4dkb - Revision history

OCA at 14:37, 14 March 2024

OCA — Thu, 14 Mar 2024 14:37:10 GMT

←Older revision		Revision as of 14:37, 14 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4dkb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DKB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DKB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4dkb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DKB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DKB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DUN:2-DEOXYURIDINE+5-ALPHA,BETA-IMIDO-DIPHOSPHATE'>DUN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.831Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DUN:2-DEOXYURIDINE+5-ALPHA,BETA-IMIDO-DIPHOSPHATE'>DUN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dkb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dkb OCA], [https://pdbe.org/4dkb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dkb RCSB], [https://www.ebi.ac.uk/pdbsum/4dkb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dkb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dkb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dkb OCA], [https://pdbe.org/4dkb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dkb RCSB], [https://www.ebi.ac.uk/pdbsum/4dkb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dkb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/Q57ZH3_TRYB2 Q57ZH3_TRYB2]]	+	[https://www.uniprot.org/uniprot/Q57ZH3_TRYB2 Q57ZH3_TRYB2]
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	The Tritryps Trypanosoma brucei, T. cruzi and Leishmania donovani are responsible for great morbidity and mortality in developing countries. Their dimeric dUTPases are members of the all-a NTP pyrophosphohydrolase family and represent promising drug targets due to their essential nature and markedly different structural and biochemical properties compared to the trimeric human enzyme. Here we present the structure of the T. brucei enzyme in open and closed conformations. Furthermore, we probe the reaction mechanism through the binding of transition state mimics both in solution and in the crystal. 31P-NMR and tryptophan fluorescence quenching in the presence of AlF3 and MgF3- identified which phosphate is subject to nucleophilic attack by a water molecule. The structures in complex with two transition state analogues confirm that the nucleophilic attack occurs on the b-phosphate in contrast to the a-phosphate in the trimeric enzymes. These results establish the structural basis of catalysis of these important house-keeping enzymes and has ramifications for the wider all-a NTP pyrophosphohydrolase family.	+
-		+
-	~~On the catalytic mechanism of dimeric dUTPases.,Hemsworth GR, Gonzalez-Pacanowska D, Wilson KS Biochem J. 2013 Sep 4. PMID:24001052<ref>PMID:24001052</ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 4dkb" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:22, 21 September 2022

OCA — Wed, 21 Sep 2022 08:22:48 GMT

←Older revision		Revision as of 08:22, 21 September 2022
Line 1:		Line 1:

	==Crystal Structure of Trypanosoma brucei dUTPase with dUpNp and Ca2+==		==Crystal Structure of Trypanosoma brucei dUTPase with dUpNp and Ca2+==
-	<StructureSection load='4dkb' size='340' side='right' caption='[[4dkb]], [[Resolution\|resolution]] 1.83Å' scene=''>	+	<StructureSection load='4dkb' size='340' side='right'caption='[[4dkb]], [[Resolution\|resolution]] 1.83Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4dkb]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Trypanosoma_(trypanozoon)_brucei~~ Trypanosoma ~~(trypanozoon)~~ brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DKB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4DKB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4dkb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DKB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DKB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DUN:2-DEOXYURIDINE+5-ALPHA,BETA-IMIDO-DIPHOSPHATE'>DUN</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DUN:2-DEOXYURIDINE+5-ALPHA,BETA-IMIDO-DIPHOSPHATE'>DUN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dk2\|4dk2]], [[4dk4\|4dk4]], [[4dl8\|4dl8]], [[4dlc\|4dlc]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dkb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dkb OCA], [https://pdbe.org/4dkb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dkb RCSB], [https://www.ebi.ac.uk/pdbsum/4dkb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dkb ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tb927.7.5160 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma (Trypanozoon) brucei])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4dkb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dkb OCA], [~~http~~://pdbe.org/4dkb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4dkb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4dkb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4dkb ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/Q57ZH3_TRYB2 Q57ZH3_TRYB2]]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~DUTP diphosphatase~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Gonzalez-Pacanowska, D~~]]	+	[[Category: Trypanosoma brucei]]
-	[[Category: ~~Hemsworth, G R~~]]	+	[[Category: Gonzalez-Pacanowska D]]
-	[[Category: ~~Wilson, K S~~]]	+	[[Category: Hemsworth GR]]
-	[[Category: ~~All alpha ntp pyrophosphatase]]~~	+	[[Category: Wilson KS]]
-	~~[[Category: All alpha ntp pyrophosphohydrolase]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex~~]]	+

OCA at 16:41, 4 August 2016

OCA — Thu, 04 Aug 2016 16:41:56 GMT

←Older revision		Revision as of 16:41, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of Trypanosoma brucei dUTPase with dUpNp and Ca2+==		==Crystal Structure of Trypanosoma brucei dUTPase with dUpNp and Ca2+==
	<StructureSection load='4dkb' size='340' side='right' caption='[[4dkb]], [[Resolution\|resolution]] 1.83Å' scene=''>		<StructureSection load='4dkb' size='340' side='right' caption='[[4dkb]], [[Resolution\|resolution]] 1.83Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4dkb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Trypanosoma_brucei~~ Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DKB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DKB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4dkb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DKB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DKB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DUN:2-DEOXYURIDINE+5-ALPHA,BETA-IMIDO-DIPHOSPHATE'>DUN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DUN:2-DEOXYURIDINE+5-ALPHA,BETA-IMIDO-DIPHOSPHATE'>DUN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dk2\|4dk2]], [[4dk4\|4dk4]], [[4dl8\|4dl8]], [[4dlc\|4dlc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dk2\|4dk2]], [[4dk4\|4dk4]], [[4dl8\|4dl8]], [[4dlc\|4dlc]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tb927.7.5160 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma brucei])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tb927.7.5160 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma (Trypanozoon) brucei])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dkb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dkb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dkb RCSB], [http://www.ebi.ac.uk/pdbsum/4dkb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dkb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dkb OCA], [http://pdbe.org/4dkb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4dkb RCSB], [http://www.ebi.ac.uk/pdbsum/4dkb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4dkb ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4dkb" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Trypanosoma brucei]]
	[[Category: DUTP diphosphatase]]		[[Category: DUTP diphosphatase]]
	[[Category: Gonzalez-Pacanowska, D]]		[[Category: Gonzalez-Pacanowska, D]]

OCA at 10:03, 21 December 2014

OCA — Sun, 21 Dec 2014 10:03:15 GMT

←Older revision		Revision as of 10:03, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4dkb\| PDB=4dkb \| SCENE= }}~~	+	==Crystal Structure of Trypanosoma brucei dUTPase with dUpNp and Ca2+==
-	===Crystal Structure of Trypanosoma brucei dUTPase with dUpNp and Ca2+===	+	<StructureSection load='4dkb' size='340' side='right' caption='[[4dkb]], [[Resolution\|resolution]] 1.83Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24001052}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4dkb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DKB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DKB FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DUN:2-DEOXYURIDINE+5-ALPHA,BETA-IMIDO-DIPHOSPHATE'>DUN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dk2\|4dk2]], [[4dk4\|4dk4]], [[4dl8\|4dl8]], [[4dlc\|4dlc]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tb927.7.5160 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma brucei])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dkb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dkb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dkb RCSB], [http://www.ebi.ac.uk/pdbsum/4dkb PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Tritryps Trypanosoma brucei, T. cruzi and Leishmania donovani are responsible for great morbidity and mortality in developing countries. Their dimeric dUTPases are members of the all-a NTP pyrophosphohydrolase family and represent promising drug targets due to their essential nature and markedly different structural and biochemical properties compared to the trimeric human enzyme. Here we present the structure of the T. brucei enzyme in open and closed conformations. Furthermore, we probe the reaction mechanism through the binding of transition state mimics both in solution and in the crystal. 31P-NMR and tryptophan fluorescence quenching in the presence of AlF3 and MgF3- identified which phosphate is subject to nucleophilic attack by a water molecule. The structures in complex with two transition state analogues confirm that the nucleophilic attack occurs on the b-phosphate in contrast to the a-phosphate in the trimeric enzymes. These results establish the structural basis of catalysis of these important house-keeping enzymes and has ramifications for the wider all-a NTP pyrophosphohydrolase family.

-	~~==About this Structure==~~	+	On the catalytic mechanism of dimeric dUTPases.,Hemsworth GR, Gonzalez-Pacanowska D, Wilson KS Biochem J. 2013 Sep 4. PMID:24001052<ref>PMID:24001052</ref>
-	~~[[4dkb]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Trypanosoma_brucei Trypanosoma brucei]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4DKB OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024001052</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Trypanosoma brucei]]		[[Category: Trypanosoma brucei]]
	[[Category: DUTP diphosphatase]]		[[Category: DUTP diphosphatase]]
-	[[Category: Gonzalez-Pacanowska, D.]]	+	[[Category: Gonzalez-Pacanowska, D]]
-	[[Category: Hemsworth, G R.]]	+	[[Category: Hemsworth, G R]]
-	[[Category: Wilson, K S.]]	+	[[Category: Wilson, K S]]
	[[Category: All alpha ntp pyrophosphatase]]		[[Category: All alpha ntp pyrophosphatase]]
	[[Category: All alpha ntp pyrophosphohydrolase]]		[[Category: All alpha ntp pyrophosphohydrolase]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 02:54, 20 September 2013

OCA — Fri, 20 Sep 2013 02:54:12 GMT

←Older revision		Revision as of 02:54, 20 September 2013
Line 1:		Line 1:
	{{STRUCTURE_4dkb\| PDB=4dkb \| SCENE= }}		{{STRUCTURE_4dkb\| PDB=4dkb \| SCENE= }}
	===Crystal Structure of Trypanosoma brucei dUTPase with dUpNp and Ca2+===		===Crystal Structure of Trypanosoma brucei dUTPase with dUpNp and Ca2+===
		+	{{ABSTRACT_PUBMED_24001052}}

	==About this Structure==		==About this Structure==
	[[4dkb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DKB OCA].		[[4dkb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DKB OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:024001052</ref><references group="xtra"/><references/>
	[[Category: Trypanosoma brucei]]		[[Category: Trypanosoma brucei]]
	[[Category: DUTP diphosphatase]]		[[Category: DUTP diphosphatase]]

OCA at 20:59, 7 August 2013

OCA — Wed, 07 Aug 2013 20:59:34 GMT

←Older revision		Revision as of 20:59, 7 August 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4dkb\| PDB=4dkb \| SCENE= }}
		+	===Crystal Structure of Trypanosoma brucei dUTPase with dUpNp and Ca2+===

-	~~The entry~~ 4dkb is ~~ON HOLD until Aug 04 2014~~	+	==About this Structure==
-		+	[[4dkb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DKB OCA].
-	~~Authors~~: ~~Hemsworth, G~~.R., Gonzalez-Pacanowska, D., Wilson, K.S.	+	[[Category: Trypanosoma brucei]]
-		+	[[Category: DUTP diphosphatase]]
-	~~Description~~: ~~Crystal Structure of Trypanosoma brucei dUTPase with dUpNp and Ca2+~~	+	[[Category: Gonzalez-Pacanowska, D.]]
		+	[[Category: Hemsworth, G R.]]
		+	[[Category: Wilson, K S.]]
		+	[[Category: All alpha ntp pyrophosphatase]]
		+	[[Category: All alpha ntp pyrophosphohydrolase]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 10:52, 19 December 2012

OCA — Wed, 19 Dec 2012 10:52:24 GMT

←Older revision		Revision as of 10:52, 19 December 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4dkb is ON HOLD until ~~Paper Publication~~	+	The entry 4dkb is ON HOLD until Aug 04 2014

	Authors: Hemsworth, G.R., Gonzalez-Pacanowska, D., Wilson, K.S.		Authors: Hemsworth, G.R., Gonzalez-Pacanowska, D., Wilson, K.S.

	Description: Crystal Structure of Trypanosoma brucei dUTPase with dUpNp and Ca2+		Description: Crystal Structure of Trypanosoma brucei dUTPase with dUpNp and Ca2+

OCA: Protected "4dkb" [edit=sysop:move=sysop]

OCA — Wed, 15 Feb 2012 06:22:00 GMT

Protected "4dkb" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:22, 15 February 2012

OCA: New page: '''Unreleased structure''' The entry 4dkb is ON HOLD until Paper Publication Authors: Hemsworth, G.R., Gonzalez-Pacanowska, D., Wilson, K.S. Description: Crystal Structure of Trypanoso...

OCA — Wed, 15 Feb 2012 06:22:00 GMT

New page: '''Unreleased structure''' The entry 4dkb is ON HOLD until Paper Publication Authors: Hemsworth, G.R., Gonzalez-Pacanowska, D., Wilson, K.S. Description: Crystal Structure of Trypanoso...

New page

'''Unreleased structure'''

The entry 4dkb is ON HOLD until Paper Publication

Authors: Hemsworth, G.R., Gonzalez-Pacanowska, D., Wilson, K.S.

Description: Crystal Structure of Trypanosoma brucei dUTPase with dUpNp and Ca2+