4ef8 - Revision history

OCA at 14:59, 14 March 2024

OCA — Thu, 14 Mar 2024 14:59:57 GMT

←Older revision		Revision as of 14:59, 14 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ef8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EF8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EF8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ef8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EF8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EF8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0FI:N-PHENYLTHIOFORMAMIDE'>0FI</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.56Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0FI:N-PHENYLTHIOFORMAMIDE'>0FI</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ef8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ef8 OCA], [https://pdbe.org/4ef8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ef8 RCSB], [https://www.ebi.ac.uk/pdbsum/4ef8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ef8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ef8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ef8 OCA], [https://pdbe.org/4ef8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ef8 RCSB], [https://www.ebi.ac.uk/pdbsum/4ef8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ef8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/Q4QEW7_LEIMA Q4QEW7_LEIMA]]	+	[https://www.uniprot.org/uniprot/Q4QEW7_LEIMA Q4QEW7_LEIMA]
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Trypanosomatids consist of a large group of flagellated parasitic protozoa, including parasites from the genera Leishmania and Trypanosoma, responsible for causing infections in millions of humans worldwide and for which currently no appropriate therapy is available. The significance of pyrimidines in cellular metabolism makes their de novo and salvage pathways ideal druggable targets for pharmacological intervention and open an opportunity for pharmaceutical innovation. In the current review, we discuss the merits in targeting the enzyme dihydroorotate dehydrogenase (DHODH), a flavin-dependent enzyme that catalyzes the fourth and only redox step in pyrimidine de novo biosynthesis, as a strategy for the development of efficient therapeutic strategies for trypanosomatid-related diseases. We also describe the advances and perspectives from the structural biology point of view in order to unravel the structure-function relationship of trypanosomatid DHODHs, and to identify and validate target sites for drug development.	+
-		+
-	~~Target sites for the design of anti-trypanosomatid drugs based on the structure of dihydroorotate.,Pinheiro MP, Emery FD, Nonato MC Curr Pharm Des. 2012 Oct 31. PMID:23116399<ref>PMID:23116399</ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 4ef8" style="background-color:#fffaf0;"></div>~~	+

	==See Also==		==See Also==
	*[[Dihydroorotate dehydrogenase 3D structures\|Dihydroorotate dehydrogenase 3D structures]]		*[[Dihydroorotate dehydrogenase 3D structures\|Dihydroorotate dehydrogenase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:08, 28 September 2022

OCA — Wed, 28 Sep 2022 07:08:40 GMT

←Older revision		Revision as of 07:08, 28 September 2022
Line 1:		Line 1:

	==Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with Phenyl isothiocyanate==		==Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with Phenyl isothiocyanate==
-	<StructureSection load='4ef8' size='340' side='right' caption='[[4ef8]], [[Resolution\|resolution]] 1.56Å' scene=''>	+	<StructureSection load='4ef8' size='340' side='right'caption='[[4ef8]], [[Resolution\|resolution]] 1.56Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ef8]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Leima Leima~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EF8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4EF8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ef8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EF8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EF8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0FI:N-PHENYLTHIOFORMAMIDE'>0FI</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0FI:N-PHENYLTHIOFORMAMIDE'>0FI</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ef9\|4ef9]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ef8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ef8 OCA], [https://pdbe.org/4ef8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ef8 RCSB], [https://www.ebi.ac.uk/pdbsum/4ef8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ef8 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHODH, lmjf16.0530, LMJF_16_0530 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5664 LEIMA])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_oxidase_(fumarate) Dihydroorotate oxidase (fumarate)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.98.1 1.3.98.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ef8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ef8 OCA], [~~http~~://pdbe.org/4ef8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ef8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ef8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ef8 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/Q4QEW7_LEIMA Q4QEW7_LEIMA]]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 20:

	==See Also==		==See Also==
-	*[[Dihydroorotate dehydrogenase\|Dihydroorotate dehydrogenase]]	+	*[[Dihydroorotate dehydrogenase 3D structures\|Dihydroorotate dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Leima]]~~	+	[[Category: Large Structures]]
-	~~[[Category: Emery, F S]]~~	+
-	~~[[Category: Nonato, M C]]~~	+
-	~~[[Category: Pinheiro, M P]]~~	+
-	~~[[Category: Dihydroorotate dehydrogenase~~]]	+
	[[Category: Leishmania major]]		[[Category: Leishmania major]]
-	[[Category: ~~Oxidoreductase~~]]	+	[[Category: Emery FS]]
-	[[Category: ~~Oxidoreductase-oxidoreductase inhibitor complex~~]]	+	[[Category: Nonato MC]]
-	[[Category: ~~Phenyl isothiocyanate]]~~	+	[[Category: Pinheiro MP]]
-	~~[[Category: Pyrd~~]]	+

OCA at 20:50, 4 August 2016

OCA — Thu, 04 Aug 2016 20:50:33 GMT

←Older revision		Revision as of 20:50, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with Phenyl isothiocyanate==		==Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with Phenyl isothiocyanate==
	<StructureSection load='4ef8' size='340' side='right' caption='[[4ef8]], [[Resolution\|resolution]] 1.56Å' scene=''>		<StructureSection load='4ef8' size='340' side='right' caption='[[4ef8]], [[Resolution\|resolution]] 1.56Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ef8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Leishmania_major Leishmania major~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EF8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EF8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ef8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leima Leima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EF8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EF8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0FI:N-PHENYLTHIOFORMAMIDE'>0FI</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0FI:N-PHENYLTHIOFORMAMIDE'>0FI</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ef9\|4ef9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ef9\|4ef9]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHODH, lmjf16.0530, LMJF_16_0530 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5664 ~~Leishmania major~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHODH, lmjf16.0530, LMJF_16_0530 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5664 LEIMA])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_oxidase_(fumarate) Dihydroorotate oxidase (fumarate)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.98.1 1.3.98.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_oxidase_(fumarate) Dihydroorotate oxidase (fumarate)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.98.1 1.3.98.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ef8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ef8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ef8 RCSB], [http://www.ebi.ac.uk/pdbsum/4ef8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ef8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ef8 OCA], [http://pdbe.org/4ef8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ef8 RCSB], [http://www.ebi.ac.uk/pdbsum/4ef8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ef8 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ef8" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Leishmania major~~]]	+	[[Category: Leima]]
	[[Category: Emery, F S]]		[[Category: Emery, F S]]
	[[Category: Nonato, M C]]		[[Category: Nonato, M C]]
	[[Category: Pinheiro, M P]]		[[Category: Pinheiro, M P]]
	[[Category: Dihydroorotate dehydrogenase]]		[[Category: Dihydroorotate dehydrogenase]]
		+	[[Category: Leishmania major]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]		[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
	[[Category: Phenyl isothiocyanate]]		[[Category: Phenyl isothiocyanate]]
	[[Category: Pyrd]]		[[Category: Pyrd]]

OCA at 11:37, 21 December 2014

OCA — Sun, 21 Dec 2014 11:37:08 GMT

←Older revision		Revision as of 11:37, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4ef8\| PDB=4ef8 \| SCENE= }}~~	+	==Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with Phenyl isothiocyanate==
-	===Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with Phenyl isothiocyanate===	+	<StructureSection load='4ef8' size='340' side='right' caption='[[4ef8]], [[Resolution\|resolution]] 1.56Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23116399}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4ef8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EF8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EF8 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0FI:N-PHENYLTHIOFORMAMIDE'>0FI</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ef9\|4ef9]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHODH, lmjf16.0530, LMJF_16_0530 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5664 Leishmania major])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_oxidase_(fumarate) Dihydroorotate oxidase (fumarate)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.98.1 1.3.98.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ef8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ef8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ef8 RCSB], [http://www.ebi.ac.uk/pdbsum/4ef8 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Trypanosomatids consist of a large group of flagellated parasitic protozoa, including parasites from the genera Leishmania and Trypanosoma, responsible for causing infections in millions of humans worldwide and for which currently no appropriate therapy is available. The significance of pyrimidines in cellular metabolism makes their de novo and salvage pathways ideal druggable targets for pharmacological intervention and open an opportunity for pharmaceutical innovation. In the current review, we discuss the merits in targeting the enzyme dihydroorotate dehydrogenase (DHODH), a flavin-dependent enzyme that catalyzes the fourth and only redox step in pyrimidine de novo biosynthesis, as a strategy for the development of efficient therapeutic strategies for trypanosomatid-related diseases. We also describe the advances and perspectives from the structural biology point of view in order to unravel the structure-function relationship of trypanosomatid DHODHs, and to identify and validate target sites for drug development.

-	~~==About this Structure==~~	+	Target sites for the design of anti-trypanosomatid drugs based on the structure of dihydroorotate.,Pinheiro MP, Emery FD, Nonato MC Curr Pharm Des. 2012 Oct 31. PMID:23116399<ref>PMID:23116399</ref>
-	~~[[4ef8]] is a 2 chain~~ structure ~~with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Leishmania_major Leishmania major]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4EF8 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group~~=~~"xtra">PMID:023116399</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+
		+	==See Also==
		+	*[[Dihydroorotate dehydrogenase\|Dihydroorotate dehydrogenase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Leishmania major]]		[[Category: Leishmania major]]
-	[[Category: Emery, F S.]]	+	[[Category: Emery, F S]]
-	[[Category: Nonato, M C.]]	+	[[Category: Nonato, M C]]
-	[[Category: Pinheiro, M P.]]	+	[[Category: Pinheiro, M P]]
	[[Category: Dihydroorotate dehydrogenase]]		[[Category: Dihydroorotate dehydrogenase]]
-	[[Category: Leishmania major]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]		[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
	[[Category: Phenyl isothiocyanate]]		[[Category: Phenyl isothiocyanate]]
	[[Category: Pyrd]]		[[Category: Pyrd]]

OCA at 06:33, 20 June 2013

OCA — Thu, 20 Jun 2013 06:33:25 GMT

←Older revision		Revision as of 06:33, 20 June 2013
Line 1:		Line 1:
-	[[Image:4ef8.jpg\|left\|200px]]
-
	{{STRUCTURE_4ef8\| PDB=4ef8 \| SCENE= }}		{{STRUCTURE_4ef8\| PDB=4ef8 \| SCENE= }}
-
	===Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with Phenyl isothiocyanate===		===Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with Phenyl isothiocyanate===
-
	{{ABSTRACT_PUBMED_23116399}}		{{ABSTRACT_PUBMED_23116399}}

	==About this Structure==		==About this Structure==
	[[4ef8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EF8 OCA].		[[4ef8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EF8 OCA].
-	~~[[Category~~: ~~Dihydroorotate oxidase]]~~	+
		+	==Reference==
		+	<ref group="xtra">PMID:023116399</ref><references group="xtra"/><references/>
	[[Category: Leishmania major]]		[[Category: Leishmania major]]
	[[Category: Emery, F S.]]		[[Category: Emery, F S.]]

OCA at 21:07, 12 December 2012

OCA — Wed, 12 Dec 2012 21:07:09 GMT

←Older revision		Revision as of 21:07, 12 December 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4ef8.jpg\|left\|200px]]

-	~~The entry~~ 4ef8 ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4ef8\| PDB=4ef8 \| SCENE= }}

-	~~Authors: Pinheiro, M.P., Emery, F.S., Nonato, M.C.~~	+	===Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with Phenyl isothiocyanate===

-	~~Description: Crystal~~ structure ~~of dihydroorotate dehydrogenase~~ from Leishmania major in complex ~~with~~ Phenyl isothiocyanate	+	{{ABSTRACT_PUBMED_23116399}}
		+
		+	==About this Structure==
		+	[[4ef8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EF8 OCA].
		+	[[Category: Dihydroorotate oxidase]]
		+	[[Category: Leishmania major]]
		+	[[Category: Emery, F S.]]
		+	[[Category: Nonato, M C.]]
		+	[[Category: Pinheiro, M P.]]
		+	[[Category: Dihydroorotate dehydrogenase]]
		+	[[Category: Leishmania major]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
		+	[[Category: Phenyl isothiocyanate]]
		+	[[Category: Pyrd]]

OCA at 07:30, 18 April 2012

OCA — Wed, 18 Apr 2012 07:30:59 GMT

←Older revision		Revision as of 07:30, 18 April 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4ef8 is ON HOLD	+	The entry 4ef8 is ON HOLD until Paper Publication

	Authors: Pinheiro, M.P., Emery, F.S., Nonato, M.C.		Authors: Pinheiro, M.P., Emery, F.S., Nonato, M.C.

	Description: Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with Phenyl isothiocyanate		Description: Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with Phenyl isothiocyanate

OCA: Protected "4ef8" [edit=sysop:move=sysop]

OCA — Wed, 04 Apr 2012 05:51:20 GMT

Protected "4ef8" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:51, 4 April 2012

OCA: New page: '''Unreleased structure''' The entry 4ef8 is ON HOLD Authors: Pinheiro, M.P., Emery, F.S., Nonato, M.C. Description: Crystal structure of dihydroorotate dehydrogenase from Leishmania m...

OCA — Wed, 04 Apr 2012 05:51:19 GMT

New page: '''Unreleased structure''' The entry 4ef8 is ON HOLD Authors: Pinheiro, M.P., Emery, F.S., Nonato, M.C. Description: Crystal structure of dihydroorotate dehydrogenase from Leishmania m...

New page

'''Unreleased structure'''

The entry 4ef8 is ON HOLD

Authors: Pinheiro, M.P., Emery, F.S., Nonato, M.C.

Description: Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with Phenyl isothiocyanate