4d9o - Revision history

OCA at 08:48, 20 March 2024

OCA — Wed, 20 Mar 2024 08:48:29 GMT

←Older revision		Revision as of 08:48, 20 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4d9o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Reston_ebolavirus_-_Reston Reston ebolavirus - Reston]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D9O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D9O FirstGlance]. <br>		<table><tr><td colspan='2'>[[4d9o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Reston_ebolavirus_-_Reston Reston ebolavirus - Reston]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D9O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D9O FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d9o OCA], [https://pdbe.org/4d9o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d9o RCSB], [https://www.ebi.ac.uk/pdbsum/4d9o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d9o ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d9o OCA], [https://pdbe.org/4d9o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d9o RCSB], [https://www.ebi.ac.uk/pdbsum/4d9o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d9o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/VP24_EBORE VP24_EBORE]] Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1, by interacting with the STAT1-binding region of host importin alpha-1/KPNA1 protein, thereby inhibiting the latter. Without the activity of this protein, activated STAT1 would not enter the nucleus and be unable to activate IFN-induced genes. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.	+	[https://www.uniprot.org/uniprot/VP24_EBORE VP24_EBORE] Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1, by interacting with the STAT1-binding region of host importin alpha-1/KPNA1 protein, thereby inhibiting the latter. Without the activity of this protein, activated STAT1 would not enter the nucleus and be unable to activate IFN-induced genes. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Ebolaviruses cause hemorrhagic fever with up to 90% lethality and in fatal cases, are characterized by early suppression of the host innate immune system. One of the proteins likely responsible for this effect is VP24. VP24 is known to antagonize interferon signaling by binding host karyopherin alpha proteins, thereby preventing them from transporting the tyrosine-phosphorylated transcription factor STAT1 to the nucleus. Here, we report that VP24 binds STAT1 directly, suggesting that VP24 can suppress at least two distinct branches of the interferon pathway. Here, we also report the first crystal structures of VP24, derived from different species of ebolavirus that are pathogenic (Sudan) and nonpathogenic to humans (Reston). These structures reveal that VP24 has a novel, pyramidal fold. A site on a particular face of the pyramid exhibits reduced solvent exchange when in complex with STAT1. This site is above two highly conserved pockets in VP24 that contain key residues previously implicated in virulence. These crystal structures and accompanying biochemical analysis map differences between pathogenic and nonpathogenic viruses, offer templates for drug design, and provide the three-dimensional framework necessary for biological dissection of the many functions of VP24 in the virus life cycle.	+
-		+
-	The ebola virus interferon antagonist VP24 directly binds STAT1 and has a novel, pyramidal fold.,Zhang AP, Bornholdt ZA, Liu T, Abelson DM, Lee DE, Li S, Woods VL Jr, Saphire EO PLoS Pathog. 2012 Feb;8(2):e1002550. Epub 2012 Feb 23. PMID:22383882<ref>PMID:22383882</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 4d9o" style="background-color:#fffaf0;"></div>~~	+

	==See Also==		==See Also==
	*[[VP24\|VP24]]		*[[VP24\|VP24]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:07, 21 September 2022

OCA — Wed, 21 Sep 2022 08:07:56 GMT

←Older revision		Revision as of 08:07, 21 September 2022
Line 1:		Line 1:

	==Structure of ebolavirus protein VP24 from Reston==		==Structure of ebolavirus protein VP24 from Reston==
-	<StructureSection load='4d9o' size='340' side='right' caption='[[4d9o]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='4d9o' size='340' side='right'caption='[[4d9o]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4d9o]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Ebore Ebore~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D9O OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4D9O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4d9o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Reston_ebolavirus_-_Reston Reston ebolavirus - Reston]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D9O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D9O FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3vne\|3vne]], [[3vnf\|3vnf]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d9o OCA], [https://pdbe.org/4d9o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d9o RCSB], [https://www.ebi.ac.uk/pdbsum/4d9o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d9o ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VP24 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=129003 EBORE])</td></tr>~~	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4d9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d9o OCA], [~~http~~://pdbe.org/4d9o PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4d9o RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4d9o PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4d9o ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/VP24_EBORE VP24_EBORE]] Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1, by interacting with the STAT1-binding region of host importin alpha-1/KPNA1 protein, thereby inhibiting the latter. Without the activity of this protein, activated STAT1 would not enter the nucleus and be unable to activate IFN-induced genes. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.	+	[[https://www.uniprot.org/uniprot/VP24_EBORE VP24_EBORE]] Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1, by interacting with the STAT1-binding region of host importin alpha-1/KPNA1 protein, thereby inhibiting the latter. Without the activity of this protein, activated STAT1 would not enter the nucleus and be unable to activate IFN-induced genes. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ebore]]~~	+	[[Category: Large Structures]]
-	~~[[Category: Zhang, A P.P]]~~	+	[[Category: Reston ebolavirus - Reston]]
-	~~[[Category: Ebolavirus]]~~	+	[[Category: Zhang APP]]
-	~~[[Category: Ifn response pathway]]~~	+
-	~~[[Category: Interferon antagonist]]~~	+
-	~~[[Category: Karyopherin alpha~~]]	+
-	[[Category: Reston]]	+
-	[[Category: ~~Stat1]]~~	+
-	~~[[Category: Sudan]]~~	+
-	~~[[Category: Viral protein]]~~	+
-	~~[[Category: Vp24]]~~	+
-	~~[[Category: Vp35]]~~	+
-	~~[[Category: Zaire~~]]	+

OCA at 11:56, 5 August 2016

OCA — Fri, 05 Aug 2016 11:56:26 GMT

←Older revision		Revision as of 11:56, 5 August 2016
Line 1:		Line 1:
		+
	==Structure of ebolavirus protein VP24 from Reston==		==Structure of ebolavirus protein VP24 from Reston==
	<StructureSection load='4d9o' size='340' side='right' caption='[[4d9o]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4d9o' size='340' side='right' caption='[[4d9o]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4d9o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Reston_ebolavirus Reston ebolavirus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D9O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D9O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4d9o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ebore Ebore]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D9O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D9O FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3vne\|3vne]], [[3vnf\|3vnf]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3vne\|3vne]], [[3vnf\|3vnf]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VP24 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~186539 Reston ebolavirus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VP24 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=129003 EBORE])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d9o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d9o RCSB], [http://www.ebi.ac.uk/pdbsum/4d9o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d9o OCA], [http://pdbe.org/4d9o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d9o RCSB], [http://www.ebi.ac.uk/pdbsum/4d9o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4d9o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4d9o" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Reston ebolavirus~~]]	+	[[Category: Ebore]]
	[[Category: Zhang, A P.P]]		[[Category: Zhang, A P.P]]
	[[Category: Ebolavirus]]		[[Category: Ebolavirus]]

OCA at 18:36, 25 December 2014

OCA — Thu, 25 Dec 2014 18:36:56 GMT

←Older revision		Revision as of 18:36, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d9o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d9o RCSB], [http://www.ebi.ac.uk/pdbsum/4d9o PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d9o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d9o RCSB], [http://www.ebi.ac.uk/pdbsum/4d9o PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/VP24_EBORE VP24_EBORE]] Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1, by interacting with the STAT1-binding region of host importin alpha-1/KPNA1 protein, thereby inhibiting the latter. Without the activity of this protein, activated STAT1 would not enter the nucleus and be unable to activate IFN-induced genes. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 15:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[VP24\|VP24]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:31, 6 November 2014

OCA — Thu, 06 Nov 2014 07:31:29 GMT

←Older revision		Revision as of 07:31, 6 November 2014
Line 1:		Line 1:
-	[[~~Image:~~4d9o.~~jpg~~\|~~left~~\|~~200px~~]]	+	==Structure of ebolavirus protein VP24 from Reston==
		+	<StructureSection load='4d9o' size='340' side='right' caption='[[4d9o]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4d9o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Reston_ebolavirus Reston ebolavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D9O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D9O FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3vne\|3vne]], [[3vnf\|3vnf]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VP24 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=186539 Reston ebolavirus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d9o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d9o RCSB], [http://www.ebi.ac.uk/pdbsum/4d9o PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ebolaviruses cause hemorrhagic fever with up to 90% lethality and in fatal cases, are characterized by early suppression of the host innate immune system. One of the proteins likely responsible for this effect is VP24. VP24 is known to antagonize interferon signaling by binding host karyopherin alpha proteins, thereby preventing them from transporting the tyrosine-phosphorylated transcription factor STAT1 to the nucleus. Here, we report that VP24 binds STAT1 directly, suggesting that VP24 can suppress at least two distinct branches of the interferon pathway. Here, we also report the first crystal structures of VP24, derived from different species of ebolavirus that are pathogenic (Sudan) and nonpathogenic to humans (Reston). These structures reveal that VP24 has a novel, pyramidal fold. A site on a particular face of the pyramid exhibits reduced solvent exchange when in complex with STAT1. This site is above two highly conserved pockets in VP24 that contain key residues previously implicated in virulence. These crystal structures and accompanying biochemical analysis map differences between pathogenic and nonpathogenic viruses, offer templates for drug design, and provide the three-dimensional framework necessary for biological dissection of the many functions of VP24 in the virus life cycle.

-	~~<!--~~	+	The ebola virus interferon antagonist VP24 directly binds STAT1 and has a novel, pyramidal fold.,Zhang AP, Bornholdt ZA, Liu T, Abelson DM, Lee DE, Li S, Woods VL Jr, Saphire EO PLoS Pathog. 2012 Feb;8(2):e1002550. Epub 2012 Feb 23. PMID:22383882<ref>PMID:22383882</ref>
-	The ~~line below this paragraph~~, ~~containing "STRUCTURE_4d9o"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_4d9o\| PDB=4d9o \| SCENE= }}~~	+

-	~~===Structure~~ of ~~ebolavirus protein VP24 from Reston===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_22383882}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22383882 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_22383882}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[4d9o]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Reston_ebolavirus Reston ebolavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D9O OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022383882<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Reston ebolavirus]]		[[Category: Reston ebolavirus]]
-	[[Category: Zhang, A P.P.]]	+	[[Category: Zhang, A P.P]]
	[[Category: Ebolavirus]]		[[Category: Ebolavirus]]
	[[Category: Ifn response pathway]]		[[Category: Ifn response pathway]]

OCA at 07:52, 18 April 2012

OCA — Wed, 18 Apr 2012 07:52:03 GMT

←Older revision		Revision as of 07:52, 18 April 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4d9o.jpg\|left\|200px]]

-	The ~~entry 4d9o~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_4d9o", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_4d9o\| PDB=4d9o \| SCENE= }}

-	~~Authors: Zhang, A.P.P.~~	+	===Structure of ebolavirus protein VP24 from Reston===

-	~~Description~~:	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22383882}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22383882 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22383882}}
		+
		+	==About this Structure==
		+	[[4d9o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Reston_ebolavirus Reston ebolavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D9O OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022383882</ref><references group="xtra"/>
		+	[[Category: Reston ebolavirus]]
		+	[[Category: Zhang, A P.P.]]
		+	[[Category: Ebolavirus]]
		+	[[Category: Ifn response pathway]]
		+	[[Category: Interferon antagonist]]
		+	[[Category: Karyopherin alpha]]
		+	[[Category: Reston]]
		+	[[Category: Stat1]]
		+	[[Category: Sudan]]
		+	[[Category: Viral protein]]
		+	[[Category: Vp24]]
		+	[[Category: Vp35]]
		+	[[Category: Zaire]]

OCA at 06:09, 8 February 2012

OCA — Wed, 08 Feb 2012 06:09:40 GMT

←Older revision		Revision as of 06:09, 8 February 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4d9o is ON HOLD	+	The entry 4d9o is ON HOLD until Paper Publication

	Authors: Zhang, A.P.P.		Authors: Zhang, A.P.P.

	Description:		Description:

OCA at 06:58, 1 February 2012

OCA — Wed, 01 Feb 2012 06:58:56 GMT

←Older revision		Revision as of 06:58, 1 February 2012
Line 5:		Line 5:
	Authors: Zhang, A.P.P.		Authors: Zhang, A.P.P.

-	Description: ~~TBA~~	+	Description:

OCA: Protected "4d9o" [edit=sysop:move=sysop]

OCA — Wed, 18 Jan 2012 10:27:55 GMT

Protected "4d9o" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:27, 18 January 2012

OCA: New page: '''Unreleased structure''' The entry 4d9o is ON HOLD Authors: Zhang, A.P.P. Description: TBA

OCA — Wed, 18 Jan 2012 10:27:54 GMT

New page: '''Unreleased structure''' The entry 4d9o is ON HOLD Authors: Zhang, A.P.P. Description: TBA

New page

'''Unreleased structure'''

The entry 4d9o is ON HOLD

Authors: Zhang, A.P.P.

Description: TBA