4dge - Revision history

OCA at 14:35, 14 March 2024

OCA — Thu, 14 Mar 2024 14:35:05 GMT

←Older revision		Revision as of 14:35, 14 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4dge]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] and [https://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DGE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DGE FirstGlance]. <br>		<table><tr><td colspan='2'>[[4dge]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] and [https://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DGE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DGE FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dge FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dge OCA], [https://pdbe.org/4dge PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dge RCSB], [https://www.ebi.ac.uk/pdbsum/4dge PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dge ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dge FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dge OCA], [https://pdbe.org/4dge PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dge RCSB], [https://www.ebi.ac.uk/pdbsum/4dge PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dge ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PPIA_MACMU PPIA_MACMU]] Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity).[UniProtKB:P17742][UniProtKB:P62937]	+	[https://www.uniprot.org/uniprot/PPIA_MACMU PPIA_MACMU] Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity).[UniProtKB:P17742][UniProtKB:P62937]
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Rhesus macaque TRIMCyp (RhTC) is a potent primate antiviral host protein that inhibits the replication of diverse HIV viruses. Here we show that it has acquired the ability to target multiple viruses by evolving an active site that interconverts between multiple conformations. Mutations that have relieved active site constraints allow RhTC to dynamically sample conformational space, including radically different conformers that target both HIV-1 and HIV-2 viruses. Introduction of a reversible constraint into RhTC allows specificity to be switched between a single conformation specific for HIV-1 and a dynamic ensemble that targets multiple viruses. These results show that conformational diversity can be used to expand the target diversity of innate immune receptors by supplementing their limited genetic variability with variability in protein structure.	+
-		+
-	Diverse HIV viruses are targeted by a conformationally dynamic antiviral.,Caines ME, Bichel K, Price AJ, McEwan WA, Towers GJ, Willett BJ, Freund SM, James LC Nat Struct Mol Biol. 2012 Mar 11. doi: 10.1038/nsmb.2253. PMID:22407016<ref>PMID:22407016</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 4dge" style="background-color:#fffaf0;"></div>~~	+

	==See Also==		==See Also==
	*[[Cyclophilin 3D structures\|Cyclophilin 3D structures]]		*[[Cyclophilin 3D structures\|Cyclophilin 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:17, 21 September 2022

OCA — Wed, 21 Sep 2022 08:17:17 GMT

←Older revision		Revision as of 08:17, 21 September 2022
Line 1:		Line 1:

	==TRIMCyp cyclophilin domain from Macaca mulatta: H70C mutant, HIV-1 CA(O-loop) complex==		==TRIMCyp cyclophilin domain from Macaca mulatta: H70C mutant, HIV-1 CA(O-loop) complex==
-	<StructureSection load='4dge' size='340' side='right' caption='[[4dge]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='4dge' size='340' side='right'caption='[[4dge]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4dge]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~9hiv1 9hiv1~~] and [~~http~~://en.wikipedia.org/wiki/~~Macmu Macmu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DGE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4DGE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4dge]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] and [https://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DGE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DGE FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dga\|4dga]], [[4dgb\|4dgb]], [[4dgc\|4dgc]], [[4dgd\|4dgd]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dge FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dge OCA], [https://pdbe.org/4dge PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dge RCSB], [https://www.ebi.ac.uk/pdbsum/4dge PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dge ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRIMCyp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9544 MACMU]), gag ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4dge FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dge OCA], [~~http~~://pdbe.org/4dge PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4dge RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4dge PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4dge ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/~~Q72497_9HIV1 Q72497_9HIV1~~]] ~~Capsid protein p24 forms~~ the ~~conical core~~ of ~~the virus~~ that ~~encapsulates~~ the ~~genomic RNA~~-~~nucleocapsid complex~~ (By similarity). ~~Nucleocapsid~~ protein ~~p7 encapsulates~~ and ~~protects viral dimeric unspliced~~ (~~genomic~~) RNA. Binds ~~these RNAs through its zinc fingers~~ (By similarity).[~~SAAS~~:~~SAAS012344_004_011858~~]	+	[[https://www.uniprot.org/uniprot/PPIA_MACMU PPIA_MACMU]] Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity).[UniProtKB:P17742][UniProtKB:P62937]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 19:

	==See Also==		==See Also==
-	*[[Cyclophilin\|Cyclophilin]]	+	*[[Cyclophilin 3D structures\|Cyclophilin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Macmu~~]]	+	[[Category: Human immunodeficiency virus 1]]
-	[[Category: ~~Peptidylprolyl isomerase~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Bichel, K~~]]	+	[[Category: Macaca mulatta]]
-	[[Category: ~~Caines, M E.C~~]]	+	[[Category: Bichel K]]
-	[[Category: ~~James, L C~~]]	+	[[Category: Caines MEC]]
-	[[Category: ~~McEwan, W A~~]]	+	[[Category: James LC]]
-	[[Category: ~~Price, A J~~]]	+	[[Category: McEwan WA]]
-	[[Category: ~~Anti-viral protein]]~~	+	[[Category: Price AJ]]
-	~~[[Category: Isomerase-viral protein complex~~]]	+

OCA at 13:12, 11 August 2016

OCA — Thu, 11 Aug 2016 13:12:12 GMT

←Older revision		Revision as of 13:12, 11 August 2016
Line 1:		Line 1:
		+
	==TRIMCyp cyclophilin domain from Macaca mulatta: H70C mutant, HIV-1 CA(O-loop) complex==		==TRIMCyp cyclophilin domain from Macaca mulatta: H70C mutant, HIV-1 CA(O-loop) complex==
	<StructureSection load='4dge' size='340' side='right' caption='[[4dge]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='4dge' size='340' side='right' caption='[[4dge]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4dge]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Human_immunodeficiency_virus_1 Human immunodeficiency virus 1~~] and [http://en.wikipedia.org/wiki/~~Macaca_mulatta Macaca mulatta~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DGE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DGE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4dge]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1] and [http://en.wikipedia.org/wiki/Macmu Macmu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DGE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DGE FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dga\|4dga]], [[4dgb\|4dgb]], [[4dgc\|4dgc]], [[4dgd\|4dgd]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dga\|4dga]], [[4dgb\|4dgb]], [[4dgc\|4dgc]], [[4dgd\|4dgd]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRIMCyp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9544 ~~Macaca mulatta~~]), gag ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 ~~Human immunodeficiency virus 1~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRIMCyp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9544 MACMU]), gag ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dge FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dge OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dge RCSB], [http://www.ebi.ac.uk/pdbsum/4dge PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dge FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dge OCA], [http://pdbe.org/4dge PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4dge RCSB], [http://www.ebi.ac.uk/pdbsum/4dge PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4dge ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q72497_9HIV1 Q72497_9HIV1]] Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity). Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers (By similarity).[SAAS:SAAS012344_004_011858]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 16:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4dge" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 23:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human immunodeficiency virus 1]]~~	+	[[Category: Macmu]]
-	~~[[Category: Macaca mulatta~~]]	+
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
	[[Category: Bichel, K]]		[[Category: Bichel, K]]

OCA at 13:26, 4 January 2015

OCA — Sun, 04 Jan 2015 13:26:14 GMT

←Older revision		Revision as of 13:26, 4 January 2015
Line 1:		Line 1:
-	[[~~Image:~~4dge.~~png~~\|~~left~~\|~~200px~~]]	+	==TRIMCyp cyclophilin domain from Macaca mulatta: H70C mutant, HIV-1 CA(O-loop) complex==
		+	<StructureSection load='4dge' size='340' side='right' caption='[[4dge]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4dge]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] and [http://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DGE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DGE FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dga\|4dga]], [[4dgb\|4dgb]], [[4dgc\|4dgc]], [[4dgd\|4dgd]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRIMCyp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9544 Macaca mulatta]), gag ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dge FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dge OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dge RCSB], [http://www.ebi.ac.uk/pdbsum/4dge PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Rhesus macaque TRIMCyp (RhTC) is a potent primate antiviral host protein that inhibits the replication of diverse HIV viruses. Here we show that it has acquired the ability to target multiple viruses by evolving an active site that interconverts between multiple conformations. Mutations that have relieved active site constraints allow RhTC to dynamically sample conformational space, including radically different conformers that target both HIV-1 and HIV-2 viruses. Introduction of a reversible constraint into RhTC allows specificity to be switched between a single conformation specific for HIV-1 and a dynamic ensemble that targets multiple viruses. These results show that conformational diversity can be used to expand the target diversity of innate immune receptors by supplementing their limited genetic variability with variability in protein structure.

-	~~<!--~~	+	Diverse HIV viruses are targeted by a conformationally dynamic antiviral.,Caines ME, Bichel K, Price AJ, McEwan WA, Towers GJ, Willett BJ, Freund SM, James LC Nat Struct Mol Biol. 2012 Mar 11. doi: 10.1038/nsmb.2253. PMID:22407016<ref>PMID:22407016</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_4dge"~~, ~~creates the "Structure Box" on the page.~~	+
-	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded)~~,	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_4dge\| PDB=4dge \| SCENE= }}~~	+

-	~~===TRIMCyp cyclophilin domain from Macaca mulatta: H70C mutant~~, ~~HIV-1 CA(O-loop) complex===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-		+	==See Also==
-	~~<!--~~	+	*[[Cyclophilin\|Cyclophilin]]
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_22407016}}, adds the Publication Abstract to the page~~	+	== References ==
-	~~(as it appears on PubMed at http://www.pubmed.gov), where 22407016 is the PubMed ID number.~~	+	<references/>
-	~~-->~~	+	__TOC__
-	~~{{ABSTRACT_PUBMED_22407016}}~~	+	</StructureSection>
-		+
-	==~~About this Structure~~==	+
-	[[~~4dge~~]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] and [http://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DGE OCA].	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022407016<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Human immunodeficiency virus 1]]		[[Category: Human immunodeficiency virus 1]]
	[[Category: Macaca mulatta]]		[[Category: Macaca mulatta]]
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
-	[[Category: Bichel, K.]]	+	[[Category: Bichel, K]]
-	[[Category: Caines, M E.C.]]	+	[[Category: Caines, M E.C]]
-	[[Category: James, L C.]]	+	[[Category: James, L C]]
-	[[Category: McEwan, W A.]]	+	[[Category: McEwan, W A]]
-	[[Category: Price, A J.]]	+	[[Category: Price, A J]]
	[[Category: Anti-viral protein]]		[[Category: Anti-viral protein]]
	[[Category: Isomerase-viral protein complex]]		[[Category: Isomerase-viral protein complex]]

OCA at 07:00, 28 March 2012

OCA — Wed, 28 Mar 2012 07:00:23 GMT

←Older revision		Revision as of 07:00, 28 March 2012
Line 1:		Line 1:
-	[[Image:4dge.~~jpg~~\|left\|200px]]	+	[[Image:4dge.png\|left\|200px]]

	<!--		<!--
Line 11:		Line 11:
	===TRIMCyp cyclophilin domain from Macaca mulatta: H70C mutant, HIV-1 CA(O-loop) complex===		===TRIMCyp cyclophilin domain from Macaca mulatta: H70C mutant, HIV-1 CA(O-loop) complex===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22407016}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22407016 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22407016}}

	==About this Structure==		==About this Structure==
	[[4dge]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] and [http://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DGE OCA].		[[4dge]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] and [http://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DGE OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022407016</ref><references group="xtra"/>
	[[Category: Human immunodeficiency virus 1]]		[[Category: Human immunodeficiency virus 1]]
	[[Category: Macaca mulatta]]		[[Category: Macaca mulatta]]

OCA at 06:46, 8 February 2012

OCA — Wed, 08 Feb 2012 06:46:47 GMT

←Older revision		Revision as of 06:46, 8 February 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4dge.jpg\|left\|200px]]

-	The ~~entry 4dge~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_4dge", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_4dge\| PDB=4dge \| SCENE= }}

-	~~Authors~~: ~~Caines~~, ~~M.E.C., Bichel, K., Price, A.J., McEwan, W.A., James, L.C.~~	+	===TRIMCyp cyclophilin domain from Macaca mulatta: H70C mutant, HIV-1 CA(O-loop) complex===

-	~~Description~~: ~~TRIMCyp cyclophilin domain~~ from Macaca mulatta: ~~H70C mutant~~, ~~HIV~~-~~1 CA(O~~-~~loop)~~ complex	+
		+	==About this Structure==
		+	[[4dge]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] and [http://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DGE OCA].
		+	[[Category: Human immunodeficiency virus 1]]
		+	[[Category: Macaca mulatta]]
		+	[[Category: Peptidylprolyl isomerase]]
		+	[[Category: Bichel, K.]]
		+	[[Category: Caines, M E.C.]]
		+	[[Category: James, L C.]]
		+	[[Category: McEwan, W A.]]
		+	[[Category: Price, A J.]]
		+	[[Category: Anti-viral protein]]
		+	[[Category: Isomerase-viral protein complex]]

OCA: Protected "4dge" [edit=sysop:move=sysop]

OCA — Wed, 01 Feb 2012 07:03:34 GMT

Protected "4dge" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:03, 1 February 2012

OCA: New page: '''Unreleased structure''' The entry 4dge is ON HOLD Authors: Caines, M.E.C., Bichel, K., Price, A.J., McEwan, W.A., James, L.C. Description: TRIMCyp cyclophilin domain from Macaca mul...

OCA — Wed, 01 Feb 2012 07:03:32 GMT

New page: '''Unreleased structure''' The entry 4dge is ON HOLD Authors: Caines, M.E.C., Bichel, K., Price, A.J., McEwan, W.A., James, L.C. Description: TRIMCyp cyclophilin domain from Macaca mul...

New page

'''Unreleased structure'''

The entry 4dge is ON HOLD

Authors: Caines, M.E.C., Bichel, K., Price, A.J., McEwan, W.A., James, L.C.

Description: TRIMCyp cyclophilin domain from Macaca mulatta: H70C mutant, HIV-1 CA(O-loop) complex