6u' size='340' side='right'caption='[[4d6u]], [[Resolution\|resolution]] 4.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4d6u]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D6U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D6U FirstGlance]. <br>		<table><tr><td colspan='2'>[[4d6u]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D6U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D6U FirstGlance]. <br>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
		+	[[Category: Large Structures]]
	[[Category: Ubiquinol--cytochrome-c reductase]]		[[Category: Ubiquinol--cytochrome-c reductase]]
	[[Category: Antonyuk, S V]]		[[Category: Antonyuk, S V]]

OCA at 10:22, 11 August 2016

OCA — Thu, 11 Aug 2016 10:22:46 GMT

←Older revision		Revision as of 10:22, 11 August 2016
Line 1:		Line 1:
		+
	==Cytochrome bc1 bound to the 4(1H)-pyridone GSK932121==		==Cytochrome bc1 bound to the 4(1H)-pyridone GSK932121==
	<StructureSection load='4d6u' size='340' side='right' caption='[[4d6u]], [[Resolution\|resolution]] 4.09Å' scene=''>		<StructureSection load='4d6u' size='340' side='right' caption='[[4d6u]], [[Resolution\|resolution]] 4.09Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d6t\|4d6t]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d6t\|4d6t]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquinol--cytochrome-c_reductase Ubiquinol--cytochrome-c reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.2.2 1.10.2.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquinol--cytochrome-c_reductase Ubiquinol--cytochrome-c reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.2.2 1.10.2.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d6u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d6u RCSB], [http://www.ebi.ac.uk/pdbsum/4d6u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d6u OCA], [http://pdbe.org/4d6u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d6u RCSB], [http://www.ebi.ac.uk/pdbsum/4d6u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4d6u ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4d6u" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cytochrome bc1 complex\|Cytochrome bc1 complex]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:19, 21 January 2015

OCA — Wed, 21 Jan 2015 11:19:21 GMT

←Older revision		Revision as of 11:19, 21 January 2015
Line 10:		Line 10:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/QCR7_BOVIN QCR7_BOVIN]] This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton pumping. [[http://www.uniprot.org/uniprot/QCR2_BOVIN QCR2_BOVIN]] This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex. [[http://www.uniprot.org/uniprot/CYB_BOVIN CYB_BOVIN]] Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. [[http://www.uniprot.org/uniprot/QCR8_BOVIN QCR8_BOVIN]] This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit, together with cytochrome b, binds to ubiquinone. [[http://www.uniprot.org/uniprot/QCR9_BOVIN QCR9_BOVIN]] This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit interacts with cytochrome c1. [[http://www.uniprot.org/uniprot/UCRI_BOVIN UCRI_BOVIN]] Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The transit peptide of the Rieske protein seems to form part of the bc1 complex and is considered to be the subunit 11/IX of that complex. [[http://www.uniprot.org/uniprot/QCR6_BOVIN QCR6_BOVIN]] This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. [[http://www.uniprot.org/uniprot/QCR1_BOVIN QCR1_BOVIN]] This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. [[http://www.uniprot.org/uniprot/CY1_BOVIN CY1_BOVIN]] This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain.		[[http://www.uniprot.org/uniprot/QCR7_BOVIN QCR7_BOVIN]] This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton pumping. [[http://www.uniprot.org/uniprot/QCR2_BOVIN QCR2_BOVIN]] This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex. [[http://www.uniprot.org/uniprot/CYB_BOVIN CYB_BOVIN]] Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. [[http://www.uniprot.org/uniprot/QCR8_BOVIN QCR8_BOVIN]] This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit, together with cytochrome b, binds to ubiquinone. [[http://www.uniprot.org/uniprot/QCR9_BOVIN QCR9_BOVIN]] This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit interacts with cytochrome c1. [[http://www.uniprot.org/uniprot/UCRI_BOVIN UCRI_BOVIN]] Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The transit peptide of the Rieske protein seems to form part of the bc1 complex and is considered to be the subunit 11/IX of that complex. [[http://www.uniprot.org/uniprot/QCR6_BOVIN QCR6_BOVIN]] This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. [[http://www.uniprot.org/uniprot/QCR1_BOVIN QCR1_BOVIN]] This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. [[http://www.uniprot.org/uniprot/CY1_BOVIN CY1_BOVIN]] This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cytochrome bc1 is a proven drug target in the prevention and treatment of malaria. The rise in drug-resistant strains of Plasmodium falciparum, the organism responsible for malaria, has generated a global effort in designing new classes of drugs. Much of the design/redesign work on overcoming this resistance has been focused on compounds that are presumed to bind the Qo site (one of two potential binding sites within cytochrome bc1) using the known crystal structure of this large membrane-bound macromolecular complex via in silico modeling. Cocrystallization of the cytochrome bc1 complex with the 4(1H)-pyridone class of inhibitors, GSK932121 and GW844520, that have been shown to be potent antimalarial agents in vivo, revealed that these inhibitors do not bind at the Qo site but bind at the Qi site. The discovery that these compounds bind at the Qi site may provide a molecular explanation for the cardiotoxicity and eventual failure of GSK932121 in phase-1 clinical trial and highlight the need for direct experimental observation of a compound bound to a target site before chemical optimization and development for clinical trials. The binding of the 4(1H)-pyridone class of inhibitors to Qi also explains the ability of this class to overcome parasite Qo-based atovaquone resistance and provides critical structural information for future design of new selective compounds with improved safety profiles.
		+
		+	Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1.,Capper MJ, O'Neill PM, Fisher N, Strange RW, Moss D, Ward SA, Berry NG, Lawrenson AS, Hasnain SS, Biagini GA, Antonyuk SV Proc Natl Acad Sci U S A. 2015 Jan 6. pii: 201416611. PMID:25564664<ref>PMID:25564664</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 13:39, 14 January 2015

OCA — Wed, 14 Jan 2015 13:39:26 GMT

←Older revision		Revision as of 13:39, 14 January 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Cytochrome bc1 bound to the 4(1H)-pyridone GSK932121==
-		+	<StructureSection load='4d6u' size='340' side='right' caption='[[4d6u]], [[Resolution\|resolution]] 4.09Å' scene=''>
-	~~The entry~~ 4d6u is ~~ON HOLD~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4d6u]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D6U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D6U FirstGlance]. <br>
-	~~Authors~~: ~~Capper, M~~.J.~~, ONeill, P~~.M., ~~Fisher~~, N., ~~Strange~~, ~~R.W.~~, ~~Moss~~, D., ~~Ward~~, S.A., ~~Berry~~, N.G., ~~Lawrenson~~, A.S., ~~Hasnain~~, S.S., ~~Biagini, G~~.A., ~~Antonyuk~~, S.V.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=G8U:3-CHLORO-6-(HYDROXYMETHYL)-2-METHYL-5-{4-[3-(TRIFLUOROMETHOXY)PHENOXY]PHENYL}PYRIDIN-4-OL'>G8U</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PEE:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>PEE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d6t\|4d6t]]</td></tr>
-	~~Description~~: ~~Cytochrome~~ bc1 ~~bound~~ to the 4(1H)-~~pyridone GSK932121~~	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquinol--cytochrome-c_reductase Ubiquinol--cytochrome-c reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.2.2 1.10.2.2] </span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d6u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d6u RCSB], [http://www.ebi.ac.uk/pdbsum/4d6u PDBsum]</span></td></tr>
-	[[Category: ~~Lawrenson~~, A.S]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/QCR7_BOVIN QCR7_BOVIN]] This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton pumping. [[http://www.uniprot.org/uniprot/QCR2_BOVIN QCR2_BOVIN]] This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex. [[http://www.uniprot.org/uniprot/CYB_BOVIN CYB_BOVIN]] Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. [[http://www.uniprot.org/uniprot/QCR8_BOVIN QCR8_BOVIN]] This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit, together with cytochrome b, binds to ubiquinone. [[http://www.uniprot.org/uniprot/QCR9_BOVIN QCR9_BOVIN]] This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit interacts with cytochrome c1. [[http://www.uniprot.org/uniprot/UCRI_BOVIN UCRI_BOVIN]] Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The transit peptide of the Rieske protein seems to form part of the bc1 complex and is considered to be the subunit 11/IX of that complex. [[http://www.uniprot.org/uniprot/QCR6_BOVIN QCR6_BOVIN]] This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. [[http://www.uniprot.org/uniprot/QCR1_BOVIN QCR1_BOVIN]] This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. [[http://www.uniprot.org/uniprot/CY1_BOVIN CY1_BOVIN]] This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bos taurus]]
		+	[[Category: Ubiquinol--cytochrome-c reductase]]
		+	[[Category: Antonyuk, S V]]
		+	[[Category: Berry, N G]]
		+	[[Category: Biagini, G A]]
		+	[[Category: Capper, M J]]
	[[Category: Fisher, N]]		[[Category: Fisher, N]]
-	~~[[Category: Berry, N.G]]~~	+	[[Category: Hasnain, S S]]
-	~~[[Category: Capper, M.J]]~~	+	[[Category: Lawrenson, A S]]
-	[[Category: Hasnain, S.S]]	+
-	[[Category: ~~Oneill~~, ~~P.M]]~~	+
-	~~[[Category: Biagini, G.~~A]]	+
-	~~[[Category: Antonyuk,~~ S~~.V]]~~	+
-	~~[[Category: Ward, S.A]]~~	+
-	~~[[Category: Strange, R.W~~]]	+
	[[Category: Moss, D]]		[[Category: Moss, D]]
		+	[[Category: ONeill, P M]]
		+	[[Category: Strange, R W]]
		+	[[Category: Ward, S A]]
		+	[[Category: Complex]]
		+	[[Category: Membrane protein]]
		+	[[Category: Oxidoreductase]]

OCA at 13:54, 24 December 2014

OCA — Wed, 24 Dec 2014 13:54:07 GMT

←Older revision		Revision as of 13:54, 24 December 2014
Line 6:		Line 6:

	Description: Cytochrome bc1 bound to the 4(1H)-pyridone GSK932121		Description: Cytochrome bc1 bound to the 4(1H)-pyridone GSK932121
		+	[[Category: Unreleased Structures]]
		+	[[Category: Lawrenson, A.S]]
		+	[[Category: Fisher, N]]
		+	[[Category: Berry, N.G]]
		+	[[Category: Capper, M.J]]
		+	[[Category: Hasnain, S.S]]
		+	[[Category: Oneill, P.M]]
		+	[[Category: Biagini, G.A]]
		+	[[Category: Antonyuk, S.V]]
		+	[[Category: Ward, S.A]]
		+	[[Category: Strange, R.W]]
		+	[[Category: Moss, D]]

OCA: Protected "4d6u" [edit=sysop:move=sysop]

OCA — Wed, 26 Nov 2014 06:27:08 GMT

Protected "4d6u" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:27, 26 November 2014

OCA: New page: '''Unreleased structure''' The entry 4d6u is ON HOLD Authors: Capper, M.J., ONeill, P.M., Fisher, N., Strange, R.W., Moss, D., Ward, S.A., Berry, N.G., Lawrenson, A.S., Hasnain, S.S., B...

OCA — Wed, 26 Nov 2014 06:27:07 GMT

New page: '''Unreleased structure''' The entry 4d6u is ON HOLD Authors: Capper, M.J., ONeill, P.M., Fisher, N., Strange, R.W., Moss, D., Ward, S.A., Berry, N.G., Lawrenson, A.S., Hasnain, S.S., B...

New page

'''Unreleased structure'''

The entry 4d6u is ON HOLD

Authors: Capper, M.J., ONeill, P.M., Fisher, N., Strange, R.W., Moss, D., Ward, S.A., Berry, N.G., Lawrenson, A.S., Hasnain, S.S., Biagini, G.A., Antonyuk, S.V.

Description: Cytochrome bc1 bound to the 4(1H)-pyridone GSK932121