4dg6 - Revision history

OCA at 08:16, 21 September 2022

OCA — Wed, 21 Sep 2022 08:16:44 GMT

←Older revision		Revision as of 08:16, 21 September 2022
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	==Crystal structure of domains 1 and 2 of LRP6==		==Crystal structure of domains 1 and 2 of LRP6==
-	<StructureSection load='4dg6' size='340' side='right' caption='[[4dg6]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<StructureSection load='4dg6' size='340' side='right'caption='[[4dg6]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4dg6]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DG6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4DG6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4dg6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DG6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DG6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=PO4:PHOSPHATE+ION'~~>~~PO4</scene>,~~ <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><~~/td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">LRP6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dg6 OCA], [https://pdbe.org/4dg6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dg6 RCSB], [https://www.ebi.ac.uk/pdbsum/4dg6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dg6 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4dg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dg6 OCA], [~~http~~://pdbe.org/4dg6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4dg6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4dg6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4dg6 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/LRP6_HUMAN LRP6_HUMAN]] Coronary artery disease - hyperlipidemia - hypertension - diabetes - osteoporosis. The disease is caused by mutations affecting the gene represented in this entry.	+	[[https://www.uniprot.org/uniprot/LRP6_HUMAN LRP6_HUMAN]] Coronary artery disease - hyperlipidemia - hypertension - diabetes - osteoporosis. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LRP6_HUMAN LRP6_HUMAN]] Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).<ref>PMID:11448771</ref> <ref>PMID:11357136</ref> <ref>PMID:15778503</ref> <ref>PMID:16341017</ref> <ref>PMID:16513652</ref> <ref>PMID:17400545</ref> <ref>PMID:17326769</ref> <ref>PMID:19107203</ref> <ref>PMID:19801552</ref> <ref>PMID:19293931</ref>	+	[[https://www.uniprot.org/uniprot/LRP6_HUMAN LRP6_HUMAN]] Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).<ref>PMID:11448771</ref> <ref>PMID:11357136</ref> <ref>PMID:15778503</ref> <ref>PMID:16341017</ref> <ref>PMID:16513652</ref> <ref>PMID:17400545</ref> <ref>PMID:17326769</ref> <ref>PMID:19107203</ref> <ref>PMID:19801552</ref> <ref>PMID:19293931</ref>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Ceska, T A~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Doyle, C~~]]	+	[[Category: Ceska TA]]
-	[[Category: ~~Slocombe, P~~]]	+	[[Category: Doyle C]]
-	[[Category: ~~6-bladed beta propeller]]~~	+	[[Category: Slocombe P]]
-	~~[[Category: Egf]]~~	+
-	~~[[Category: Mesd]]~~	+
-	~~[[Category: Sclerostin receptor]]~~	+
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Wnt~~]]	+

OCA at 18:21, 11 August 2016

OCA — Thu, 11 Aug 2016 18:21:49 GMT

←Older revision		Revision as of 18:21, 11 August 2016
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		+
	==Crystal structure of domains 1 and 2 of LRP6==		==Crystal structure of domains 1 and 2 of LRP6==
	<StructureSection load='4dg6' size='340' side='right' caption='[[4dg6]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='4dg6' size='340' side='right' caption='[[4dg6]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4dg6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DG6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DG6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4dg6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DG6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DG6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LRP6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LRP6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dg6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dg6 RCSB], [http://www.ebi.ac.uk/pdbsum/4dg6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dg6 OCA], [http://pdbe.org/4dg6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4dg6 RCSB], [http://www.ebi.ac.uk/pdbsum/4dg6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4dg6 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 15:		Line 16:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Ceska, T A]]		[[Category: Ceska, T A]]
	[[Category: Doyle, C]]		[[Category: Doyle, C]]

OCA at 13:12, 4 January 2015

OCA — Sun, 04 Jan 2015 13:12:25 GMT

←Older revision		Revision as of 13:12, 4 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4dg6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DG6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DG6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4dg6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DG6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DG6 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LRP6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LRP6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dg6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dg6 RCSB], [http://www.ebi.ac.uk/pdbsum/4dg6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dg6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dg6 RCSB], [http://www.ebi.ac.uk/pdbsum/4dg6 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/LRP6_HUMAN LRP6_HUMAN]] Coronary artery disease - hyperlipidemia - hypertension - diabetes - osteoporosis. The disease is caused by mutations affecting the gene represented in this entry.		[[http://www.uniprot.org/uniprot/LRP6_HUMAN LRP6_HUMAN]] Coronary artery disease - hyperlipidemia - hypertension - diabetes - osteoporosis. The disease is caused by mutations affecting the gene represented in this entry.
Line 16:		Line 16:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Ceska, T A.]]	+	[[Category: Ceska, T A]]
-	[[Category: Doyle, C.]]	+	[[Category: Doyle, C]]
-	[[Category: Slocombe, P.]]	+	[[Category: Slocombe, P]]
	[[Category: 6-bladed beta propeller]]		[[Category: 6-bladed beta propeller]]
	[[Category: Egf]]		[[Category: Egf]]

OCA at 08:19, 5 June 2014

OCA — Thu, 05 Jun 2014 08:19:28 GMT

←Older revision		Revision as of 08:19, 5 June 2014
Line 1:		Line 1:
-	~~[[Image:4dg6.jpg\|left\|200px]]~~	+	==Crystal structure of domains 1 and 2 of LRP6==
-		+	<StructureSection load='4dg6' size='340' side='right' caption='[[4dg6]], [[Resolution\|resolution]] 2.90Å' scene=''>
-	~~<!--~~	+	== Structural highlights ==
-	~~The line below this paragraph, containing "STRUCTURE_4dg6", creates the "Structure Box" on the page.~~	+	<table><tr><td colspan='2'>[[4dg6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DG6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DG6 FirstGlance]. <br>
-	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LRP6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	~~or leave the SCENE parameter empty for the default display.~~	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dg6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dg6 RCSB], [http://www.ebi.ac.uk/pdbsum/4dg6 PDBsum]</span></td></tr>
-	~~-->~~	+	<table>
-	~~{{STRUCTURE_4dg6\| PDB=4dg6 \| SCENE= }}~~	+	== Disease ==
-		+	[[http://www.uniprot.org/uniprot/LRP6_HUMAN LRP6_HUMAN]] Coronary artery disease - hyperlipidemia - hypertension - diabetes - osteoporosis. The disease is caused by mutations affecting the gene represented in this entry.
-	===Crystal structure of domains 1 and 2 of LRP6===	+	== Function ==
-		+	[[http://www.uniprot.org/uniprot/LRP6_HUMAN LRP6_HUMAN]] Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).<ref>PMID:11448771</ref> <ref>PMID:11357136</ref> <ref>PMID:15778503</ref> <ref>PMID:16341017</ref> <ref>PMID:16513652</ref> <ref>PMID:17400545</ref> <ref>PMID:17326769</ref> <ref>PMID:19107203</ref> <ref>PMID:19801552</ref> <ref>PMID:19293931</ref>
-		+	== References ==
-	==~~About this Structure~~==	+	<references/>
-	[[4dg6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DG6 OCA].	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ceska, T A.]]		[[Category: Ceska, T A.]]

OCA at 06:22, 13 June 2012

OCA — Wed, 13 Jun 2012 06:22:30 GMT

←Older revision		Revision as of 06:22, 13 June 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4dg6.jpg\|left\|200px]]

-	The ~~entry 4dg6~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_4dg6", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_4dg6\| PDB=4dg6 \| SCENE= }}

-	~~Authors: Ceska, T.A., Doyle, C., Slocombe, P.~~	+	===Crystal structure of domains 1 and 2 of LRP6===

-	~~Description: Crystal structure of domains~~ 1 ~~and 2 of LRP6~~	+
		+	==About this Structure==
		+	[[4dg6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DG6 OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Ceska, T A.]]
		+	[[Category: Doyle, C.]]
		+	[[Category: Slocombe, P.]]
		+	[[Category: 6-bladed beta propeller]]
		+	[[Category: Egf]]
		+	[[Category: Mesd]]
		+	[[Category: Sclerostin receptor]]
		+	[[Category: Signaling protein]]
		+	[[Category: Wnt]]

OCA at 08:48, 25 April 2012

OCA — Wed, 25 Apr 2012 08:48:53 GMT

←Older revision		Revision as of 08:48, 25 April 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4dg6 is ON HOLD	+	The entry 4dg6 is ON HOLD until Paper Publication

	Authors: Ceska, T.A., Doyle, C., Slocombe, P.		Authors: Ceska, T.A., Doyle, C., Slocombe, P.

	Description: Crystal structure of domains 1 and 2 of LRP6		Description: Crystal structure of domains 1 and 2 of LRP6

OCA: Protected "4dg6" [edit=sysop:move=sysop]

OCA — Wed, 01 Feb 2012 07:03:20 GMT

Protected "4dg6" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:03, 1 February 2012

OCA: New page: '''Unreleased structure''' The entry 4dg6 is ON HOLD Authors: Ceska, T.A., Doyle, C., Slocombe, P. Description: Crystal structure of domains 1 and 2 of LRP6

OCA — Wed, 01 Feb 2012 07:03:19 GMT

New page: '''Unreleased structure''' The entry 4dg6 is ON HOLD Authors: Ceska, T.A., Doyle, C., Slocombe, P. Description: Crystal structure of domains 1 and 2 of LRP6

New page

'''Unreleased structure'''

The entry 4dg6 is ON HOLD

Authors: Ceska, T.A., Doyle, C., Slocombe, P.

Description: Crystal structure of domains 1 and 2 of LRP6