4dq8 - Revision history

OCA at 14:42, 14 March 2024

OCA — Thu, 14 Mar 2024 14:42:22 GMT

←Older revision		Revision as of 14:42, 14 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4dq8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_marinum_M Mycobacterium marinum M]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DQ8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4dq8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_marinum_M Mycobacterium marinum M]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DQ8 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dq8 OCA], [https://pdbe.org/4dq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dq8 RCSB], [https://www.ebi.ac.uk/pdbsum/4dq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dq8 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.25Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dq8 OCA], [https://pdbe.org/4dq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dq8 RCSB], [https://www.ebi.ac.uk/pdbsum/4dq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dq8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ACKA_MYCMM ACKA_MYCMM]] Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.[HAMAP-Rule:MF_00020]	+	[https://www.uniprot.org/uniprot/ACKA_MYCMM ACKA_MYCMM] Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.[HAMAP-Rule:MF_00020]
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	High-resolution three-dimensional structures of essential Mycobacterium tuberculosis (Mtb) proteins provide templates for TB drug design, but are available for only a small fraction of the Mtb proteome. Here we evaluate an intra-genus "homolog-rescue" strategy to increase the structural information available for TB drug discovery by using mycobacterial homologs with conserved active sites. Of 179 potential TB drug targets selected for x-ray structure determination, only 16 yielded a crystal structure. By adding 1675 homologs from nine other mycobacterial species to the pipeline, structures representing an additional 52 otherwise intractable targets were solved. To determine whether these homolog structures would be useful surrogates in TB drug design, we compared the active sites of 106 pairs of Mtb and non-TB mycobacterial (NTM) enzyme homologs with experimentally determined structures, using three metrics of active site similarity, including superposition of continuous pharmacophoric property distributions. Pair-wise structural comparisons revealed that 19/22 pairs with >55% overall sequence identity had active site Calpha RMSD <1 A, >85% side chain identity, and >/=80% PSAPF (similarity based on pharmacophoric properties) indicating highly conserved active site shape and chemistry. Applying these results to the 52 NTM structures described above, 41 shared >55% sequence identity with the Mtb target, thus increasing the effective structural coverage of the 179 Mtb targets over three-fold (from 9% to 32%). The utility of these structures in TB drug design can be tested by designing inhibitors using the homolog structure and assaying the cognate Mtb enzyme; a promising test case, Mtb cytidylate kinase, is described. The homolog-rescue strategy evaluated here for TB is also generalizable to drug targets for other diseases.	+
-		+
-	Increasing the structural coverage of tuberculosis drug targets.,Baugh L, Phan I, Begley DW, Clifton MC, Armour B, Dranow DM, Taylor BM, Muruthi MM, Abendroth J, Fairman JW, Fox D 3rd, Dieterich SH, Staker BL, Gardberg AS, Choi R, Hewitt SN, Napuli AJ, Myers J, Barrett LK, Zhang Y, Ferrell M, Mundt E, Thompkins K, Tran N, Lyons-Abbott S, Abramov A, Sekar A, Serbzhinskiy D, Lorimer D, Buchko GW, Stacy R, Stewart LJ, Edwards TE, Van Voorhis WC, Myler PJ Tuberculosis (Edinb). 2014 Dec 19. pii: S1472-9792(14)20565-8. doi:, 10.1016/j.tube.2014.12.003. PMID:25613812<ref>PMID:25613812</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 4dq8" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mycobacterium marinum M]]		[[Category: Mycobacterium marinum M]]

OCA at 08:34, 21 September 2022

OCA — Wed, 21 Sep 2022 08:34:09 GMT

←Older revision		Revision as of 08:34, 21 September 2022
Line 1:		Line 1:

	==Crystal structure of acetate kinase AckA from Mycobacterium marinum==		==Crystal structure of acetate kinase AckA from Mycobacterium marinum==
-	<StructureSection load='4dq8' size='340' side='right' caption='[[4dq8]], [[Resolution\|resolution]] 2.25Å' scene=''>	+	<StructureSection load='4dq8' size='340' side='right'caption='[[4dq8]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4dq8]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Mycmm Mycmm~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DQ8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4DQ8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4dq8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_marinum_M Mycobacterium marinum M]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DQ8 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ackA, MMAR_0711 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216594 MYCMM])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dq8 OCA], [https://pdbe.org/4dq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dq8 RCSB], [https://www.ebi.ac.uk/pdbsum/4dq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dq8 ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetate_kinase Acetate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.1 2.7.2.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4dq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dq8 OCA], [~~http~~://pdbe.org/4dq8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4dq8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4dq8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4dq8 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ACKA_MYCMM ACKA_MYCMM]] Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.[HAMAP-Rule:MF_00020]	+	[[https://www.uniprot.org/uniprot/ACKA_MYCMM ACKA_MYCMM]] Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.[HAMAP-Rule:MF_00020]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Acetate kinase]]~~	+	[[Category: Large Structures]]
-	~~[[Category: Mycmm]]~~	+	[[Category: Mycobacterium marinum M]]
-	~~[[Category: Structural genomic]]~~	+
-	~~[[Category: Acetokinase]]~~	+
-	~~[[Category: Acetyl-coa biosynthesis]]~~	+
-	~~[[Category: Atp-dependent]]~~	+
-	~~[[Category: Cytoplasmic]]~~	+
-	~~[[Category: Metabolic intermediate biosynthesis~~]]	+
-	[[Category: Mycobacterium]]	+
-	~~[[Category: Transferase~~]]	+

OCA at 18:38, 1 February 2017

OCA — Wed, 01 Feb 2017 18:38:08 GMT

←Older revision		Revision as of 18:38, 1 February 2017
Line 1:		Line 1:
		+
	==Crystal structure of acetate kinase AckA from Mycobacterium marinum==		==Crystal structure of acetate kinase AckA from Mycobacterium marinum==
	<StructureSection load='4dq8' size='340' side='right' caption='[[4dq8]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='4dq8' size='340' side='right' caption='[[4dq8]], [[Resolution\|resolution]] 2.25Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ackA, MMAR_0711 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216594 MYCMM])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ackA, MMAR_0711 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216594 MYCMM])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetate_kinase Acetate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.1 2.7.2.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetate_kinase Acetate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.1 2.7.2.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dq8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dq8 RCSB], [http://www.ebi.ac.uk/pdbsum/4dq8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dq8 OCA], [http://pdbe.org/4dq8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4dq8 RCSB], [http://www.ebi.ac.uk/pdbsum/4dq8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4dq8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4dq8" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:37, 22 April 2015

OCA — Wed, 22 Apr 2015 06:37:28 GMT

←Older revision		Revision as of 06:37, 22 April 2015
Line 2:		Line 2:
	<StructureSection load='4dq8' size='340' side='right' caption='[[4dq8]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='4dq8' size='340' side='right' caption='[[4dq8]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4dq8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_marinum Mycobacterium marinum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DQ8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DQ8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4dq8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycmm Mycmm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DQ8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DQ8 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ackA, MMAR_0711 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~1781 Mycobacterium marinum~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ackA, MMAR_0711 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216594 MYCMM])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetate_kinase Acetate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.1 2.7.2.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetate_kinase Acetate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.1 2.7.2.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dq8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dq8 RCSB], [http://www.ebi.ac.uk/pdbsum/4dq8 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dq8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dq8 RCSB], [http://www.ebi.ac.uk/pdbsum/4dq8 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~B2HPZ3_MYCMM B2HPZ3_MYCMM~~]] Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction ~~(By similarity)~~.[HAMAP-Rule:MF_00020]	+	[[http://www.uniprot.org/uniprot/ACKA_MYCMM ACKA_MYCMM]] Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.[HAMAP-Rule:MF_00020]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	High-resolution three-dimensional structures of essential Mycobacterium tuberculosis (Mtb) proteins provide templates for TB drug design, but are available for only a small fraction of the Mtb proteome. Here we evaluate an intra-genus "homolog-rescue" strategy to increase the structural information available for TB drug discovery by using mycobacterial homologs with conserved active sites. Of 179 potential TB drug targets selected for x-ray structure determination, only 16 yielded a crystal structure. By adding 1675 homologs from nine other mycobacterial species to the pipeline, structures representing an additional 52 otherwise intractable targets were solved. To determine whether these homolog structures would be useful surrogates in TB drug design, we compared the active sites of 106 pairs of Mtb and non-TB mycobacterial (NTM) enzyme homologs with experimentally determined structures, using three metrics of active site similarity, including superposition of continuous pharmacophoric property distributions. Pair-wise structural comparisons revealed that 19/22 pairs with >55% overall sequence identity had active site Calpha RMSD <1 A, >85% side chain identity, and >/=80% PSAPF (similarity based on pharmacophoric properties) indicating highly conserved active site shape and chemistry. Applying these results to the 52 NTM structures described above, 41 shared >55% sequence identity with the Mtb target, thus increasing the effective structural coverage of the 179 Mtb targets over three-fold (from 9% to 32%). The utility of these structures in TB drug design can be tested by designing inhibitors using the homolog structure and assaying the cognate Mtb enzyme; a promising test case, Mtb cytidylate kinase, is described. The homolog-rescue strategy evaluated here for TB is also generalizable to drug targets for other diseases.
		+
		+	Increasing the structural coverage of tuberculosis drug targets.,Baugh L, Phan I, Begley DW, Clifton MC, Armour B, Dranow DM, Taylor BM, Muruthi MM, Abendroth J, Fairman JW, Fox D 3rd, Dieterich SH, Staker BL, Gardberg AS, Choi R, Hewitt SN, Napuli AJ, Myers J, Barrett LK, Zhang Y, Ferrell M, Mundt E, Thompkins K, Tran N, Lyons-Abbott S, Abramov A, Sekar A, Serbzhinskiy D, Lorimer D, Buchko GW, Stacy R, Stewart LJ, Edwards TE, Van Voorhis WC, Myler PJ Tuberculosis (Edinb). 2014 Dec 19. pii: S1472-9792(14)20565-8. doi:, 10.1016/j.tube.2014.12.003. PMID:25613812<ref>PMID:25613812</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Acetate kinase]]		[[Category: Acetate kinase]]
-	[[Category: ~~Mycobacterium marinum~~]]	+	[[Category: Mycmm]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Acetokinase]]		[[Category: Acetokinase]]

OCA at 06:46, 24 December 2014

OCA — Wed, 24 Dec 2014 06:46:02 GMT

←Older revision		Revision as of 06:46, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4dq8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_marinum Mycobacterium marinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DQ8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DQ8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4dq8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_marinum Mycobacterium marinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DQ8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DQ8 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ackA, MMAR_0711 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1781 Mycobacterium marinum])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ackA, MMAR_0711 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1781 Mycobacterium marinum])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetate_kinase Acetate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.1 2.7.2.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetate_kinase Acetate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.1 2.7.2.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dq8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dq8 RCSB], [http://www.ebi.ac.uk/pdbsum/4dq8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dq8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dq8 RCSB], [http://www.ebi.ac.uk/pdbsum/4dq8 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/B2HPZ3_MYCMM B2HPZ3_MYCMM]] Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity).[HAMAP-Rule:MF_00020]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Acetate kinase]]		[[Category: Acetate kinase]]
	[[Category: Mycobacterium marinum]]		[[Category: Mycobacterium marinum]]
-	[[Category: ~~SSGCID, Seattle~~ Structural ~~Genomics Center for Infectious Disease.~~]]	+	[[Category: Structural genomic]]
	[[Category: Acetokinase]]		[[Category: Acetokinase]]
	[[Category: Acetyl-coa biosynthesis]]		[[Category: Acetyl-coa biosynthesis]]

OCA at 07:18, 5 June 2014

OCA — Thu, 05 Jun 2014 07:18:21 GMT

←Older revision		Revision as of 07:18, 5 June 2014
Line 1:		Line 1:
-	~~[[Image:4dq8.jpg\|left\|200px]]~~	+	==Crystal structure of acetate kinase AckA from Mycobacterium marinum==
-		+	<StructureSection load='4dq8' size='340' side='right' caption='[[4dq8]], [[Resolution\|resolution]] 2.25Å' scene=''>
-	~~<!--~~	+	== Structural highlights ==
-	~~The line below this paragraph, containing "STRUCTURE_4dq8", creates the "Structure Box" on the page.~~	+	<table><tr><td colspan='2'>[[4dq8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_marinum Mycobacterium marinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DQ8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DQ8 FirstGlance]. <br>
-	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~	+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ackA, MMAR_0711 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1781 Mycobacterium marinum])</td></tr>
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetate_kinase Acetate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.1 2.7.2.1] </span></td></tr>
-	~~or leave the SCENE parameter empty for the default display.~~	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dq8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dq8 RCSB], [http://www.ebi.ac.uk/pdbsum/4dq8 PDBsum]</span></td></tr>
-	~~-->~~	+	<table>
-	~~{{STRUCTURE_4dq8\| PDB=4dq8 \| SCENE= }}~~	+	__TOC__
-		+	</StructureSection>
-	===Crystal structure of acetate kinase AckA from Mycobacterium marinum===	+
-		+
-		+
-	==~~About this Structure~~==	+
-	[[4dq8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_marinum Mycobacterium marinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DQ8 OCA].	+
	[[Category: Acetate kinase]]		[[Category: Acetate kinase]]
	[[Category: Mycobacterium marinum]]		[[Category: Mycobacterium marinum]]

OCA: Protected "4dq8" [edit=sysop:move=sysop]

OCA — Wed, 22 Feb 2012 08:05:06 GMT

Protected "4dq8" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:05, 22 February 2012