4d78 - Revision history

OCA at 12:21, 20 December 2023

OCA — Wed, 20 Dec 2023 12:21:59 GMT

←Older revision		Revision as of 12:21, 20 December 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4d78]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D78 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D78 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4d78]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D78 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D78 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=J9K:TERT-BUTYL+[(2S)-1-({3-OXO-3-[(PYRIDIN-3-YLMETHYL)AMINO]PROPYL}SULFANYL)-3-PHENYLPROPAN-2-YL]CARBAMATE'>J9K</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=J9K:TERT-BUTYL+[(2S)-1-({3-OXO-3-[(PYRIDIN-3-YLMETHYL)AMINO]PROPYL}SULFANYL)-3-PHENYLPROPAN-2-YL]CARBAMATE'>J9K</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d78 OCA], [https://pdbe.org/4d78 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d78 RCSB], [https://www.ebi.ac.uk/pdbsum/4d78 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d78 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d78 OCA], [https://pdbe.org/4d78 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d78 RCSB], [https://www.ebi.ac.uk/pdbsum/4d78 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d78 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CP3A4_HUMAN CP3A4_HUMAN]] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.<ref>PMID:11159812</ref>	+	[https://www.uniprot.org/uniprot/CP3A4_HUMAN CP3A4_HUMAN] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.<ref>PMID:11159812</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:50, 14 September 2022

OCA — Wed, 14 Sep 2022 07:50:35 GMT

←Older revision		Revision as of 07:50, 14 September 2022
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	<StructureSection load='4d78' size='340' side='right'caption='[[4d78]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4d78' size='340' side='right'caption='[[4d78]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4d78]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D78 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4D78 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4d78]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D78 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D78 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=J9K:TERT-BUTYL+[(2S)-1-({3-OXO-3-[(PYRIDIN-3-YLMETHYL)AMINO]PROPYL}SULFANYL)-3-PHENYLPROPAN-2-YL]CARBAMATE'>J9K</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=J9K:TERT-BUTYL+[(2S)-1-({3-OXO-3-[(PYRIDIN-3-YLMETHYL)AMINO]PROPYL}SULFANYL)-3-PHENYLPROPAN-2-YL]CARBAMATE'>J9K</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d6z\|4d6z]], [[4d75\|4d75]], [[4d7d\|4d7d]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d78 OCA], [https://pdbe.org/4d78 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d78 RCSB], [https://www.ebi.ac.uk/pdbsum/4d78 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d78 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4d78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d78 OCA], [~~http~~://pdbe.org/4d78 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4d78 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4d78 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4d78 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CP3A4_HUMAN CP3A4_HUMAN]] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.<ref>PMID:11159812</ref>	+	[[https://www.uniprot.org/uniprot/CP3A4_HUMAN CP3A4_HUMAN]] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.<ref>PMID:11159812</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 20:

	==See Also==		==See Also==
-	*[[Cytochrome P450\|Cytochrome P450]]	+	*[[Cytochrome P450 3D structures\|Cytochrome P450 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Poulos, T]]	+	[[Category: Poulos T]]
-	[[Category: Sevrioukova, I]]	+	[[Category: Sevrioukova I]]
-	~~[[Category: Human cyp3a4]]~~	+
-	~~[[Category: Inhibitory complex]]~~	+
-	~~[[Category: Monooxygenase]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 12:53, 10 May 2019

OCA — Fri, 10 May 2019 12:53:01 GMT

←Older revision		Revision as of 12:53, 10 May 2019
Line 1:		Line 1:

	==Cytochrome P450 3A4 bound to an inhibitor==		==Cytochrome P450 3A4 bound to an inhibitor==
-	<StructureSection load='4d78' size='340' side='right' caption='[[4d78]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='4d78' size='340' side='right'caption='[[4d78]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4d78]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D78 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D78 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4d78]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D78 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D78 FirstGlance]. <br>
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4d78" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4d78" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cytochrome P450\|Cytochrome P450]]
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Poulos, T]]		[[Category: Poulos, T]]
	[[Category: Sevrioukova, I]]		[[Category: Sevrioukova, I]]

OCA at 15:10, 16 November 2017

OCA — Thu, 16 Nov 2017 15:10:00 GMT

←Older revision		Revision as of 15:10, 16 November 2017
Line 3:		Line 3:
	<StructureSection load='4d78' size='340' side='right' caption='[[4d78]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4d78' size='340' side='right' caption='[[4d78]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4d78]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D78 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D78 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4d78]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D78 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D78 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=J9K:TERT-BUTYL+[(2S)-1-({3-OXO-3-[(PYRIDIN-3-YLMETHYL)AMINO]PROPYL}SULFANYL)-3-PHENYLPROPAN-2-YL]CARBAMATE'>J9K</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=J9K:TERT-BUTYL+[(2S)-1-({3-OXO-3-[(PYRIDIN-3-YLMETHYL)AMINO]PROPYL}SULFANYL)-3-PHENYLPROPAN-2-YL]CARBAMATE'>J9K</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d6z\|4d6z]], [[4d75\|4d75]], [[4d7d\|4d7d]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d6z\|4d6z]], [[4d75\|4d75]], [[4d7d\|4d7d]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d78 OCA], [http://pdbe.org/4d78 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d78 RCSB], [http://www.ebi.ac.uk/pdbsum/4d78 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d78 OCA], [http://pdbe.org/4d78 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d78 RCSB], [http://www.ebi.ac.uk/pdbsum/4d78 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4d78 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Poulos, T]]		[[Category: Poulos, T]]
	[[Category: Sevrioukova, I]]		[[Category: Sevrioukova, I]]

OCA at 08:31, 1 June 2016

OCA — Wed, 01 Jun 2016 08:31:47 GMT

←Older revision		Revision as of 08:31, 1 June 2016
Line 1:		Line 1:
		+
	==Cytochrome P450 3A4 bound to an inhibitor==		==Cytochrome P450 3A4 bound to an inhibitor==
	<StructureSection load='4d78' size='340' side='right' caption='[[4d78]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4d78' size='340' side='right' caption='[[4d78]], [[Resolution\|resolution]] 2.80Å' scene=''>

OCA at 07:57, 30 September 2015

OCA — Wed, 30 Sep 2015 07:57:56 GMT

←Older revision		Revision as of 07:57, 30 September 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Cytochrome P450 3A4 bound to an inhibitor==
		+	<StructureSection load='4d78' size='340' side='right' caption='[[4d78]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4d78]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D78 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D78 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=J9K:TERT-BUTYL+[(2S)-1-({3-OXO-3-[(PYRIDIN-3-YLMETHYL)AMINO]PROPYL}SULFANYL)-3-PHENYLPROPAN-2-YL]CARBAMATE'>J9K</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d6z\|4d6z]], [[4d75\|4d75]], [[4d7d\|4d7d]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d78 OCA], [http://pdbe.org/4d78 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d78 RCSB], [http://www.ebi.ac.uk/pdbsum/4d78 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CP3A4_HUMAN CP3A4_HUMAN]] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.<ref>PMID:11159812</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human cytochrome P450 3A4 (CYP3A4) is a key xenobiotic-metabolizing enzyme that oxidizes and clears the majority of drugs. CYP3A4 inhibition may lead to drug-drug interactions, toxicity and other adverse effects but, in some cases, could be beneficial and enhance therapeutic efficiency of co-administered pharmaceuticals that are metabolized by CYP3A4. Based on our investigations of analogs of ritonavir, a potent CYP3A4 inactivator and pharmacoenhancer, we have built a pharmacophore model for a CYP3A4-specific inhibitor. This study is the first attempt to test this model using a set of rationally designed compounds. The functional and structural data presented here agree well with the proposed pharmacophore. In particular, we confirmed the importance of a flexible backbone, the H-bond donor/acceptor moiety and aromaticity of the side group analogous to Phe-2 of ritonavir, and demonstrated the leading role of hydrophobic interactions at the sites adjacent to the heme and phenylalanine cluster in the ligand binding process. The X-ray structures of CYP3A4 bound to the rationally designed inhibitors provide deeper insights into the mechanism of the CYP3A4-ligand interaction. Most importantly, two of our compounds (15a and 15b) that are less complex than ritonavir have comparable sub-micromolar affinity and inhibitory potency for CYP3A4 and, thus, could serve as templates for synthesis of second generation inhibitors for further evaluation and optimization of the pharmacophore model.

-	~~The entry 4d78 is ON HOLD until Paper Publication~~	+	Structure-based inhibitor design for evaluation of a CYP3A4 pharmacophore model.,Kaur P, Chamberlin R, Poulos TL, Sevrioukova IF J Med Chem. 2015 Sep 29. PMID:26371436<ref>PMID:26371436</ref>

-	~~Authors: Sevrioukova~~, I.~~, Poulos, T~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Cytochrome P450 3A4 bound to an inhibitor~~	+	<div class="pdbe-citations 4d78" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Unreleased Structures~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Poulos, T]]
	[[Category: Sevrioukova, I]]		[[Category: Sevrioukova, I]]
-	[[Category: ~~Poulos, T~~]]	+	[[Category: Human cyp3a4]]
		+	[[Category: Inhibitory complex]]
		+	[[Category: Monooxygenase]]
		+	[[Category: Oxidoreductase]]

OCA at 13:56, 24 December 2014

OCA — Wed, 24 Dec 2014 13:56:23 GMT

←Older revision		Revision as of 13:56, 24 December 2014
Line 6:		Line 6:

	Description: Cytochrome P450 3A4 bound to an inhibitor		Description: Cytochrome P450 3A4 bound to an inhibitor
		+	[[Category: Unreleased Structures]]
		+	[[Category: Sevrioukova, I]]
		+	[[Category: Poulos, T]]

OCA at 08:01, 3 December 2014

OCA — Wed, 03 Dec 2014 08:01:46 GMT

←Older revision		Revision as of 08:01, 3 December 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4d78 is ON HOLD until ~~sometime in the future~~	+	The entry 4d78 is ON HOLD until Paper Publication

	Authors: Sevrioukova, I., Poulos, T.		Authors: Sevrioukova, I., Poulos, T.

	Description: Cytochrome P450 3A4 bound to an inhibitor		Description: Cytochrome P450 3A4 bound to an inhibitor

OCA: Protected "4d78" [edit=sysop:move=sysop]

OCA — Wed, 26 Nov 2014 06:27:43 GMT

Protected "4d78" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:27, 26 November 2014

OCA: New page: '''Unreleased structure''' The entry 4d78 is ON HOLD until sometime in the future Authors: Sevrioukova, I., Poulos, T. Description: Cytochrome P450 3A4 bound to an inhibitor

OCA — Wed, 26 Nov 2014 06:27:42 GMT

New page: '''Unreleased structure''' The entry 4d78 is ON HOLD until sometime in the future Authors: Sevrioukova, I., Poulos, T. Description: Cytochrome P450 3A4 bound to an inhibitor

New page

'''Unreleased structure'''

The entry 4d78 is ON HOLD until sometime in the future

Authors: Sevrioukova, I., Poulos, T.

Description: Cytochrome P450 3A4 bound to an inhibitor