4e6z - Revision history

OCA at 06:54, 28 September 2022

OCA — Wed, 28 Sep 2022 06:54:32 GMT

←Older revision		Revision as of 06:54, 28 September 2022
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	==Tic22 from Plasmodium falciparum==		==Tic22 from Plasmodium falciparum==
-	<StructureSection load='4e6z' size='340' side='right' caption='[[4e6z]], [[Resolution\|resolution]] 2.15Å' scene=''>	+	<StructureSection load='4e6z' size='340' side='right'caption='[[4e6z]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4e6z]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Plaf7 Plaf7~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E6Z OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4E6Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4e6z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E6Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E6Z FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>~~</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e6z OCA], [https://pdbe.org/4e6z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e6z RCSB], [https://www.ebi.ac.uk/pdbsum/4e6z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e6z ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PFE1460w ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4e6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e6z OCA], [~~http~~://pdbe.org/4e6z PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4e6z RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4e6z PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4e6z ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/Q8I3H4_PLAF7 Q8I3H4_PLAF7]]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Plaf7~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Glaser, S~~]]	+	[[Category: Plasmodium falciparum 3D7]]
-	[[Category: ~~Higgins, M K~~]]	+	[[Category: Glaser S]]
-	[[Category: ~~Apicoplast]]~~	+	[[Category: Higgins MK]]
-	~~[[Category: Import protein]]~~	+
-	~~[[Category: Tic complex]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 02:51, 11 December 2016

OCA — Sun, 11 Dec 2016 02:51:31 GMT

←Older revision		Revision as of 02:51, 11 December 2016
Line 1:		Line 1:
		+
	==Tic22 from Plasmodium falciparum==		==Tic22 from Plasmodium falciparum==
	<StructureSection load='4e6z' size='340' side='right' caption='[[4e6z]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='4e6z' size='340' side='right' caption='[[4e6z]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4e6z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E6Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4E6Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4e6z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E6Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4E6Z FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PFE1460w ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 ~~Plasmodium falciparum 3D7~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PFE1460w ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e6z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4e6z RCSB], [http://www.ebi.ac.uk/pdbsum/4e6z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e6z OCA], [http://pdbe.org/4e6z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4e6z RCSB], [http://www.ebi.ac.uk/pdbsum/4e6z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4e6z ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4e6z" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Plasmodium falciparum 3d7~~]]	+	[[Category: Plaf7]]
	[[Category: Glaser, S]]		[[Category: Glaser, S]]
	[[Category: Higgins, M K]]		[[Category: Higgins, M K]]

OCA at 16:08, 9 December 2014

OCA — Tue, 09 Dec 2014 16:08:37 GMT

←Older revision		Revision as of 16:08, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4e6z.~~png~~\|~~left~~\|~~200px~~]]	+	==Tic22 from Plasmodium falciparum==
		+	<StructureSection load='4e6z' size='340' side='right' caption='[[4e6z]], [[Resolution\|resolution]] 2.15Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4e6z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E6Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4E6Z FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PFE1460w ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 Plasmodium falciparum 3D7])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e6z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4e6z RCSB], [http://www.ebi.ac.uk/pdbsum/4e6z PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Most plastids proteins are post-translationally imported into organelles through multisubunit translocons. The TIC and TOC complexes perform this role in the two membranes of the plant chloroplast and in the inner two membranes of the apicoplasts of the apicomplexan parasites, T. gondii and P. falciparum. Tic22 is a ubiquitous intermembrane translocon component that interacts with translocating proteins. Here, we demonstrate that T. gondii Tic22 is an apicoplast-localized protein, essential for parasite survival and protein import into the apicoplast stroma. The structure of Tic22 from P. falciparum reveals a fold conserved from cyanobacteria to plants, which displays a non-polar groove on each sides of the molecule. We show that these grooves allow Tic22 to act as a chaperone. General chaperones are common components of protein translocation systems where they maintain cargo proteins in an unfolded conformation during transit. Such a chaperone had not been identified in the intermembrane space of plastids and we propose that Tic22 fulfils this role.

-	~~{{STRUCTURE_4e6z\| PDB=4e6z \| SCENE= }}~~	+	Tic22 is an essential chaperone required for protein import into the apicoplast.,Glaser S, van Dooren GG, Agrawal S, Brooks CF, McFadden GI, Striepen B, Higgins MK J Biol Chem. 2012 Oct 1. PMID:23027875<ref>PMID:23027875</ref>

-	~~===Tic22 from Plasmodium falciparum===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_23027875}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[4e6z]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E6Z OCA].~~	+	</StructureSection>
	[[Category: Plasmodium falciparum 3d7]]		[[Category: Plasmodium falciparum 3d7]]
-	[[Category: Glaser, S.]]	+	[[Category: Glaser, S]]
-	[[Category: Higgins, M K.]]	+	[[Category: Higgins, M K]]
	[[Category: Apicoplast]]		[[Category: Apicoplast]]
	[[Category: Import protein]]		[[Category: Import protein]]
	[[Category: Tic complex]]		[[Category: Tic complex]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 09:54, 5 December 2012

OCA — Wed, 05 Dec 2012 09:54:54 GMT

←Older revision		Revision as of 09:54, 5 December 2012
Line 5:		Line 5:
	===Tic22 from Plasmodium falciparum===		===Tic22 from Plasmodium falciparum===

		+	{{ABSTRACT_PUBMED_23027875}}

	==About this Structure==		==About this Structure==

OCA at 13:49, 8 November 2012

OCA — Thu, 08 Nov 2012 13:49:18 GMT

←Older revision		Revision as of 13:49, 8 November 2012
Line 1:		Line 1:
-	[[Image:4e6z.~~jpg~~\|left\|200px]]	+	[[Image:4e6z.png\|left\|200px]]

	{{STRUCTURE_4e6z\| PDB=4e6z \| SCENE= }}		{{STRUCTURE_4e6z\| PDB=4e6z \| SCENE= }}
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[4e6z]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E6Z OCA].	+	[[4e6z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E6Z OCA].
		+	[[Category: Plasmodium falciparum 3d7]]
	[[Category: Glaser, S.]]		[[Category: Glaser, S.]]
	[[Category: Higgins, M K.]]		[[Category: Higgins, M K.]]

OCA at 07:27, 10 October 2012

OCA — Wed, 10 Oct 2012 07:27:18 GMT

←Older revision		Revision as of 07:27, 10 October 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4e6z.jpg\|left\|200px]]

-	~~The entry~~ 4e6z ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4e6z\| PDB=4e6z \| SCENE= }}

-	~~Authors: Glaser, S., Higgins, M.K.~~	+	===Tic22 from Plasmodium falciparum===

-	~~Description: Tic22~~ from ~~Plasmodium falciparum~~	+
		+	==About this Structure==
		+	[[4e6z]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E6Z OCA].
		+	[[Category: Glaser, S.]]
		+	[[Category: Higgins, M K.]]
		+	[[Category: Apicoplast]]
		+	[[Category: Import protein]]
		+	[[Category: Tic complex]]
		+	[[Category: Transport protein]]

OCA: Protected "4e6z" [edit=sysop:move=sysop]

OCA — Wed, 28 Mar 2012 07:22:52 GMT

Protected "4e6z" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:22, 28 March 2012

OCA: New page: '''Unreleased structure''' The entry 4e6z is ON HOLD until Paper Publication Authors: Glaser, S., Higgins, M.K. Description: Tic22 from Plasmodium falciparum

OCA — Wed, 28 Mar 2012 07:22:51 GMT

New page: '''Unreleased structure''' The entry 4e6z is ON HOLD until Paper Publication Authors: Glaser, S., Higgins, M.K. Description: Tic22 from Plasmodium falciparum

New page

'''Unreleased structure'''

The entry 4e6z is ON HOLD until Paper Publication

Authors: Glaser, S., Higgins, M.K.

Description: Tic22 from Plasmodium falciparum