4dt8 - Revision history

OCA at 10:56, 1 March 2024

OCA — Fri, 01 Mar 2024 10:56:35 GMT

←Older revision		Revision as of 10:56, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4dt8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_casseliflavus Enterococcus casseliflavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DT8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DT8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4dt8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_casseliflavus Enterococcus casseliflavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DT8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DT8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.15Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dt8 OCA], [https://pdbe.org/4dt8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dt8 RCSB], [https://www.ebi.ac.uk/pdbsum/4dt8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dt8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dt8 OCA], [https://pdbe.org/4dt8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dt8 RCSB], [https://www.ebi.ac.uk/pdbsum/4dt8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dt8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/O68183_ENTCA O68183_ENTCA]]	+	[https://www.uniprot.org/uniprot/O68183_ENTCA O68183_ENTCA]
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Enzymatic phosphorylation through a family of enzymes called aminoglycoside O-phosphotransferases (APHs) is a major mechanism by which bacteria confer resistance to aminoglycoside antibiotics. Members of the APH(2'') subfamily are of particular clinical interest because of their prevalence in pathogenic strains and their broad substrate spectra. APH(2'') enzymes display differential preferences between ATP or GTP as the phosphate donor, with aminoglycoside 2''-phosphotransferase IVa (APH(2'')-IVa) being a member that utilizes both nucleotides at comparable efficiencies. We report here four crystal structures of APH(2'')-IVa, two of the wild type enzyme and two of single amino acid mutants, each in complex with either adenosine or guanosine. Together, these structures afford a detailed look at the nucleoside-binding site architecture for this enzyme and reveal key elements that confer dual nucleotide specificity, including a solvent network in the interior of the nucleoside-binding pocket and the conformation of an interdomain linker loop. Steady state kinetic studies, as well as sequence and structural comparisons with members of the APH(2'') subfamily and other aminoglycoside kinases, rationalize the different substrate preferences for these enzymes. Finally, despite poor overall sequence similarity and structural homology, analysis of the nucleoside-binding pocket of APH(2'')-IVa shows a striking resemblance to that of eukaryotic casein kinase 2 (CK2), which also exhibits dual nucleotide specificity. These results, in complement with the multitude of existing inhibitors against CK2, can serve as a structural basis for the design of nucleotide-competitive inhibitors against clinically relevant APH enzymes.	+
-		+
-	Structural Basis for Dual Nucleotide Selectivity of Aminoglycoside 2''-Phosphotransferase IVa Provides Insight on Determinants of Nucleotide Specificity of Aminoglycoside Kinases.,Shi K, Berghuis AM J Biol Chem. 2012 Apr 13;287(16):13094-102. Epub 2012 Feb 24. PMID:22371504<ref>PMID:22371504</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 4dt8" style="background-color:#fffaf0;"></div>~~	+

	==See Also==		==See Also==
	*[[Phosphotransferase 3D structures\|Phosphotransferase 3D structures]]		*[[Phosphotransferase 3D structures\|Phosphotransferase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:37, 21 September 2022

OCA — Wed, 21 Sep 2022 08:37:39 GMT

←Older revision		Revision as of 08:37, 21 September 2022
Line 1:		Line 1:

	==Crystal Structure of Aminoglycoside-2''-Phosphotransferase Type IVa in Complex with Adenosine==		==Crystal Structure of Aminoglycoside-2''-Phosphotransferase Type IVa in Complex with Adenosine==
-	<StructureSection load='4dt8' size='340' side='right' caption='[[4dt8]], [[Resolution\|resolution]] 2.15Å' scene=''>	+	<StructureSection load='4dt8' size='340' side='right'caption='[[4dt8]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4dt8]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"streptococcus_casseliflavus"_vaughan_et_al._1979 "streptococcus~~ casseliflavus~~" vaughan et al. 1979~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DT8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4DT8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4dt8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_casseliflavus Enterococcus casseliflavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DT8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DT8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dt9\|4dt9]], [[4dta\|4dta]], [[4dtb\|4dtb]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dt8 OCA], [https://pdbe.org/4dt8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dt8 RCSB], [https://www.ebi.ac.uk/pdbsum/4dt8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dt8 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aph(2'')-Id ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=37734 "Streptococcus casseliflavus" Vaughan et al. 1979])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4dt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dt8 OCA], [~~http~~://pdbe.org/4dt8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4dt8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4dt8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4dt8 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/O68183_ENTCA O68183_ENTCA]]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Phosphotransferase\|Phosphotransferase]]	+	*[[Phosphotransferase 3D structures\|Phosphotransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Streptococcus~~ casseliflavus ~~vaughan et al. 1979~~]]	+	[[Category: Enterococcus casseliflavus]]
-	[[Category: ~~Berghuis, A M~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Shi, K~~]]	+	[[Category: Berghuis AM]]
-	[[Category: ~~Aminoglycoside kinase]]~~	+	[[Category: Shi K]]
-	~~[[Category: Transferase~~]]	+

OCA at 02:42, 11 December 2016

OCA — Sun, 11 Dec 2016 02:42:49 GMT

←Older revision		Revision as of 02:42, 11 December 2016
Line 1:		Line 1:
		+
	==Crystal Structure of Aminoglycoside-2''-Phosphotransferase Type IVa in Complex with Adenosine==		==Crystal Structure of Aminoglycoside-2''-Phosphotransferase Type IVa in Complex with Adenosine==
	<StructureSection load='4dt8' size='340' side='right' caption='[[4dt8]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='4dt8' size='340' side='right' caption='[[4dt8]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4dt8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Enterococcus_casseliflavus Enterococcus~~ casseliflavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DT8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DT8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4dt8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"streptococcus_casseliflavus"_vaughan_et_al._1979 "streptococcus casseliflavus" vaughan et al. 1979]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DT8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DT8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dt9\|4dt9]], [[4dta\|4dta]], [[4dtb\|4dtb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dt9\|4dt9]], [[4dta\|4dta]], [[4dtb\|4dtb]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aph(2'')-Id ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=37734 ~~Enterococcus~~ casseliflavus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aph(2'')-Id ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=37734 "Streptococcus casseliflavus" Vaughan et al. 1979])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dt8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dt8 RCSB], [http://www.ebi.ac.uk/pdbsum/4dt8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dt8 OCA], [http://pdbe.org/4dt8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4dt8 RCSB], [http://www.ebi.ac.uk/pdbsum/4dt8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4dt8 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4dt8" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 23:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Enterococcus~~ casseliflavus]]	+	[[Category: Streptococcus casseliflavus vaughan et al. 1979]]
	[[Category: Berghuis, A M]]		[[Category: Berghuis, A M]]
	[[Category: Shi, K]]		[[Category: Shi, K]]
	[[Category: Aminoglycoside kinase]]		[[Category: Aminoglycoside kinase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 17:25, 9 December 2014

OCA — Tue, 09 Dec 2014 17:25:15 GMT

←Older revision		Revision as of 17:25, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4dt8.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal Structure of Aminoglycoside-2''-Phosphotransferase Type IVa in Complex with Adenosine==
		+	<StructureSection load='4dt8' size='340' side='right' caption='[[4dt8]], [[Resolution\|resolution]] 2.15Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4dt8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_casseliflavus Enterococcus casseliflavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DT8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DT8 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dt9\|4dt9]], [[4dta\|4dta]], [[4dtb\|4dtb]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aph(2'')-Id ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=37734 Enterococcus casseliflavus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dt8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dt8 RCSB], [http://www.ebi.ac.uk/pdbsum/4dt8 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Enzymatic phosphorylation through a family of enzymes called aminoglycoside O-phosphotransferases (APHs) is a major mechanism by which bacteria confer resistance to aminoglycoside antibiotics. Members of the APH(2'') subfamily are of particular clinical interest because of their prevalence in pathogenic strains and their broad substrate spectra. APH(2'') enzymes display differential preferences between ATP or GTP as the phosphate donor, with aminoglycoside 2''-phosphotransferase IVa (APH(2'')-IVa) being a member that utilizes both nucleotides at comparable efficiencies. We report here four crystal structures of APH(2'')-IVa, two of the wild type enzyme and two of single amino acid mutants, each in complex with either adenosine or guanosine. Together, these structures afford a detailed look at the nucleoside-binding site architecture for this enzyme and reveal key elements that confer dual nucleotide specificity, including a solvent network in the interior of the nucleoside-binding pocket and the conformation of an interdomain linker loop. Steady state kinetic studies, as well as sequence and structural comparisons with members of the APH(2'') subfamily and other aminoglycoside kinases, rationalize the different substrate preferences for these enzymes. Finally, despite poor overall sequence similarity and structural homology, analysis of the nucleoside-binding pocket of APH(2'')-IVa shows a striking resemblance to that of eukaryotic casein kinase 2 (CK2), which also exhibits dual nucleotide specificity. These results, in complement with the multitude of existing inhibitors against CK2, can serve as a structural basis for the design of nucleotide-competitive inhibitors against clinically relevant APH enzymes.

-	~~{{STRUCTURE_4dt8\| PDB=4dt8 \| SCENE= }}~~	+	Structural Basis for Dual Nucleotide Selectivity of Aminoglycoside 2''-Phosphotransferase IVa Provides Insight on Determinants of Nucleotide Specificity of Aminoglycoside Kinases.,Shi K, Berghuis AM J Biol Chem. 2012 Apr 13;287(16):13094-102. Epub 2012 Feb 24. PMID:22371504<ref>PMID:22371504</ref>

-	~~===Crystal Structure~~ of ~~Aminoglycoside-2''-Phosphotransferase Type IVa in Complex with Adenosine===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22371504}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[4dt8]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Enterococcus_casseliflavus Enterococcus casseliflavus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4DT8 OCA].~~	+

	==See Also==		==See Also==
	*[[Phosphotransferase\|Phosphotransferase]]		*[[Phosphotransferase\|Phosphotransferase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:022371504<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Enterococcus casseliflavus]]		[[Category: Enterococcus casseliflavus]]
-	[[Category: Berghuis, A M.]]	+	[[Category: Berghuis, A M]]
-	[[Category: Shi, K.]]	+	[[Category: Shi, K]]
	[[Category: Aminoglycoside kinase]]		[[Category: Aminoglycoside kinase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 08:24, 20 October 2012

OCA — Sat, 20 Oct 2012 08:24:40 GMT

←Older revision		Revision as of 08:24, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[4dt8]] is a 2 chain structure ~~of [[Phosphotransferase]]~~ with sequence from [http://en.wikipedia.org/wiki/Enterococcus_casseliflavus Enterococcus casseliflavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DT8 OCA].	+	[[4dt8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_casseliflavus Enterococcus casseliflavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DT8 OCA].

	==See Also==		==See Also==

OCA at 19:26, 25 July 2012

OCA — Wed, 25 Jul 2012 19:26:27 GMT

←Older revision		Revision as of 19:26, 25 July 2012
Line 1:		Line 1:
	[[Image:4dt8.png\|left\|200px]]		[[Image:4dt8.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_4dt8", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_4dt8\| PDB=4dt8 \| SCENE= }}		{{STRUCTURE_4dt8\| PDB=4dt8 \| SCENE= }}

	===Crystal Structure of Aminoglycoside-2''-Phosphotransferase Type IVa in Complex with Adenosine===		===Crystal Structure of Aminoglycoside-2''-Phosphotransferase Type IVa in Complex with Adenosine===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_22371504}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 22371504 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_22371504}}		{{ABSTRACT_PUBMED_22371504}}

	==About this Structure==		==About this Structure==
-	[[4dt8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_casseliflavus Enterococcus casseliflavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DT8 OCA].	+	[[4dt8]] is a 2 chain structure of [[Phosphotransferase]] with sequence from [http://en.wikipedia.org/wiki/Enterococcus_casseliflavus Enterococcus casseliflavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DT8 OCA].
		+
		+	==See Also==
		+	*[[Phosphotransferase\|Phosphotransferase]]

	==Reference==		==Reference==

OCA at 08:24, 9 May 2012

OCA — Wed, 09 May 2012 08:24:15 GMT

←Older revision		Revision as of 08:24, 9 May 2012
Line 1:		Line 1:
-	[[Image:4dt8.~~jpg~~\|left\|200px]]	+	[[Image:4dt8.png\|left\|200px]]

	<!--		<!--
Line 11:		Line 11:
	===Crystal Structure of Aminoglycoside-2''-Phosphotransferase Type IVa in Complex with Adenosine===		===Crystal Structure of Aminoglycoside-2''-Phosphotransferase Type IVa in Complex with Adenosine===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22371504}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22371504 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22371504}}

	==About this Structure==		==About this Structure==
	[[4dt8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_casseliflavus Enterococcus casseliflavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DT8 OCA].		[[4dt8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_casseliflavus Enterococcus casseliflavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DT8 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022371504</ref><references group="xtra"/>
	[[Category: Enterococcus casseliflavus]]		[[Category: Enterococcus casseliflavus]]
	[[Category: Berghuis, A M.]]		[[Category: Berghuis, A M.]]

OCA at 06:00, 8 March 2012

OCA — Thu, 08 Mar 2012 06:00:09 GMT

←Older revision		Revision as of 06:00, 8 March 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4dt8.jpg\|left\|200px]]

-	The ~~entry 4dt8~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_4dt8", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_4dt8\| PDB=4dt8 \| SCENE= }}

-	~~Authors: Shi, K., Berghuis, A.M.~~	+	===Crystal Structure of Aminoglycoside-2''-Phosphotransferase Type IVa in Complex with Adenosine===

-	~~Description: Crystal~~ Structure ~~of Aminoglycoside-~~2~~''-Phosphotransferase Type IVa in Complex~~ with ~~Adenosine~~	+
		+	==About this Structure==
		+	[[4dt8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_casseliflavus Enterococcus casseliflavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DT8 OCA].
		+	[[Category: Enterococcus casseliflavus]]
		+	[[Category: Berghuis, A M.]]
		+	[[Category: Shi, K.]]
		+	[[Category: Aminoglycoside kinase]]
		+	[[Category: Transferase]]

OCA: Protected "4dt8" [edit=sysop:move=sysop]

OCA — Wed, 29 Feb 2012 08:27:00 GMT

Protected "4dt8" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:27, 29 February 2012

OCA: New page: '''Unreleased structure''' The entry 4dt8 is ON HOLD Authors: Shi, K., Berghuis, A.M. Description: Crystal Structure of Aminoglycoside-2''-Phosphotransferase Type IVa in Complex with A...

OCA — Wed, 29 Feb 2012 08:26:59 GMT

New page: '''Unreleased structure''' The entry 4dt8 is ON HOLD Authors: Shi, K., Berghuis, A.M. Description: Crystal Structure of Aminoglycoside-2''-Phosphotransferase Type IVa in Complex with A...

New page

'''Unreleased structure'''

The entry 4dt8 is ON HOLD

Authors: Shi, K., Berghuis, A.M.

Description: Crystal Structure of Aminoglycoside-2''-Phosphotransferase Type IVa in Complex with Adenosine