4d7j - Revision history

OCA at 12:22, 20 December 2023

OCA — Wed, 20 Dec 2023 12:22:08 GMT

←Older revision		Revision as of 12:22, 20 December 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4d7j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D7J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D7J FirstGlance]. <br>		<table><tr><td colspan='2'>[[4d7j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D7J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D7J FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0GD:6-[4-({[2-(3-FLUOROPHENYL)ETHYL]AMINO}METHYL)PHENYL]-4-METHYLPYRIDIN-2-AMINE'>0GD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=POL:N-PROPANOL'>POL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.55Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0GD:6-[4-({[2-(3-FLUOROPHENYL)ETHYL]AMINO}METHYL)PHENYL]-4-METHYLPYRIDIN-2-AMINE'>0GD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=POL:N-PROPANOL'>POL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d7j OCA], [https://pdbe.org/4d7j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d7j RCSB], [https://www.ebi.ac.uk/pdbsum/4d7j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d7j ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d7j OCA], [https://pdbe.org/4d7j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d7j RCSB], [https://www.ebi.ac.uk/pdbsum/4d7j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d7j ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/NOSO_BACSU NOSO_BACSU]] Catalyzes the production of nitric oxide.	+	[https://www.uniprot.org/uniprot/NOSO_BACSU NOSO_BACSU] Catalyzes the production of nitric oxide.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:51, 14 September 2022

OCA — Wed, 14 Sep 2022 07:51:01 GMT

←Older revision		Revision as of 07:51, 14 September 2022
Line 3:		Line 3:
	<StructureSection load='4d7j' size='340' side='right'caption='[[4d7j]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='4d7j' size='340' side='right'caption='[[4d7j]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4d7j]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Bacsu Bacsu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D7J OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=4D7J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4d7j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D7J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D7J FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0GD:6-[4-({[2-(3-FLUOROPHENYL)ETHYL]AMINO}METHYL)PHENYL]-4-METHYLPYRIDIN-2-AMINE'>0GD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=POL:N-PROPANOL'>POL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0GD:6-[4-({[2-(3-FLUOROPHENYL)ETHYL]AMINO}METHYL)PHENYL]-4-METHYLPYRIDIN-2-AMINE'>0GD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=POL:N-PROPANOL'>POL</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d7h\|4d7h]], [[4d7i\|4d7i]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d7j OCA], [https://pdbe.org/4d7j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d7j RCSB], [https://www.ebi.ac.uk/pdbsum/4d7j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d7j ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NAD(P)H-dependent) Nitric-oxide synthase (NAD(P)H-dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.165 1.14.13.165] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=4d7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d7j OCA], [~~http~~://pdbe.org/4d7j PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4d7j RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4d7j PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4d7j ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NOSO_BACSU NOSO_BACSU]] Catalyzes the production of nitric oxide.	+	[[https://www.uniprot.org/uniprot/NOSO_BACSU NOSO_BACSU]] Catalyzes the production of nitric oxide.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacsu~~]]	+	[[Category: Bacillus subtilis subsp. subtilis str. 168]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Holden~~, J K~~]]	+	[[Category: Holden JK]]
-	[[Category: Poulos~~, T L]]~~	+	[[Category: Poulos TL]]
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 08:19, 4 November 2020

OCA — Wed, 04 Nov 2020 08:19:28 GMT

←Older revision		Revision as of 08:19, 4 November 2020
Line 1:		Line 1:

	==Structure of Bacillus subtilis nitric oxide synthase in complex with 6-(4-(((3-Fluorophenethyl)amino)methyl)phenyl)-4-methylpyridin-2- amine==		==Structure of Bacillus subtilis nitric oxide synthase in complex with 6-(4-(((3-Fluorophenethyl)amino)methyl)phenyl)-4-methylpyridin-2- amine==
-	<StructureSection load='4d7j' size='340' side='right' caption='[[4d7j]], [[Resolution\|resolution]] 1.55Å' scene=''>	+	<StructureSection load='4d7j' size='340' side='right'caption='[[4d7j]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4d7j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacsu Bacsu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D7J OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4D7J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4d7j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacsu Bacsu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D7J OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=4D7J FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0GD:6-[4-({[2-(3-FLUOROPHENYL)ETHYL]AMINO}METHYL)PHENYL]-4-METHYLPYRIDIN-2-AMINE'>0GD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=POL:N-PROPANOL'>POL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0GD:6-[4-({[2-(3-FLUOROPHENYL)ETHYL]AMINO}METHYL)PHENYL]-4-METHYLPYRIDIN-2-AMINE'>0GD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=POL:N-PROPANOL'>POL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d7h\|4d7h]], [[4d7i\|4d7i]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d7h\|4d7h]], [[4d7i\|4d7i]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NAD(P)H-dependent) Nitric-oxide synthase (NAD(P)H-dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.165 1.14.13.165] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NAD(P)H-dependent) Nitric-oxide synthase (NAD(P)H-dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.165 1.14.13.165] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4d7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d7j OCA], [http://pdbe.org/4d7j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d7j RCSB], [http://www.ebi.ac.uk/pdbsum/4d7j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4d7j ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=4d7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d7j OCA], [http://pdbe.org/4d7j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d7j RCSB], [http://www.ebi.ac.uk/pdbsum/4d7j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4d7j ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Nitric Oxide Synthase\|Nitric Oxide Synthase]]	+	*[[Nitric Oxide Synthase 3D structures\|Nitric Oxide Synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Bacsu]]		[[Category: Bacsu]]
		+	[[Category: Large Structures]]
	[[Category: Holden, J K]]		[[Category: Holden, J K]]
	[[Category: Poulos, T L]]		[[Category: Poulos, T L]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 09:12, 30 January 2019

OCA — Wed, 30 Jan 2019 09:12:30 GMT

←Older revision		Revision as of 09:12, 30 January 2019
Line 3:		Line 3:
	<StructureSection load='4d7j' size='340' side='right' caption='[[4d7j]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='4d7j' size='340' side='right' caption='[[4d7j]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4d7j]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D7J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D7J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4d7j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacsu Bacsu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D7J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D7J FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0GD:6-[4-({[2-(3-FLUOROPHENYL)ETHYL]AMINO}METHYL)PHENYL]-4-METHYLPYRIDIN-2-AMINE'>0GD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=POL:N-PROPANOL'>POL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0GD:6-[4-({[2-(3-FLUOROPHENYL)ETHYL]AMINO}METHYL)PHENYL]-4-METHYLPYRIDIN-2-AMINE'>0GD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=POL:N-PROPANOL'>POL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d7h\|4d7h]], [[4d7i\|4d7i]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d7h\|4d7h]], [[4d7i\|4d7i]]</td></tr>
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4d7j" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4d7j" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Nitric Oxide Synthase\|Nitric Oxide Synthase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacsu]]
	[[Category: Holden, J K]]		[[Category: Holden, J K]]
	[[Category: Poulos, T L]]		[[Category: Poulos, T L]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 13:30, 19 April 2017

OCA — Wed, 19 Apr 2017 13:30:16 GMT

←Older revision		Revision as of 13:30, 19 April 2017
Line 1:		Line 1:
		+
	==Structure of Bacillus subtilis nitric oxide synthase in complex with 6-(4-(((3-Fluorophenethyl)amino)methyl)phenyl)-4-methylpyridin-2- amine==		==Structure of Bacillus subtilis nitric oxide synthase in complex with 6-(4-(((3-Fluorophenethyl)amino)methyl)phenyl)-4-methylpyridin-2- amine==
	<StructureSection load='4d7j' size='340' side='right' caption='[[4d7j]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='4d7j' size='340' side='right' caption='[[4d7j]], [[Resolution\|resolution]] 1.55Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d7h\|4d7h]], [[4d7i\|4d7i]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d7h\|4d7h]], [[4d7i\|4d7i]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NAD(P)H-dependent) Nitric-oxide synthase (NAD(P)H-dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.165 1.14.13.165] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NAD(P)H-dependent) Nitric-oxide synthase (NAD(P)H-dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.165 1.14.13.165] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d7j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d7j RCSB], [http://www.ebi.ac.uk/pdbsum/4d7j PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d7j OCA], [http://pdbe.org/4d7j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d7j RCSB], [http://www.ebi.ac.uk/pdbsum/4d7j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4d7j ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4d7j" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:49, 15 July 2015

OCA — Wed, 15 Jul 2015 07:49:04 GMT

←Older revision		Revision as of 07:49, 15 July 2015
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/NOSO_BACSU NOSO_BACSU]] Catalyzes the production of nitric oxide.		[[http://www.uniprot.org/uniprot/NOSO_BACSU NOSO_BACSU]] Catalyzes the production of nitric oxide.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bacterial infections associated with methicillin-resistant Staphylococcus aureus (MRSA) are a major economic burden to hospitals, and confer high rates of morbidity and mortality among those infected. Exploitation of novel therapeutic targets is thus necessary to combat this dangerous pathogen. Here, we report on the identification and characterization, including crystal structures, of two nitric oxide synthase (NOS) inhibitors that function as antimicrobials against MRSA. These data provide the first evidence that bacterial NOS (bNOS) inhibitors can work synergistically with oxidative stress to enhance MRSA killing. Crystal structures show that each inhibitor contacts an active site Ile residue in bNOS that is Val in the mammalian NOS isoforms. Mutagenesis studies show that the additional nonpolar contacts provided by the Ile in bNOS contribute to tighter binding toward the bacterial enzyme.
		+
		+	Nitric Oxide Synthase as a Target for Methicillin-Resistant Staphylococcus aureus.,Holden JK, Kang S, Beasley FC, Cinelli MA, Li H, Roy SG, Dejam D, Edinger AL, Nizet V, Silverman RB, Poulos TL Chem Biol. 2015 Jun 18;22(6):785-92. doi: 10.1016/j.chembiol.2015.05.013. PMID:26091171<ref>PMID:26091171</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 12:17, 1 July 2015

OCA — Wed, 01 Jul 2015 12:17:02 GMT

←Older revision		Revision as of 12:17, 1 July 2015
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-	~~'''Unreleased structure'''~~	+	==Structure of Bacillus subtilis nitric oxide synthase in complex with 6-(4-(((3-Fluorophenethyl)amino)methyl)phenyl)-4-methylpyridin-2- amine==
-		+	<StructureSection load='4d7j' size='340' side='right' caption='[[4d7j]], [[Resolution\|resolution]] 1.55Å' scene=''>
-	~~The entry 4d7j is ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4d7j]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D7J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D7J FirstGlance]. <br>
-	~~Authors: Holden, J.K., Poulos, T.L.~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0GD:6-[4-({[2-(3-FLUOROPHENYL)ETHYL]AMINO}METHYL)PHENYL]-4-METHYLPYRIDIN-2-AMINE'>0GD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=POL:N-PROPANOL'>POL</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4d7h\|4d7h]], [[4d7i\|4d7i]]</td></tr>
-	~~Description:~~ Structure of Bacillus subtilis nitric oxide synthase in complex with 6-(4-(((3-Fluorophenethyl)amino)methyl)phenyl)-4-methylpyridin-2-amine	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NAD(P)H-dependent) Nitric-oxide synthase (NAD(P)H-dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.165 1.14.13.165] </span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d7j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d7j RCSB], [http://www.ebi.ac.uk/pdbsum/4d7j PDBsum]</span></td></tr>
-	[[Category: Holden, J.K]]	+	</table>
-	[[Category: Poulos, T.L]]	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NOSO_BACSU NOSO_BACSU]] Catalyzes the production of nitric oxide.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Holden, J K]]
		+	[[Category: Poulos, T L]]
		+	[[Category: Oxidoreductase]]

OCA at 06:51, 4 March 2015

OCA — Wed, 04 Mar 2015 06:51:15 GMT

←Older revision		Revision as of 06:51, 4 March 2015
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4d7j is ON HOLD	+	The entry 4d7j is ON HOLD until Paper Publication

	Authors: Holden, J.K., Poulos, T.L.		Authors: Holden, J.K., Poulos, T.L.

OCA at 13:57, 24 December 2014

OCA — Wed, 24 Dec 2014 13:57:14 GMT

←Older revision		Revision as of 13:57, 24 December 2014
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	Description: Structure of Bacillus subtilis nitric oxide synthase in complex with 6-(4-(((3-Fluorophenethyl)amino)methyl)phenyl)-4-methylpyridin-2-amine		Description: Structure of Bacillus subtilis nitric oxide synthase in complex with 6-(4-(((3-Fluorophenethyl)amino)methyl)phenyl)-4-methylpyridin-2-amine
		+	[[Category: Unreleased Structures]]
		+	[[Category: Holden, J.K]]
		+	[[Category: Poulos, T.L]]

OCA: Protected "4d7j" [edit=sysop:move=sysop]

OCA — Wed, 03 Dec 2014 08:02:12 GMT

Protected "4d7j" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:02, 3 December 2014